{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:29:56Z","timestamp":1769660996632,"version":"3.49.0"},"reference-count":92,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Postoperative cognitive dysfunction (POCD) represents a significant and potentially preventable complication in elderly patients undergoing colorectal cancer surgery, with reported incidence ranging from 2.8% to 62.2% depending on perioperative management strategies and assessment methods. This narrative review synthesizes current evidence on the epidemiology, pathophysiology, risk factors, and prevention strategies for POCD in this vulnerable population. Methods: A comprehensive narrative review was conducted to examine the current literature on POCD in elderly colorectal cancer patients. Evidence was synthesized from published studies addressing epidemiology, assessment tools, risk factors, pathophysiological mechanisms, and prevention strategies, with a particular focus on Enhanced Recovery After Surgery (ERAS) protocols and multicomponent interventions. Results: Advanced age, pre-existing cognitive impairment, frailty, and surgical complexity emerge as key risk factors for POCD. ERAS protocols demonstrate substantial protective effects, reducing POCD incidence from 35% under conventional care to as low as 2.8% in optimized pathways. The pathophysiology involves multifactorial mechanisms, including neuroinflammation, blood\u2013brain barrier disruption, neurotransmitter dysregulation, and oxidative stress, with surgical trauma triggering systemic inflammatory cascades that activate microglial responses within the central nervous system. Evidence-based prevention strategies include preoperative cognitive and frailty screening, minimally invasive surgical techniques, multimodal opioid-sparing analgesia, regional anesthesia, depth-of-anesthesia monitoring, and structured postoperative care bundles adapted from the Hospital Elder Life Program. Conclusions: The integration of comprehensive perioperative cognitive care protocols represents a critical priority as surgical volumes in elderly populations continue to expand globally. Emerging directions include biomarker development for early detection and risk stratification, precision medicine approaches targeting individual vulnerability profiles, and novel therapeutic interventions addressing neuroinflammatory pathways. Standardized assessment tools, multidisciplinary collaboration, and implementation of evidence-based preventive interventions offer substantial promise for preserving cognitive function and improving long-term quality of life in elderly colorectal cancer patients.<\/jats:p>","DOI":"10.3390\/cancers18030417","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:56:12Z","timestamp":1769615772000},"page":"417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive Impact of Colorectal Cancer Surgery in Elderly Patients: A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-6481","authenticated-orcid":false,"given":"Oswaldo Moraes","family":"Filho","sequence":"first","affiliation":[{"name":"Coloproctology Service, University Hospital of Bras\u00edlia, University of Brasilia, Bras\u00edlia 70830-200, DF, Brazil"},{"name":"SHIN Qi 8 Conjunto 3 casa 13, Lago Norte, Bras\u00edlia 71520-230, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-2341","authenticated-orcid":false,"given":"Bruno Augusto","family":"Alves Martins","sequence":"additional","affiliation":[{"name":"Coloproctology Service, University Hospital of Bras\u00edlia, University of Brasilia, Bras\u00edlia 70830-200, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuane","family":"Colles","sequence":"additional","affiliation":[{"name":"Coloproctology Service, University Hospital of Bras\u00edlia, University of Brasilia, Bras\u00edlia 70830-200, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romulo Medeiros","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Coloproctology Service, University Hospital of Bras\u00edlia, University of Brasilia, Bras\u00edlia 70830-200, DF, Brazil"},{"name":"School of Medicine, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6314-9505","authenticated-orcid":false,"given":"Jo\u00e3o Batista","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Coloproctology Service, University Hospital of Bras\u00edlia, University of Brasilia, Bras\u00edlia 70830-200, DF, Brazil"},{"name":"School of Medicine, University of Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. 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