{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:25:25Z","timestamp":1776835525922,"version":"3.51.2"},"reference-count":42,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: To determine whether long-term oncological follow-up is required following fertility-sparing surgery (FSS) for mucinous borderline ovarian tumours (MBOTs). Methods: A retrospective cohort study set in the tertiary gynaecology oncology centre at Imperial College Healthcare NHS Trust. Patients included were those under follow-up post-surgery for an MBOT in the ovarian clinic from 2007 to 2025. Rate of recurrence was compared amongst patients who underwent ovarian cystectomy, unilateral salpingo-oophorectomy (USO) or bilateral salpingo-oophorectomy (BSO) +\/\u2212 hysterectomy. Results: From 74 patients diagnosed with MBOT, 36.5% (27\/74) underwent BSO +\/\u2212 hysterectomy and 63.5% (47\/74) had FSS. Of the patients who underwent FSS, 59.6% (28\/47) had an initial USO and 40.4% (19\/47) underwent ovarian cystectomy. Subsequently, 63.2% (12\/19) of patients who initially had ovarian cystectomy proceeded with completion USO, leading to a total of 40 USOs performed. There were no recurrences following BSO +\/\u2212 hysterectomy, primary USO or completion USO after a median follow-up of 49.0, 65.5 and 48.0 months, respectively. Of the patients who underwent ovarian cystectomy, 15.8% (3\/19) were found to have residual MBOT (n = 1) two months post-cystectomy or MBOT recurrence (n = 2) at 10- and 66-months post-cystectomy, all diagnosed at USO. There is a significant association between ovarian cystectomy and disease recurrence (Fisher\u2019s exact test p = 0.015). Conclusions: Patients of reproductive age who undergo USO for a MBOT can be offered a reduced follow-up schedule as the risk of recurrence is very low. In contrast, patients who are managed by ovarian cystectomy have a higher risk of recurrence and require long-term surveillance monitoring.<\/jats:p>","DOI":"10.3390\/cancers17233825","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:34:01Z","timestamp":1764758041000},"page":"3825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Oncological Follow-Up of Fertility Sparing Surgery for Mucinous Borderline Ovarian Tumours: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1519-3021","authenticated-orcid":false,"given":"Nicholas","family":"Anson","sequence":"first","affiliation":[{"name":"Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Cox","sequence":"additional","affiliation":[{"name":"Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine S.","family":"Kasaven","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Landolfo","sequence":"additional","affiliation":[{"name":"Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK"},{"name":"Department of Metabolism, Digestion & Reproduction, Faculty of Medicine, Imperial College London, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Al-Memar","sequence":"additional","affiliation":[{"name":"Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Queen Charlotte\u2019s and Chelsea Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK"},{"name":"The Lister Fertility Clinic, The Lister Hospital, Chelsea Bridge Road, London SW1W 8RH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdjan","family":"Saso","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-9618","authenticated-orcid":false,"given":"Mona","family":"El-Bahrawy","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-5080","authenticated-orcid":false,"given":"Sadaf","family":"Ghaem-Maghami","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Yazbek","sequence":"additional","affiliation":[{"name":"Division of Surgery and Cancer, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","unstructured":"Kurman, R.J., Carcangiu, M.L., Herrington, C.S., and Young, R.H. 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