{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T15:00:05Z","timestamp":1775487605379,"version":"3.50.1"},"reference-count":129,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Epithelial-mesenchymal transition (EMT) is a key driver of invasion, metastasis, and treatment resistance in gastric cancer, yet its post-transcriptional regulation by microRNAs (miRNAs) is not fully delineated. We performed a structured literature search in PubMed, Web of Science, and Scopus for studies evaluating miRNAs in relation to EMT in gastric cancer and synthesised tumor-intrinsic, microenvironmental, and circulating EMT-related miRNA networks. Downregulated, predominantly tumor-suppressive miRNAs, including miR-34a, miR-200 family, miR-148a, miR-204, miR-30a, miR-101, miR-218, miR-26a, miR-375, miR-506, and others, converge on EMT transcription factors and pathways such as ZEB1\/2, Snail, TGF-\u03b2\/SMAD, Wnt\/\u03b2-catenin, c-Met, and PI3K\/AKT, and their restoration reverses EMT phenotypes in preclinical models. Upregulated oncomiRs, such as miR-21, miR-17-5p, miR-106b-5p, miR-23a, miR-130a-3p, miR-196a-5p, miR-181a, miR-616-3p, miR-301a-3p, miR-150, miR-27a-3p and miR-192\/215, target tumor suppressors and reinforce these pathways. Cancer-associated fibroblast, macrophage, neutrophil, and natural killer cell-derived miRNAs, together with systemic indices such as the neutrophil-to-lymphocyte ratio and mediators like FAM3C, add microenvironmental layers of EMT regulation. Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.<\/jats:p>","DOI":"10.3390\/cancers18030462","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:04:46Z","timestamp":1769778286000},"page":"462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4040-8068","authenticated-orcid":false,"given":"Maciej","family":"Biskupski","sequence":"first","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-2500","authenticated-orcid":false,"given":"Adam","family":"Brachet","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Hunek","sequence":"additional","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Karabin","sequence":"additional","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Czerski","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiktoria","family":"Bojarska","sequence":"additional","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-8503","authenticated-orcid":false,"given":"Robert","family":"Karpi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Machine Design and Mechatronics, Faculty of 1 Mechanical Engineering, Lublin University of Technology, Nadbystrzycka 36, 20-618 Lublin, Poland"},{"name":"Institute of Medical Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, Konstantyn\u00f3w 1H, 20-708 Lublin, Poland"},{"name":"1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, G\u0142uska 1, 20-439 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4184-9305","authenticated-orcid":false,"given":"Grzegorz","family":"Teresi\u0144ski","sequence":"additional","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-7627","authenticated-orcid":false,"given":"Alicja","family":"Forma","sequence":"additional","affiliation":[{"name":"Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-8987","authenticated-orcid":false,"given":"Jacek","family":"Baj","sequence":"additional","affiliation":[{"name":"Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","article-title":"Updates on global epidemiology, risk and prognostic factors of gastric cancer","volume":"29","author":"Yang","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e75728","DOI":"10.2196\/75728","article-title":"The Burden and Risk Factors of Gastric Cancer in Eastern Asia From 1990 to 2021: Longitudinal Observational Study of the Global Burden of Disease Study 2021","volume":"11","author":"Kong","year":"2025","journal-title":"JMIR Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3748\/wjg.v28.i12.1187","article-title":"Epidemiology of stomach cancer","volume":"28","author":"Ilic","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.ejca.2008.07.031","article-title":"Oestrogen and the enigmatic male predominance of gastric cancer","volume":"44","author":"Chandanos","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"ref_5","first-page":"100845","article-title":"Gastric cancer-Epidemiology, modifiable and non-modifiable risk factors, challenges and opportunities: An updated review","volume":"41","author":"Mamun","year":"2024","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/CMR.00011-10","article-title":"Helicobacter pylori and gastric cancer: Factors that modulate disease risk","volume":"23","author":"Wroblewski","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Reyes, V.E. (2023). Helicobacter pylori and its role in gastric cancer. Microorganisms, 11.","DOI":"10.3390\/microorganisms11051312"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jaroenlapnopparat, A., Bhatia, K., and Coban, S. (2022). Inflammation and gastric cancer. Diseases, 10.","DOI":"10.3390\/diseases10030035"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrrev.2013.09.002","article-title":"Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis","volume":"759","author":"He","year":"2014","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1158\/1055-9965.EPI-13-1057","article-title":"Gastric cancer: Descriptive epidemiology, risk factors, screening, and prevention","volume":"23","author":"Karimi","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Machlowska, J., Baj, J., Sitarz, M., Maciejewski, R., and Sitarz, R. (2020). Gastric cancer: Epidemiology, risk factors, classification, genomic characteristics and treatment strategies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21114012"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.omtn.2022.12.014","article-title":"A molecular classification of gastric cancer associated with distinct clinical outcomes and validated by an XGBoost-based prediction model","volume":"31","author":"Li","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.3892\/ol.2016.4337","article-title":"Lauren classification and individualized chemotherapy in gastric cancer","volume":"11","author":"Ma","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41388-021-02067-y","article-title":"Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer","volume":"41","author":"Yu","year":"2022","journal-title":"Oncogene"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s12967-025-06422-5","article-title":"Epithelial-mesenchymal transition orchestrates tumor microenvironment: Current perceptions and challenges","volume":"23","author":"Xie","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.3748\/wjg.v20.i18.5403","article-title":"Role of epithelial-mesenchymal transition in gastric cancer initiation and progression","volume":"20","author":"Peng","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kozak, J., Forma, A., Czeczelewski, M., Kozyra, P., Sitarz, R., Radzikowska-B\u00fcchner, E., Sitarz, M., and Baj, J. (2021). Inhibition or reversal of the epithelial-mesenchymal transition in gastric cancer: Pharmacological approaches. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010277"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1158\/0008-5472.CAN-17-0032","article-title":"Epithelial-to-mesenchymal and mesenchymal-to-epithelial transition in mesenchymal tumors: A paradox in sarcomas?","volume":"77","author":"Sannino","year":"2017","journal-title":"Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.3748\/wjg.v22.i29.6619","article-title":"Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer","volume":"22","author":"Ma","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Baj, J., Brzozowska, K., Forma, A., Maani, A., Sitarz, E., and Portincasa, P. (2020). Immunological aspects of the tumor microenvironment and epithelial-mesenchymal transition in gastric carcinogenesis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072544"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Baj, J., Korona-G\u0142owniak, I., Forma, A., Maani, A., Sitarz, E., Rahnama-Hezavah, M., Radzikowska, E., and Portincasa, P. (2020). Mechanisms of the epithelial-mesenchymal transition and tumor microenvironment in Helicobacter pylori-induced gastric cancer. Cells, 9.","DOI":"10.3390\/cells9041055"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.gene.2019.03.043","article-title":"MicroRNA-574-3p regulates epithelial mesenchymal transition and cisplatin resistance via targeting ZEB1 in human gastric carcinoma cells","volume":"700","author":"Wang","year":"2019","journal-title":"Gene"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/jcmm.12209","article-title":"RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric cancer cells","volume":"18","author":"Liu","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"G147","DOI":"10.1152\/ajpgi.00284.2018","article-title":"MicroRNA-33a prevents epithelial-mesenchymal transition, invasion, and metastasis of gastric cancer cells through the Snail\/Slug pathway","volume":"317","author":"Chen","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172426","DOI":"10.1016\/j.ejphar.2019.172426","article-title":"The expression level changes of microRNAs 200a\/205 in the development of invasive properties in gastric cancer cells through epithelial-mesenchymal transition","volume":"857","author":"Mirzaei","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/1476-4598-13-136","article-title":"Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells","volume":"13","author":"Li","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1096\/fj.201601140RR","article-title":"MiR-2392 suppresses metastasis and epithelial-mesenchymal transition by targeting MAML3 and WHSC1 in gastric cancer","volume":"31","author":"Li","year":"2017","journal-title":"FASEB J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3892\/ijo.2016.3480","article-title":"Interaction between Wnt\/\u03b2-catenin pathway and microRNAs regulates epithelial-mesenchymal transition in gastric cancer (Review)","volume":"48","author":"Wu","year":"2016","journal-title":"Int. J. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/cam4.1237","article-title":"SMG-1 inhibition by miR-192\/-215 causes epithelial-mesenchymal transition in gastric carcinogenesis via activation of Wnt signaling","volume":"7","author":"Zhang","year":"2018","journal-title":"Cancer Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41392-022-01190-w","article-title":"Signaling pathways and therapeutic interventions in gastric cancer","volume":"7","author":"Lei","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kim, Y., Bae, Y.J., Kim, J.H., Kim, H., Shin, S.J., Jung, D.H., and Park, H. (2023). Wnt\/\u03b2-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11447-4"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1038\/s41598-025-86220-7","article-title":"Kindlin-1 promotes gastric cancer cell motility through the Wnt\/\u03b2-catenin signaling pathway","volume":"15","author":"Jang","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shi, R., Cao, Z., Li, J., Ji, R., and Guo, Z. (2025). Targeting the Wnt\/\u03b2-catenin pathway and epithelial-mesenchymal transition in gastric cancer: Mechanisms, therapeutic strategies, and clinical challenges. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1633699"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"a022129","DOI":"10.1101\/cshperspect.a022129","article-title":"Non-Smad signaling pathways of the TGF-\u03b2 family","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"102285","DOI":"10.1016\/j.ctrv.2021.102285","article-title":"The role of transforming growth factor \u03b2 in upper gastrointestinal cancers: A systematic review","volume":"100","author":"Veen","year":"2021","journal-title":"Cancer Treat. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41419-024-06744-0","article-title":"A novel TGFbeta\/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression","volume":"15","author":"Qin","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, J., Hayder, H., Zayed, Y., and Peng, C. (2018). Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00402"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Su, E.C., Chen, Y.S., Tien, Y.C., Liu, J., Ho, B.C., Yu, S.L., and Singh, S. (2016). ChemiRs: A web application for microRNAs and chemicals. BMC Bioinform., 17.","DOI":"10.1186\/s12859-016-1002-0"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1261\/rna.055301.115","article-title":"Guidelines for the functional annotation of microRNAs using the Gene Ontology","volume":"22","author":"Huntley","year":"2016","journal-title":"RNA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12935-015-0185-1","article-title":"MicroRNA (miRNA) in cancer","volume":"15","author":"Reddy","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"111528","DOI":"10.1016\/j.biopha.2021.111528","article-title":"MicroRNA: A signature for cancer progression","volume":"138","author":"Hussen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/cdd.2013.125","article-title":"The miR-17\/92 cluster: A comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease","volume":"20","author":"Mogilyansky","year":"2013","journal-title":"Cell Death Differ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117077","DOI":"10.1016\/j.lfs.2019.117077","article-title":"An insight of microRNAs performance in carcinogenesis and tumorigenesis; an overview of cancer therapy","volume":"240","author":"Babaei","year":"2020","journal-title":"Life Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.trsl.2011.02.001","article-title":"MicroRNAs: miRRORS of health and disease","volume":"157","author":"Montano","year":"2011","journal-title":"Transl. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104718","DOI":"10.1016\/j.yexmp.2021.104718","article-title":"Regulation of CDK inhibitor p27 by microRNA 222 in breast cancer patients","volume":"123","author":"Said","year":"2021","journal-title":"Exp. Mol. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gruszka, R., Zakrzewski, K., Liberski, P.P., and Zakrzewska, M. (2021). mRNA and miRNA expression analyses of the MYC\/E2F\/miR-17-92 network in the most common pediatric brain tumors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020543"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.21873\/anticanres.14308","article-title":"Investigation of the effects of microRNA-221 expression levels in glioblastoma multiforme tumors","volume":"40","author":"Ozdogan","year":"2020","journal-title":"Anticancer Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41419-017-0080-x","article-title":"miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA\/BBC3 and BTG2","volume":"9","author":"Fiori","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: New dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105179","DOI":"10.1016\/j.phrs.2020.105179","article-title":"The P53\/microRNA network: A potential tumor suppressor with a role in anticancer therapy","volume":"160","author":"Sargolzaei","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2017.159","article-title":"BCL2 and miR-15\/16: From gene discovery to treatment","volume":"25","author":"Pekarsky","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1089\/dna.2022.0274","article-title":"The tumor suppressor roles and mechanisms of miR-491 in human cancers","volume":"41","author":"Sadri","year":"2022","journal-title":"DNA Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Moro, M., Fortunato, O., Bertolini, G., Mensah, M., Borzi, C., Centonze, G., Andriani, F., Di Paolo, D., Perri, P., and Ponzoni, M. (2022). MiR-486-5p targets CD133+ lung cancer stem cells through the p85\/AKT pathway. Pharmaceuticals, 15.","DOI":"10.3390\/ph15030297"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3892\/etm.2021.9650","article-title":"miR-155 promotes proliferation and epithelial-mesenchymal transition of MCF-7 cells","volume":"21","author":"Liu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4161\/cbt.10.3.12548","article-title":"The role of the miR-200 family in epithelial-mesenchymal transition","volume":"10","author":"Mongroo","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e1802","DOI":"10.1038\/cddis.2015.150","article-title":"LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4470778","DOI":"10.1155\/2021\/4470778","article-title":"MiR-200b suppresses gastric cancer cell migration and invasion by inhibiting NRG1 through ERBB2\/ERBB3 signaling","volume":"2021","author":"Xu","year":"2021","journal-title":"J. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1007\/s13277-013-0954-1","article-title":"MicroRNA-148a suppresses human gastric cancer cell metastasis by reversing epithelial-to-mesenchymal transition","volume":"34","author":"Wang","year":"2013","journal-title":"Tumour Biol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wang, X., and Chen, P. (2013). MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. BMC Cancer, 13.","DOI":"10.1186\/1471-2407-13-290"},{"key":"ref_61","first-page":"1733","article-title":"MiR-30a increases cisplatin sensitivity of gastric cancer cells through suppressing epithelial-to-mesenchymal transition (EMT)","volume":"20","author":"Wang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"106538","DOI":"10.18632\/oncotarget.20860","article-title":"Low plasma levels of miR-101 are associated with tumor progression in gastric cancer","volume":"8","author":"Imamura","year":"2017","journal-title":"Oncotarget"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3727\/096504016X14738114257367","article-title":"miR-218 inhibits proliferation, migration, and EMT of gastric cancer cells by targeting WASF3","volume":"25","author":"Wang","year":"2017","journal-title":"Oncol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Deng, M., Tang, H.L., Lu, X.H., Liu, M.Y., Lu, X.M., Gu, Y.X., Liu, J.F., and He, Z.M. (2013). miR-26a suppresses tumor growth and metastasis by targeting FGF9 in gastric cancer. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072662"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12957-021-02381-5","article-title":"Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress","volume":"19","author":"Lin","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41420-022-01177-0","article-title":"Circular RNA circPGD contributes to gastric cancer progression via the sponging miR-16-5p\/ABL2 axis and encodes a novel PGD-219aa protein","volume":"8","author":"Liu","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s13287-021-02394-7","article-title":"MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis","volume":"12","author":"Ni","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.2147\/CMAR.S352081","article-title":"LINC01232 promotes metastasis and EMT by regulating miR-506-5p\/PAK1 axis in gastric cancer","volume":"14","author":"Chen","year":"2022","journal-title":"Cancer Manag. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1245\/s10434-015-4418-2","article-title":"The miR-506-induced epithelial-mesenchymal transition is involved in poor prognosis for patients with gastric cancer","volume":"22","author":"Sakimura","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15222","DOI":"10.18632\/oncotarget.3835","article-title":"MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1\/Met\/Akt signaling","volume":"6","author":"Huang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.7150\/ijbs.57338","article-title":"MiR-17-5p and MKL-1 modulate stem cell characteristics of gastric cancer cells","volume":"17","author":"Dai","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/j.febslet.2014.04.036","article-title":"miR-17-5p promotes proliferation by targeting SOCS6 in gastric cancer cells","volume":"588","author":"Wu","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"606","DOI":"10.33594\/000000043","article-title":"miR-106b promotes metastasis of early gastric cancer by targeting ALEX1 in vitro and in vivo","volume":"52","author":"Zhu","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_74","first-page":"877","article-title":"MicroRNA-23a regulates cell migration and invasion by targeting PTEN in gastric cancer","volume":"9","author":"Li","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"11634","DOI":"10.1080\/21655979.2021.1995099","article-title":"MicroRNA miR-130a-3p promotes gastric cancer by targeting glucosaminyl N-acetyl transferase 4 (GCNT4) to regulate the TGF-\u03b21\/SMAD3 pathway","volume":"12","author":"Hu","year":"2021","journal-title":"Bioengineered"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3892\/ijo.2017.3965","article-title":"miR-196a-5p modulates gastric cancer stem cell characteristics by targeting Smad4","volume":"50","author":"Pan","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Lu, Q., Chen, Y., Sun, D., Wang, S., Ding, K., Liu, M., Zhang, Y., Miao, Y., Liu, H., and Zhou, F. (2019). MicroRNA-181a functions as an oncogene in gastric cancer by targeting Caprin-1. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01565"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbrc.2018.05.109","article-title":"MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN\/AKT\/mTOR pathway","volume":"501","author":"Wu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1038\/s41388-020-01425-6","article-title":"Hypoxic gastric cancer-derived exosomes promote progression and metastasis via miR-301a-3p\/PHD3\/HIF-1\u03b1 positive feedback loop","volume":"39","author":"Xia","year":"2020","journal-title":"Oncogene"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"10749","DOI":"10.18632\/aging.202895","article-title":"Dual activation of Hedgehog and Wnt\/\u03b2-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer","volume":"13","author":"Peng","year":"2021","journal-title":"Aging"},{"key":"ref_81","first-page":"1615","article-title":"MicroRNA-27a-3p promotes epithelial-mesenchymal transition by targeting NOVA alternative splicing regulator 1 in gastric cancer","volume":"21","author":"Li","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e992","DOI":"10.1002\/ctm2.992","article-title":"MiR-192-5p\/RB1\/NF-\u03baBp65 signaling axis promotes IL-10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment","volume":"12","author":"Song","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41419-022-05320-8","article-title":"The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9717","DOI":"10.3748\/wjg.v21.i33.9717","article-title":"Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer","volume":"21","author":"Yan","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2019.04.002","article-title":"Cancer-associated fibroblasts-derived IL-8 mediates resistance to cisplatin in human gastric cancer","volume":"454","author":"Zhai","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1136\/jclinpath-2014-202561","article-title":"Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology","volume":"67","author":"Valcz","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.molmed.2013.05.004","article-title":"\u2018Cancer associated fibroblasts\u2019-More than meets the eye","volume":"19","author":"Madar","year":"2013","journal-title":"Trends Mol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.semcancer.2014.01.005","article-title":"Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth","volume":"25","author":"Lisanti","year":"2014","journal-title":"Semin. Cancer Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1158\/0008-5472.CAN-17-2268","article-title":"IL-6 mediates cross-talk between tumor cells and activated fibroblasts in the tumor microenvironment","volume":"78","author":"Karakasheva","year":"2018","journal-title":"Cancer Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e1386","DOI":"10.1002\/ctm2.1386","article-title":"Tumour-associated macrophages in gastric cancer: From function and mechanism to application","volume":"13","author":"Li","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zhang, J., Hu, C., Zhang, R., Xu, J., Zhang, Y., Yuan, L., Zhang, S., Pan, S., Cao, M., and Qin, J. (2023). The role of macrophages in gastric cancer. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1282176"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41419-019-2131-y","article-title":"Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_93","first-page":"595","article-title":"IL-10 secreted by cancer-associated macrophages regulates proliferation and invasion in gastric cancer cells via c-Met\/STAT3 signaling","volume":"42","author":"Chen","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3892\/or.2017.5877","article-title":"Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells","volume":"38","author":"Guo","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ucaryilmaz Metin, C., and Ozcan, G. (2022). The HIF-1\u03b1 as a potent inducer of the hallmarks in gastric cancer. Cancers, 14.","DOI":"10.3390\/cancers14112711"},{"key":"ref_96","first-page":"203192","article-title":"Exosomal miR-15b-5p derived from gastric cancer cells enhances immune infiltrating of tumor-associated macrophages through the WIF1\/WNT5A axis","volume":"13","author":"Sun","year":"2021","journal-title":"Aging"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Xiao, H., Fu, J., Liu, R., Yan, L., Zhou, Z., and Yuan, J. (2024). Gastric cancer cell-derived exosomal miR-541-5p induces M2 macrophage polarization through DUSP3\/JAK2\/STAT3 pathway. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12672-1"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/15384101.2021.1878326","article-title":"Exosomal miR-487a derived from M2 macrophage promotes the progression of gastric cancer","volume":"20","author":"Yang","year":"2021","journal-title":"Cell Cycle"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.3748\/wjg.v27.i36.6079","article-title":"Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells","volume":"27","author":"Cui","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-017-0528-y","article-title":"Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells","volume":"36","author":"Zheng","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00262-023-03601-5","article-title":"CD204-positive M2-like tumor-associated macrophages increase migration of gastric cancer cells by upregulating miR-210 to reduce NTN4 expression","volume":"73","author":"Chen","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1111\/cas.14110","article-title":"Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA-30c and mTOR in human gastric cancer","volume":"110","author":"Yun","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Qiu, Y., Lu, G., Li, N., Hu, Y., Tan, H., and Jiang, C. (2024). Exosome-mediated communication between gastric cancer cells and macrophages: Implications for tumor microenvironment. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1327281"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13046-019-1168-1","article-title":"Correction to: Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells","volume":"38","author":"Li","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_105","first-page":"13","article-title":"Neutrophils in the tumor microenvironment: Role in tumor progression and potential targeted therapeutic strategy","volume":"10","author":"Shi","year":"2024","journal-title":"J. Cancer Metastasis Treat."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3892\/ijmm.2021.4960","article-title":"Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial-mesenchymal transition","volume":"48","author":"Zhu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1038\/s41467-025-57805-7","article-title":"Author Correction: Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications","volume":"16","author":"Xia","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"100958","DOI":"10.1016\/j.identj.2025.100958","article-title":"Initial insights into the NET-associated ceRNA network in pulpitis: Transcriptomic and functional exploration","volume":"75","author":"Guo","year":"2025","journal-title":"Int. Dent. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12943-024-02116-6","article-title":"Exosomal miR-4745-5p\/3911 from N2-polarized tumor-associated neutrophils promotes gastric cancer metastasis by regulating SLIT2","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"117773","DOI":"10.1016\/j.cca.2024.117773","article-title":"Exosomal miRNAs from neutrophils act as accurate biomarkers for gastric cancer diagnosis","volume":"554","author":"Yu","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1007\/s10620-024-08536-0","article-title":"Regulation of the PD-1\/PD-L1 axis and NK cell dysfunction by exosomal miR-552-5p in gastric cancer","volume":"69","author":"Tang","year":"2024","journal-title":"Dig. Dis. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Dong, H., Ye, C., Yu, X., and Shao, Y. (2025). Non-coding RNAs in gastric cancer immunotherapy: Mechanisms and clinical implications. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1688181"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"406","DOI":"10.7150\/jca.102360","article-title":"Exosomal miR-552-5p regulates the role of NK cells in EMT of gastric cancer via the PD-1\/PD-L1 axis","volume":"16","author":"Qin","year":"2025","journal-title":"J. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12943-024-02084-x","article-title":"The role of microRNAs in the gastric cancer tumor microenvironment","volume":"23","author":"Yu","year":"2024","journal-title":"Mol. Cancer"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.4149\/neo_2020_191014N1034","article-title":"Long non-coding RNA GAS5 promotes natural killer cell cytotoxicity against gastric cancer by regulating miR-18a","volume":"67","author":"Wei","year":"2020","journal-title":"Neoplasma"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhu, Y., Sheng, P., Guo, X., Li, X., Li, R., Zhao, Z., Li, L., and Gong, K. (Res. Sq., 2024). Mechanism of gastric cancer cell-derived exosomal circPDSS1 promoting ferroptosis of natural killer cells by regulating the miR-1278\/GOT1 molecular axis, Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-3865289\/v1"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Yasui, S., Takata, T., Kamitani, Y., Mae, Y., Kurumi, H., Ikebuchi, Y., Yoshida, A., Kawaguchi, K., Yashima, K., and Isomoto, H. (2021). Neutrophil-to-lymphocyte ratio is a useful marker for predicting histological types of early gastric cancer. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040791"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.6061\/clinics\/2018\/e360","article-title":"Prognostic role of neutrophil\/lymphocyte ratio in resected gastric cancer: A systematic review and meta-analysis","volume":"73","author":"Szor","year":"2018","journal-title":"Clinics"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/kjm2.12694","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in gastric cancer patients treated with immune checkpoint inhibitors: A meta-analysis","volume":"39","author":"Li","year":"2023","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_120","first-page":"4247","article-title":"Overexpression of FAM3C protein as a novel biomarker for epithelial-mesenchymal transition and poor outcome in gastric cancer","volume":"11","author":"Yin","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Noguchi, K., Dalton, A.C., Howley, B.V., McCall, B.J., Yoshida, A., Diehl, J.A., and Howe, P.H. (2017). Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177830"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.7150\/ijbs.79022","article-title":"Neutrophils promote tumor invasion via FAM3C-mediated epithelial-to-mesenchymal transition in gastric cancer","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/kjm2.12176","article-title":"miR-574-3p inhibits proliferation and invasion in esophageal cancer by targeting FAM3C and MAPK1","volume":"36","author":"Jin","year":"2020","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2217\/bmm-2020-0179","article-title":"FAM3C: An emerging biomarker and potential therapeutic target for cancer","volume":"15","author":"Zhu","year":"2021","journal-title":"Biomark. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","article-title":"EMT, MET, plasticity, and tumor metastasis","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Ban, E., and Song, E.J. (2022). Considerations and suggestions for the reliable analysis of miRNA in plasma using qRT-PCR. Genes, 13.","DOI":"10.3390\/genes13020328"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbrc.2014.10.064","article-title":"U6 is not a suitable endogenous control for the quantification of circulating microRNAs","volume":"454","author":"Xiang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/s41416-020-0802-1","article-title":"Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours","volume":"122","author":"Hong","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s12276-023-01050-9","article-title":"MicroRNA: Trends in clinical trials of cancer diagnosis and therapy strategies","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/3\/462\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:33:51Z","timestamp":1770788031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/3\/462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":129,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cancers18030462"],"URL":"https:\/\/doi.org\/10.3390\/cancers18030462","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]}}}