{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:57:04Z","timestamp":1770418624464,"version":"3.49.0"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objectives: To develop a prediction model able to accurately predict which patients will harbor higher risk prostate cancer in the systematic biopsy template compared to the targeted biopsy during MRI\/US fusion biopsy. Methods: We included patients who underwent fusion biopsy. Clinical and radiographic variables were collected from patients\u2019 records. The outcome of the model was higher risk prostate cancer in the systematic compared with targeted biopsies. An extreme gradient boosting model was trained and tested. We evaluated variable importance and clinical benefit. Results: Five hundred and twenty-nine patients were included. Eighty-two (15.5%) patients had higher risk prostate cancer in the systematic biopsies. The area under the ROC curve and negative predictive value were 0.82 and 0.92, respectively. The four most important features for outcome prediction were prostate volume, PSAD, patient\u2019s age, and PSA. The decision curve showed increased clinical benefit of our model at threshold probabilities of 0\u20130.5. Limitations include the retrospective design of the study and the lack of external validation of the model. Conclusions: We developed a prediction model able to accurately predict which patients must undergo systematic and targeted biopsy. This prediction model has the potential to help in the decision whether to perform SB and thus may lower the adverse event rate while keeping a high detection rate.<\/jats:p>","DOI":"10.3390\/cancers18030517","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:20:14Z","timestamp":1770225614000},"page":"517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Systematic Biopsy Mandatory in All MRI-Guided Fusion Prostate Biopsies? A Machine Learning Prediction Model"],"prefix":"10.3390","volume":"18","author":[{"given":"Omer","family":"Longo","sequence":"first","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Urology, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Raviv","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Urology, Sheba Medical Center, Ramat Gan 5265601, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-4170","authenticated-orcid":false,"given":"Miki","family":"Haifler","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Urology, Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref_1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. 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