{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:11:49Z","timestamp":1788909109945,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81803900"],"award-info":[{"award-number":["81803900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>PCa is one of the most common malignant tumors in male patients [...]<\/jats:p>","DOI":"10.3390\/cancers18050804","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:18:45Z","timestamp":1772554725000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anticancer Effect of Icaritin on Prostate Cancer via Regulating Abundance of Akkermansiaceae and Vitamin K2 in Intestinal Fecal"],"prefix":"10.3390","volume":"18","author":[{"given":"Jimeng","family":"Hu","sequence":"first","affiliation":[{"name":"Departments of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-4637","authenticated-orcid":false,"given":"Xiaobo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Departments of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China"},{"name":"Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"115","article-title":"Cancer statistics in China, 2015","volume":"66","author":"Chen","year":"2016","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Li, W., Wang, Y., Liu, X., Wu, S., Wang, M., Turowski, S.G., Spernyak, J.A., Tracz, A., Abdelaal, A.M., and Sudarshan, K. (2024). Developing Folate-Conjugated miR-34a Therapeutic for Prostate Cancer: Challenges and Promises. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042123"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102193","DOI":"10.1016\/j.omtn.2024.102193","article-title":"Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent","volume":"35","author":"Abdelaal","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/CEJ.0b013e3283647394","article-title":"Dietary factors and risk for advanced prostate cancer","volume":"23","author":"Zhang","year":"2014","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/ijc.30642","article-title":"Dairy intake in relation to prostate cancer survival","volume":"140","author":"Downer","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1097\/01.ju.0000107838.33623.19","article-title":"Dietary fat and prostate cancer","volume":"171","author":"Fleshner","year":"2004","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1017\/S0007114509993291","article-title":"Dietary fat and early-onset prostate cancer risk","volume":"103","author":"Lophatananon","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"21100","DOI":"10.18632\/oncotarget.4228","article-title":"Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: An explanation for poor outcomes in obese women","volume":"6","author":"Kato","year":"2015","journal-title":"Oncotarget"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1158\/1078-0432.CCR-12-0930","article-title":"Molecular pathways: Adiponectin and leptin signaling in cancer","volume":"19","author":"VanSaun","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1590\/s1677-5538.ibju.2018.0261","article-title":"Role of Adiponectin in prostate cancer","volume":"45","author":"Hu","year":"2019","journal-title":"Int. Braz J. Urol. Off. J. Braz. Soc. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/1097-0045(200101)46:1<62::AID-PROS1009>3.0.CO;2-V","article-title":"Leptin and prostate cancer","volume":"46","author":"Chang","year":"2001","journal-title":"Prostate"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrmicro.2017.44","article-title":"Anticancer effects of the microbiome and its products","volume":"15","author":"Zitvogel","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1053\/j.gastro.2019.04.013","article-title":"High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett\u2019s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome","volume":"157","author":"Fang","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s10620-017-4538-6","article-title":"Influences of the Gut Microbiota on DNA Methylation and Histone Modification","volume":"62","author":"Ye","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Wang, T., Song, J., Qu, M., Gao, X., Zhang, W., Wang, Z., Zhao, L., Wang, Y., Li, B., and Li, J. (2021). Integrative Epigenome Map of the Normal Human Prostate Provides Insights Into Prostate Cancer Predisposition. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.723676"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1039\/D0FO00713G","article-title":"Synergic interactions between polyphenols and gut microbiota in mitigating inflammatory bowel diseases","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Buigues, C., Navarro-Mart\u00ednez, R., S\u00e1nchez-Mart\u00ednez, V., Serrano-Carrascosa, M., Rubio-Briones, J., and Cauli, O. (2020). Interleukin-6 and Lymphocyte Count Associated and Predicted the Progression of Frailty Syndrome in Prostate Cancer Patients Undergoing Antiandrogen Therapy. Cancers, 12.","DOI":"10.3390\/cancers12071716"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e004191","DOI":"10.1136\/jitc-2021-004191","article-title":"Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer","volume":"10","author":"Terrisse","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1038\/s41467-020-18649-5","article-title":"Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients","volume":"11","author":"Daisley","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bbrc.2022.09.038","article-title":"Monosodium glutamate consumption reduces the renal excretion of trimethylamine N-oxide and the abundance of Akkermansia muciniphila in the gut","volume":"630","author":"Kyaw","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"104087","DOI":"10.1016\/j.ebiom.2022.104087","article-title":"Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis","volume":"82","author":"Luo","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s13668-024-00521-3","article-title":"The Interplay Between Dietary Choline and Cardiometabolic Disorders: A Review of Current Evidence","volume":"13","author":"Vallianou","year":"2024","journal-title":"Curr. Nutr. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"106916","DOI":"10.1016\/j.phrs.2023.106916","article-title":"Akkermansia muciniphila: A potential target and pending issues for oncotherapy","volume":"196","author":"Zhao","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bone.2017.08.028","article-title":"The prenylflavonoid Icaritin enhances osteoblast proliferation and function by signal transducer and activator of transcription factor 3 (STAT-3) regulation of C-X-C chemokine receptor type 4 (CXCR4) expression","volume":"105","author":"Lim","year":"2017","journal-title":"Bone"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, S., Priceman, S.J., Xin, H., Zhang, W., Deng, J., Liu, Y., Huang, J., Zhu, W., Chen, M., and Hu, W. (2013). Icaritin inhibits JAK\/STAT3 signaling and growth of renal cell carcinoma. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081657"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/CAD.0000000000000976","article-title":"Icaritin inhibits lung cancer-induced osteoclastogenesis by suppressing the expression of IL-6 and TNF-a and through AMPK\/mTOR signaling pathway","volume":"31","author":"Zhao","year":"2020","journal-title":"Anticancer. Drugs"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13046-021-01881-2","article-title":"HBP1-mediated transcriptional repression of AFP inhibits hepatoma progression","volume":"40","author":"Cao","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/CAD.0000000000000420","article-title":"Antitumoral action of icaritin in LNCaP prostate cancer cells by regulating PEA3\/HER2\/AR signaling","volume":"27","author":"Hu","year":"2016","journal-title":"Anticancer. Drugs"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/carcin\/bgv040","article-title":"A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants","volume":"36","author":"Sun","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.7150\/jca.48413","article-title":"Icaritin reduces prostate cancer progression via inhibiting high-fat diet-induced serum adipokine in TRAMP mice model","volume":"11","author":"Wu","year":"2020","journal-title":"J. Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s11255-016-1341-9","article-title":"A novel anticancer agent icaritin inhibited proinflammatory cytokines in TRAMP mice","volume":"48","author":"Hu","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.bbrc.2005.12.103","article-title":"Adiponectin as a growth inhibitor in prostate cancer cells","volume":"340","author":"Bub","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fan, Y., Li, S., Ding, X., Yue, J., Jiang, J., Zhao, H., Hao, R., Qiu, W., Liu, K., and Li, Y. (2019). First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: Preliminary results of safety, durable survival and immune biomarkers. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5471-1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1142\/S0192415X25500089","article-title":"Advances in Pharmacological Research on Icaritin: A Comprehensive Review","volume":"53","author":"Guo","year":"2025","journal-title":"Am. J. Chin. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1073\/pnas.92.8.3439","article-title":"Prostate cancer in a transgenic mouse","volume":"92","author":"Greenberg","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/s41598-025-87429-2","article-title":"Icaritin alleviates motor impairment and osteoporosis in Parkinson\u2019s disease mice via the ER-PI3K\/Akt pathway","volume":"15","author":"Lin","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Elisia, I., Nakamura, H., Lam, V., Hofs, E., Cederberg, R., Cait, J., Hughes, M.R., Lee, L., Jia, W., and Adomat, H.H. (2016). DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152538"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JME-16-0054","article-title":"Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice","volume":"58","author":"Zhao","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12986-019-0351-x","article-title":"High dietary fat intake lowers serum equol concentration and promotes prostate carcinogenesis in a transgenic mouse prostate model","volume":"16","author":"Liu","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: Fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Salzberg","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3177\/jnsv.53.464","article-title":"Vitamin K content of foods and dietary vitamin K intake in Japanese young women","volume":"53","author":"Kamao","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.1038\/s41598-018-27607-7","article-title":"Hexane-Isopropanolic Extract of Tungrymbai, a North-East Indian fermented soybean food prevents hepatic steatosis via regulating AMPK-mediated SREBP\/FAS\/ACC\/HMGCR and PPAR\u03b1\/CPT1A\/UCP2 pathways","volume":"8","author":"Dihingia","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.lfs.2018.12.002","article-title":"Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model: A good alternative to study PCa progression and chemoprevention approaches","volume":"217","author":"Kido","year":"2019","journal-title":"Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1101\/gr.122705.111","article-title":"The human gut virome: Inter-individual variation and dynamic response to diet","volume":"21","author":"Minot","year":"2011","journal-title":"Genome Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/pros.23760","article-title":"Combined maternal and post-weaning high fat diet inhibits male offspring\u2019s prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model","volume":"79","author":"Liu","year":"2019","journal-title":"Prostate"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mSphere.00351-17","article-title":"High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut","volume":"2","author":"Heisel","year":"2017","journal-title":"mSphere"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s12185-013-1317-9","article-title":"Icaritin induces AML cell apoptosis via the MAPK\/ERK and PI3K\/AKT signal pathways","volume":"97","author":"Li","year":"2013","journal-title":"Int. J. Hematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1002\/cam4.2630","article-title":"Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C","volume":"8","author":"Hu","year":"2019","journal-title":"Cancer Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/1751-7915.13410","article-title":"Akkermansia muciniphila is a promising probiotic","volume":"12","author":"Zhang","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e17257","DOI":"10.1097\/MD.0000000000017257","article-title":"Immunohistochemistry of immune checkpoint markers PD-1 and PD-L1 in prostate cancer","volume":"98","author":"Sharma","year":"2019","journal-title":"Medicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.fct.2018.02.018","article-title":"Vitamin K2, a menaquinone present in dairy products targets castration-resistant prostate cancer cell-line by activating apoptosis signaling","volume":"115","author":"Dasari","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"287358","DOI":"10.1155\/2013\/287358","article-title":"Vitamin k2, a naturally occurring menaquinone, exerts therapeutic effects on both hormone-dependent and hormone-independent prostate cancer cells","volume":"2013","author":"Samykutty","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/ajcn\/87.4.985","article-title":"Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)","volume":"87","author":"Nimptsch","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.3892\/ijo.2015.2845","article-title":"Longterm exposure to leptin enhances the growth of prostate cancer cells","volume":"46","author":"Noda","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.amjsurg.2004.07.031","article-title":"Leptin induces cell migration and the expression of growth factors in human prostate cancer cells","volume":"188","author":"Frankenberry","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_61","first-page":"1341","article-title":"Leptin is associated with increased prostate cancer risk: A nested case-referent study","volume":"86","author":"Stattin","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.5301\/jbm.5000124","article-title":"The role of circulating adiponectin in prostate cancer: A meta-analysis","volume":"30","author":"Liao","year":"2015","journal-title":"Int. J. Biol. Markers"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e22175","DOI":"10.1002\/ddr.22175","article-title":"New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives","volume":"85","author":"Kipchakbayeva","year":"2024","journal-title":"Drug Dev. Res."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Liu, X., Yang, F., Jia, D., Dong, X., Zhang, Y., and Wu, Z. (2023). Case report: A case study on the treatment using icaritin soft capsules in combination with lenvatinib achieving impressive PR and stage reduction in unresectable locally progressive pancreatic cancer and a literature review. Front. Genet., 14.","DOI":"10.3389\/fgene.2023.1167470"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Szab\u00f3, R., R\u00e1cz, C.P., and Dulf, F.V. (2022). Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147519"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/5\/804\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:25:19Z","timestamp":1772688319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/5\/804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["cancers18050804"],"URL":"https:\/\/doi.org\/10.3390\/cancers18050804","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}