{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:58:25Z","timestamp":1791032305863,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Breast reconstruction following mastectomy has become an essential procedure in breast cancer treatment due to its positive impact on patients\u2019 quality of life. Among the various reconstruction techniques, the use of expanders followed by implants has gained popularity. In this context, acellular dermal matrices (ADM) have been introduced as an adjunct to improve implant coverage, lower pole support, and aesthetic outcomes. However, their use has also been associated with higher costs and a potential increase in postoperative complications, which remains a matter of debate. We aimed to determine the relationship between acellular dermal matrix and postoperative outcomes and complications. Methods: An observational retrospective study was conducted with patients who underwent immediately breast mastectomy followed by tissue expander reconstruction from January 2022 to June 2024. Patients were divided into two groups depending on reconstructive plane. Results: The final cohort contained 87 patients. Smoking, radiotherapy and dermal matrix were associated with a higher complication rates. After risk-adjustment, dermal matrix use led to a higher rates of surgical site infection (OR 7.62, p = 0.029) in the prepectoral plane, and higher rates of overall complications (OR 3.34, p = 0.05) and surgical wound dehiscence (OR 6.04, p = 0.048) in the retropectoral plane. Conclusions: These findings highlight the importance of individualized surgical planning, particularly concerning the use of acellular dermal matrix, which were associated with increased risks of surgical site infection, dehiscence, and global complications. Further research is required to establish standardized guidelines for the optimal selection surgical technique.<\/jats:p>","DOI":"10.3390\/cancers17193185","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:54:48Z","timestamp":1759229688000},"page":"3185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Acellular Dermal Matrix in Postoperative Outcomes in Tissue Expander Breast Reconstruction After Immediate Mastectomy"],"prefix":"10.3390","volume":"17","author":[{"given":"\u00d3scar","family":"Nova-Tayant","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Saor\u00edn-Gasc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n A.","family":"Moreno-Villalba","sequence":"additional","affiliation":[{"name":"Breast Unit Surgery, Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s\/n, El Palmar, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Mora-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemente J.","family":"Fern\u00e1ndez-Pascual","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4072-3046","authenticated-orcid":false,"given":"Pablo J.","family":"Vera-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-8318","authenticated-orcid":false,"given":"Antonio","family":"Pi\u00f1ero-Madrona","sequence":"additional","affiliation":[{"name":"Breast Unit Surgery, Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s\/n, El Palmar, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"ref_1","first-page":"457","article-title":"Breast reconstruction with breast implants","volume":"89","author":"Michele","year":"2018","journal-title":"Acta Biomed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1055\/s-2004-829040","article-title":"History of Breast Reconstruction","volume":"18","author":"Uroskie","year":"2004","journal-title":"Semin Plast. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manrique, O.J., Charafeddine, A., Abu-Ghname, A., Banuelos, J., Jacobson, S.R., Martinez-Jorge, J., Nguyen, M.-D., Harless, C., Tran, N.V., and Sharaf, B. (2019). Two-Staged Implant-Based Breast Reconstruction: A Long-Term Outcome Study in a Young Population. 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