{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:49:25Z","timestamp":1787240965468,"version":"build-2736575974"},"reference-count":64,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Melanomas may develop de novo or in association with a pre-existing nevus (nevus-associated melanoma, NAM). Whether these subtypes differ in their clinical and biological behavior remains uncertain. We aimed to compare the clinicopathologic features and outcomes of NAM and de novo melanoma (DNM) in a large single-center cohort. Methods: We retrospectively analyzed 378 patients with invasive melanoma diagnosed between 2007 and 2021 at a tertiary referral center. Tumors were classified as NAM when histopathologic continuity with a nevus was present, and as DNM otherwise. Clinical, histologic, and prognostic variables were compared using univariate and multivariate analyses. Results: Of 378 melanomas, 90 (24%) were NAM and 288 (76%) were DNM. Patients with NAM were slightly younger (mean 52 vs. 54 years) and more often presented with tumors on the trunk (65.6% vs. 51.7%). NAMs exhibited lower Breslow thickness (0.55 vs. 0.84 mm), reduced mitotic activity (0.17 vs. 1.21\/mm2), and less frequent ulceration (2.2% vs. 9.4%). Distant metastases occurred only in DNM (6.6%). Sentinel lymph node positivity (1.1% vs. 6.3%) and melanoma-specific mortality (0% vs. 0.69%) did not differ significantly. Multivariate analysis identified Breslow thickness and mitotic rate as independent predictors of subtype. Conclusions: NAMs present with more favorable histopathologic features than DNMs, yet long-term outcomes appear similar. These findings support divergent pathways of melanoma development and underscore the need for molecular and imaging studies to refine risk stratification and guide management.<\/jats:p>","DOI":"10.3390\/cancers17233859","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:34:01Z","timestamp":1764758041000},"page":"3859","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nevus-Associated and De Novo Melanoma: A Cross-Sectional Study on Prognostic Differences"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-2861","authenticated-orcid":false,"given":"Emi","family":"Dika","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-4172","authenticated-orcid":false,"given":"Federico","family":"Venturi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-1726","authenticated-orcid":false,"given":"Biagio","family":"Scotti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gualandi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Vaccari","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Posenato","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-9216","authenticated-orcid":false,"given":"Corrado","family":"Zengarini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Veneziano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ardig\u00f2","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3263-4353","authenticated-orcid":false,"given":"Elisabetta","family":"Magnaterra","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy"},{"name":"Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaad.2024.09.035","article-title":"Global trends in melanoma burden: A comprehensive analysis from the Global Burden of Disease Study, 1990\u20132021","volume":"92","author":"Sun","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115124","DOI":"10.1016\/j.ejca.2024.115124","article-title":"An update on access to novel treatment for metastatic melanoma in Europe\u2014A 2024 survey of the European melanoma registry and the European association of dermato-oncology","volume":"216","author":"Kandolf","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1038\/nrdp.2015.3","article-title":"Melanoma","volume":"1","author":"Schadendorf","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","article-title":"Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040","volume":"158","author":"Arnold","year":"2022","journal-title":"JAMA Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"adv00425","DOI":"10.2340\/00015555-3780","article-title":"Clinicopathological, Genetic and Survival Advantages of Naevus-associated Melanomas: A Cohort Study","volume":"101","author":"Podlipnik","year":"2021","journal-title":"Acta Derm.-Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2340\/00015555-2009","article-title":"Dermoscopy of Naevus-associated Melanomas","volume":"95","author":"Shitara","year":"2015","journal-title":"Acta Derm.-Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/ijd.14918","article-title":"Digital dermoscopic changes during follow-up of de-novo and nevus-associated melanoma: A cohort study","volume":"59","author":"Pampena","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jaad.2020.04.120","article-title":"Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas","volume":"83","author":"Zalaudek","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jid.2020.07.022","article-title":"The Distinctive Genomic Landscape of Giant Congenital Melanocytic Nevi","volume":"141","author":"Stark","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Shreberk-Hassidim, R., Ostrowski, S.M., and Fisher, D.E. (2023). The Complex Interplay between Nevi and Melanoma: Risk Factors and Precursors. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043541"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/bjd.13524","article-title":"Morphological features of naevoid melanoma: Results of a multicentre study of the International Dermoscopy Society","volume":"172","author":"Longo","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/jdv.18453","article-title":"A review of nevus-associated melanoma: What is the evidence?","volume":"36","author":"Dessinioti","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e70015","DOI":"10.1111\/pcmr.70015","article-title":"New Dermoscopy Pattern in Nevus-Associated Melanomas","volume":"38","author":"Hartmann","year":"2025","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_14","first-page":"66","article-title":"Melanocytic Tumour Classification and the Pathway Concept of Melanoma Pathogenesis","volume":"Volume 11","author":"Elder","year":"2018","journal-title":"WHO Classification of Skin Tumours"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2020028","DOI":"10.5826\/dpc.1002a28","article-title":"Is There More Than One Road to Nevus-Associated Melanoma?","volume":"10","author":"Vezzoni","year":"2020","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000546226","article-title":"A retrospective study of nevus-associated melanoma in situ","volume":"241","author":"Dessinioti","year":"2025","journal-title":"Dermatology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gosman, L.M., \u021a\u0103poi, D.A., and Costache, M. (2023). Cutaneous Melanoma: A Review of Multifactorial Pathogenesis, Immunohistochemistry, and Emerging Biomarkers for Early Detection and Management. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115881"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1056\/NEJM199909023411017","article-title":"The pathogenesis of melanoma induced by ultraviolet radiation","volume":"341","author":"Mack","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/jdv.17244","article-title":"Unveiling melanomagenesis through the dermatoscope","volume":"35","author":"Jaimes","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1684\/ejd.2023.4454","article-title":"Comparative dermoscopy assessment of nevus-associated versus de novo in situ melanoma","volume":"33","author":"Bellinato","year":"2023","journal-title":"Eur. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jaad.2017.06.149","article-title":"A meta-analysis of nevus-associated melanoma: Preva-lence and practical implications","volume":"77","author":"Pampena","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","first-page":"e2022094","article-title":"Prevalence and clinical-pathological features of nevus-associated versus de novo melanoma: A retrospective cross-sectional study of 2806 cases","volume":"12","author":"Lai","year":"2022","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Rapanotti, M.C., Cenci, T., Scioli, M.G., Cugini, E., Anzillotti, S., Savino, L., Coletta, D., Di Raimondo, C., Campione, E., and Roselli, M. (2024). Circulating Tumor Cells: Origin, Role, Current Applications, and Future Perspectives for Personalized Medicine. Biomedicines, 12.","DOI":"10.3390\/biomedicines12092137"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/ajcp\/aqz209","article-title":"BRAF, KIT, and NRAS Mutations of Acral Melanoma in White Patients","volume":"153","author":"Dika","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_25","unstructured":"WHO Classification of Tumours Editorial Board (2023). Skin Tumours, International Agency for Research on Cancer. [5th ed.]."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccell.2018.06.005","article-title":"Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution","volume":"34","author":"Shain","year":"2018","journal-title":"Cancer Cell."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc.2016.37","article-title":"From melanocytes to melanomas","volume":"16","author":"Shain","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/bjd.13829","article-title":"Mutational status of naevus-associated melanomas","volume":"173","author":"Shitara","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ricci, C., Dika, E., Ambrosi, F., Lambertini, M., Veronesi, G., and Barbara, C. (2022). Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115911"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/CMR.0000000000000160","article-title":"Spitzoid tumors in children and adults","volume":"25","author":"Dika","year":"2015","journal-title":"Melanoma Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1016\/j.jid.2020.03.949","article-title":"Defining the Prognostic Role of MicroRNAs in Cutaneous Melanoma","volume":"140","author":"Dika","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","first-page":"243","article-title":"Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma","volume":"158","author":"Sini","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/bjd.14613","article-title":"Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: About mutation-specific immunohistochemistry: Reply from the authors","volume":"175","author":"Shitara","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153942","DOI":"10.1016\/j.prp.2022.153942","article-title":"Dysplastic nevi and melanoma: MicroRNAs tell a divergent story","volume":"235","author":"Durante","year":"2022","journal-title":"Pathol.-Res. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rapanotti, M.C., Cugini, E., Campione, E., Di Raimondo, C., Costanza, G., Rossi, P., Ferlosio, A., Bernardini, S., Orlandi, A., and De Luca, A. (2023). Epithelial-to-Mesenchymal Transition Gene Signature in Circulating Melanoma Cells: Biological and Clinical Relevance. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411792"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/14737159.2022.2049243","article-title":"Circulating microRNA biomarkers in melanoma and non-melanoma skin cancer","volume":"22","author":"Durante","year":"2022","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_37","first-page":"e14165","article-title":"The role of topical imiquimod in melanoma cutaneous metastases: A critical review of the literature","volume":"33","author":"Patrizi","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0846.2007.00218.x","article-title":"Tape-stripping method in man: Comparison of evaporimetric methods","volume":"13","author":"Zhai","year":"2007","journal-title":"Ski. Res. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cosio, T., Di Prete, M., Di Raimondo, C., Garofalo, V., Lozzi, F., Lanna, C., Dika, E., Orlandi, A., Rapanotti, M.C., and Bianchi, L. (2021). Patidegib in Dermatology: A Current Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910725"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1042\/EBC20200048","article-title":"Non-coding RNA dysregulation in skin cancers","volume":"65","author":"Durante","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/CMR.0000000000001056","article-title":"Peripheral blood inflammation indexes correlate with advanced stages in cutaneous melanoma: A single-center retrospective study","volume":"35","author":"Fico","year":"2025","journal-title":"Melanoma Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dika, E., Lambertini, M., Pellegrini, C., Veronesi, G., Melotti, B., Riefolo, M., Sperandi, F., Patrizi, A., Ricci, C., and Mussi, M. (2021). Cutaneous and Mucosal Melanomas of Uncommon Sites: Where Do We Stand Now?. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030478"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"153805","DOI":"10.1016\/j.prp.2022.153805","article-title":"The EORTC protocol for sentinel lymph node biopsy (SLNB) reveals a high number of nodal nevi and a strong association with nevus-associated melanoma","volume":"233","author":"Ricci","year":"2022","journal-title":"Pathol.-Res. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/jdv.20736","article-title":"Acral melanoma: Molecular subtyping as a gateway to precision medicine","volume":"39","author":"Dika","year":"2025","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2024.11.006","article-title":"Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"36","author":"Amaral","year":"2025","journal-title":"Ann Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jaad.2018.01.030","article-title":"Prognostic value of sentinel lymph node biopsy according to Breslow thickness for cutaneous melanoma","volume":"78","author":"Stiegel","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ejca.2009.05.034","article-title":"Clinical and histopathological risk factors to predict sentinel lymph node positivity, disease-free and overall survival in clinical stages I-II AJCC skin melanoma: Outcome analysis from a single-institution prospectively collected database","volume":"45","author":"Imberti","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jaad.2016.08.066","article-title":"Mitotic rate correlates with sentinel lymph node status and outcome in cutaneous melanoma greater than 1 millimeter in thickness: A multi-institutional study of 1524 cases","volume":"76","author":"Galli","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.suronc.2010.11.001","article-title":"Clinico-pathologic features of primary melanoma and sentinel lymph node predictive for non-sentinel lymph node involvement and overall survival in melanoma patients: A single centre observational cohort study","volume":"20","author":"Quaglino","year":"2011","journal-title":"Surg. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1111\/jdv.14485","article-title":"Is mitotic rate still useful in the management of patients with thin melanoma?","volume":"31","author":"Gallego","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1002\/cam4.2358","article-title":"Survival analysis and sentinel lymph node status in thin cutaneous melanoma: A multicenter observational study","volume":"8","author":"Ribero","year":"2019","journal-title":"Cancer Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaad.2018.08.051","article-title":"Predictors of sentinel lymph node positivity in thin melanoma using the National Cancer Database","volume":"80","author":"Conic","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1708539","article-title":"Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma","volume":"377","author":"Long","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa2005493","article-title":"Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma","volume":"383","author":"Dummer","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1470-2045(20)30002-4","article-title":"Adjuvant therapy for melanoma: How to choose?","volume":"21","author":"Karakousis","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"102962","DOI":"10.1016\/j.esmoop.2024.102962","article-title":"Adjuvant immunotherapy for melanoma patients: Progress and opportunities","volume":"9","author":"Sussman","year":"2024","journal-title":"ESMO Open"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jaad.2024.11.029","article-title":"Nevus-associated acral melanoma has lower risk of recurrence and mortality than de novo acral melanoma: A multicenter, retrospective analysis of 482 patients","volume":"92","author":"Zhang","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1245\/s10434-025-16945-2","article-title":"Prognostic Value of Nevus-Associated Melanoma in Patients with Melanoma","volume":"32","author":"Riaz","year":"2025","journal-title":"Ann. Surg. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jaad.2014.09.028","article-title":"Outcome of patients with de novo versus nevus-associated melanoma","volume":"72","author":"Lin","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"djw121","DOI":"10.1093\/jnci\/djw121","article-title":"De Novo vs Nevus-Associated Melanomas: Differences in Associations With Prognostic Indicators and Survival","volume":"108","author":"Cymerman","year":"2016","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/1346-8138.14737","article-title":"Histogenesis of cutaneous malignant melanoma: The vast majority do not develop from melanocytic nevus but arise de novo as melanoma in situ","volume":"46","author":"Saida","year":"2019","journal-title":"J. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s12253-020-00858-4","article-title":"De Novo and Nevus-Associated Melanomas: Different Histopathologic Characteristics but Similar Survival Rates","volume":"26","author":"Tas","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000510221","article-title":"Cutaneous Melanoma Arising in Congenital Melanocytic Nevus: A Retrospective Observational Study","volume":"237","author":"Caccavale","year":"2020","journal-title":"Dermatology"},{"key":"ref_64","first-page":"65","article-title":"Nevus-associated melanoma: Facts and controversies","volume":"155","author":"Pampena","year":"2020","journal-title":"Ital. J. Dermatol. Venereol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/23\/3859\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:52:42Z","timestamp":1764759162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/17\/23\/3859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,30]]},"references-count":64,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["cancers17233859"],"URL":"https:\/\/doi.org\/10.3390\/cancers17233859","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,30]]}}}