{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:04:47Z","timestamp":1788447887831,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological Development (CNPq, MCTI, Brazil)","award":["400120\/2023-2"],"award-info":[{"award-number":["400120\/2023-2"]}]},{"name":"National Council for Scientific and Technological Development (CNPq, MCTI, Brazil)","award":["407575\/2024-3"],"award-info":[{"award-number":["407575\/2024-3"]}]},{"name":"National Council for Scientific and Technological Development (CNPq, MCTI, Brazil)","award":["406484\/2022-8"],"award-info":[{"award-number":["406484\/2022-8"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Hepatoblastoma is a rare malignant liver tumor that accounts for 1\u20132% of pediatric cancers. Despite its low incidence, it is a significant cause of cancer-related mortality in early childhood. Methods: This ecological study analyzed hepatoblastoma mortality in Brazilian children and adolescents (2008\u20132023) using data from the Mortality Information System (SIM\/DATASUS). Mortality rates were calculated using official population estimates. Temporal trends were assessed using Prais-Winsten regression. Age and sex differences were analyzed using the chi-square test. Global mortality estimates (2008\u20132021) were obtained from the Global Burden of Disease Study for descriptive comparison. Results: A total of 267 deaths were recorded, most (66.7%) in children aged 0\u20134 years. Males accounted for 61.4% of cases. Although no significant mortality trends were observed for younger age groups, a significant annual decline was found among adolescents aged 15\u201319 years (Annual Percent Change (APC) = \u221238.4%, p = 0.016). Regional disparities were evident, with the Southeast presenting the highest number of deaths. Globally, the estimated number of deaths and age-specific mortality rate (ASMR) decreased over time, particularly among children under five. Conclusions: Hepatoblastoma remains a significant cause of mortality in early childhood. While Brazilian mortality rates remained stable in younger groups, mortality in adolescents showed a marked reduction. Global estimates suggest a progressive reduction in mortality.<\/jats:p>","DOI":"10.3390\/cancers17182970","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:50:04Z","timestamp":1757587804000},"page":"2970","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality Trends in Pediatric Hepatoblastoma: A Brazilian and Global Perspective"],"prefix":"10.3390","volume":"17","author":[{"given":"Raquel Francine Liermann","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"Graduate Program in Health and Environmental Sciences, University of the Joinville Region (UNIVILLE), Joinville 89219-710, SC, Brazil"},{"name":"S\u00e3o Jos\u00e9 City Hospital, Joinville 89202-030, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"S\u00e3o Jos\u00e9 City Hospital, Joinville 89202-030, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Guilherme","family":"Pickler","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"Graduate Program in Health and Environmental Sciences, University of the Joinville Region (UNIVILLE), Joinville 89219-710, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Rosseti","family":"Pedack","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"Graduate Program in Health and Environmental Sciences, University of the Joinville Region (UNIVILLE), Joinville 89219-710, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Evangelista","family":"Garcia","sequence":"additional","affiliation":[{"name":"S\u00e3o Jos\u00e9 City Hospital, Joinville 89202-030, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hercilio","family":"Fronza Junior","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Louise","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"Department of Mechanical Engineering, Center for Technological Sciences, Santa Catarina State University (UDESC), Joinville 89219-710, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1750-9132","authenticated-orcid":false,"given":"Paulo Henrique Condeixa","family":"de Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Graduate Program in Health and Environmental Sciences, University of the Joinville Region (UNIVILLE), Joinville 89219-710, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-2626","authenticated-orcid":false,"given":"B\u00e1rbara Sarni","family":"Sanches","sequence":"additional","affiliation":[{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil"},{"name":"Department of Clinical Medicine, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-3167","authenticated-orcid":false,"given":"Marcelo Gerardin Poirot","family":"Land","sequence":"additional","affiliation":[{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil"},{"name":"Department of Clinical Medicine, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"},{"name":"Martag\u00e3o Gesteira Childcare and Pediatrics Institute, Federal University of Rio de Janeiro (IPPMG-UFRJ), Rio de Janeiro 21941-912, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6016-2261","authenticated-orcid":false,"given":"Rafael","family":"Roesler","sequence":"additional","affiliation":[{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil"},{"name":"Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"},{"name":"Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"},{"name":"Graduate Program in Medical Sciences, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Munhoz","family":"de Paula Alves Coelho","sequence":"additional","affiliation":[{"name":"Department of Scientific Development and Innovation (DECIPE), Center for Anatomo-Pathological Diagnosis (CEDAP), Joinville 89201-330, SC, Brazil"},{"name":"Graduate Program in Health and Environmental Sciences, University of the Joinville Region (UNIVILLE), Joinville 89219-710, SC, Brazil"},{"name":"National Science and Technology Institute for Children\u2019s Cancer Biology and Pediatric Oncology-INCT BioOncoPed, Porto Alegre 90035-003, RS, Brazil"},{"name":"Graduate Program in Medical Sciences, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1053\/j.semdp.2016.12.015","article-title":"Hepatoblastoma","volume":"34","author":"Sharma","year":"2017","journal-title":"Semin. 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