{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:13:46Z","timestamp":1793812426002,"version":"4.6.1"},"reference-count":46,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MDPI","award":["APC Grant, email sent by John Li the 26th june 2025 (Guest editor Mauro Ragonese)"],"award-info":[{"award-number":["APC Grant, email sent by John Li the 26th june 2025 (Guest editor Mauro Ragonese)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. Methods: Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo radiotherapy, hormone therapy, or transurethral resection of the prostate, and who had a follow-up longer than 12 months were selected. For each patient, a radiology physician evaluated the preoperative magnetic resonance imaging, measuring prostatic and membranous urethral length, classifying prostatic apex according to the Lee Type, and estimating the presence of the median lobe and its intravesical protrusion. Multivariate logistic regression models evaluated the influence of anatomic features measured in magnetic resonance imaging on urinary continence recovery, defined as daily pad usage less than or equal to one, considering age, body mass index, prostate volume, International Prostatic Symptoms Score, the usage of a nerve sparing technique, and the International Society of Urological Pathology classification. Results: A total of 95 patients who underwent robot-assisted radical prostatectomy were enrolled. Median age, median body mass index, and median PSA density were respectively 66 years (62, 70), 26.12 kg\/m2 (23.88, 28.09), and 0.16 ng\/mL\/cc (0.10, 0.26). Patients with urinary continence ranged from 32 (33.7%) at baseline to 93 (97.8%) after one year from surgery. At preoperative magnetic resonance, Lee Type was almost equally distributed, but Type C was less represented (18 patients, 18.9%) and Type D was more frequent (31 patients, 32.2%). Median prostatic urethral length, median membranous urethral length, and median intravesical prostatic protrusion were respectively 36 mm (31, 42), 15 mm (13, 16), and 0 mm (0, 0). Multivariate logistic regression models showed no statistical significance, except for Lee Type C and A comparison at vesical catheter removal after surgery (OR 0.17; 95% CI 0.04\u20130.71; p-value 0.01). Conclusions: The results of this study showed that patients who had Lee Type C might have higher probability of early urinary continence recovery, but no further statistically significant correlations were found.<\/jats:p>","DOI":"10.3390\/cancers17183004","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:51:33Z","timestamp":1757933493000},"page":"3004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preoperative MRI Predictors for Post-Prostatectomy Urinary Incontinence"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-8001","authenticated-orcid":false,"given":"Franco Alchiede","family":"Simonato","sequence":"first","affiliation":[{"name":"Urology Clinic, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-4523","authenticated-orcid":false,"given":"Guglielmo","family":"Mantica","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genoa, 16126 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0900","authenticated-orcid":false,"given":"Martina","family":"Beverini","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Department of Urology, UMC+, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-0758","authenticated-orcid":false,"given":"Francesco","family":"Chierigo","sequence":"additional","affiliation":[{"name":"Department of Urology, ASST Santi Paolo E Carlo, University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Giasotto","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7355-7625","authenticated-orcid":false,"given":"Nicola","family":"Pavan","sequence":"additional","affiliation":[{"name":"Urology Clinic, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-4869","authenticated-orcid":false,"given":"Alchiede","family":"Simonato","sequence":"additional","affiliation":[{"name":"Urology Clinic, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Terrone","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genoa, 16126 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.eururo.2022.12.031","article-title":"Mapping European Association of Urology Guideline Practice Across Europe: An Audit of Androgen Deprivation Therapy Use Before Prostate Cancer Surgery in 6598 Cases in 187 Hospitals Across 31 European Countries","volume":"83","author":"MacLennan","year":"2023","journal-title":"Eur. Urol."},{"key":"ref_2","unstructured":"O\u2019Toole, C.C., Boakye, N.F., Hannigan, A., and Jalali, A. (2025). Clinical impact of MRI-based risk calculators for prostate cancer diagnosis: A systematic review and meta-analysis. Prostate Cancer Prostatic Dis., 1\u201311."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/bju.15935","article-title":"Findings from an international survey of urology trainee experience with prostate biopsy","volume":"131","author":"Brant","year":"2022","journal-title":"BJU Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s00345-018-2599-6","article-title":"Developing a five-step training model for transperineal prostate biopsies in a na\u00efve residents\u2019 group: A prospective observational randomised study of two different techniques","volume":"37","author":"Mantica","year":"2018","journal-title":"World J. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bauckneht, M., Rebuzzi, S.E., Ponzano, M., Borea, R., Signori, A., Frantellizzi, V., Rizzini, E.L., Mascia, M., Lavelli, V., and Miceli, A. (2022). Prognostic Value of the BIO-Ra Score in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Radium-223 after the European Medicines Agency Restricted Use: Secondary Investigations of the Multicentric BIO-Ra Study. Cancers, 14.","DOI":"10.3390\/cancers14071744"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2517583","DOI":"10.1080\/21623945.2025.2517583","article-title":"A nomogram based on radiomic features from peri-prostatic adipose tissue for predicting bone metastasis in first-time diagnosed prostate cancer patients","volume":"14","author":"Liu","year":"2025","journal-title":"Adipocyte"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.ejso.2021.04.033","article-title":"Rotterdam mobile phone app including MRI data for the prediction of prostate cancer: A multicenter external validation","volume":"47","author":"Lombardo","year":"2021","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"ref_8","first-page":"369","article-title":"Urology apps: Overview of current types and use","volume":"73","author":"Mantica","year":"2020","journal-title":"Cent. Eur. J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Telecan, T., Chiorean, A., Sipos-Lascu, R., Caraiani, C., Boca, B., Hendea, R.M., Buliga, T., Andras, I., Crisan, N., and Lupsor-Platon, M. (2025). ISUP Grade Prediction of Prostate Nodules on T2WI Acquisitions Using Clinical Features, Textural Parameters and Machine Learning-Based Algorithms. Cancers, 17.","DOI":"10.3390\/cancers17122035"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fredman, E., Tschernichovsky, R., Shemesh, D., Weinstock-Sabbah, M., Azuz, R.D., Radus, R., Moore, A., and Limon, D. (2025). Stereotactic Radiotherapy to the Prostate and Pelvic Lymph Nodes for High-Risk and Very High-Risk Prostate Cancer in a Setting with a Hydrogel Spacer: A Toxicity Report. Cancers, 17.","DOI":"10.3390\/cancers17121970"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kwon, W.-A., and Joung, J.Y. (2025). T-Cell Engager Therapy in Prostate Cancer: Molecular Insights into a New Frontier in Immunotherapy. Cancers, 17.","DOI":"10.20944\/preprints202505.1265.v1"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sharifi, M., Armstrong, C.M., Ning, S., Leslie, A.R., Schaaf, Z.A., Maine, J.P., Lou, W., Li, P.-K., Xu, H., and Liu, C. (2025). Steroid Sulfatase Regulates Metabolic Reprogramming in Advanced Prostate Cancer. Cancers, 17.","DOI":"10.3390\/cancers17121959"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21037\/amj-20-166","article-title":"Robotic surgery in urology: A narrative review from the beginning to the single-site","volume":"7","author":"Mantica","year":"2022","journal-title":"AME Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Valenzi, F.M., Santarelli, V., Avesani, G., Aljoulani, M., Haberal, H.B., Anguiano, J.R.T., Morgantini, L.A., Calvo, R.S., Biasatti, A., and Fuschi, A. (2025). Single-Port Versus Multi-Port Robotic Radical Prostatectomy in Elderly Patients. Cancers, 17.","DOI":"10.3390\/cancers17111857"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00345-025-05715-0","article-title":"Comparative effectiveness of robot-assisted vs. open prostatectomy: A real-life nationwide study","volume":"43","author":"Robert","year":"2025","journal-title":"World J. Urol."},{"key":"ref_16","first-page":"555","article-title":"Conservative management of urinary incontinence following robot-assisted radical prostatectomy","volume":"72","author":"Marchioni","year":"2020","journal-title":"Minerva Urol. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s11255-015-1019-8","article-title":"MRI factors to predict urinary incontinence after retropubic\/laparoscopic radical prostatectomy","volume":"47","author":"Tienza","year":"2015","journal-title":"Int. Urol. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"108668","DOI":"10.1016\/j.ejrad.2019.108668","article-title":"Predictors of short and long term urinary incontinence after radical prostatectomy in prostate MRI: Significance and reliability of standardized measurements","volume":"120","author":"Sauer","year":"2019","journal-title":"Eur. J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/TCRM.S283305","article-title":"Management of Urinary Incontinence Following Radical Prostatectomy: Challenges and Solutions","volume":"2023","author":"Castellan","year":"2023","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_20","first-page":"81","article-title":"Assessment of Physical Therapy Strategies for Recovery of Urinary Continence after Prostatectomy","volume":"18","author":"Santos","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Szczygielska, D., Knapik, A., Pop, T., Rottermund, J., and Saulicz, E. (2022). The Effectiveness of Pelvic Floor Muscle Training in Men after Radical Prostatectomy Measured with the Insert Test. Int. J. Environ. Res. Public Heal., 19.","DOI":"10.3390\/ijerph19052890"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gurwin, A., Kowalczyk, K., Knecht-Gurwin, K., Stelmach, P., Nowak, \u0141., Krajewski, W., Szyde\u0142ko, T., and Ma\u0142kiewicz, B. (2022). Alternatives for MRI in Prostate Cancer Diagnostics\u2014Review of Current Ultrasound-Based Techniques. Cancers, 14.","DOI":"10.20944\/preprints202203.0273.v1"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Hikita, K., Honda, M., Teraoka, S., Nishikawa, R., Kimura, Y., Tsounapi, P., Iwamoto, H., Morizane, S., and Takenaka, A. (2020). Intravesical prostatic protrusion may affect early postoperative continence undergoing robot-assisted radical prostatectomy. BMC Urol., 20.","DOI":"10.1186\/s12894-020-00740-0"},{"key":"ref_24","first-page":"646","article-title":"Membranous urethral length and urinary incontinence following robot-assisted radical prostatectomy: A systematic review and meta-analysis","volume":"133","author":"Sugrue","year":"2023","journal-title":"BJU Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/bju.13087","article-title":"Preoperative predictive model of recovery of urinary continence after radical prostatectomy","volume":"116","author":"Matsushita","year":"2015","journal-title":"BJU Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.eururo.2016.06.023","article-title":"Preoperative Membranous Urethral Length Measurement and Continence Recovery Following Radical Prostatectomy: A Systematic Review and Meta-analysis","volume":"71","author":"Mungovan","year":"2017","journal-title":"Eur. Urol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.juro.2011.10.143","article-title":"Recovery of Urinary Function After Radical Prostatectomy: Predictors of Urinary Function on Preoperative Prostate Magnetic Resonance Imaging","volume":"187","author":"Matsushita","year":"2012","journal-title":"J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.juro.2006.09.022","article-title":"Open Versus Laparoscopic Radical Prostatectomy: A Prospective Comparison of Postoperative Urinary Incontinence Rates","volume":"177","author":"Jacobsen","year":"2007","journal-title":"J. Urol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.urology.2014.05.052","article-title":"Long-term Outcomes in Severe Lower Urinary Tract Symptoms in Men Undergoing Robotic-assisted Radical Prostatectomy","volume":"84","author":"Gordon","year":"2014","journal-title":"Urology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Gacci, M., De Nunzio, C., Sakalis, V., Rieken, M., Cornu, J.-N., and Gravas, S. (2023). Latest Evidence on Post-Prostatectomy Urinary Incontinence. J. Clin. Med., 12.","DOI":"10.3390\/jcm12031190"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0022-5347(05)64568-5","article-title":"Urinary continence after radical retropubic prosta-tectomy: Relationship with membranous urethral length on preoperative endorectal magnetic resonance imaging","volume":"168","author":"Coakley","year":"2002","journal-title":"J Urol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.urology.2006.01.021","article-title":"Impact of variations in prostatic apex shape on early recovery of urinary continence after radical retropubic prostatectomy","volume":"68","author":"Lee","year":"2006","journal-title":"Urology"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Hoeh, B., Wenzel, M., M\u00fcller, M., Wittler, C., Schlenke, E., Hohenhorst, J.L., K\u00f6llermann, J., Steuber, T., Graefen, M., and Tilki, D. (2022). Urethral Sphincter Length but Not Prostatic Apex Shape in Preoperative MRI Is Associated with Mid-Term Continence Rates after Radical Prostatectomy. Diagnostics, 12.","DOI":"10.3390\/diagnostics12030701"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1007\/s00330-023-10180-7","article-title":"Membranous urethral length measurement on preoperative MRI to predict incontinence after radical prostatectomy: A literature review towards a proposal for measurement standardization","volume":"34","author":"Boellaard","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.euf.2022.01.015","article-title":"Value of Different Magnetic Resonance Imaging-based Measurements of Anatomical Structures on Preoperative Prostate Imaging in Predicting Urinary Continence After Radical Prostatectomy in Men with Prostate Cancer: A Systematic Review and Meta-analysis","volume":"8","author":"Haan","year":"2022","journal-title":"Eur. Urol. Focus."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41391-022-00563-0","article-title":"The role of preoperative prostatic shape in the recovery of urinary continence after robotic radical prostatectomy: A single cohort analysis","volume":"26","author":"Iacovelli","year":"2022","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1148\/radiol.210500","article-title":"Preoperative Prostate MRI Predictors of Urinary Continence Following Radical Prostatectomy","volume":"303","author":"Lamberg","year":"2022","journal-title":"Radiology"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Maruo, M., Goto, Y., Miyazaki, K., Inoue, A., Kurokawa, K., Enomoto, A., Tanaka, S., Katsura, S., Sugawara, S., and Fuse, M. (2024). Novel nerve-sparing robot-assisted radical prostatectomy with endopelvic fascia preservation and long-term outcomes for a single surgeon. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-51598-3"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12957-024-03340-6","article-title":"Is there any difference in urinary continence between bilateral and unilateral nerve sparing during radical prostatectomy? A systematic review and meta-analysis","volume":"22","author":"Xiang","year":"2024","journal-title":"World J. Surg. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.eururo.2014.10.020","article-title":"Preservation of the Neurovascular Bundles Is Associated with Improved Time to Continence After Radical Prostatectomy But Not Long-term Continence Rates: Results of a Systematic Review and Meta-analysis","volume":"68","author":"Reeves","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_41","first-page":"387","article-title":"Predictors of Long-Term Urinary Incontinence After Robot\u2013Assisted Laparoscopic Prostatectomy","volume":"2023","author":"Yamashita","year":"2023","journal-title":"Res. Rep. Urol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000099142","article-title":"Architectonic Arrangement of the Vasa Vasorum of the Human Great Saphenous Vein","volume":"44","author":"Kachlik","year":"2007","journal-title":"J. Vasc. Res."},{"key":"ref_43","first-page":"168","article-title":"Quality of an Informed Consent Prior to a Surgical Intervention","volume":"2","author":"Irem","year":"2015","journal-title":"Patient Saf. Qual. Improv."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Agozzino, E., Borrelli, S., Cancellieri, M., Carfora, F.M., Di Lorenzo, T., and Attena, F. (2018). Does written informed consent adequately inform surgical patients?. BMC Med. Ethics, 20.","DOI":"10.1186\/s12910-018-0340-z"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e030","DOI":"10.1097\/AS9.0000000000000030","article-title":"Improving Surgical Informed Consent","volume":"2","author":"Raper","year":"2021","journal-title":"Ann. Surg. Open"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Convie, L.J., Carson, E., McCusker, D., McCain, R.S., McKinley, N., Campbell, W.J., Kirk, S.J., and Clarke, M. (2020). The patient and clinician experience of informed consent for surgery. BMC Med. Ethics., 21.","DOI":"10.1186\/s12910-020-00501-6"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/18\/3004\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:45:41Z","timestamp":1760035541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/18\/3004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,15]]},"references-count":46,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["cancers17183004"],"URL":"https:\/\/doi.org\/10.3390\/cancers17183004","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,15]]}}}