{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:02:18Z","timestamp":1773403338079,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["22K15980"],"award-info":[{"award-number":["22K15980"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["25K11186"],"award-info":[{"award-number":["25K11186"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Maruyama Memorial Research Grant"},{"name":"Alumni Association of Nippon Medical School"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The incidence of colorectal cancer diagnosed before age 50 has been increasing worldwide. However, limited data describe the endoscopic and pathological features of colorectal lesions encountered and treated during routine colonoscopy in younger adults. This study aimed to characterize age-related differences in endoscopically resected colorectal neoplasia. Methods: We conducted a retrospective, single-center observational study of consecutively endoscopically resected colorectal neoplasia at a high-volume academic teaching hospital in Japan. Patient-level and lesion-level characteristics were compared between early-onset (&lt;50 years) and later-onset (\u226550 years) groups. Lesions were evaluated for location, morphology, size, histology, resection method, and advanced neoplasia status. Results: A total of 1299 patients with 3399 lesions were analyzed, including 498 early-onset patients with 940 lesions. Early-onset neoplasia showed a left-sided predominance, with higher proportions in the distal colon and rectum. Pedunculated morphology was more frequently observed in early-onset lesions. Early-onset disease was also associated with larger lesion size, a higher prevalence of high-grade tubular adenoma, and increased rates of advanced adenoma and advanced neoplasia, resulting in more frequent use of endoscopic mucosal resection or submucosal dissection. Conclusions: Endoscopically resected colorectal lesions in younger adults exhibit distinct anatomical and morphological features compared with later-onset cases, indicating heterogeneity at the premalignant stage.<\/jats:p>","DOI":"10.3390\/cancers18030509","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:02:01Z","timestamp":1770195721000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Features of Endoscopically Resected Early-Onset Colorectal Neoplasia Compared with Later-Onset Cases"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-4143","authenticated-orcid":false,"given":"Naohiko","family":"Akimoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Nakagome","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Motomiya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugumi","family":"Habu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-6288","authenticated-orcid":false,"given":"Kazutoshi","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Integrated Diagnostic Pathology, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-8837","authenticated-orcid":false,"given":"Atsushi","family":"Tatsuguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Iwakiri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref_1","first-page":"233","article-title":"Colorectal cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","article-title":"Colorectal cancer incidence trends in younger versus older adults: An analysis of population-based cancer registry data","volume":"26","author":"Sung","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41571-020-00445-1","article-title":"Rising incidence of early-onset colorectal cancer\u2014A call to action","volume":"18","author":"Akimoto","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Yue, B., Lu, Z., Zong, D., Hu, Y., and Yang, Z. (2025). Global, regional, and national burden of early-onset and late-onset colorectal cancer attributable to high body-mass index from 1990 to 2021: A trend analysis and forecasts up to 2040 based on the global burden of disease study 2021. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-04432-7"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Su, J., Liang, Y., and He, X. (2024). The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990-2019: A secondary analysis for the global burden of disease study 2019. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1384352"},{"key":"ref_6","unstructured":"GBD 2023 Disease and Injury and Risk Factor Collaborators (2025). Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990\u20132023: A systematic analysis for the Global Burden of Disease Study 2023. Lancet, 406, 1873\u20131922."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jamasurg.2014.1756","article-title":"Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975\u20132010","volume":"150","author":"Bailey","year":"2015","journal-title":"JAMA Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"U. S. Preventive Services Task Force, Davidson, K.W., Barry, M.J., Mangione, C.M., Cabana, M., Caughey, A.B., Davis, E.M., Donahue, K.E., Doubeni, C.A., and Krist, A.H. (2021). Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA, 325, 1965\u20131977.","DOI":"10.1001\/jama.2021.6238"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1053\/j.gastro.2021.06.006","article-title":"Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis","volume":"161","author":"Kolb","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.gastro.2022.05.036","article-title":"Age-Stratified Prevalence and Predictors of Neoplasia Among U.S. Adults Undergoing Screening Colonoscopy in a National Endoscopy Registry","volume":"163","author":"Liang","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.gie.2017.05.011","article-title":"Metachronous colon polyps in younger versus older adults: A case-control study","volume":"87","author":"Nagpal","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Akimoto, N., Zhao, M., Ugai, T., Zhong, R., Lau, M.C., Fujiyoshi, K., Kishikawa, J., Haruki, K., Arima, K., and Twombly, T.S. (2021). Tumor Long Interspersed Nucleotide Element-1 (LINE-1) Hypomethylation in Relation to Age of Colorectal Cancer Diagnosis and Prognosis. Cancers, 13.","DOI":"10.3390\/cancers13092016"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1016\/S1470-2045(21)00588-X","article-title":"A comprehensive framework for early-onset colorectal cancer research","volume":"23","author":"Eng","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/DCR.0000000000001062","article-title":"Left-Sided Dominance of Early-Onset Colorectal Cancers: A Rationale for Screening Flexible Sigmoidoscopy in the Young","volume":"61","author":"Segev","year":"2018","journal-title":"Dis. Colon. Rectum"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/jamasurg.2021.2380","article-title":"Characteristics of Early-Onset vs. Late-Onset Colorectal Cancer: A Review","volume":"156","author":"Zaborowski","year":"2021","journal-title":"JAMA Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S2468-1253(21)00426-X","article-title":"The rising tide of early-onset colorectal cancer: A comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection","volume":"7","author":"Patel","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e920","DOI":"10.1634\/theoncologist.2019-0815","article-title":"Inverse Association of Age with Risk of Lymph Node Metastasis in Superficial Colorectal Cancer: A Large Population-Based Study","volume":"25","author":"Zhang","year":"2020","journal-title":"Oncologist"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.gie.2024.04.2905","article-title":"Quality indicators for colonoscopy","volume":"100","author":"Rex","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cgh.2022.12.006","article-title":"Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines","volume":"21","author":"Cavestro","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Japanese Society for Cancer of the Colon and Rectum (2019). Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: The 3d English Edition [Secondary Publication]. J. Anus Rectum Colon., 3, 175\u2013195.","DOI":"10.23922\/jarc.2019-018"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.cgh.2020.04.092","article-title":"Systematic Review of Prevalence, Risk Factors, and Risk for Metachronous Advanced Neoplasia in Patients With Young-Onset Colorectal Adenoma","volume":"19","author":"Enwerem","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.14309\/ajg.0000000000002296","article-title":"Risk of Incident and Fatal Colorectal Cancer After Young-Onset Adenoma Diagnosis: A National Cohort Study","volume":"118","author":"Casey","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.3748\/wjg.v22.i10.2981","article-title":"Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population","volume":"22","author":"Lee","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s10620-014-3245-9","article-title":"Advanced colorectal adenomas in patients under 45 years of age are mostly sporadic","volume":"59","author":"Kushnir","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.dld.2019.12.147","article-title":"Risk of metachronous neoplasia on surveillance colonoscopy among young and older patients after polypectomy","volume":"52","author":"Laish","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jgh.13167","article-title":"Risk of developing advanced colorectal neoplasia after removing high-risk adenoma detected at index colonoscopy in young patients: A KASID study","volume":"31","author":"Park","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/jnci\/djaa164","article-title":"Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer","volume":"113","author":"Zheng","year":"2021","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/j.gastro.2021.03.028","article-title":"Simple Sugar and Sugar-Sweetened Beverage Intake During Adolescence and Risk of Colorectal Cancer Precursors","volume":"161","author":"Joh","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_30","first-page":"3176","article-title":"Higher LNM rate and poorer prognosis of early-onset compared to late-onset T1 stage colorectal cancer: A large-population based study","volume":"11","author":"Tang","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.gie.2017.05.049","article-title":"Optical diagnosis of early colorectal cancer: Riding the highs and lows of the Japanese Narrow-Band Imaging Expert Team classification","volume":"86","author":"McGill","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e42475","DOI":"10.1097\/MD.0000000000042475","article-title":"Profile of colorectal polyps in young patients: A retrospective study","volume":"104","author":"Shen","year":"2025","journal-title":"Medicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1590\/S0102-67202014000200006","article-title":"Influence of patient age and colorectal polyp size on histopathology findings","volume":"27","author":"Silva","year":"2014","journal-title":"Arq. Bras. Cir. Dig."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/3\/509\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:31:14Z","timestamp":1773394274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/3\/509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cancers18030509"],"URL":"https:\/\/doi.org\/10.3390\/cancers18030509","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}