{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:45:13Z","timestamp":1790779513244,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objective: The simultaneous occurrence of brain aneurysms and brain tumors creates a complicated clinical scenario requiring extensive surgical planning. The study seeks to illuminate the safety, effectiveness, and prospective advantages of combination surgical intervention. Materials and Methods: We analyzed 10 patients concurrently diagnosed with both cerebral aneurysm and meningioma who received simultaneous microsurgical intervention. Clinical and demographic data, encompassing lesion characteristics, surgical specifics, complications, and outcomes, was extracted. The Karnofsky Performance Status Scale (KPS) was utilized to assess functional status preoperatively, after discharge, and during the final follow-up. Descriptive statistics and visualizations were produced via Python tools and libraries. Results: The predominant demographic was female (90%), with a median surgical age of 58 years. All patients presented with WHO Grade 1 meningiomas and predominantly incidental aneurysms, typically situated in the middle cerebral artery. At a median follow-up of 27 months, functional results demonstrated improvement, with 10% of patients reporting tumor recurrence or necessitating resurgery, while the total death rate was 20%. Conclusion: The simultaneous occurrence of intracranial aneurysms and brain tumors is infrequent. This study demonstrates that simultaneous aneurysm clipping and tumor resection with the same method is both viable and secure. A comprehensive evaluation of the patient and an extensively devised surgical plan are essential for the effective management of these complex cases.<\/jats:p>","DOI":"10.3390\/cancers17172908","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T15:31:21Z","timestamp":1756999881000},"page":"2908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Concomitant Intracranial Aneurysm Clipping and Meningioma Resection: Surgical Strategy and Considerations"],"prefix":"10.3390","volume":"17","author":[{"given":"Oday","family":"Atallah","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Evangelic Hospital Oldenburg, Carl Von Ossietzky University Oldenburg, 26111 Oldenburg, Germany"},{"name":"Medical School Hannover, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadeja","family":"Alrefaie","sequence":"additional","affiliation":[{"name":"Kuwait Institute for Medical Specialization, Sulibekhat 15503, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Badary","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University Lausitz, 03048 Cottbus, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"ref_1","first-page":"e8183","article-title":"Contemporaneous Clipping of Unruptured Anterior Cerebral Artery Proximal A1 Segment Aneurysm and Resection of Dural-Based Brain Tumor","volume":"12","author":"Aljuboori","year":"2020","journal-title":"Cureus"},{"key":"ref_2","first-page":"13","article-title":"Magnetic resonance imaging finding of coexistence of bilateral paraclinoid aneurysms in a patient with a nonfunctioning macroadenoma, simultaneous resection, and clipping: Illustrative case","volume":"3","year":"2022","journal-title":"J. Neurosurg. Case Lessons"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4103\/0028-3886.59475","article-title":"Association of meningioma and intracranial aneurysm: Report of five cases and review of literature","volume":"57","author":"Javalkar","year":"2009","journal-title":"Neurol. India"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2176\/nmc.21.601","article-title":"Coexistence of brain tumors and cerebral aneurysms\u2014Clinical considerations from eight cases","volume":"21","author":"Okamura","year":"1981","journal-title":"Neurol. Med. Chir."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/BF02074799","article-title":"Brain tumour associated with intracranial arterial aneurysm","volume":"53","author":"Gokalp","year":"1980","journal-title":"Acta Neurochir."},{"key":"ref_6","first-page":"e52919","article-title":"Co-occurrence of Meningioma and Intracranial Aneurysm: A Systematic Review","volume":"16","author":"Albahrani","year":"2024","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"rjz013","DOI":"10.1093\/jscr\/rjz013","article-title":"Coexistence of intracranial solitary fibrous tumor\/hemangiopericytoma and right middle cerebral artery aneurysm","volume":"2019","author":"Yip","year":"2019","journal-title":"J. Surg. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100031","DOI":"10.1016\/j.wnsx.2019.100031","article-title":"Refractory De Novo Multiple Cerebral Aneurysms After Radiotherapy and Multistaged \u201cOpen\u201d Surgical Treatment for Low-Grade Glioma During Long-Term Follow-Up: A Case Report and Review of the Literature","volume":"3","author":"Maruyama","year":"2019","journal-title":"World Neurosurg. X"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yao, Y., Tong, X., Mei, Y., Yu, F., Shan, Y., Liu, A., and Chen, D. (2022). Hemodynamic indicators of the formation of tandem intracranial aneurysm based on a vascular restoration algorithm. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1010777"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yang, W.H., Yang, Y.H., Chen, P.C., Wang, T.C., Chen, K.J., Cheng, C.Y., and Lai, C.H. (2019). Intracranial aneurysms formation after radiotherapy for head and neck cancer: A 10-year nationwide follow-up study. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5766-2"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wei, R.J., Wu, X.L., Xia, F., and Chen, J.C. (2022). Case report and literature review: Treatment of multiple meningiomas combined with multiple unruptured aneurysms in a single operation. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.971068"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.wneu.2019.05.023","article-title":"Follow-Up and Treatment of Patients with Coexisting Brain Tumor and Intracranial Aneurysm","volume":"129","author":"Lee","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10143-013-0477-7","article-title":"Surgical treatment of brain tumor coexisted with intracranial aneurysm\u2014Case series and review of the literature","volume":"36","author":"Zhong","year":"2013","journal-title":"Neurosurg. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12017-019-08537-7","article-title":"Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms","volume":"21","author":"Xu","year":"2019","journal-title":"Neuromol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pan, T., Shi, Y., Yu, G., Mamtimin, A., and Zhu, W. (2023). Intracranial Aneurysms and Lipid Metabolism Disorders: From Molecular Mechanisms to Clinical Implications. Biomolecules, 13.","DOI":"10.3390\/biom13111652"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5469\/neuroint.2018.01011","article-title":"New Pathophysiological Considerations on Cerebral Aneurysms","volume":"13","author":"Jung","year":"2018","journal-title":"Neurointervention"},{"key":"ref_17","first-page":"1535","article-title":"Asymptomatic unruptured intracranial aneurysms: Approach to screening and treatment","volume":"54","author":"Lysack","year":"2008","journal-title":"Can. Fam. Physician"},{"key":"ref_18","first-page":"141","article-title":"An overview of intracranial aneurysms","volume":"9","author":"Keedy","year":"2006","journal-title":"McGill J. Med."},{"key":"ref_19","unstructured":"Koutsothanasis, G.A., and Sampath, R. (2025). Berry Aneurysm. StatPearls, StatPearls Publishing."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, J., Li, M., Zhu, X., Chen, Y., Zhang, C., Shi, W., Chen, Q., and Wang, Y. (2020). Anterior Communicating Artery Aneurysms: Anatomical Considerations and Microsurgical Strategies. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.01020"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2147\/VHRM.S415213","article-title":"Clinical and Morphological Factors for Ruptured Anterior Communicating Artery Aneurysms","volume":"19","author":"Rilianto","year":"2023","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.7461\/jcen.2023.E2022.11.004","article-title":"Geometric influence of anterior cerebral artery rotation on the formation of anterior communicating artery aneurysm","volume":"25","author":"Heng","year":"2023","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"ref_23","first-page":"451","article-title":"Angiographic and clinical results of anterior communicating artery aneurysm endovascular treatment","volume":"14","author":"Brzegowy","year":"2019","journal-title":"Wideochir Inne Tech. Maloinwazyjne"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Yarabarla, V., Mylarapu, A., Han, T.J., McGovern, S.L., Raza, S.M., and Beckham, T.H. (2023). Intracranial meningiomas: An update of the 2021 World Health Organization classifications and review of management with a focus on radiation therapy. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1137849"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/neuonc\/noae082","article-title":"Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients","volume":"26","author":"Wang","year":"2024","journal-title":"Neuro Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Patel, B., Desai, R., Pugazenthi, S., Butt, O.H., Huang, J., and Kim, A.H. (2022). Identification and Management of Aggressive Meningiomas. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.851758"},{"key":"ref_27","first-page":"118","article-title":"Meningiomas among intracranial neoplasms in Johannesburg, South Africa: Prevalence, clinical observations and review of the literature","volume":"13","author":"Ibebuike","year":"2013","journal-title":"Afr. Health Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.critrevonc.2008.01.010","article-title":"Meningioma","volume":"67","author":"Marosi","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ogasawara, C., Philbrick, B.D., and Adamson, D.C. (2021). Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030319"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101756","DOI":"10.1016\/j.bas.2023.101756","article-title":"The role of extended coagulation screening in adult cranial neurosurgery","volume":"3","author":"Wagner","year":"2023","journal-title":"Brain Spine"},{"key":"ref_31","first-page":"388","article-title":"Relationship Between Brain Tumors and Intracranial Aneurysms: A Systematic Review","volume":"34","author":"Rabello","year":"2024","journal-title":"Turk. Neurosurg."},{"key":"ref_32","first-page":"358","article-title":"Multiple Intracranial Aneurysms Concurrent with a Clinoid Meningioma: A Case Report","volume":"34","author":"Zhou","year":"2024","journal-title":"Turk. Neurosurg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1590\/S0004-282X2005000200028","article-title":"Clip readjustment in aneurysm surgery after flow evaluation using the ultrasonic perivascular probe: Case report","volume":"63","author":"Hoffman","year":"2005","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_34","first-page":"1294","article-title":"Microsurgical clip obliteration of middle cerebral aneurysm using intraoperative flow assessment","volume":"31","author":"Carter","year":"2009","journal-title":"J. Vis. Exp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.25259\/SNI_699_2024","article-title":"Concurrent meningioma and intracranial aneurysm: Insights from an updated systematic review and a case report","volume":"15","author":"McGuire","year":"2024","journal-title":"Surg. Neurol. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/0972-2327.186784","article-title":"Endovascular treatment of unruptured posterior circulation intracranial aneurysms","volume":"19","author":"Lv","year":"2016","journal-title":"Ann. Indian Acad. Neurol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/17\/2908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:39:41Z","timestamp":1760035181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/17\/2908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,4]]},"references-count":36,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cancers17172908"],"URL":"https:\/\/doi.org\/10.3390\/cancers17172908","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,4]]}}}