{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:26:44Z","timestamp":1764325604031,"version":"3.46.0"},"reference-count":38,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Preoperative localization of non-palpable breast lesions is critical for accurate resection and margin control in breast-conserving surgery. Traditional methods, such as wire or radioguided localization, have limitations in terms of logistics, patient comfort, and procedural flexibility. SCOUT\u00ae is a wireless, radar-based alternative that may improve surgical precision and workflow. This study aimed to evaluate the clinical performance of the SCOUT\u00ae in the localization of non-palpable breast and axillary lesions, including detection success, margin status, reoperation rates, and device-related events. Methods: We conducted a retrospective, single-centre observational study including 427 patients who underwent breast-conserving surgery after preoperative localization using the SCOUT\u00ae between January 2023 and May 2024 at a tertiary academic hospital. Variables included lesion type, location, neoadjuvant treatment, device detection, seed deactivation, MRI interference, margin status, and reoperation rate. Results: The mean age was 58 \u00b1 12.7 years, with malignant pathology in 88.5% of cases. SCOUT\u00ae achieved a 100% detection rate in axillary localizations and 98.1% in breast lesions. Seed deactivation occurred in 1.2% of cases, all successfully managed intraoperatively. MRI artefacts were observed in 1.6% of patients, without diagnostic interference. Positive margins were reported in 8.3% of cases, representing an improvement compared with the institution\u2019s historic 12% rate, with 5.9% requiring reoperation. Carcinoma in situ showed the highest rate of positive margins, at 26%. Conclusions: SCOUT\u00ae was associated with high detection rates, a low incidence of device-related events, and favourable margin outcomes, supporting its reliability for the localization of non-palpable breast lesions.<\/jats:p>","DOI":"10.3390\/cancers17233816","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:56:02Z","timestamp":1764323762000},"page":"3816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SCOUT\u00ae Radar Reflector for Nonpalpable Breast Lesion Localization: Clinical Outcomes from a Single-Center Experience"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1369-191X","authenticated-orcid":false,"given":"Julieta","family":"Puente-Monserrat","sequence":"first","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3201-8841","authenticated-orcid":false,"given":"Ernesto","family":"Mu\u00f1oz-Sornosa","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0984-4667","authenticated-orcid":false,"given":"Vicente","family":"L\u00f3pez-Flor","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-7361","authenticated-orcid":false,"given":"Marcos","family":"Adrianz\u00e9n-Vargas","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0937-6189","authenticated-orcid":false,"given":"Dixie","family":"Huntley-Pascual","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5286-4218","authenticated-orcid":false,"given":"Georgy","family":"Kadzhaya-Khlystov","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Soriano-Mena","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Cl\u00ednico Universitario, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7800-9935","authenticated-orcid":false,"given":"Elvira","family":"Buch-Villa","sequence":"additional","affiliation":[{"name":"Breast Unit, Department of General and Digestive Surgery, Hospital Cl\u00ednico Universitario of Valencia, 46010 Valencia, Spain"},{"name":"Biomedical Research Institute, INCLIVA, 46010 Valencia, Spain"},{"name":"Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","unstructured":"Asociacion Espanola Contra el Cancer (2025, February 26). 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