{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:12:00Z","timestamp":1792145520515,"version":"4.4.0"},"reference-count":101,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health \u201cRicerca Corrente\u2014Linea 2 progetto 3 \u2014INMI L. Spallanzani I.R.C.C.S. funding\u201d"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cancers"],"abstract":"<jats:p>Primary aggressive oral lymphomas (PAOL) are a rare subset of extranodal non-Hodgkin lymphomas arising in the oral cavity without evidence of other systemic involvement at diagnosis. PAOL accounts for only about 2\u20133% of all lymphomas. They most commonly belong to aggressive B-cell subtypes such as Diffuse large B-cell lymphoma (DLBCL) and plasmablastic lymphoma (PBL), with occasional cases of Burkitt lymphoma and T-cell\/NK-cell lymphomas. Clinically, these malignancies often present with non-specific symptoms (e.g., swelling, pain, ulceration, tooth mobility) that mimic benign dental conditions, leading to diagnostic delays. An integrated diagnostic approach\u2014combining thorough oral examination, imaging (CT, MRI, PET), and definitive biopsy with immunohistochemistry and genetic studies\u2014is critical for accurate diagnosis and staging. Treatment typically involves systemic chemotherapy, often combined with rituximab for CD20+ tumors and adjunctive radiotherapy for localized disease. Ongoing research into the genomic and microenvironmental landscape of PAOL is paving the way for novel targeted therapies to improve outcomes. In HIV+ or transplant patients, PAOL are often driven by viral co-infections (EBV, HHV-8) and may require tailored therapy, including optimization of immune status. The dentist\u2019s role encompasses not only diagnosis but also active participation in cancer therapy through preventive and supportive dental care, and persists thereafter by monitoring for recurrence and treating chronic treatment sequelae. This review provides a comprehensive overview of PAOL\u2018s epidemiology, clinical-pathologic and molecular features, current and emerging treatments, and the essential collaborative role of dentists and hematologists in patient care.<\/jats:p>","DOI":"10.3390\/cancers17193138","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T14:50:38Z","timestamp":1758898238000},"page":"3138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary Aggressive Oral Lymphomas (PAOL): A Narrative Review of Diagnosis, Molecular Features, Therapeutic Approaches, and the Integrated Role of Dentists and Hematologists"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-7759","authenticated-orcid":false,"given":"Michele","family":"Bibas","sequence":"first","affiliation":[{"name":"Department of Clinical Research: Hematology, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d I.R.C.S.S., 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilloni","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmondo","family":"Maggio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-4684","authenticated-orcid":false,"given":"Andrea","family":"Antinori","sequence":"additional","affiliation":[{"name":"Department of Clinical Research: Infectious Diseases, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d I.R.C.S.S., 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-7504","authenticated-orcid":false,"given":"Valentina","family":"Mazzotta","sequence":"additional","affiliation":[{"name":"Department of Clinical Research: Infectious Diseases, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d I.R.C.S.S., 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Barone, S., Buffone, C., Ferrillo, M., Pasqua, F., Parrotta, S., Salviati, M., Bennardo, F., and Antonelli, A. (2022). Oral Malignant Non-Hodgkin Lymphoma: A Retrospective Single-Center Study. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19052605"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3332\/ecancer.2016.665","article-title":"Oral manifestations of lymphoma: A systematic review","volume":"10","author":"Silva","year":"2016","journal-title":"Ecancermedicalscience"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kijowska, J., Grzegorczyk, J., Gliwa, K., J\u0119dras, A., and Sitarz, M. (2024). Epidemiology, Diagnostics, and Therapy of Oral Cancer-Update Review. Cancers, 16.","DOI":"10.3390\/cancers16183156"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S1368-8375(00)00047-6","article-title":"Oral mucosal non-Hodgkin\u2019s lymphoma\u2014A dangerous mimic","volume":"36","author":"Richards","year":"2000","journal-title":"Oral Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"bcr2016218686","DOI":"10.1136\/bcr-2016-218686","article-title":"Lymphoma presenting as a toothache: A wolf in sheep\u2019s clothing","volume":"2017","author":"Hassona","year":"2017","journal-title":"BMJ Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1051\/mbcb\/2025007","article-title":"Extra-nodal non-Hodgkin\u2019s lymphoma (ENHL) affecting oral cavity misinterpreted as painful dental infection, delaying diagnosis\u2014Case report","volume":"31","author":"Bugueno","year":"2025","journal-title":"J. Oral Med. Oral Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tripleo.2007.02.019","article-title":"Oral non-Hodgkin\u2019s lymphoma: Review of the literature and World Health Organization classification with reference to 40 cases","volume":"105","author":"Kemp","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1067\/moe.2001.116062","article-title":"Characteristics of oral and paraoral malignant lymphoma: A population-based review of 361 cases","volume":"92","author":"Epstein","year":"2001","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tripleo.2004.03.028","article-title":"Localized B-cell non-Hodgkin\u2019s lymphoma of oral cavity and maxillofacial region: A clinical study","volume":"99","author":"Kolokotronis","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1016\/j.joms.2012.01.018","article-title":"Extranodal non-hodgkin lymphomas of the oral cavity and maxillofacial region: A clinical study of 58 cases and review of the literature","volume":"70","author":"Triantafillidou","year":"2012","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bibas, M., Antinori, A., Mazzotta, V., Marafioti, T., and Castillo, J.J. (2025). The Genetic and Epigenetic Alterations of Plasmablastic Lymphoma: A Narrative Review. Cancers, 17.","DOI":"10.3390\/cancers17121914"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e2024007","DOI":"10.4084\/MJHID.2024.007","article-title":"Plasmablastic Lymphoma. A State-of-the-Art Review: Part 1-Epidemiology, Pathogenesis, Clinicopathologic Characteristics, Differential Diagnosis, Prognostic Factors, and Special Populations","volume":"16","author":"Bibas","year":"2024","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1182\/blood-2014-10-567479","article-title":"The biology and treatment of plasmablastic lymphoma","volume":"125","author":"Castillo","year":"2015","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1177\/0194599817707208","article-title":"Posttransplant Lymphoproliferative Disorder: Otolaryngological Manifestations and Management","volume":"157","author":"Heyes","year":"2017","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.oooo.2024.08.011","article-title":"Oral manifestations of peripheral T cell lymphoma, not otherwise specified: Case series and review of the current literature","volume":"139","author":"Penafort","year":"2025","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/jop.13211","article-title":"Oral and oropharyngeal lymphomas: A multi-institutional collaborative study","volume":"50","author":"Schuch","year":"2021","journal-title":"J. Oral Pathol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00405-019-05544-z","article-title":"Oral lesion as the primary diagnosis of non-Hodgkin\u2019s lymphoma: A 20-year experience from an oral pathology service and review of the literature","volume":"276","author":"Kusuke","year":"2019","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.oooo.2023.03.011","article-title":"Clinical diagnostic approach for oral lymphomas: A multi-institutional, observational study based on 107 cases","volume":"136","author":"Vargas","year":"2023","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jfma.2020.05.025","article-title":"Clinical manifestations of oral lymphomas\u2014Retrospective study of 15 cases in a Taiwanese population and a review of 592 cases from the literature","volume":"120","author":"Tseng","year":"2021","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of Mature Lymphoid Neoplasms: A report from the Clinical Advisory Committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.blre.2016.09.004","article-title":"High grade B-cell lymphoma with rearrangements of MYC and BCL2 and\/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma","volume":"31","author":"Rosenthal","year":"2017","journal-title":"Blood Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.18632\/oncotarget.6262","article-title":"Prognostic impact of concurrent MYC and BCL6 rearrangements and expression in de novo diffuse large B-cell lymphoma","volume":"7","author":"Ye","year":"2016","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1182\/blood-2017-04-737320","article-title":"How I treat double-hit lymphoma","volume":"130","author":"Friedberg","year":"2017","journal-title":"Blood"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41375-019-0691-6","article-title":"Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC\/BCL2 double-hit","volume":"34","author":"Cucco","year":"2020","journal-title":"Leukemia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pathol.2023.12.001","article-title":"Predictive and prognostic molecular biomarkers in lymphomas","volume":"56","author":"Iorgulescu","year":"2024","journal-title":"Pathology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5948170","DOI":"10.1155\/2024\/5948170","article-title":"Advancements in B-Cell Non-Hodgkin\u2019s Lymphoma: From Signaling Pathways to Targeted Therapies","volume":"2024","author":"Alfaifi","year":"2024","journal-title":"Adv. Hematol."},{"key":"ref_28","first-page":"1043","article-title":"A genetic profiling guideline to support diagnosis and clinical management of lymphomas","volume":"26","author":"Guirado","year":"2024","journal-title":"Clin. Transl. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"156036","DOI":"10.1016\/j.prp.2025.156036","article-title":"B-cell lymphoma: Advances in pathogenesis, diagnosis, and targeted therapies","volume":"271","author":"Patil","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"ref_30","first-page":"e2009032","article-title":"EBV and HIV-Related Lymphoma","volume":"1","author":"Bibas","year":"2009","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Alibrahim, M.N., Gloghini, A., and Carbone, A. (2025). Immune Deficiency\/Dysregulation-Associated EBV-Positive Classic Hodgkin Lymphoma. Cancers, 17.","DOI":"10.3390\/cancers17091433"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41392-025-02197-9","article-title":"Viral oncogenesis in cancer: From mechanisms to therapeutics","volume":"10","author":"Xiao","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"110544","DOI":"10.1016\/j.virol.2025.110544","article-title":"Understanding EBV infection and EBV-associated lymphomas in children","volume":"608","author":"Chabay","year":"2025","journal-title":"Virology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00000478-200401000-00003","article-title":"Oral plasmablastic lymphomas in AIDS patients are associated with human herpesvirus 8","volume":"28","author":"Cioc","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/CCO.0000000000000884","article-title":"HHV-8 associated lymphoma","volume":"34","author":"Oksenhendler","year":"2022","journal-title":"Curr. Opin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/ijc.30518","article-title":"Periodontal disease and risk of non-Hodgkin lymphoma in the Health Professionals Follow-Up Study","volume":"140","author":"Bertrand","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_37","first-page":"173","article-title":"Evidence accumulates indicating periodontal disease as a risk factor for colorectal cancer or lymphoma","volume":"67","author":"Barton","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_38","first-page":"5","article-title":"Staging and response assessment in lymphomas: The new Lugano classification","volume":"4","author":"Cheson","year":"2015","journal-title":"Chin. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.3324\/haematol.2023.284070","article-title":"The International Prognostic Index in aggressive B-cell lymphoma","volume":"108","author":"Maurer","year":"2023","journal-title":"Haematologica"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Imbesi Bellantoni, M., Picciolo, G., Pirrotta, I., Irrera, N., Vaccaro, M., Vaccaro, F., Squadrito, F., and Pallio, G. (2023). Oral Cavity Squamous Cell Carcinoma: An Update of the Pharmacological Treatment. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041112"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.4103\/jomfp.jomfp_398_21","article-title":"Plasma cells in oral lesion: A clue to diagnosis or a diagnostic dilemma","volume":"26","author":"Kaur","year":"2022","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.12998\/wjcc.v12.i32.6526","article-title":"Diagnostic and therapeutic challenges of myeloid sarcoma in the oral cavity","volume":"12","year":"2024","journal-title":"World J. Clin. Cases"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/hematolrep15030051","article-title":"Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia","volume":"15","author":"Soares","year":"2023","journal-title":"Hematol. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.adaj.2024.10.009","article-title":"An unusual oral manifestation of chronic lymphocytic leukemia: A case report and review of the literature","volume":"156","author":"Lodolo","year":"2025","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/hon.2865","article-title":"Low grade, indolent lymphomas of the head and neck: Comparative toxicity of standard versus very low dose radiation therapy","volume":"39","author":"Chelius","year":"2021","journal-title":"Hematol. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1610-0387.2007.06625.x","article-title":"Reactive hyperplasias, precancerous and malignant lesions of the oral mucosa","volume":"6","author":"Krahl","year":"2008","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12105-024-01678-7","article-title":"Causes of Oral Granulomatous Disorders: An Update and Narrative Review of the Literature","volume":"18","author":"Alamoudi","year":"2024","journal-title":"Head Neck Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/00325481.2022.2134624","article-title":"Eosinophilic granulomatosis with polyangiitis","volume":"135","year":"2023","journal-title":"Postgrad. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1601-0825.2005.01014.x","article-title":"Oral sarcoidosis: A review of literature","volume":"11","author":"Suresh","year":"2005","journal-title":"Oral Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/jop.13207","article-title":"Langerhans cell histiocytosis in the oral and maxillofacial region: An update","volume":"50","author":"Faustino","year":"2021","journal-title":"J. Oral Pathol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jamadermatol.2018.4079","article-title":"Oral Kaposi Sarcoma","volume":"155","author":"Sanchez","year":"2019","journal-title":"JAMA Dermatol."},{"key":"ref_52","first-page":"815","article-title":"Primary oral melanoma: A clinicopathologic review and case presentation","volume":"48","author":"Reis","year":"2017","journal-title":"Quintessence Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5005\/jp-journals-10024-1526","article-title":"Metastatic tumors of the oral cavity","volume":"15","author":"Rao","year":"2014","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1182\/blood.2021013998","article-title":"Limited-stage diffuse large B-cell lymphoma","volume":"139","author":"Hawkes","year":"2022","journal-title":"Blood"},{"key":"ref_55","first-page":"718","article-title":"The Evolving Role of Radiation Therapy in DLBCL: From Early-Stage to Refractory Disease","volume":"36","author":"Jones","year":"2022","journal-title":"Oncology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5045\/br.2021.2021164","article-title":"Clinical characteristics and treatment outcomes of children and adolescents with aggressive mature B-cell lymphoma: A single-center analysis","volume":"57","author":"Jeon","year":"2022","journal-title":"Blood Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s44276-024-00087-1","article-title":"CNS prophylaxis is (mostly) futile in DLBCL","volume":"2","author":"Shieh","year":"2024","journal-title":"BJC Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1056\/NEJM199807023390104","article-title":"Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin\u2019s lymphoma","volume":"339","author":"Miller","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1200\/JCO.2007.13.6929","article-title":"Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma: Southwest Oncology Group study 0014","volume":"26","author":"Persky","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1182\/blood-2017-07-793984","article-title":"R-CHOP 14 with or without radiotherapy in nonbulky limited-stage diffuse large B-cell lymphoma","volume":"131","author":"Lamy","year":"2018","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/S0140-6736(19)33008-9","article-title":"Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): A randomised, phase 3, non-inferiority trial","volume":"394","author":"Poeschel","year":"2019","journal-title":"Lancet"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"67","DOI":"10.6004\/jadpro.2023.14.1.6","article-title":"Polatuzumab Vedotin for the Front-Line Treatment of Diffuse Large B-Cell Lymphoma: A New Standard of Care?","volume":"14","author":"Davis","year":"2023","journal-title":"J. Adv. Pract. Oncol."},{"key":"ref_63","unstructured":"National Comprehensive Cancer Network (NCCN) (2025, February 10). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): B-Cell Lymphomas. Version 2.2025. Available online: https:\/\/www.nccn.org\/login?ReturnURL=https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/b-cell_blocks.pdf."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.20892\/j.issn.2095-3941.2022.0403","article-title":"Update on diffuse large B-cell lymphoma: Highlights from the 2022 ASCO Annual Meeting","volume":"19","author":"Minghan","year":"2022","journal-title":"Cancer Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/ajh.27376","article-title":"Plasmablastic lymphoma: 2024 update on diagnosis, risk stratification, and management","volume":"99","author":"Florindez","year":"2024","journal-title":"Am. J. Hematol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ajh.26784","article-title":"Outcomes of patients with limited-stage plasmablastic lymphoma: A multi-institutional retrospective study","volume":"98","author":"Hess","year":"2023","journal-title":"Am. J. Hematol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e2024015","DOI":"10.4084\/MJHID.2024.015","article-title":"Plasmablastic Lymphoma. A State-of-the-Art Review: Part 2-Focus on Therapy","volume":"16","author":"Bibas","year":"2024","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e138","DOI":"10.1016\/S2352-3026(24)00351-X","article-title":"Diagnosis and treatment of Burkitt lymphoma in adults: Clinical practice guidelines from ERN-EuroBloodNet","volume":"12","author":"Ribrag","year":"2025","journal-title":"Lancet Haematol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/CM9.0000000000001386","article-title":"Treatment outcome in children with central nervous system-positive Burkitt lymphoma using only intrathecal and systemic chemotherapy combined with rituximab","volume":"134","author":"Huang","year":"2021","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.annonc.2025.01.023","article-title":"Peripheral T- and natural killer-cell lymphomas: ESMO-EHA Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"36","author":"Federico","year":"2025","journal-title":"Ann. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Sorigue, M., and Kuittinen, O. (2022). Controversies in the Front-Line Treatment of Systemic Peripheral T Cell Lymphomas. Cancers, 15.","DOI":"10.3390\/cancers15010220"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ajh.26803","article-title":"Outcome of limited-stage peripheral T-Cell lymphoma after CHOP(-like) therapy: A population based study of 239 patients from the Nordic lymphoma epidemiology group","volume":"98","author":"Cederleuf","year":"2023","journal-title":"Am. J. Hematol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0140-6736(18)32984-2","article-title":"Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): A global, double-blind, randomised, phase 3 trial","volume":"393","author":"Horwitz","year":"2019","journal-title":"Lancet"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.annonc.2021.12.002","article-title":"The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma","volume":"33","author":"Horwitz","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_75","unstructured":"(2025, May 28). NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): T-Cell Lymphomas. Version 2.2025. Available online: https:\/\/www.nccn.org\/login?ReturnURL=https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/t-cell_blocks.pdf."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1182\/blood-2012-12-475558","article-title":"Trends in survival of patients with Burkitt lymphoma\/leukemia in the USA: An. analysis of 3691 cases","volume":"121","author":"Costa","year":"2013","journal-title":"Blood"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1182\/blood.2020006926","article-title":"Burkitt lymphoma in the modern era: Real-world outcomes and prognostication across 30 US cancer centers","volume":"137","author":"Evens","year":"2021","journal-title":"Blood"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s12105-020-01182-8","article-title":"Extranodal NK\/T Cell Lymphoma, Nasal Type with Palatal Involvement: A Rare Case Report and Literature Review","volume":"15","author":"Andreou","year":"2021","journal-title":"Head Neck Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1843::AID-CNCR26>3.0.CO;2-R","article-title":"A prospective pilot study to evaluate a new dental assessment and treatment paradigm for patients scheduled to undergo intensive chemotherapy for cancer","volume":"85","author":"Toljanic","year":"1999","journal-title":"Cancer"},{"key":"ref_80","first-page":"400","article-title":"Oral complications of cancer and cancer therapy: From cancer treatment to survivorship","volume":"62","author":"Epstein","year":"2012","journal-title":"CA Cancer J. Clin."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"105604","DOI":"10.1016\/j.oraloncology.2021.105604","article-title":"Clinical practice guidelines for dental management prior to radiation for head and neck cancer","volume":"123","author":"Watson","year":"2021","journal-title":"Oral Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cden.2007.10.003","article-title":"Dental treatment planning and management in the patient who has cancer","volume":"52","author":"Brennan","year":"2008","journal-title":"Dent. Clin. N. Am."},{"key":"ref_83","first-page":"314","article-title":"A retrospective cohort study of the oral healthcare needs of cancer patients","volume":"33","author":"Beaumont","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.oraloncology.2014.11.017","article-title":"Evidence supporting pre-radiation elimination of oral foci of infection in head and neck cancer patients to prevent oral sequelae. A systematic review","volume":"51","author":"Schuurhuis","year":"2015","journal-title":"Oral Oncol."},{"key":"ref_85","first-page":"2473","article-title":"Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines","volume":"28","author":"Saunders","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_86","first-page":"3949","article-title":"Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines","volume":"27","author":"Hong","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1002\/cncr.33100","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"126","author":"Elad","year":"2020","journal-title":"Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.2147\/JPR.S533351","article-title":"Addressing Pain in Oral Mucositis: Narrative Review of Current Practices and Emerging Treatments","volume":"18","author":"Villa","year":"2025","journal-title":"J. Pain Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Cronshaw, M., Parker, S., Anagnostaki, E., Mylona, V., Lynch, E., and Grootveld, M. (2020). Photobiomodulation and Oral Mucositis: A Systematic Review. Dent. J., 8.","DOI":"10.3390\/dj8030087"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13256-025-05180-8","article-title":"Oral ulcers in hematological malignancy patients undergoing chemotherapy: Is it chemotherapy or neutropenia?: A case report and review of the literature","volume":"19","author":"Martini","year":"2025","journal-title":"J. Med. Case Rep."},{"key":"ref_91","first-page":"71","article-title":"Candida infections among neutropenic patients","volume":"7","author":"Mohammadi","year":"2016","journal-title":"Casp. J. Intern. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Kishimoto, M., Akashi, M., Tsuji, K., Kusumoto, J., Furudoi, S., Shibuya, Y., Inui, Y., Yakushijin, K., Kawamoto, S., and Okamura, A. (2017). Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182021"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.hemonc.2021.01.006","article-title":"Current Practice of Oral Care for Hematopoietic Stem Cell Transplant Patients: A Survey of the Eastern Mediterranean Blood and Marrow Transplantation Group","volume":"16","author":"Mawardi","year":"2023","journal-title":"Hematol. Oncol. Stem Cell Ther."},{"key":"ref_94","first-page":"9141","article-title":"The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation","volume":"30","author":"Nakagaki","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/s40001-024-02167-x","article-title":"Cancer treatment-related xerostomia: Basics, therapeutics, and future perspectives","volume":"29","author":"Hosseini","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_96","first-page":"305","article-title":"Radiation-induced trismus in head and neck cancer patients","volume":"16","author":"Brennan","year":"2008","journal-title":"Support. Care Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Singh, A., Huryn, J.M., Kronstadt, K.L., Yom, S.K., Randazzo, J.R., and Estilo, C.L. (2022). Osteoradionecrosis of the jaw: A mini review. Front. Oral Health, 3.","DOI":"10.3389\/froh.2022.980786"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"lgz007","DOI":"10.1093\/jncimonographs\/lgz007","article-title":"Oral Complications of Chronic Graft-Versus-Host Disease","volume":"2019","author":"Pavletic","year":"2019","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"973","DOI":"10.5306\/wjco.v5.i5.973","article-title":"Radiation-induced sarcomas of the head and neck","volume":"5","author":"Thiagarajan","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","article-title":"Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: Definition and management of the risk related to zoledronic acid","volume":"8","author":"Cafro","year":"2008","journal-title":"Clin. Lymphoma Myeloma"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.sdentj.2022.01.003","article-title":"Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review of Pathophysiology, Risk Factors, Preventive Measures and Treatment Strategies","volume":"34","author":"AlRowis","year":"2022","journal-title":"Saudi Dent. 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