{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:30:47Z","timestamp":1775341847803,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Financial toxicity (FT) refers to the financial burden directly or indirectly caused by a patient\u2019s medical care. Patients with head and neck cancer (HNC) are particularly vulnerable to FT due to lower rates of return to work and higher out-of-pocket payments (OOPP). In this cross-sectional study, we assessed the amount and types of OOPP, as well as the prevalence of FT, in HNC patients who had completed curative radiotherapy. Methods: We included HNC patients who underwent curative-intent radiotherapy at four private clinics in Romania, within 12 months of completing treatment. Participants completed a 25-item questionnaire capturing sociodemographic information, insurance status, income, and OOPP. To assess subjective FT, we used the validated nine-item Financial Index of Toxicity (FIT), which measures three FT domains: financial stress, financial strain, and lost productivity. Each domain and the total score range from 0 to 100, with higher scores indicating greater financial toxicity. Descriptive statistics were used to summarize patient characteristics. Pearson\u2019s chi-square, t-tests, and one-way ANOVA were used to assess statistical associations, with a significance threshold of p &lt; 0.05. Results: Among 113 patients (mean age: 59), the majority were male (74.3%) and married (74.3%), with 40% having completed university or higher education. The most frequent tumor sites were the oropharynx (29 cases), larynx (22), and oral cavity (21). Concurrent chemoradiation was the most common treatment modality (47%). The mean total FT score was 18.8. Overall, 39.8% of patients experienced financial toxicity, and 29.2% scored above the mean in financial stress. Moderate financial strain (score &gt; 21) was reported by 39.8% of participants, and approximately one-third reported loss of productivity. Transportation and nutritional supplements were the most common OOPP categories. Notably, 42% of patients spent at least 400 euros\u2014equivalent to Romania\u2019s monthly minimum income\u2014on transportation during radiotherapy. FT was significantly associated with employment and marital status, but not with tumor site or treatment type. Conclusions: Among Romanian HNC patients treated with curative radiotherapy, we found substantial OOPP, particularly for transportation and nutritional supplements. While overall FT levels were moderate, divorced patients and those retired due to other chronic conditions were the most vulnerable to financial distress. Financial toxicity can directly affect treatment adherence, survival, and quality of life. By integrating financial counseling, social support, and broader coverage of treatment-related expenses, healthcare systems can mitigate FT for these patients.<\/jats:p>","DOI":"10.3390\/cancers18010003","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T08:26:36Z","timestamp":1766132796000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient-Reported Financial Burden in Head and Neck Cancer Undergoing Radiotherapy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3217-0630","authenticated-orcid":false,"given":"Renata","family":"Zahu","sequence":"first","affiliation":[{"name":"Department of Oncology and Radiotherapy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"},{"name":"Amethyst Radiotherapy Center Cluj, 407280 Flore\u0219ti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica Emilia","family":"Chirila","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"},{"name":"Amethyst Radiotherapy Center Cluj, 407280 Flore\u0219ti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1686-526X","authenticated-orcid":false,"given":"Otilia","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Elena","family":"Sturzu","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Cluj, 407280 Flore\u0219ti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Timisoara, 307160 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Timisoara, 307160 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi","family":"Besenyodi","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Alba Iulia, 510040 Alba Iulia, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalina","family":"Vesel-Pop","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Alba Iulia, 510040 Alba Iulia, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavius","family":"Co\u0219er","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Alba Iulia, 510040 Alba Iulia, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Costache","sequence":"additional","affiliation":[{"name":"Amethyst Radiotherapy Center Bucuresti, 075100 Otopeni, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Kacso","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania"},{"name":"Amethyst Radiotherapy Center Cluj, 407280 Flore\u0219ti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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