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Aberrant re-expression of FSIP1 and FSIP2, however, has been frequently reported in multiple malignancies, driving oncogenic processes including uncontrolled proliferation, invasion, migration, and metastasis, and correlating with unfavorable clinical outcomes. Their restricted expression in normal tissues, together with their consistent association with poor prognosis across cancer types, highlights their potential as diagnostic biomarkers, therapeutic targets, and prognostic indicators. This review summarizes the structural features and biological functions of the FSIP family, emphasizes recent advances in elucidating their regulatory roles in tumor-associated signaling pathways, and outlines the major challenges and future perspectives in this emerging field.<\/jats:p>","DOI":"10.3390\/cancers17193107","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:43:12Z","timestamp":1758706992000},"page":"3107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The FSIP Family: Roles in Health and Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-8423","authenticated-orcid":false,"given":"Zhan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China"},{"name":"Cancer Stem Cell and Translational Medicine Laboratory, Shengjing Hospital of China Medical University, Shenyang 110022, China"},{"name":"Innovative Cancer Drug Research and Development Engineering Center of Liaoning Province, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mone","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Mount Sinai Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-2839","authenticated-orcid":false,"given":"Caigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110022, China"},{"name":"Cancer Stem Cell and Translational Medicine Laboratory, Shengjing Hospital of China Medical University, Shenyang 110022, China"},{"name":"Innovative Cancer Drug Research and Development Engineering Center of Liaoning Province, Shenyang 110022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7683","DOI":"10.1073\/pnas.1621486114","article-title":"FSIP1 binds HER2 directly to regulate breast cancer growth and invasiveness","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. 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