{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:20:04Z","timestamp":1771586404060,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Image-guided adaptive brachytherapy (IGABT) has transformed the standard of care for locally advanced cervical cancer (LACC), enabling volumetric target definition and dose\u2013volume histogram (DVH)-based planning to improve pelvic tumor control while limiting severe late toxicity. Methods: A comprehensive literature search of PubMed\/MEDLINE and Embase was done for articles published up to August 2024, using combinations of the following keywords and Medical Subject Heading (MeSH) terms: \u201ccervical cancer\u201d, \u201cendometrial cancer\u201d, \u201cvaginal cancer\u201d, \u201cuterine neoplasms\u201d, \u201cbrachytherapy\u201d, \u201chigh-dose-rate\u201d, \u201cimage-guided\u201d, \u201cMRI-guided\u201d, \u201c3D brachytherapy\u201d, \u201cIGABT\u201d, \u201cinterstitial\u201d, \u201clocoregional control\u201d, \u201ctoxicity\u201d, \u201cquality of life\u201d, and \u201cpatient-reported outcomes\u201d. Results: We summarized the contemporary evidence on IGABT for cervical, endometrial, and primary or recurrent vaginal cancers, focusing on local control, survival, late morbidity, and patient-reported outcomes. We described the key target volume concepts (gross tumor volume, high- and intermediate-risk clinical target volumes), and the role of MRI-, CT-, and ultrasound-based planning with intracavitary, intracavitary\u2013interstitial, and interstitial applicators. Conclusions: Image-guided adaptive brachytherapy has redefined the standard of care for the management of locally advanced cervical cancer. Through the integration of volumetric target concepts, DVH-based dose reporting, and advanced imaging, IGABT has enabled consistent dose escalation to the residual tumor while accounting for organ-at-risk constraints, resulting in high local control rates and reduced severe morbidity compared with historical 2D brachytherapy.<\/jats:p>","DOI":"10.3390\/cancers18040693","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:32:37Z","timestamp":1771583557000},"page":"693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Image-Guided Adaptive Brachytherapy for Uterine Cancer: A Comprehensive Review"],"prefix":"10.3390","volume":"18","author":[{"given":"Yi-Ching","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Research, Tungs Taichung MetroHarbor Hospital, Wuchi District, Taichung 435403, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yuan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Tungs Taichung MetroHarbor Hospital, Wuchi District, Taichung 435403, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.brachy.2020.07.015","article-title":"Addressing the burden of cervical cancer through IAEA global brachytherapy initiatives","volume":"19","author":"Grover","year":"2020","journal-title":"Brachytherapy"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Anghel, B., Serboiu, C., Marinescu, A., Taciuc, I.-A., Bobirca, F., and Stanescu, A.D. (2023). Recent Advances and Adaptive Strategies in Image Guidance for Cervical Cancer Radiotherapy. Medicina, 59.","DOI":"10.3390\/medicina59101735"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ijgo.13865","article-title":"Cancer of the cervix uteri: 2021 update","volume":"155","author":"Bhatla","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5114\/jcb.2022.118831","article-title":"Early clinical outcomes of hybrid brachytherapy for locally advanced cervical cancer: Making adverse situations in a favorable scenario","volume":"14","author":"Cagetti","year":"2022","journal-title":"J. Contemp. Brachyther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.21873\/anticanres.13434","article-title":"Effectiveness of Image-guided Brachytherapy in Patients with Locally Advanced Cervical Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy","volume":"39","author":"Chen","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5114\/jcb.2018.73955","article-title":"Impact of brachytherapy technique (2D versus 3D) on outcome following radiotherapy of cervical cancer","volume":"10","author":"Derks","year":"2018","journal-title":"J. Contemp. Brachyther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Eustace, N., Liu, J., Ladbury, C., Tam, A., Glaser, S., Liu, A., and Chen, Y.-J. (2024). Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer. Cancers, 16.","DOI":"10.3390\/cancers16051031"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5114\/jcb.2023.124936","article-title":"Prognostic factors of local control and progression-free survival in AJCC stages T1 and T2 cervical cancer patients treated with adjuvant brachytherapy after chemoradiotherapy","volume":"15","author":"Faivre","year":"2023","journal-title":"J. Contemp. Brachyther."},{"key":"ref_9","unstructured":"ICRU, International Commission of Radiation Units and Measurements (1985). Dose and Volume Specification for Reporting Intracavitary Therapy in Gynaecology ICRU Report 38, International Commission on Radiation Units and Measurements."},{"key":"ref_10","unstructured":"ICRU, International Commission of Radiation Units and Measurements (2016). Prescribing, Recording, and Reporting Brachytherapy for Cancer of the Cervix ICRU Report 89, International Commission on Radiation Units and Measurements."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.radonc.2011.12.024","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy","volume":"103","author":"Dimopoulos","year":"2012","journal-title":"Radiother. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.radonc.2016.03.020","article-title":"Image guided adaptive brachytherapy with combined intracavitary and interstitial technique improves the therapeutic ratio in locally advanced cervical cancer: Analysis from the retroEMBRACE study","volume":"120","author":"Fokdal","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.radonc.2005.11.014","article-title":"Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy-3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology","volume":"78","author":"Barillot","year":"2006","journal-title":"Radiother. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.radonc.2004.12.015","article-title":"Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (I): Concepts and terms in 3D image-based 3D treatment planning in cervix cancer brachytherapy with emphasis on MRI assessment of GTV and CTV","volume":"74","author":"Briot","year":"2005","journal-title":"Radiother. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.3390\/curroncol30050375","article-title":"Safety and Efficacy of 2D Brachytherapy vs. 3D Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer\u2014A Single Institution Retrospective Study","volume":"30","author":"Faye","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e34904","DOI":"10.1097\/MD.0000000000034904","article-title":"Observation of hemostatic effectiveness and safety of ultrasound-CT guided 3D intracavitary and interstitial brachytherapy in the treatment of larger cervical cancer with bleeding: A retrospective study","volume":"102","author":"Hu","year":"2023","journal-title":"Medicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/IGC.0000000000000609","article-title":"ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up","volume":"26","author":"Colombo","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00066-022-01912-7","article-title":"First clinical experience with a novel, mobile cone-beam CT system for treatment quality assurance in brachytherapy","volume":"198","author":"Karius","year":"2022","journal-title":"Strahlenther. Onkol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ijrobp.2021.06.019","article-title":"Dose Summation Strategies for External Beam Radiation Therapy and Brachytherapy in Gynecologic Malignancy: A Review from the NRG Oncology and NCTN Medical Physics Subcommittees","volume":"111","author":"Kim","year":"2021","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4143\/crt.2022.418","article-title":"Image-Guided Versus Conventional Brachytherapy for Locally Advanced Cervical Cancer: Experience of Single Institution with the Same Practitioner and Time Period","volume":"55","author":"Lee","year":"2023","journal-title":"Cancer Res. Treat."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Li, F., Shi, D., Bu, M., Lu, S., and Zhao, H. (2022). Four-Dimensional Image-Guided Adaptive Brachytherapy for Cervical Cancer: A Systematic Review and Meta-Regression Analysis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.870570"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.ijrobp.2018.11.012","article-title":"Intensity Modulated Radiation Therapy and Image-Guided Adapted Brachytherapy for Cervix Cancer","volume":"103","author":"Lin","year":"2019","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.radonc.2021.05.010","article-title":"IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer","volume":"160","author":"Mahantshetty","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/ijgc-2021-002493","article-title":"Vaginal brachytherapy management of stage I and II endometrial cancer","volume":"32","author":"Horeweg","year":"2022","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gong, X., Sun, S., Yan, J., Wang, W., Ren, K., Hou, X., Hu, K., and Zhang, F. (2024). Clinical outcomes analysis of image-guided brachytherapy as definitive treatment for inoperable endometrial cancer. BMC Women\u2019s Health, 24.","DOI":"10.1186\/s12905-024-03361-z"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rovirosa, \u00c1., Zhang, Y., Tanderup, K., Ascaso, C., Chargari, C., Van der Steen-Banasik, E., Wojcieszek, P., Stankiewicz, M., Najjari-Jamal, D., and Hoskin, P. (2023). Stages I-III Inoperable Endometrial Carcinoma: A Retrospective Analysis by the Gynaecological Cancer GEC-ESTRO Working Group of Patients Treated with External Beam Irradiation and 3D-Image Guided Brachytherapy. Cancers, 15.","DOI":"10.3390\/cancers15194750"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/IGC.0000000000001305","article-title":"A Clinical Evaluation of American Brachytherapy Society Consensus Guideline for Bulky Vaginal Mass in Gynecological Cancer","volume":"28","author":"Murofushi","year":"2018","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Westerveld, H., Schmid, M.P., Nout, R.A., Chargari, C., Pieters, B.R., Creutzberg, C.L., Sturdza, A., Lindegaard, J.C., van Kesteren, Z., and Mazeron, R. (2021). Image-Guided Adaptive Brachytherapy (IGABT) for Primary Vaginal Cancer: Results of the International Multicenter RetroEMBRAVE Cohort Study. Cancers, 13.","DOI":"10.3390\/cancers13061459"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5114\/jcb.2021.108596","article-title":"Clinical outcomes of distal vaginal and vulvar cancer treated with image-guided brachytherapy","volume":"13","author":"Yaney","year":"2021","journal-title":"J. Contemp. Brachyther."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Manea, E., Chitoran, E., Rotaru, V., Ionescu, S., Luca, D., Cirimbei, C., Alecu, M., Capsa, C., Gafton, B., and Prutianu, I. (2024). Integration of Ultrasound in Image-Guided Adaptive Brachytherapy in Cancer of the Uterine Cervix. Bioengineering, 11.","DOI":"10.3390\/bioengineering11050506"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1634\/theoncologist.2012-0367","article-title":"Adaptive 3D Image-Guided Brachytherapy: A Strong Argument in the Debate on Systematic Radical Hysterectomy for Locally Advanced Cervical Cancer","volume":"18","author":"Mazeron","year":"2013","journal-title":"Oncologist"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.radonc.2016.06.006","article-title":"Dose-volume effect relationships for late rectal morbidity in patients treated with chemoradiation and MRI-guided adaptive brachytherapy for locally advanced cervical cancer: Results from the prospective multicenter EMBRACE study","volume":"120","author":"Mazeron","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5114\/jcb.2023.132553","article-title":"Combination of image-guided IMRT and IGBT in locally advanced carcinoma cervix: Prospective evaluation of toxicities and clinical outcomes from a tertiary cancer center in India","volume":"15","author":"Mishra","year":"2023","journal-title":"J. Contemp. Brachyther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijrobp.2019.03.038","article-title":"Change in Patterns of Failure After Image-Guided Brachytherapy for Cervical Cancer: Analysis from the RetroEMBRACE Study","volume":"104","author":"Tan","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): A multicentre prospective cohort study","volume":"22","author":"Tanderup","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3802\/jgo.2014.25.3.206","article-title":"Ultrasound guided conformal brachytherapy of cervix cancer: Survival, patterns of failure, and late complications","volume":"25","author":"Narayan","year":"2014","journal-title":"J. Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/jrr\/rry009","article-title":"Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique","volume":"59","author":"Nishikawa","year":"2018","journal-title":"J. Radiat. Res."},{"key":"ref_38","first-page":"48","article-title":"The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies","volume":"9","author":"Tanderup","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/ijgc-2022-004230","article-title":"Improvement in radiation techniques for locally advanced cervical cancer during the last two decades","volume":"33","author":"Sagae","year":"2023","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/1748-717X-8-266","article-title":"Equivalence of Gyn GEC-ESTRO guidelines for image guided cervical brachytherapy with EUD-based dose prescription","volume":"8","author":"Shaw","year":"2013","journal-title":"Radiat. Oncol."},{"key":"ref_41","first-page":"e66218","article-title":"Cone-Beam Computed Tomography (CBCT)-Guided Adaptive Boost Radiotherapy for a Patient with Locally Advanced Cervical Cancer Ineligible for Brachytherapy","volume":"16","author":"Silberstein","year":"2024","journal-title":"Cureus"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00066-020-01656-2","article-title":"Hybrid TRUS\/CT with optical tracking for target delineation in image-guided adaptive brachytherapy for cervical cancer","volume":"196","author":"Smet","year":"2020","journal-title":"Strahlenther. Onkol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1200\/JCO.22.01096","article-title":"Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study","volume":"41","author":"Schmid","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.radonc.2016.03.011","article-title":"Image guided brachytherapy in locally advanced cervical cancer: Improved pelvic control and survival in RetroEMBRACE, a multicenter cohort study","volume":"120","author":"Sturdza","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/ijgc-2021-003056","article-title":"Image-guided brachytherapy in cervical cancer including fractionation","volume":"32","author":"Sturdza","year":"2022","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"764","DOI":"10.5306\/wjco.v5.i4.764","article-title":"Brachytherapy in cancer cervix: Time to move ahead from point A?","volume":"5","author":"Srivastava","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13014-023-02240-5","article-title":"Safety and efficacy of single insertion accelerated MR-image guided brachytherapy following chemo\u2013radiation in locally advanced cervix cancer: Modifying our EMBRACE during the COVID pandemic","volume":"18","author":"Stevens","year":"2023","journal-title":"Radiat. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.radonc.2016.05.014","article-title":"Effect of tumor dose, volume and overall treatment time on local control after radiochemotherapy including MRI guided brachytherapy of locally advanced cervical cancer","volume":"120","author":"Tanderup","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.brachy.2020.02.012","article-title":"Dose-effect response in image-guided adaptive brachytherapy for cervical cancer: A systematic review and meta-regression analysis","volume":"19","author":"Tang","year":"2020","journal-title":"Brachytherapy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.brachy.2021.03.004","article-title":"Effects of 3D image-guided brachytherapy compared to 2D conventional brachytherapy on clinical outcomes in patients with cervical cancer: A systematic review and meta-analyses","volume":"20","author":"Suzumura","year":"2021","journal-title":"Brachytherapy"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.31083\/j.ejgo.2021.01.2189","article-title":"3D image guided adaptive brachytherapy in patients with locally advanced cervical cancer: Experience and clinical results from a minimum of six years of follow-up","volume":"42","author":"Sundset","year":"2021","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.semradonc.2014.02.007","article-title":"Magnetic Resonance Image Guided Brachytherapy","volume":"24","author":"Tanderup","year":"2014","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41416-018-0310-8","article-title":"Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: Improving patient selection for adjuvant therapy","volume":"119","author":"Wortman","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Terlizzi, M., Minard, V., Haie-Meder, C., Espenel, S., Martelli, H., Gu\u00e9rin, F., and Chargari, C. (2022). Implementation of Image-Guided Brachytherapy for Pediatric Vaginal Cancers: Feasibility and Early Clinical Results. Cancers, 14.","DOI":"10.3390\/cancers14133247"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/jrr\/rrae043","article-title":"Preliminary result of combined treatment with scanning carbon-ion radiotherapy and image-guided brachytherapy for locally advanced cervical adenocarcinoma","volume":"65","author":"Tsuchida","year":"2024","journal-title":"J. Radiat. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/jrr\/rrac025","article-title":"Survival outcome of cervical cancer patients treated by image-guided brachytherapy: A \u2018real world\u2019 single center experience in Thailand from 2008 to 2018","volume":"63","author":"Tharavichitkul","year":"2022","journal-title":"J. Radiat. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Wang, W., Liu, X., Wang, D., Ren, K., Zhou, Y., Zhou, Z., Qiu, J., Zhang, F., and Hu, K. (2021). The 100 Most Cited Papers in Radiotherapy or Chemoradiotherapy for Cervical Cancer: 1990\u20132020. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.642018"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13014-021-01870-x","article-title":"Intra-fractional dosimetric analysis of image-guided intracavitary brachytherapy of cervical cancer","volume":"16","author":"Yan","year":"2021","journal-title":"Radiat. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/4\/693\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:36:05Z","timestamp":1771583765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/4\/693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["cancers18040693"],"URL":"https:\/\/doi.org\/10.3390\/cancers18040693","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]}}}