{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:18:20Z","timestamp":1790882300223,"version":"4.1.0"},"reference-count":256,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011597","name":"Penn State Cancer Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011597","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Molecular and Precision Medicine"},{"name":"Kenneth F. Noel Memorial Fund"},{"name":"Delbert J. McQuaide Cancer Research Fund"},{"name":"Four Diamonds Transformative Fund"},{"name":"CII-SERB Prime Minister\u2019s Fellowship"},{"name":"Government of India"},{"name":"Novick Biosciences Pvt. 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Accumulating evidence has shown the involvement of kinase targets in the induction of drug resistance in high-risk (HR) HPV-CC. Molecularly, the genome of high-risk HPV is reported to control the expression of host kinases. In particular, Aurora kinases A, B, and C (ARKA, ARKB, and ARKC), phosphotidylinositol\u2013trisphosphate kinase (PI3K)-Akt, and Glycogen synthase kinase3-\u03b1\/\u03b2 (GSK3 \u03b1\/\u03b2) promote the transformation of infected cells, and also enhance the resistance of cells to various chemotherapeutic agents such as nelfinavir and cisplatin. However, the precise mechanisms through which HPV activates these kinases are yet to be fully elucidated. Furthermore, there is still ambiguity surrounding whether targeting HPV-induced kinases along with HPV-targeted therapies (such as phytopharmaceuticals and PROTAC\/CRISPR-CAS-based systems) synergistically inhibit cervical tumor growth. Given the critical role of kinases in the pathogenesis and treatment of CC, a comprehensive review of current evidence is warranted. This review aims to provide key insights into the mechanisms of HPV-induced CC development, the involvement of kinases in drug resistance induction, and the rationale for combination therapies to improve clinical outcomes.<\/jats:p>","DOI":"10.3390\/cancers18020318","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:24:34Z","timestamp":1768901074000},"page":"318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["An Overview of the Mechanisms of HPV-Induced Cervical Cancer: The Role of Kinase Targets in Pathogenesis and Drug Resistance"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-8004","authenticated-orcid":false,"given":"Medha","family":"Karnik","sequence":"first","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-8814","authenticated-orcid":false,"given":"SubbaRao V.","family":"Tulimilli","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi G.","family":"Anantharaju","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali Devi S.","family":"Bettadapura","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma M.","family":"Natraj","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4217-5063","authenticated-orcid":false,"given":"Habeeb S.","family":"Mohideen","sequence":"additional","affiliation":[{"name":"Bioinformatics and Integrative Omics Lab, Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Chennai 603203, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Dovat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7178-949X","authenticated-orcid":false,"given":"Arati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Molecular and Precision Medicine, Center for Cannabis and Natural Product Pharmaceuticals (CCNPP), Penn State Cancer Institute, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-9271","authenticated-orcid":false,"given":"SubbaRao V.","family":"Madhunapantula","sequence":"additional","affiliation":[{"name":"Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR) Laboratory (A DST-FIST Supported Center and ICMR-Collaborating Center of Excellence), Department of Biochemistry (A DST-FIST Supported Department), JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysore 570015, Karnataka, India"},{"name":"Special Interest Group in Cancer Biology 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