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Methods: We conducted a comprehensive analysis using bioinformatics tools and experimental validations, examining RBP expression profiles across cancer types based on data from The Cancer Genome Atlas (TCGA). We employed survival analysis using the Kaplan\u2013Meier method and utilized single-cell RNA sequencing (scRNA-seq) to investigate the roles of RBP4 and RBP7 in the tumor microenvironment. Results: Our analysis revealed significant downregulation of RBPs in multiple cancers, with RBP4 and RBP7 showing notable expression variations linked to tumor stages and grades. Cox analysis identified RBP4 as a protective gene in kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), and mesothelioma (MESO), while RBP7 exhibited protective effects in breast cancer (BRCA) and uveal melanoma (UVM). Conclusions: This pan-cancer and single-cell integrative analysis highlights the complex roles of RBPs in cancer progression and their potential as prognostic biomarkers, particularly RBP4 and RBP7 in breast cancer. These findings warrant further investigation into the functional mechanisms of RBPs, which may provide valuable strategies for therapeutic interventions.<\/jats:p>","DOI":"10.3390\/cancers17223706","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:44:53Z","timestamp":1763631893000},"page":"3706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated Pan-Cancer Analysis and Experimental Verification of the Roles of Retinoid-Binding Proteins in Breast Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3422-3407","authenticated-orcid":false,"given":"Yuchu","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-4124","authenticated-orcid":false,"given":"Yaoxi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-5070","authenticated-orcid":false,"given":"Linghong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1989-5719","authenticated-orcid":false,"given":"Siliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology & Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast Cancer Treatment: A Review","volume":"321","author":"Waks","year":"2019","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/s41467-021-22024-3","article-title":"Epigenetic mechanisms in breast cancer therapy and resistance","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Stabellini, N., Cullen, J., Cao, L., Shanahan, J., Hamerschlak, N., Waite, K., Barnholtz-Sloan, J.S., and Montero, A.J. (2023). Racial disparities in breast cancer treatment patterns and treatment related adverse events. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-27578-4"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.addr.2010.07.003","article-title":"Retinoid pathway and cancer therapeutics","volume":"62","author":"Bushue","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Borel, P., and Desmarchelier, C. (2017). Genetic Variations Associated with Vitamin A Status and Vitamin A Bioavailability. Nutrients, 9.","DOI":"10.3390\/nu9030246"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zeng, S., Zhang, T., Madigan, M.C., Fernando, N., Aggio-Bruce, R., Zhou, F., Pierce, M., Chen, Y., Huang, L., and Natoli, R. (2020). Interphotoreceptor Retinoid-Binding Protein (IRBP) in Retinal Health and Disease. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.577935"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9039110","DOI":"10.1155\/2022\/9039110","article-title":"Methylation-Mediated Silencing of Rbp7 Promotes Breast Cancer Progression through Ppar and Pi3k\/Akt Pathway","volume":"2022","author":"Lin","year":"2022","journal-title":"J. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.7150\/jca.35180","article-title":"RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer","volume":"10","author":"Elmasry","year":"2019","journal-title":"J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jiao, C., Cui, L., Ma, A., Li, N., and Si, H. (2016). Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167498"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2147\/CMAR.S480337","article-title":"Retinol Binding Protein 4 Serves as a Potential Tumor Biomarker and Promotes Malignant Behavior in Gastric Cancer","volume":"16","author":"Yu","year":"2024","journal-title":"Cancer Manag. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101979","DOI":"10.1016\/j.tranon.2024.101979","article-title":"Retinol-binding protein 4 as a promising serum biomarker for the diagnosis and prognosis of hepatocellular Carcinoma","volume":"45","author":"Wan","year":"2024","journal-title":"Transl. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"bqac171","DOI":"10.1210\/endocr\/bqac171","article-title":"CRABP2 Is Associated with Thyroid Cancer Recurrence and Promotes Invasion via the Integrin\/FAK\/AKT Pathway","volume":"163","author":"Liu","year":"2022","journal-title":"Endocrinology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wu, J.-I., Lin, Y.-P., Tseng, C.-W., Chen, H.-J., and Wang, L.-H. (2019). Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin \u03b21\/FAK\/ERK Signaling. Sci. Rep., 9.","DOI":"10.1038\/s41598-018-37443-4"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2174\/1871520623666221219090047","article-title":"Reduced Expression of RBP7 is Associated with Resistance to Tamoxifen In Luminal A Breast Cancer","volume":"23","author":"Yan","year":"2023","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12935-024-03299-0","article-title":"RBP7 functions as a tumor suppressor in HR+ breast cancer by inhibiting the AKT\/SREBP1 pathway and reducing fatty acid","volume":"24","author":"Yu","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sun, Y., Liu, C., Liu, Z., Zhao, T., Jiang, J., Li, J., Xu, X., and Yang, H. (2021). Genome-Wide Identification, Characterization and Expression Analysis of the Jaz Gene Family in Resistance to Gray Leaf Spots in Tomato. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22189974"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Han, Y., and Luthe, D. (2021). Identification and evolution analysis of the JAZ gene family in maize. BMC Genom., 22.","DOI":"10.1186\/s12864-021-07522-4"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: Homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.molp.2020.06.009","article-title":"TBtools: An Integrative Toolkit Developed for Interactive Analyses of Big Biological Data","volume":"13","author":"Chen","year":"2020","journal-title":"Mol. Plant"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: Protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Park, S.J., Yoon, B.H., Kim, S.K., and Kim, S.Y. (2019). Gent2: An Updated Gene Expression Database for Normal and Tumor Tissues. BMC Med. Genom., 12.","DOI":"10.1186\/s12920-019-0514-7"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1111\/bph.70215","article-title":"Pathway-level mutational signatures predict breast cancer outcomes and reveal therapeutic targets","volume":"182","author":"Posta","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41419-020-2693-8","article-title":"The Rbp1-Ckap4 Axis Activates Oncogenic Autophagy and Promotes Cancer Progression in Oral Squamous Cell Carcinoma","volume":"11","author":"Gao","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_27","first-page":"1013","article-title":"Loss of Cellular Retinol-Binding Protein 1 Gene Expression in Microdissected Human Ovarian Cancer","volume":"9","author":"Williams","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.1038\/sj.onc.1204749","article-title":"CRBP suppresses breast cancer cell survival and anchorage-independent growth","volume":"20","author":"Kuppumbatti","year":"2001","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/modpathol.3800586","article-title":"Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: Diagnostic and possible therapeutic implications","volume":"19","author":"Orlandi","year":"2006","journal-title":"Mod. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5435523","DOI":"10.1155\/2022\/5435523","article-title":"Positive Expression of Retinol-Binding Protein 4 Is Related to the Malignant Clinical Features Leading to Poor Prognosis of Glioblastoma","volume":"2022","author":"Deng","year":"2022","journal-title":"Genet. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13048-018-0397-9","article-title":"Adipokine Rbp4 Drives Ovarian Cancer Cell Migration","volume":"11","author":"Wang","year":"2018","journal-title":"J. Ovarian Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3892\/ijo.2013.1954","article-title":"Induction of retinol-binding protein 4 and placenta-specific 8 expression in human prostate cancer cells remaining in bone following osteolytic tumor growth inhibition by osteoprotegerin","volume":"43","author":"Uehara","year":"2013","journal-title":"Int. J. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Papiernik, D., Urbaniak, A., K\u0142opotowska, D., Nasulewicz-Goldeman, A., Ekiert, M., Nowak, M., Jarosz, J., Cuprych, M., Strzykalska, A., and Ugorski, M. (2020). Retinol-Binding Protein 4 Accelerates Metastatic Spread and Increases Impairment of Blood Flow in Mouse Mammary Gland Tumors. Cancers, 12.","DOI":"10.3390\/cancers12030623"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00432-007-0230-0","article-title":"Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma","volume":"133","author":"Ho","year":"2007","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.112.5.965","article-title":"Overexpression of the Cellular Retinoic Acid Binding Protein-I (Crabp-I) Results in a Reduction in Differentiation-Specific Gene Expression in F9 Teratocarcinoma Cells","volume":"112","author":"Boylan","year":"1991","journal-title":"J. Cell Biol."},{"key":"ref_36","first-page":"914","article-title":"In Vitro All-Trans Retinoic Acid (Atra) Sensitivity and Cellular Retinoic Acid Binding Protein (Crabp) Levels in Relapse Leukemic Cells after Remission Induction by Atra in Acute Promyelocytic Leukemia","volume":"8","author":"Cornic","year":"1994","journal-title":"Leukemia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"23533","DOI":"10.18632\/oncotarget.4372","article-title":"Mir-93\/Mir-106b\/Mir-375-Cic-Crabp1: A Novel Regulatory Axis in Prostate Cancer Progression","volume":"6","author":"Choi","year":"2015","journal-title":"Oncotarget"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12943-015-0380-7","article-title":"CRABP1 is associated with a poor prognosis in breast cancer: Adding to the complexity of breast cancer cell response to retinoic acid","volume":"14","author":"Liu","year":"2015","journal-title":"Mol. Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1038\/sj.onc.1210459","article-title":"Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma","volume":"26","author":"Tanaka","year":"2007","journal-title":"Oncogene"},{"key":"ref_40","first-page":"5770","article-title":"Constitutive Expression of Cellular Retinoic Acid Binding Protein Ii and Lack of Correlation with Sensitivity to All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells","volume":"58","author":"Zhou","year":"1998","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"151557","DOI":"10.1016\/j.anndiagpath.2020.151557","article-title":"CRABP2 and FABP5 expression levels in diseased and normal pancreas","volume":"47","author":"Hughes","year":"2020","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_42","first-page":"1273","article-title":"Cellular retinoic acid-binding protein 2 is down-regulated in prostate cancer","volume":"27","author":"Okuducu","year":"2005","journal-title":"Int. J. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s13046-019-1345-2","article-title":"Crabp2 Regulates Invasion and Metastasis of Breast Cancer through Hippo Pathway Dependent on ER Status","volume":"38","author":"Feng","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1533033821992081","DOI":"10.1177\/1533033821992081","article-title":"Identification of Novel Biomarkers Associated with the Prognosis and Potential Pathogenesis of Breast Cancer via Integrated Bioinformatics Analysis","volume":"20","author":"Wu","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e91738","DOI":"10.1172\/jci.insight.91738","article-title":"Retinol-Binding Protein 7 Is an Endothelium-Specific Ppar\u03b3 Cofactor Mediating an Antioxidant Response through Adiponectin","volume":"2","author":"Hu","year":"2017","journal-title":"JCI Insight"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cai, X.X., Zhang, Z.Z., Yang, X.X., Shen, W.R., Yuan, L.W., Ding, X., Yu, Y., and Cai, W.Y. (2025). Unveiling the Impact of Lipid Metabolism on Triple-Negative Breast Cancer Growth and Treatment Options. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1579423"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.2147\/JIR.S419576","article-title":"Single-Cell Rna Sequencing and Transcriptome Analysis Revealed the Immune Microenvironment and Gene Markers of Acute Respiratory Distress Syndrome","volume":"16","author":"He","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"ref_48","first-page":"1239","article-title":"Promising Diagnostic and Prognostic Value of Six Genes in Human Hepatocellular Carcinoma","volume":"12","author":"Zhang","year":"2020","journal-title":"Am. J. Transl. Res."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/22\/3706\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:30:44Z","timestamp":1763703044000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/22\/3706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":48,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["cancers17223706"],"URL":"https:\/\/doi.org\/10.3390\/cancers17223706","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}