{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:51:57Z","timestamp":1788817917095,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"University of Szeged, Faculty of Medicine Research Fund-Het\u00e9nyi G\u00e9za","doi-asserted-by":"publisher","award":["IV-134-62-1\/2024.SZAOK"],"award-info":[{"award-number":["IV-134-62-1\/2024.SZAOK"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00e1nos Bolyai Research Fellowship of the Hungarian Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Appendiceal neoplasms are rare, but recent data indicate a rising trend, particularly in patients under the age of 50. These tumours are often diagnosed incidentally during histopathological examination. This study has aimed to examine the incidence and histological subtypes of appendiceal neoplasms in a Southern Hungarian population. Methods: Our study included neoplastic appendix specimens processed at the University of Szeged between 2014 and 2023. Results: Neoplasms were identified in 71 cases from 3640 appendectomies (1.9%). Benign lesions were present in 37% of cases (n = 26), with the most common subtype being the sessile serrated lesion (n = 20). Mucinous and malignant neoplasms were found in 63% of cases (n = 45), most frequently low-grade appendiceal mucinous neoplasm (n = 19), followed by neuroendocrine tumour (n = 17). Notably, colorectal neoplasm was identified in 50% of benign, and 42.2% of mucinous and malignant cases during a mean follow-up of 33.4 months. Significant associations were found between histological subtype and age (p = 0.022), complete resection (p = 0.012), presence of vascular invasion (p = 0.007), and localisation of potentially associated colorectal carcinoma (p = 0.018). Additionally, tumour dignity showed significant correlations with tumour, node, metastasis (TNM) stage (p &lt; 0.001), vascular invasion (p = 0.017), and lastly, occurrence (p = 0.031) and localisation (p = 0.003) of associated colorectal carcinoma. Conclusions: The prevalence and characteristics observed in this Southern Hungarian population were consistent with international data, although raw case numbers suggested an upward trend. The high rate of associated colorectal neoplasms underscores the importance of thorough pathological evaluation and long-term surveillance.<\/jats:p>","DOI":"10.3390\/cancers17244028","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:15:21Z","timestamp":1766049321000},"page":"4028","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Examination of Appendiceal Neoplasms\u2014A Retrospective, Single-Centre, Cohort Study"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4235-8606","authenticated-orcid":false,"given":"Berkenye","family":"Csonka","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-7313","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Lantos","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Informatics, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-2989","authenticated-orcid":false,"given":"Anita","family":"Sejben","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Constantin, M., Petrescu, L., M\u0103tanie, C., Vrancianu, C.O., Niculescu, A.G., Andronic, O., and Bolocan, A. 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