{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:37:41Z","timestamp":1776105461018,"version":"3.50.1"},"reference-count":83,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: A wide percentage (25\u201340%) of patients affected by head and neck squamous cell carcinoma (HNSCC) are over 70 years old, and they present with different characteristics if compared to younger patients. Elderly patients often receive less intensive, non-surgical, and non-multimodal treatments. Although age does not mean frailty, the elderly are at a higher risk of developing toxicity. In fact, several studies enrolling patients treated with cisplatin + radiotherapy (CISPLATIN + RT) or cetuximab + radiotherapy (Cet + RT) showed reduced efficacy over 65 years. Methods: We conducted a multicenter retrospective analysis in patients with Locally Advanced HNSCC aged over 65 years, who underwent Cet-RT, diagnosed in the period between 2017 and 2024. The primary endpoint was to describe Overall Survival (OS), the secondary endpoints were Progression Free Survival (PFS) and the percentage and type of Adverse Events (AEs). Patients received a geriatric assessment using the G8 questionnaire. Results: Data regarding Eighty-Two (82) patients were analyzed, median age was 74 years (range 65\u201384), most patients had oral cavity (26.8%) and laryngeal cancer (37.8%). Fifty-six point one (56.1%) of patients were smokers, and 17.1% reported alcohol consumption. All patients completed radiotherapy, and 80.5% of them developed AEs, which in 25.6% of cases were G3\u20134 toxicities. No relationship was found between G3\u20134 AEs and age (p = 0.596), G8score &lt; 14 (p = 0.804), and smoking (p = 0.245)\/drinking habits (p = 0.341). Median OS was 58 months, with a slightly non-significant positive trend in OS for patients who were non-smokers and those who did not develop G3\u20134 AEs (p = 0.786 and 0.799, respectively). Association between folliculitis and OS was statistically significant (p = 0.001). Conclusions: In elderly patients, Cet-RT represents a feasible, well-tolerated option, although further prospective studies are needed.<\/jats:p>","DOI":"10.3390\/cancers17213550","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:40:48Z","timestamp":1762180848000},"page":"3550","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Retrospective Trial on Cetuximab Plus Radiotherapy in Elderly Patients with Head and Neck Squamous Cell Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0782-8778","authenticated-orcid":false,"given":"Morena","family":"Fasano","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8158-7509","authenticated-orcid":false,"given":"Francesco","family":"Perri","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Unit, Istituto Nazionale Tumori di Napoli IRCCS \u201cG. Pascale\u201d, Via Semmola 53, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pirozzi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine (DIMET), University of Eastern Piedmont (UPO), 28100 Novara, Italy"},{"name":"SCDU Oncologia, AOU Maggiore della Carit\u00e0 di Novara, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-0316","authenticated-orcid":false,"given":"Chiara Lucrezia","family":"Deantoni","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Emergency Department, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-9569","authenticated-orcid":false,"given":"Alessio","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Pathological Sciences, Sapienza University, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-8060","authenticated-orcid":false,"given":"Raffaele","family":"Addeo","sequence":"additional","affiliation":[{"name":"Oncology Operative Unit, Hospital of Frattamaggiore, ASL Napoli 2 Nord, Via D. Pirozzi 66, Frattamaggiore, 80027 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Vitale","sequence":"additional","affiliation":[{"name":"Oncology Operative Unit, Hospital of Frattamaggiore, ASL Napoli 2 Nord, Via D. Pirozzi 66, Frattamaggiore, 80027 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-8358","authenticated-orcid":false,"given":"Francesca","family":"De Felice","sequence":"additional","affiliation":[{"name":"Department of Radiological, Oncological and Pathological Sciences, Sapienza University, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tralongo","sequence":"additional","affiliation":[{"name":"UOC Oncologia Medica, Ospedale Umberto I, Via Giuseppe Testaferrata 1, 96100 Siracusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Farese","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Ruffilli","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine (DIMET), University of Eastern Piedmont (UPO), 28100 Novara, Italy"},{"name":"SCDU Oncologia, AOU Maggiore della Carit\u00e0 di Novara, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Romano","sequence":"additional","affiliation":[{"name":"UOC Oncologia Medica, Ospedale Umberto I, Via Giuseppe Testaferrata 1, 96100 Siracusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilda","family":"Guizzardi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-4205","authenticated-orcid":false,"given":"Leone","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Pontone","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Unit, Istituto Nazionale Tumori di Napoli IRCCS \u201cG. Pascale\u201d, Via Semmola 53, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-1022","authenticated-orcid":false,"given":"Maria Luisa","family":"Marciano","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Unit, Istituto Nazionale Tumori di Napoli IRCCS \u201cG. Pascale\u201d, Via Semmola 53, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Raffaella","family":"Rampetta","sequence":"additional","affiliation":[{"name":"Head and Neck Oncology Unit, Istituto Nazionale Tumori di Napoli IRCCS \u201cG. Pascale\u201d, Via Semmola 53, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-2953","authenticated-orcid":false,"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[{"name":"Otolaryngology and MaxilloFacial Unit, INT IRCCS Foundation G Pascale, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fortunato","family":"Ciardiello","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-0940","authenticated-orcid":false,"given":"Aurora","family":"Mirabile","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"International Agency for Research on Cancer (IARC) (2024, September 29). Global Cancer Observatory. Available online: https:\/\/gco.iarc.fr\/en."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S1470-2045(17)30445-X","article-title":"Burden and Centralised Treatment in Europe of Rare Tumours: Results of RARECAREnet-a Population-Based Study","volume":"18","author":"Gatta","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1002\/cncr.23931","article-title":"Head and Neck Squamous Cell Carcinoma in Patients Aged > or = 80 Years: Patterns of Care and Survival","volume":"113","author":"Italiano","year":"2008","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.radonc.2009.07.015","article-title":"Oral Cavity Squamous Cell Carcinoma in 260 Patients Aged 80years or More","volume":"93","author":"Ortholan","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACH-NC): An Update on 93 Randomised Trials and 17,346 Patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1046\/j.1365-2273.1998.2360496.x","article-title":"Radical Radiotherapy for Squamous Cell Carcinoma of the Larynx, Oropharynx and Hypopharynx: Patterns of Recurrence, Treatment and Survival","volume":"23","author":"Jones","year":"1998","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1001\/archotol.1995.01890030006001","article-title":"Squamous Cell Carcinoma of the Head and Neck in the Elderly","volume":"121","author":"Koch","year":"1995","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0360-3016(90)90403-7","article-title":"Radiation Therapy for Head and Neck Cancers in the Elderly","volume":"18","author":"Lusinchi","year":"1990","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.annonc.2020.07.011","article-title":"Squamous Cell Carcinoma of the Oral Cavity, Larynx, Oropharynx and Hypopharynx: EHNS\u2013ESMO\u2013ESTRO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up\u2020","volume":"31","author":"Machiels","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_12","unstructured":"AIOM (Associazione Italiana di Oncologia Medica) (2024, September 28). LINEE GUIDA TUMORI DELLA TESTA E DEL COLLO|AIOM. Available online: https:\/\/www.aiom.it\/linee-guida-aiom-2021-tumori-della-testa-e-del-collo\/."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jgo.2018.03.016","article-title":"Managing Older Patients with Head and Neck Cancer: The Non-Surgical Curative Approach","volume":"9","author":"Iqbal","year":"2018","journal-title":"J. Geriatr. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.radonc.2021.01.013","article-title":"Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACH-NC): An Update on 107 Randomized Trials and 19,805 Patients, on Behalf of MACH-NC Group","volume":"156","author":"Lacas","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(09)70311-0","article-title":"Radiotherapy plus Cetuximab for Locoregionally Advanced Head and Neck Cancer: 5-Year Survival Data from a Phase 3 Randomised Trial, and Relation between Cetuximab-Induced Rash and Survival","volume":"11","author":"Bonner","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archotol.130.2.161","article-title":"Postoperative Adjuvant Chemoradiotherapy in Older Patients with Head and Neck Cancer","volume":"130","author":"Airoldi","year":"2004","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1200\/JCO.2004.08.039","article-title":"Outcome of Elderly Patients with Recurrent or Metastatic Head and Neck Cancer Treated with Cisplatin-Based Chemotherapy","volume":"22","author":"Argiris","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00005537-200302000-00030","article-title":"A Matched Survival Analysis for Squamous Cell Carcinoma of the Head and Neck in the Elderly","volume":"113","author":"Bhattacharyya","year":"2003","journal-title":"Laryngoscope"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors Associated with Severe Late Toxicity after Concurrent Chemoradiation for Locally Advanced Head and Neck Cancer: An RTOG Analysis","volume":"26","author":"Machtay","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.ijrobp.2017.02.022","article-title":"The Older Adult With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: Knowledge Gaps and Future Direction in Assessment and Treatment","volume":"98","author":"Maggiore","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00106-016-0138-6","article-title":"Treatment in Elderly Patients with Head and Neck Cancer: A Challenging Dilemma","volume":"64","author":"Teymoortash","year":"2016","journal-title":"HNO"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.amjoto.2013.07.010","article-title":"Feasibility and Toxicity of Concurrent Chemoradiation for Elderly Patients with Head and Neck Cancer","volume":"34","author":"Daly","year":"2013","journal-title":"Am. J. Otolaryngol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.oraloncology.2015.11.019","article-title":"Clinical Recommendations for Defining Platinum Unsuitable Head and Neck Cancer Patient Populations on Chemoradiotherapy: A Literature Review","volume":"53","author":"Ahn","year":"2016","journal-title":"Oral Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00066-011-0006-y","article-title":"Prospective Phase II Trial of Cetuximab plus VMAT-SIB in Locally Advanced Head and Neck Squamous Cell Carcinoma. Feasibility and Tolerability in Elderly and Chemotherapy-Ineligible Patients","volume":"188","author":"Alongi","year":"2012","journal-title":"Strahlenther. Onkol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1758-3284-2-34","article-title":"Cetuximab and Radiation for Primary and Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN) in the Elderly and Multi-Morbid Patient: A Single-Centre Experience","volume":"2","author":"Jensen","year":"2010","journal-title":"Head Neck Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","article-title":"Radiotherapy plus Cetuximab or Cisplatin in Human Papillomavirus-Positive Oropharyngeal Cancer (NRG Oncology RTOG 1016): A Randomised, Multicentre, Non-Inferiority Trial","volume":"393","author":"Gillison","year":"2019","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ijrobp.2021.04.015","article-title":"Randomized Trial of Radiation Therapy With Weekly Cisplatin or Cetuximab in Low-Risk HPV-Associated Oropharyngeal Cancer (TROG 12.01)\u2014A Trans-Tasman Radiation Oncology Group Study","volume":"111","author":"Rischin","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1200\/JCO.20.02072","article-title":"ARTSCAN III: A Randomized Phase III Study Comparing Chemoradiotherapy with Cisplatin versus Cetuximab in Patients with Locoregionally Advanced Head and Neck Squamous Cell Cancer","volume":"39","author":"Brun","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(18)32752-1","article-title":"Radiotherapy plus Cisplatin or Cetuximab in Low-Risk Human Papillomavirus-Positive Oropharyngeal Cancer (De-ESCALaTE HPV): An Open-Label Randomised Controlled Phase 3 Trial","volume":"393","author":"Mehanna","year":"2019","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamaoto.2022.2791","article-title":"Cetuximab-Based vs Carboplatin-Based Chemoradiotherapy for Patients With Head and Neck Cancer","volume":"148","author":"Sun","year":"2022","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ijc.32736","article-title":"Platinum-Based Regimens versus Cetuximab in Definitive Chemoradiation for Human Papillomavirus-Unrelated Head and Neck Cancer","volume":"147","author":"Beckham","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S556","DOI":"10.1016\/j.annonc.2023.09.2003","article-title":"857O MACH-EGFR: Individual Patient Data (IPD) Meta-Analysis of Anti-EGFR Monoclonal Antibodies (Ab) in Patients (Pts) with Locally Advanced (LA) Squamous Cell Carcinomas of Head and Neck (SCCHN)","volume":"34","author":"Blanchard","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","article-title":"International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients with Cancer","volume":"32","author":"Wildiers","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.1016\/S1470-2045(12)70259-0","article-title":"Frailty Screening Methods for Predicting Outcome of a Comprehensive Geriatric Assessment in Elderly Patients with Cancer: A Systematic Review","volume":"13","author":"Hamaker","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_35","first-page":"401","article-title":"Serial Comprehensive Geriatric Assessment in Elderly Head and Neck Cancer Patients Undergoing Curative Radiotherapy Identifies Evolution of Multidimensional Health Problems and Is Indicative of Quality of Life","volume":"23","author":"Pottel","year":"2014","journal-title":"Eur. J. Cancer Care"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pottel, L., Lycke, M., Boterberg, T., Pottel, H., Goethals, L., Duprez, F., Rottey, S., Lievens, Y., Van Den Noortgate, N., and Geldhof, K. (2015). G-8 Indicates Overall and Quality-Adjusted Survival in Older Head and Neck Cancer Patients Treated with Curative Radiochemotherapy. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1800-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.jgo.2021.03.008","article-title":"Use of the Geriatric-8 Screening Tool to Predict Prognosis and Complications in Older Adults with Head and Neck Cancer: A Prospective, Observational Study","volume":"12","author":"Ishii","year":"2021","journal-title":"J. Geriatr. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1200\/JCO.2013.51.1345","article-title":"Performance of Two Geriatric Screening Tools in Older Patients with Cancer","volume":"32","author":"Kenis","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"405","DOI":"10.14639\/0392-100X-N0618","article-title":"Results of a Survey on Elderly Head and Neck Cancer Patients on Behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)","volume":"40","author":"Belgioia","year":"2020","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Fasano, M., D\u2019onofrio, I., Belfiore, M.P., Angrisani, A., Caliendo, V., Della Corte, C.M., Pirozzi, M., Facchini, S., Caterino, M., and Guida, C. (2022). Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy. Cancers, 14.","DOI":"10.3390\/cancers14030472"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","article-title":"An Intergroup Phase III Comparison of Standard Radiation Therapy and Two Schedules of Concurrent Chemoradiotherapy in Patients with Unresectable Squamous Cell Head and Neck Cancer","volume":"21","author":"Adelstein","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1200\/JCO.2012.43.6097","article-title":"Long-Term Results of RTOG 91-11: A Comparison of Three Nonsurgical Treatment Strategies to Preserve the Larynx in Patients with Locally Advanced Larynx Cancer","volume":"31","author":"Forastiere","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/annonc\/mdr587","article-title":"Screening Older Cancer Patients: First Evaluation of the G-8 Geriatric Screening Tool","volume":"23","author":"Bellera","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.critrevonc.2017.10.011","article-title":"Incidence of Skin Toxicity in Squamous Cell Carcinoma of the Head and Neck Treated with Radiotherapy and Cetuximab: A Systematic Review","volume":"120","author":"Bonomo","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jgo.2011.11.006","article-title":"Determination of an Adequate Screening Tool for Identification of Vulnerable Elderly Head and Neck Cancer Patients Treated with Radio(Chemo)Therapy","volume":"3","author":"Pottel","year":"2012","journal-title":"J. Geriatr. Oncol."},{"key":"ref_47","first-page":"40","article-title":"De-Intensification for HPV Positive Oropharyngeal Cancer: And yet It Moves!: 2019 in Review","volume":"22","author":"Bonomo","year":"2020","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/hed.25969","article-title":"Outcomes for Elderly Patients 75 Years and Older Treated with Curative Intent Radiotherapy for Mucosal Squamous Cell Carcinomas of the Head and Neck","volume":"42","author":"Horsley","year":"2020","journal-title":"Head Neck"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijrobp.2017.02.214","article-title":"Survival Patterns in Elderly Head and Neck Squamous Cell Carcinoma Patients Treated With Definitive Radiation Therapy","volume":"98","author":"Sommers","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1001\/jamaoncol.2017.0973","article-title":"Patterns of Treatment Failure and Postrecurrence Outcomes Among Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma After Chemoradiotherapy Using Modern Radiation Techniques","volume":"3","author":"Leeman","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1200\/JCO.2008.18.2188","article-title":"Pretreatment Health Behaviors Predict Survival among Patients with Head and Neck Squamous Cell Carcinoma","volume":"27","author":"Duffy","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1158\/1055-9965.EPI-14-0311","article-title":"Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study","volume":"23","author":"Sharp","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2019.02.021","article-title":"The Effects of Continued Smoking in Head and Neck Cancer Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis","volume":"135","author":"Smith","year":"2019","journal-title":"Radiother. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.critrevonc.2014.07.005","article-title":"Correlation of Cetuximab-Induced Skin Rash and Outcomes of Solid Tumor Patients Treated with Cetuximab: A Systematic Review and Meta-Analysis","volume":"93","author":"Fouad","year":"2015","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.ijrobp.2016.03.011","article-title":"Correlation Between the Severity of Cetuximab-Induced Skin Rash and Clinical Outcome for Head and Neck Cancer Patients: The RTOG Experience","volume":"95","author":"Zhang","year":"2016","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_57","first-page":"84","article-title":"The Role of Immunosenescence in the Development of Age-Related Diseases","volume":"68","author":"Dupuis","year":"2016","journal-title":"Rev. Investig. Clin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/bjc.2011.554","article-title":"Cetuximab-Based Therapy in Elderly Comorbid Patients with Metastatic Colorectal Cancer","volume":"106","author":"Jehn","year":"2012","journal-title":"Br. J. Cancer"},{"key":"ref_59","first-page":"3497","article-title":"Prospective Practice Survey of Management of Cetuximab-Related Skin Reactions","volume":"29","author":"Lugtenberg","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/jamadermatol.2020.1795","article-title":"Evaluation of a Comprehensive Skin Toxicity Program for Patients Treated With Epidermal Growth Factor Receptor Inhibitors at a Cancer Treatment Center","volume":"156","author":"Yu","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000500714","article-title":"Efficacy and Safety of Cetuximab plus Radiotherapy in Cisplatin-Unfit Elderly Patients with Advanced Squamous Cell Head and Neck Carcinoma: A Retrospective Study","volume":"64","author":"Addeo","year":"2019","journal-title":"Chemotherapy"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12032-019-1292-y","article-title":"Hypofractionated Radiotherapy Combined with Cetuximab in Vulnerable Elderly Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma","volume":"36","author":"Vetrone","year":"2019","journal-title":"Med. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.radonc.2009.05.005","article-title":"Radiotherapy Compliance Is Maintained with Hypofractionation and Concurrent Cetuximab in Locally Advanced Head and Neck Cancer","volume":"93","author":"Chan","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2008.09.018","article-title":"Enhanced Toxicity with Concurrent Cetuximab and Radiotherapy in Head and Neck Cancer","volume":"90","author":"Pryor","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S1310","DOI":"10.1016\/j.annonc.2021.08.2112","article-title":"LBA35 Avelumab-Cetuximab-Radiotherapy versus Standards of Care in Patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck (LA-SCCHN): Randomized Phase III GORTEC-REACH Trial","volume":"32","author":"Bourhis","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S616","DOI":"10.1016\/j.annonc.2024.08.915","article-title":"854MO Avelumab-Cetuximab-Radiotherapy (RT) versus Standards of Care in Patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck (LA-SCCHN): Final Analysis of Randomized Phase III GORTEC 2017-01 REACH Trial","volume":"35","author":"Therapeutics","year":"2024","journal-title":"Ann. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1470-2045(24)00100-1","article-title":"Pembrolizumab plus Concurrent Chemoradiotherapy versus Placebo plus Concurrent Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck (KEYNOTE-412): A Randomised, Double-Blind, Phase 3 Trial","volume":"25","author":"Machiels","year":"2024","journal-title":"Lancet Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"LBA2","DOI":"10.1200\/JCO.2025.43.17_suppl.LBA2","article-title":"NIVOPOSTOP (GORTEC 2018-01): A Phase III Randomized Trial of Adjuvant Nivolumab Added to Radio-Chemotherapy in Patients with Resected Head and Neck Squamous Cell Carcinoma at High Risk of Relapse","volume":"43","author":"Bourhis","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1200\/JCO.2023.41.16_suppl.6007","article-title":"Neoadjuvant Nivolumab, Paclitaxel, and Carboplatin Followed by Response-Stratified Chemoradiation in Locoregionally Advanced HPV Negative Head and Neck Squamous Cell Carcinoma (HNSCC): The DEPEND Trial","volume":"41","author":"Rosenberg","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_70","unstructured":"European Medicines Agency (EMA) (2025, July 26). Erbitux\u2014SUMMARY OF PRODUCT CHARACTERISTICS. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/erbitux-epar-product-information_en.pdf."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"S1401","DOI":"10.14309\/01.ajg.0000712748.34500.f6","article-title":"S2675 Cetuximab-Induced Liver Injury: A Side Effect of What We Thought Is \u201can Innocent Subject\u201d!","volume":"115","author":"Nimri","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_72","first-page":"118","article-title":"Cetuximab-Associated Pulmonary Toxicity","volume":"8","author":"Chua","year":"2009","journal-title":"Clin. Color. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1002\/hed.25727","article-title":"Incidence and Risk Factors of Interstitial Lung Disease of Patients with Head and Neck Cancer Treated with Cetuximab","volume":"41","author":"Nakano","year":"2019","journal-title":"Head Neck"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1200\/JCO.2022.40.28_suppl.321","article-title":"Prevention and Management of Cetuximab-Related Hypomagnesemia","volume":"40","author":"Tejpar","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.critrevonc.2015.06.004","article-title":"Risk of Grade 3-4 Diarrhea and Mucositis in Colorectal Cancer Patients Receiving Anti-EGFR Monoclonal Antibodies Regimens: A Meta-Analysis of 18 Randomized Controlled Clinical Trials","volume":"96","author":"Miroddi","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_76","first-page":"1079","article-title":"Clinical Practice Guidelines for the Prevention and Treatment of EGFR Inhibitor-Associated Dermatologic Toxicities","volume":"19","author":"Lacouture","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s10147-012-0427-3","article-title":"Cetuximab-Induced Skin Reactions Are Suppressed by Cigarette Smoking in Patients with Advanced Colorectal Cancer","volume":"18","author":"Kajizono","year":"2013","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1517\/14712590903081694","article-title":"Cigarettes Smoking Habit May Reduce Benefit from Cetuximab-Based Treatment in Advanced Colorectal Cancer Patients","volume":"9","author":"Vincenzi","year":"2009","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.oraloncology.2011.07.023","article-title":"Distinct Patterns of Stomatitis with Concurrent Cetuximab and Radiotherapy for Head and Neck Squamous Cell Carcinoma","volume":"47","author":"Pryor","year":"2011","journal-title":"Oral. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s13555-024-01198-w","article-title":"Psoriasis in the Era of Targeted Cancer Therapeutics: A Systematic Review on De Novo and Pre-Existing Psoriasis in Oncologic Patients Treated with Emerging Anti-Neoplastic Agents","volume":"14","author":"Madan","year":"2024","journal-title":"Dermatol. Ther."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/annonc\/mdi279","article-title":"Clinical Signs, Pathophysiology and Management of Skin Toxicity during Therapy with Epidermal Growth Factor Receptor Inhibitors","volume":"16","author":"Segaert","year":"2005","journal-title":"Ann. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1634\/theoncologist.2010-0082","article-title":"Does Sunscreen Prevent Epidermal Growth Factor Receptor (EGFR) Inhibitor\u2013Induced Rash? Results of a Placebo-Controlled Trial from the North Central Cancer Treatment Group (N05C4)","volume":"15","author":"Jatoi","year":"2010","journal-title":"Oncologist"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1016\/j.ijrobp.2023.06.462","article-title":"Hearing Outcomes in Cisplatin or Cetuximab Combined with Radiation for Patients with HPV-Associated Oropharyngeal Cancer in NRG\/RTOG 1016","volume":"117","author":"Runge","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. 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