{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:04:36Z","timestamp":1790910276297,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Florida Health Cancer Center","award":["P30CA247796"],"award-info":[{"award-number":["P30CA247796"]}]},{"name":"Florida Statute \u00a7 381.915","award":["P30CA247796"],"award-info":[{"award-number":["P30CA247796"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: The individual and combined effects of diverse dental problems on site-specific respiratory tract cancer remain insufficiently addressed. This study investigated the associations between six oral conditions\u2014dentures, loose teeth, painful gums, bleeding gums, toothache, and mouth ulcers\u2014and the risk of developing cancers of the lung, bronchus, larynx, and trachea, both individually and collectively. Methods: This prospective cohort study, utilizing baseline data from the UK Biobank, analyzed 438,762 participants aged 40\u201369 years. Multivariable Cox proportional hazards models were employed to estimate hazard ratios (HRs) and 95% CIs for incident respiratory tract cancer associated with individual oral conditions and their cumulative impact. Effect modification by sociodemographics, lifestyle, and underlying medical conditions was further assessed. Results: During the follow-up (median = 11.0 years), 3568 participants developed respiratory tract cancer. After adjusting for confounders, including smoking history, individuals with any oral issues exhibited a 35\u201376% higher risk of respiratory tract cancer (HR [95% CI]: 1.35 [1.25\u20131.46] for the total risk, 1.34 [1.24\u20131.45] for bronchus\/lung cancer, and 1.76 [1.23\u20132.52] for laryngeal cancer). Dentures (1.48 [1.36\u20131.60]), loose teeth (1.36 [1.20\u20131.54]), and painful gums (1.25 [1.04\u20131.50]) had a strong association with respiratory tract cancer. The overall risk escalated progressively with the number of concurrent problems (HR [95% CI] of 1.32 [1.22\u20131.43] for one, 1.42 [1.25\u20131.62] for two, 1.57 [1.23\u20131.98] for three, and 1.71 [1.16\u20132.50] for \u2265four). Associations were pronounced among smokers (p-interaction = 0.002). Conclusions: Poor oral health is linked to a heightened risk of respiratory tract cancer, especially when coupled with smoking, underscoring the importance of oral health promotion in cancer prevention strategies.<\/jats:p>","DOI":"10.3390\/cancers17183028","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:31:41Z","timestamp":1758033101000},"page":"3028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Poor Oral Health and Risk of Respiratory Tract Cancer: A Prospective Cohort Study from the UK Biobank"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-8581","authenticated-orcid":false,"given":"Danting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6368-2684","authenticated-orcid":false,"given":"Hyung-Suk","family":"Yoon","sequence":"additional","affiliation":[{"name":"University of Florida Health Cancer Center, Gainesville, FL 32610, USA"},{"name":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Hashemian","sequence":"additional","affiliation":[{"name":"University of Florida Health Cancer Center, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5687","authenticated-orcid":false,"given":"Young-Rock","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine, Emory University, Atlanta, GA 30322, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-6908","authenticated-orcid":false,"given":"Shama D.","family":"Karanth","sequence":"additional","affiliation":[{"name":"University of Florida Health Cancer Center, Gainesville, FL 32610, USA"},{"name":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"El-Ahmad","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"},{"name":"Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-5648","authenticated-orcid":false,"given":"Qiuyin","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Florida Health Cancer Center, Gainesville, FL 32610, USA"},{"name":"Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-2243","authenticated-orcid":false,"given":"Jae Jeong","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Florida Health Cancer Center, Gainesville, FL 32610, USA"},{"name":"Department of Surgery, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12398","article-title":"Oral Health\u2019s Inextricable Connection to Systemic Health: Special Populations Bring to Bear Multimodal Relationships and Factors Connecting Periodontal Disease to Systemic Diseases and Conditions","volume":"87","author":"Kapila","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bj.2018.12.001","article-title":"Association between Periodontal Pathogens and Systemic Disease","volume":"42","author":"Bui","year":"2019","journal-title":"Biomed. 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