{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:43:39Z","timestamp":1778190219324,"version":"3.51.4"},"reference-count":45,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Pelvic exenteration is a complex surgery considered for locally advanced or recurrent pelvic malignancies, entailing a radical en-block resection of multiple adjacent pelvic organs, followed by reconstructive surgery. Achieving R0 resection (complete removal of macroscopic and microscopic disease) is critical for improving survival outcomes. This study aimed to define patient, tumour, and surgical predictors of R0 resection in an irradiated field, thereby optimising patient selection and establishing a surgical roadmap for pelvic exenterations. Methods: Our retrospective observational cohort study includes consecutive patients undergoing exenteration post-radiotherapy for non-ovarian gynaecological malignancies at Oxford University Hospitals between 1 January 2011 and 31 December 2024. The primary outcome was margin status. Secondary outcomes were intraoperative and postoperative complications. Results: Twenty-seven patients were identified, with a median age of 63 years (range 41\u201381) and median BMI of 27 (range 17\u201345). Primary tumour sites included the vulva (11.1%), vagina (14.8%), cervix (40.7%), and uterus (33.3%). R0 was achieved in 77.8% (n = 21) of cases. Intraoperative complications occurred in 29.6%, and significant postoperative complications (Clavien-Dindo IIIA\/IIIB) in 22.2% of patients. R0 resection was significantly associated with younger age (median 61 vs. 70 years, p = 0.035) and primary cervical tumours (p = 0.036). On univariable logistic regression, tumour size on imaging (p = 0.038, OR 2.9) and on histology (p = 0.020, OR 2.01), and estimated blood loss (p = 0.048, OR 1.002) were significant predictors of R0 resection. None of these variables retained significance in multivariable logistic regression. Conclusions: Tumour size, primary tumour site, and patient age should be considered when selecting patients for pelvic exenteration following radiotherapy, and blood loss should be kept minimal in order to maximise the chances of achieving R0 resection.<\/jats:p>","DOI":"10.3390\/cancers17223679","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:05:31Z","timestamp":1763463931000},"page":"3679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Preoperative Prognosticators of Surgical Margins (R0 vs. R1) in Pelvic Exenteration\u2014A 14-Year Retrospective Study from a Tertiary Referral Centre"],"prefix":"10.3390","volume":"17","author":[{"given":"Sabina Ioana","family":"Nistor","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology, Churchill Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0021-6050","authenticated-orcid":false,"given":"Roman","family":"Mykula","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Urology, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5879-0535","authenticated-orcid":false,"given":"William","family":"Gietzmann","sequence":"additional","affiliation":[{"name":"Department of Urology, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2045-9800","authenticated-orcid":false,"given":"Mahmoud","family":"Awaly","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Churchill Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-6772","authenticated-orcid":false,"given":"Alaa","family":"Elzarka","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Churchill Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0711-6134","authenticated-orcid":false,"given":"Jennifer","family":"Thorne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2831-2134","authenticated-orcid":false,"given":"Jacopo","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Churchill Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-8903","authenticated-orcid":false,"given":"Nicholas","family":"Symons","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-5321","authenticated-orcid":false,"given":"Hooman","family":"Soleymani majd","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, Churchill Hospital, Oxford University Hospitals, National Health Service (NHS) Foundation Trust, Oxford OX3 7LE, UK"},{"name":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Oxford OX3 9DU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00006254-194906000-00067","article-title":"Complete excision of pelvic viscera for advanced carcinoma: A one-stage abdominoperineal operation with end colostomy and bilateral ureteral implantation into the colon above the colostomy","volume":"4","author":"Brunschwig","year":"1949","journal-title":"Obstet. 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Cancers, 16.","DOI":"10.3390\/cancers16020276"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/22\/3679\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T11:21:50Z","timestamp":1763464910000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/22\/3679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":45,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["cancers17223679"],"URL":"https:\/\/doi.org\/10.3390\/cancers17223679","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}