{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:41:41Z","timestamp":1789962101723,"version":"4.0.1"},"reference-count":97,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>For more than 20 years, after the introduction of the first robotic system, research on prostate cancer (PCa) surgery has mainly focused on evaluating outcomes of Robotic-Assisted Radical Prostatectomy (RARP). In the last few years, however, a new generation of innovative techniques, surgical approaches, and expanded indications have emerged. The Single Port (SP) robotic system was the first real hardware innovation in robotic surgery, and has already demonstrated advantages in terms of shorter length of stay, better cosmetic results and reduced postoperative pain. Artificial Intelligence (AI)-powered algorithms are being proposed as reliable tools for surgical assistance, aiding in standardization and mass implementation of robotic training. New surgical indications are emerging on the basis of patient and tumor characteristics. The extensive adoption of PCa screening and the precision of diagnostic tools have increased the rate of PCa diagnoses in a localized stage. Partial prostatectomy, despite needing further validation, has emerged as a safe and minimally invasive treatment option for confined tumors, able to minimize the side effects of prostate surgery. For locally advanced PCa, radioguided surgery has not only enhanced the oncological effectiveness of lymphadenectomy by enabling the precise identification and extraction of pathological lymph nodes, but has also contributed to minimizing the side effects associated with unnecessarily extensive dissections. Finally, in light of the increased efficacy of modern systemic therapies and the longer life expectancy, RP is currently being evaluated for primary tumor management in the metastatic phase. Despite the novelty of the aforementioned treatment options, they are already set to shape the future evolution of PCa management and international guidelines.<\/jats:p>","DOI":"10.3390\/cancers17183053","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:24:25Z","timestamp":1758198265000},"page":"3053","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Latest Advancements and Future Directions in Prostate Cancer Surgery: Reducing Invasiveness and Expanding Indications"],"prefix":"10.3390","volume":"17","author":[{"given":"Valerio","family":"Santarelli","sequence":"first","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"},{"name":"Department of Urology, University of Illinois at Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3168-1435","authenticated-orcid":false,"given":"Roberta","family":"Corvino","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4873-3257","authenticated-orcid":false,"given":"Stefano","family":"Salciccia","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Di Lascio","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-5988","authenticated-orcid":false,"given":"Francesco","family":"Del Giudice","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Di Pierro","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Crivellaro","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Illinois at Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-8056","authenticated-orcid":false,"given":"Alessandro","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. 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