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We also discuss the role of architectural proteins in maintaining chromatin topology while allowing dynamic changes to chromatin structure, thereby influencing gene expression. Growing evidence indicates that disruptions in HOCS contribute to a diverse array of human diseases, including cancer, aging-related disorders, and congenital abnormalities, primarily through aberrant gene regulation. We further discuss the concept of distinct genomic areas, in which specific chromatin regions orchestrate three-dimensional (3D) genome dynamics, positioning them as potential biomarkers and therapeutic targets. By emphasizing chromatin architecture on a global scale rather than at the level of individual genes, this review underscores its emerging relevance to precision medicine. Finally, we synthesize current technical advances, outline future directions for leveraging chromatin topology in disease diagnosis and treatment, and highlight key biological insights to reshape our understanding of genome function.<\/jats:p>","DOI":"10.3390\/cancers18030483","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:12:46Z","timestamp":1770041566000},"page":"483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epigenetic Regulation of Higher-Order Chromatin Structure (HOCS) and Its Implication in Human Diseases"],"prefix":"10.3390","volume":"18","author":[{"given":"Luisa","family":"Ladel","sequence":"first","affiliation":[{"name":"Surgical Oncology Research Laboratories, Department of Surgery, Yale School of Medicine, New Haven, CT 06510, USA"},{"name":"Department of Internal Medicine, Norwalk Hospital, Norwalk, CT 06856, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethsebie","family":"Sailo","sequence":"additional","affiliation":[{"name":"Surgical Oncology Research Laboratories, Department of Surgery, Yale School of Medicine, New Haven, CT 06510, USA"},{"name":"Center for Precision Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA"},{"name":"Department of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paromita","family":"Das","sequence":"additional","affiliation":[{"name":"Surgical Oncology Research Laboratories, Department of Surgery, Yale School of Medicine, New Haven, CT 06510, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan Samuel","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA"},{"name":"Department of Medicine, Division of Hematology, Oncology and Palliative Care, University of Wisconsin-Madison, Madison, WI 53705, USA"},{"name":"William S. 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