{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:25:01Z","timestamp":1790889901101,"version":"4.1.0"},"reference-count":75,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Robert and Colleen Haas"},{"name":"Graduate Division at the University of California-Berkeley"},{"name":"Start-Up Fund at University of California-Berkeley"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Kaposi\u2019s sarcoma (KS), an AIDS-defining illness, is caused by Kaposi\u2019s sarcoma-associated herpesvirus (KSHV). A member of the human herpesvirus family, designated as human herpesvirus 8 (HHV-8), KSHV is also linked to other oncogenic manifestations such as primary effusion lymphoma (PEL). The current dearth of available compounds against KSHV necessitates development of effective antiviral treatments. As with other herpesviruses, KSHV can result in both lytic and latent infections. KSHV pathogenesis and the development of KS have been associated with the expression of KSHV genes and transcripts during viral infections. The transcriptome of KSHV heavily intersects with regulatory pathways and mechanisms involved with a multitude of diseases in humans. Circular RNAs (circRNAs) have recently been discovered to be expressed by KSHV. Research endeavors on KSHV circRNAs have focused on the roles they play throughout latent and lytic infection. Understanding the specific functions and interactions of KSHV circRNAs with the viral and host transcriptomes, as well as how they are identified and analyzed, will be the primary focus of this review. Overall, recent advances in KSHV circRNA research have deepened our understanding of the KSHV transcriptome and pathogenesis and are paving the way for the development of circRNA-based antiviral therapies.<\/jats:p>","DOI":"10.3390\/cancers17233743","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:47:22Z","timestamp":1763984842000},"page":"3743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent Studies on Kaposi\u2019s Sarcoma-Associated Herpesvirus Circular RNAs"],"prefix":"10.3390","volume":"17","author":[{"given":"Cristian J.","family":"Pagtalunan","sequence":"first","affiliation":[{"name":"School of Public Health, University of California, Berkeley, CA 94720, USA"},{"name":"Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6606-3959","authenticated-orcid":false,"given":"Isadora","family":"Zhang","sequence":"additional","affiliation":[{"name":"Program in Comparative Biochemistry, University of California, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariella","family":"Turley","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California, Berkeley, CA 94720, USA"},{"name":"Department of Chemistry, University of California, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health, University of California, Berkeley, CA 94720, USA"},{"name":"Program in Comparative Biochemistry, University of California, Berkeley, CA 94720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi\u2019s sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science"},{"key":"ref_2","first-page":"513","article-title":"Kaposi\u2019s Sarcoma Herpesvirus","volume":"Volume 1","author":"Knipe","year":"2021","journal-title":"Fields Virology: DNA Viruses"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.3390\/v6114178","article-title":"Epidemiology and Transmission of Kaposi\u2019s Sarcoma-Associated Herpesvirus","volume":"6","author":"Minhas","year":"2014","journal-title":"Viruses"},{"key":"ref_4","first-page":"212","article-title":"The Family Herpesviridae: A Brief Introduction","volume":"Volume 1","author":"Knipe","year":"2021","journal-title":"Fields Virology: DNA Viruses"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2009.07.004","article-title":"Kaposi sarcoma-associated herpesvirus (KSHV): Molecular biology and oncogenesis","volume":"289","author":"Wen","year":"2010","journal-title":"Cancer Lett."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.tripleo.2011.05.011","article-title":"Kaposi sarcoma: Review and medical management update","volume":"113","author":"Fatahzadeh","year":"2012","journal-title":"Oral. 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