{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:16:13Z","timestamp":1790907373035,"version":"4.1.0"},"reference-count":14,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This perspective provides a short overview of cancer biomarkers, balancing the technical details with the broad implications for biomarker discovery and innovation; early detection and screening; personalized treatment and monitoring; and emerging technologies. It also briefly discusses challenges in their clinical translation while exploring recent advancements and future implications for clinical practice. Finally, we offer thoughts on the role of artificial intelligence (AI) in biomarker development. AI is accelerating the discovery and validation of biomarkers by mining complex datasets, identifying hidden patterns, and improving the predictive accuracy. AI-powered tools enhance image-based diagnostics, automate genomic interpretation, and facilitate real-time monitoring of treatment responses. By integrating multi-omics data, AI offers new avenues for precision medicine and scalable cancer diagnostics, pushing biomarker development into a new era of intelligent, data-driven oncology. This editorial is a reflection on the state of biomarkers based on the contributions to the Special Issue \u201cCancer Biomarkers: Recent Progress, Innovations, and Future Clinical Implications\u201d.<\/jats:p>","DOI":"10.3390\/cancers17182981","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:08:16Z","timestamp":1757678896000},"page":"2981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cancer Biomarkers: Reflection on Recent Progress, Emerging Innovations, and the Clinical Horizon"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-1922","authenticated-orcid":false,"given":"M. Walid","family":"Qoronfleh","sequence":"first","affiliation":[{"name":"Healthcare Research & Policy Division, Q3 Research Institute (QRI), Ypsilanti, MI 48917, USA"},{"name":"Healix Lab, Al Khuwair South, Muscat 123, Oman"},{"name":"AtomGen, Esen\u015fehir Mah. G\u00fcneyli Sokak No:15\/1, 34776 \u00dcmraniye, \u0130stanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-1135","authenticated-orcid":false,"given":"Nader","family":"Al-Dewik","sequence":"additional","affiliation":[{"name":"Department of Research & Pediatrics, Women\u2019s Wellness and Research Center, Hamad Medical Corporation, Doha 00974, Qatar"},{"name":"Genomics and Precision Medicine (GPM), College of Health & Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha 34110, Qatar"},{"name":"Faculty of Health and Social Care Sciences, Kingston University, St. George\u2019s University of London, London KT1 2EE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Al-Dewik, N.I., Younes, S.N., Essa, M.M., Pathak, S., and Qoronfleh, M.W. (2022). Making Biomarkers Relevant to Healthcare Innovation and Precision Medicine. Processes, 10.","DOI":"10.3390\/pr10061107"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","article-title":"Cancer biomarkers: Emerging trends and clinical implications for personalized treatment","volume":"187","author":"Passaro","year":"2024","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1126\/science.aar3247","article-title":"Detection and localization of surgically resectable cancers with a multi-analyte blood test","volume":"359","author":"Cohen","year":"2018","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Linga, B.G., Mohammed, S.G.A.A., Farrell, T., Rifai, H.A., Al-Dewik, N., and Qoronfleh, M.W. (2024). Genomic Newborn Screening for Pediatric Cancer Predisposition Syndromes: A Holistic Approach. Cancers, 16.","DOI":"10.3390\/cancers16112017"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Adhikary, S., Pathak, S., Palani, V., Acar, A., Banerjee, A., Al-Dewik, N.I., Essa, M.M., Mohammed, S.G.A.A., and Qoronfleh, M.W. (2024). Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach. Biomedicines, 12.","DOI":"10.3390\/biomedicines12010217"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41698-025-01020-6","article-title":"Inflammation and limited adaptive immunity predict worse outcomes on immunotherapy in head and neck cancer","volume":"9","author":"Paschold","year":"2025","journal-title":"NPJ Precis Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chenthamara, D., Subramaniam, S., Ramakrishnan, S.G., Krishnaswamy, S., Essa, M.M., Lin, F.H., and Qoronfleh, M.W. (2019). Therapeutic efficacy of nanoparticles and routes of administration. Biomater. Res., 23.","DOI":"10.1186\/s40824-019-0166-x"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2196866","DOI":"10.1080\/16078454.2023.2196866","article-title":"Management of chronic myeloid leukaemia: Current treatment options, challenges, and future strategies","volume":"28","author":"Younes","year":"2023","journal-title":"Hematology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature12065","article-title":"Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA","volume":"497","author":"Murtaza","year":"2013","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Basar, O.Y., Mohammed, S., Qoronfleh, M.W., and Acar, A. (2024). Optimizing cancer therapy: A review of the multifaceted effects of metronomic chemotherapy. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1369597"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.34190\/ejkm.20.3.2968","article-title":"Healthcare fusion: An innovative framework for health information management","volume":"20","author":"Zhai","year":"2022","journal-title":"Electron. J. Knowl. Manag."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhai, K., Yousef, M.S., Mohammed, S., Al-Dewik, N.I., and Qoronfleh, M.W. (2023). Optimizing Clinical Workflow Using Precision Medicine and Advanced Data Analytics. Processes, 11.","DOI":"10.3390\/pr11030939"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Mohammed, S.G.A.A., Qoronfleh, M.W., Acar, A., and Al-Dewik, N.I. (2025). Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine. 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