{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:26:12Z","timestamp":1785821172449,"version":"3.56.0"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"public university"},{"name":"Swiss Cancer League","award":["KLS-5650-08-2022"],"award-info":[{"award-number":["KLS-5650-08-2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Hodgkin lymphoma (HL) primarily affects individuals of reproductive age, making gonadal dysfunction after chemotherapy a critical survivorship concern. While fertility preservation options including gamete and gonadal tissue cryopreservation are available before treatment, evidence-based counseling requires regimen-specific risk estimates accounting for patient age and sex. Therefore, a meta-analysis was performed to assess presumed infertility in HL patients, stratified by chemotherapy regimen, age, and sex. Methods: This systematic review and meta-analysis, conducted within the FertiTOX project, included studies published between 2000 and February 2024. Eligible studies reported gonadal function outcomes \u2265 1 year after chemotherapy, excluding patients who received pelvic radiotherapy or stem cell transplantation, or had recurrent disease. Presumed infertility was defined by surrogate markers, including amenorrhea, premature ovarian failure, or abnormal hormonal levels in women, and azoospermia, oligozoospermia, or abnormal hormonal levels in men. Results: Of 2376 screened studies, 50 were included (meta-analysis: 43 studies; 5564 female and 1631 male patients). Overall presumed infertility prevalence was 21% in women (95% CI: 0.14\u20130.29) and 45% in men (95% CI: 0.29\u20130.62). The highest prevalence occurred after BEACOPP (women 38%; men 81%), while ABVD was associated with the lowest (6% each in women and men). Childhood\/adolescent HL treatment resulted in lower prevalence in women (8%) but remained high in men (67%). Conclusions: Fertility risk depends on regimen, age, and sex, requiring tailored counseling. For female children\/adolescents and all patients receiving ABVD, post-treatment fertility evaluation and treatment may suffice. However, pre-treatment fertility preservation is strongly recommended for male adolescents and patients receiving other regimens.<\/jats:p>","DOI":"10.3390\/cancers18030425","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:56:12Z","timestamp":1769615772000},"page":"425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hodgkin Lymphoma\u2014The Effect of Chemotherapy on Gonadal Function and Fertility Is Strongly Related to the Treatment Regimen, Age, and Sex: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"18","author":[{"given":"Mareike","family":"Roth-Hochreutener","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Karakitsiou","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-6200","authenticated-orcid":false,"given":"Angela","family":"Vidal","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Weidlinger","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7858-2288","authenticated-orcid":false,"given":"Janna","family":"Pape","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1200-7149","authenticated-orcid":false,"given":"Tanya","family":"Karrer","sequence":"additional","affiliation":[{"name":"Medical Library, University Library Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-1784","authenticated-orcid":false,"given":"Karolin","family":"Behringer","sequence":"additional","affiliation":[{"name":"Hodgkin Study Group (GHSG), Department I of Internal Medicine, University Hospital Cologne, 50924 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4303-2734","authenticated-orcid":false,"given":"Michael","family":"von Wolff","sequence":"additional","affiliation":[{"name":"Division of Gynecological Endocrinology and Reproductive Medicine, University Women\u2019s Hospital, Inselspital Bern, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e3239","DOI":"10.1002\/hon.3239","article-title":"Classic Hodgkin lymphoma","volume":"42","author":"Kahn","year":"2024","journal-title":"Hematol. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-022-01281-9","article-title":"Incidence, mortality, risk factors, and trends for Hodgkin lymphoma: A global data analysis","volume":"15","author":"Huang","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"ref_3","unstructured":"Robert Koch Institute, Department of Epidemiology and Health Monitoring (2025, February 03). Available online: https:\/\/www.krebsdaten.de\/Krebs\/DE\/Content\/Krebsarten\/Morbus%20Hodgkin\/morbus%20hodgkin_node.html."},{"key":"ref_4","unstructured":"AWMF (2025, March 01). S3-Leitlinie Version 3.2: Diagnostik, Therapie und Nachsorge des Hodgkin Lymphoms bei Erwachsenen Patienten, Stand. Available online: https:\/\/register.awmf.org\/assets\/guidelines\/018-029OLl_S3_Hodgkin-Lymphom_Erwachsene_Diagnostik_Therapie_Nachsorge_2022-10.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1000067","article-title":"Reduced treatment intensity in patients with early-stage Hodgkin\u2019s lymphoma","volume":"363","author":"Engert","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1016\/S0140-6736(17)32134-7","article-title":"PET-guided treatment in patients with advanced-stage Hodgkin\u2019s lymphoma (HD18): Final results of an open-label, international, randomised phase 3 trial by the German Hodgkin Study Group","volume":"390","author":"Borchmann","year":"2017","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(24)01315-1","article-title":"Assessing the efficacy and tolerability of PET-guided BrECADD versus eBEACOPP in advanced-stage, classical Hodgkin lymphoma (HD21): A randomised, multicentre, parallel, open-label, phase 3 trial","volume":"404","author":"Borchmann","year":"2024","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S1470-2045(25)00262-1","article-title":"Fertility in patients with advanced-stage classic Hodgkin lymphoma treated with BrECADD versus eBEACOPP: A secondary analysis of the multicentre, randomised, parallel, open-label, phase 3 HD21 trial","volume":"26","author":"Ferdinandus","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/sj.bjc.6604892","article-title":"Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy","volume":"100","author":"Kiserud","year":"2009","journal-title":"Br. J. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00000421-199708000-00006","article-title":"Gonadal function following ABVD therapy for Hodgkin\u2019s disease","volume":"20","author":"Kulkarni","year":"1997","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/humrep\/dem313","article-title":"Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin\u2019s lymphoma with chemotherapy during childhood","volume":"22","author":"Smit","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00404-025-08253-7","article-title":"Development of medical freezing measures in women during the last decade from 2014 to 2023: Registry data of the tri-national network FertiPROTEKT","volume":"313","author":"Vidal","year":"2026","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1200\/JCO.2005.08.138","article-title":"Secondary amenorrhea after Hodgkin\u2019s lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: A report from the German Hodgkin\u2019s Lymphoma Study Group","volume":"23","author":"Behringer","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1200\/JCO.2012.44.3721","article-title":"Gonadal function and fertility in survivors after Hodgkin lymphoma treatment within the German Hodgkin Study Group HD13 to HD15 trials","volume":"31","author":"Behringer","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e51145","DOI":"10.2196\/51145","article-title":"Evaluation of the Gonadotoxicity of Cancer Therapies to Improve Counseling of Patients About Fertility and Fertility Preservation Measures: Protocol for a Retrospective Systematic Data Analysis and a Prospective Cohort Study","volume":"13","author":"Germeyer","year":"2024","journal-title":"JMIR Res. Protoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1089\/jayao.2023.0185","article-title":"A Systematic Review of the Gonadotoxicity of Osteosarcoma and Ewing\u2019s Sarcoma Chemotherapies in Postpubertal Females and Males","volume":"13","author":"Weidlinger","year":"2024","journal-title":"J. Adolesc. Young Adult Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104514","DOI":"10.1016\/j.breast.2025.104514","article-title":"High impact of chemotherapy on ovarian reserve in breast cancer survivors of reproductive age: A systematic review and meta-analysis","volume":"82","author":"Weidlinger","year":"2025","journal-title":"Breast"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1089\/jayao.2024.0057","article-title":"Systematic Review of the Gonadotoxicity and Risk of Infertility of Soft Tissue Sarcoma Chemotherapies in Pre- and Postpubertal Females and Males","volume":"13","author":"Steinmann","year":"2024","journal-title":"J. Adolesc. Young Adult Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/andr.13741","article-title":"Oncological treatments have limited effects on the fertility prognosis in testicular cancer: A systematic review and meta-analysis","volume":"13","author":"Pape","year":"2025","journal-title":"Andrology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Anthon, C., Vidal, A., Recker, H., Piccand, E., Pape, J., Weidlinger, S., Kornmann, M., Karrer, T., and von Wolff, M. (2024). Long-Term Effects on Gonadal Function After Treatment of Colorectal Cancer: A Systematic Review and Meta-Analysis. Cancers, 16.","DOI":"10.3390\/cancers16234005"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41409-025-02520-6","article-title":"Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: A systematic review and meta-analysis","volume":"60","author":"Vidal","year":"2025","journal-title":"Bone Marrow Transplant."},{"key":"ref_22","first-page":"691","article-title":"Long-term effects on fertility after central nervous system cancer: A systematic review and meta-analysis","volume":"11","author":"Pape","year":"2024","journal-title":"Neurooncol. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13643-022-02045-9","article-title":"Reducing systematic review burden using Deduklick: A novel, automated, reliable, and explainable deduplication algorithm to foster medical research","volume":"11","author":"Borissov","year":"2022","journal-title":"Syst. Rev."},{"key":"ref_25","first-page":"508","article-title":"Software tools for literature screening in systematic reviews in biomedical research","volume":"36","author":"Tsaioun","year":"2019","journal-title":"ALTEX\u2014Altern. Anim. Exp."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/13697137.2024.2408922","article-title":"Evidence-based guideline: Premature ovarian insufficiency","volume":"27","author":"Panay","year":"2024","journal-title":"Climacteric"},{"key":"ref_27","unstructured":"(2025, August 03). The Joanna Briggs Institute Critical Appraisal Tools for Use in JBI Systematic Reviews: Checklist for Cohort Studies. Available online: https:\/\/jbi.global\/sites\/default\/files\/2019-05\/JBI_Critical_Appraisal-Checklist_for_Cohort_Studies2017_0.pdf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1080\/00016340600677043","article-title":"Optimal treatment of premature ovarian failure after treatment for Hodgkin\u2019s lymphoma is often withheld","volume":"85","author":"Verschuuren","year":"2006","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/annonc\/mdl149","article-title":"Treatment-related premature ovarian failure as a long-term complication after Hodgkin\u2019s lymphoma","volume":"17","author":"Haukvik","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10245330600954072","article-title":"Ovarian function after cancer treatment in young women affected by Hodgkin disease (HD)","volume":"12","author":"Giuseppe","year":"2007","journal-title":"Hematology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/humrep\/den005","article-title":"Prevention of ovarian function damage by a GnRH analogue during chemotherapy in Hodgkin lymphoma patients","volume":"23","author":"Huser","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fertnstert.2007.02.010","article-title":"Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma","volume":"89","author":"Blumenfeld","year":"2008","journal-title":"Fertil. Steril."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1182\/blood-2007-05-090225","article-title":"Treatment-related risk factors for premature menopause following Hodgkin lymphoma","volume":"111","author":"Huisbrink","year":"2008","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00404-009-1308-5","article-title":"GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin\u2019s lymphoma patients","volume":"282","author":"Nitzschke","year":"2010","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1093\/annonc\/mdq066","article-title":"No protection of the ovarian follicle pool with the use of GnRH-analogues or oral contraceptives in young women treated with escalated BEACOPP for advanced-stage Hodgkin lymphoma. Final results of a phase II trial from the German Hodgkin Study Group","volume":"21","author":"Behringer","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ajh.22187","article-title":"A 10-year experience with treatment of high and standard risk Hodgkin disease: Six cycles of tailored BEACOPP, with interim scintigraphy, are effective and female fertility is preserved","volume":"87","author":"Dann","year":"2012","journal-title":"Am. J. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/annonc\/mdr575","article-title":"Fertility and gonadal function in female survivors after treatment of early unfavorable Hodgkin lymphoma (HL) within the German Hodgkin Study Group HD14 trial","volume":"23","author":"Behringer","year":"2012","journal-title":"Ann. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1200\/JCO.2011.37.1989","article-title":"Premature ovarian failure and fertility in long-term survivors of Hodgkin\u2019s lymphoma: A European Organisation for Research and Treatment of Cancer Lymphoma Group and Groupe d\u2019Etude des Lymphomes de l\u2019Adulte Cohort Study","volume":"30","author":"Heutte","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"dju207","DOI":"10.1093\/jnci\/dju207","article-title":"Risk of premature menopause after treatment for Hodgkin\u2019s lymphoma","volume":"106","author":"Swerdlow","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s10815-015-0452-z","article-title":"Fertility status of Hodgkin lymphoma patients treated with chemotherapy and adjuvant gonadotropin-releasing hormone analogues","volume":"32","author":"Huser","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10815-015-0636-6","article-title":"Fertility in young patients following treatment for Hodgkin\u2019s lymphoma: A single center survey","volume":"33","year":"2016","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S1470-2045(18)30500-X","article-title":"Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin\u2019s lymphoma (RATHL): A secondary analysis of a randomised phase 3 trial","volume":"19","author":"Anderson","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1200\/JCO.21.00068","article-title":"Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011)","volume":"39","author":"Demeestere","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/humrep\/deab189","article-title":"Longitudinal study of AMH variations in 122 Adolescents and Young Adults (AYA) and non-AYA lymphoma patients to evaluate the chemo-induced ovarian toxicity to further personalise fertility preservation counselling","volume":"36","author":"Decanter","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/hematolrep14020013","article-title":"Reproductive Issues in Long-Term Surviving Patients following Therapy for Hodgkin\u2019s Disease in the Republic of North Macedonia: Risks of Infertility According to First-Line Treatment Regimens","volume":"14","author":"Amzai","year":"2022","journal-title":"Hematol. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Ciccarone, M., Cavaceppi, P., Tesei, C., Brunetti, S., Pulsoni, A., Annibali, O., Gasparoli, C., Battistini, R., Hohaus, S., and Pelliccia, S. (2023). Effects of ABVD chemotherapy on ovarian function: Epidemiology, hormonal dosages and ultrasound morphologic analyses in 270 patients with Hodgkin\u2019s disease. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1059393"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12978-022-01559-8","article-title":"Premature ovarian insufficiency in female adolescent and young adult survivors of non-gynecological cancers: A population-based cohort study","volume":"20","author":"Flatt","year":"2023","journal-title":"Reprod. Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s11764-023-01388-z","article-title":"Chemotherapy alone vs. chemotherapy plus radiotherapy in female adolescent and young adults with Hodgkin\u2019s lymphoma: Reproductive health outcomes","volume":"18","author":"Luong","year":"2024","journal-title":"J. Cancer Surviv."},{"key":"ref_49","first-page":"44","article-title":"NOVP chemotherapy for Hodgkin\u2019s disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21","volume":"63","author":"Frias","year":"2003","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.rbmo.2011.11.015","article-title":"Sperm cryopreservation before cancer treatment: A 15-year monocentric experience","volume":"24","author":"Bizet","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1200\/JCO.2006.10.2020","article-title":"Gonadal function in males after chemotherapy for early-stage Hodgkin\u2019s lymphoma treated in four subsequent trials by the European Organisation for Research and Treatment of Cancer: EORTC Lymphoma Group and the Groupe d\u2019Etude des Lymphomes de l\u2019Adulte","volume":"25","author":"Heutte","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/annonc\/mdn376","article-title":"Assessment of male fertility in patients with Hodgkin\u2019s lymphoma treated in the German Hodgkin Study Group (GHSG) clinical trials","volume":"19","author":"Sieniawski","year":"2008","journal-title":"Ann. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humrep\/den361","article-title":"Fertility preservation in adolescent males: Experience over 22 years at Rouen University Hospital","volume":"24","author":"Menon","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/andr.12045","article-title":"Review and follow-up of patients using a regional sperm cryopreservation service: Ensuring that resources are targeted to those patients most in need","volume":"3","author":"Tomlinson","year":"2015","journal-title":"Andrology"},{"key":"ref_55","first-page":"263","article-title":"Spermatogenesis in Hodgkin\u2019s lymphoma patients: A retrospective study of semen quality before and after different chemotherapy regimens","volume":"31","author":"Paoli","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/bjh.17767","article-title":"In male Hodgkin lymphoma patients, impaired fertility may be improved by non-gonadotoxic therapy","volume":"196","author":"Laddaga","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/pbc.10422","article-title":"Decreasing the number of MOPP courses reduces gonadal damage in survivors of childhood Hodgkin disease","volume":"42","author":"Furstner","year":"2004","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jpag.2016.04.009","article-title":"Anti-M\u00fcllerian Hormone in Female Adolescent Cancer Patients Before, During, and After Completion of Therapy: A Pilot Feasibility Study","volume":"29","author":"Gupta","year":"2016","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/humrep\/deae112","article-title":"The impact of treatment for childhood classical Hodgkin lymphoma according to the EuroNet-PHL-C2 protocol on serum anti-M\u00fcllerian Hormone","volume":"39","author":"Drechsel","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/088800100276415","article-title":"Male gonadal function in survivors of childhood Hodgkin and non-Hodgkin lymphoma","volume":"17","author":"Solt","year":"2000","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1515\/JPEM.2004.17.6.879","article-title":"Decreased serum inhibin B\/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence","volume":"17","author":"Bordallo","year":"2004","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/pbc.20172","article-title":"Fertility in males treated for Hodgkins disease with COPP\/ABV hybrid","volume":"44","author":"Hobbie","year":"2005","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2605.2010.01058.x","article-title":"High risk of azoospermia in men treated for childhood cancer","volume":"34","author":"Romerius","year":"2011","journal-title":"Int. J. Androl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1439-0272.2011.01167.x","article-title":"Low inhibin B levels alone are not a reliable marker of dysfunctional spermatogenesis in childhood cancer survivors","volume":"44","author":"Rendtorff","year":"2012","journal-title":"Andrologia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/08880018.2015.1085933","article-title":"Dose-Effect Relationship of Alkylating Agents on Testicular Function in Male Survivors of Childhood Lymphoma","volume":"32","author":"Servitzoglou","year":"2015","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Duca, Y., Di Cataldo, A., Russo, G., Cannata, E., Burgio, G., Compagnone, M., Alamo, A., Condorelli, R.A., La Vignera, S., and Calogero, A.E. (2019). Testicular Function of Childhood Cancer Survivors: Who Is Worse?. J. Clin. Med., 8.","DOI":"10.3390\/jcm8122204"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/and.12451","article-title":"Do malignant diseases affect semen quality? Sperm parameters of men with cancers","volume":"48","author":"Caponecchia","year":"2016","journal-title":"Andrologia"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00404-025-08104-5","article-title":"Fertility preservation in females requiring gonadotoxic therapy should be more than freezing measures before therapy\u2014Secondary fertility preservation and menopause care management after therapy should also be considered","volume":"312","author":"Imboden","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5195\/jmla.2017.183","article-title":"Updating search strategies for systematic reviews using EndNote","volume":"105","author":"Bramer","year":"2017","journal-title":"J. Med. Libr. 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