{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:51Z","timestamp":1790856771564,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Central nervous system (CNS) tumors during pregnancy are rare but present significant diagnostic, therapeutic, and ethical challenges. These include both primary and metastatic lesions, which share overlapping clinical features and management complexities. Their clinical course is influenced by gestational physiological changes, which can mask symptoms and delay diagnosis, thereby increasing maternal and fetal risks. Objective: This review aims to synthesize current evidence on the epidemiology, pathophysiology, clinical presentation, diagnostic strategies, treatment options, prognosis, and ethical considerations related to CNS tumors in pregnant patients. Methods: A comprehensive literature review was conducted, including retrospective and prospective studies, clinical guidelines, and systematic reviews focusing on brain and spinal tumors diagnosed during pregnancy. Particular attention was given to the impact of gestational age, tumor histology, and maternal condition on treatment outcomes. Results: Hormone-sensitive tumors such as meningiomas and prolactinomas may exhibit accelerated growth during pregnancy due to elevated progesterone and prolactin levels. Diagnosis is often delayed due to symptom overlap with normal gestational changes. MRI without contrast remains the imaging modality of choice. Glucocorticoids and selected chemotherapy agents can be cautiously used depending on gestational age. Surgical resection, particularly in the second trimester, has been shown to be safe and effective in appropriate clinical scenarios. Multidisciplinary coordination is essential. Prognosis varies based on tumor type and timing of intervention, with maternal survival prioritized in high-risk situations. Ethical management hinges on patient autonomy, informed consent, and proportionality of medical interventions. Conclusions: CNS tumors during pregnancy require early recognition, individualized treatment planning, and ethical vigilance. Multidisciplinary collaboration is vital to optimizing outcomes for both mother and fetus. Future efforts should focus on developing standardized protocols and expanding evidence through multicenter studies.<\/jats:p>","DOI":"10.3390\/cancers17233854","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:34:01Z","timestamp":1764758041000},"page":"3854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Brain Tumors in Pregnancy: A Review of Pathophysiology, Clinical Management, and Ethical Dilemmas"],"prefix":"10.3390","volume":"17","author":[{"given":"Muratbek A.","family":"Tleubergenov","sequence":"first","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniyar K.","family":"Zhamoldin","sequence":"additional","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dauren S.","family":"Baymukhanov","sequence":"additional","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel S.","family":"Omarova","sequence":"additional","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurzhan A.","family":"Ryskeldiyev","sequence":"additional","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidos","family":"Doskaliyev","sequence":"additional","affiliation":[{"name":"Department of Brain Neurosurgery, JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-0727","authenticated-orcid":false,"given":"Talshyn M.","family":"Ukybassova","sequence":"additional","affiliation":[{"name":"Department of Gynecology, JSC \u201cUniversity Medical Center\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serik","family":"Akshulakov","sequence":"additional","affiliation":[{"name":"JSC \u201cNational Centre for Neurosurgery\u201d, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","first-page":"239","article-title":"Benign and malignant tumors of the central nervous system and pregnancy","volume":"Volume 172","author":"Steegers","year":"2020","journal-title":"Neurology and Pregnancy: Neuro-Obstetric Disorders. 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