{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:52:48Z","timestamp":1790362368897,"version":"4.1.0"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Early death (ED) remains the primary barrier to long-term survival in acute promyelocytic leukemia (APL). Since current risk stratification models rely solely on static baseline parameters, they fail to capture the high biological volatility during the induction phase. We aimed to evaluate the prognostic value of the dynamic evolution of the endothelial activation and stress index (EASIX). Materials and Methods: This multicenter, retrospective study analyzed 131 newly diagnosed adult APL patients treated with the AIDA protocol. EASIX scores were calculated at admission (D0) and day 7 (D7). ROC, landmark, multivariable logistic and Cox regression analyses were performed to assess the impact of dynamic endothelial changes (\u0394EASIX) on mortality and survival. Results: The ED rate was 25.2%. While baseline EASIX successfully predicted very early death (&lt;7 days), dynamic assessment provided superior risk stratification. Worsening endothelial status (\u0394EASIX &gt; 0.35) was an independent predictor of early mortality (OR: 12.41, p = 0.007), inferior EFS (HR: 5.70, p = 0.004), and poor OS (HR: 3.69, p = 0.023). Landmark analysis stratified by the kinetic trajectory of \u2206EASIX confirmed that patients above the optimal cut-off had significantly inferior 3-year EFS (56.3% vs. 77.8%, p = 0.041) and OS (59.5% vs. 78.0%, p = 0.026). Conclusions: To our knowledge, this is the first study to establish EASIX as a dynamic prognostic marker in APL. Our findings indicate that the \u201ckinetic trajectory\u201d of endothelial stress is a more accurate predictor of survival than static baseline assessment alone. While dynamic EASIX monitoring offers a valuable tool for real-time risk reclassification, these results require validation through prospective studies.<\/jats:p>","DOI":"10.3390\/cancers18050843","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:11:22Z","timestamp":1772716282000},"page":"843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Dynamic Endothelial Activation and Stress Index (EASIX) as a Predictor of Early Death and Long-Term Survival in Acute Promyelocytic Leukemia (APL): A Multicenter Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4991-9830","authenticated-orcid":false,"given":"Faz\u0131l \u00c7a\u011fr\u0131","family":"Hunutlu","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, University of Health Sciences, Bursa Sehir Training and Research Hospital, 16110 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vildan","family":"\u00d6zkocaman","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Baysal","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, 59030 Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-3791","authenticated-orcid":false,"given":"Hikmet","family":"\u00d6ztop","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-1879","authenticated-orcid":false,"given":"Saide Elif","family":"G\u00fcll\u00fcl\u00fc Boz","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Health Sciences, Bursa Y\u00fcksek Ihtisas Training and Research Hospital, 16310 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevriye G\u00fcl","family":"Ada Tak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9150-935X","authenticated-orcid":false,"given":"O\u011fuzhan","family":"Sertkaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, 59030 Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Akar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, 59030 Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e\u00fcheda","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, 59030 Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Mert","family":"Yan\u0131k","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, University of Health Sciences, Bursa Sehir Training and Research Hospital, 16110 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"G\u00fcll\u00fc Koca","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, University of Health Sciences, Bursa Sehir Training and Research Hospital, 16110 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Ethem","family":"P\u0131nar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vildan","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5419-3221","authenticated-orcid":false,"given":"Tuba","family":"Ersal","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seval","family":"Akp\u0131nar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Tekirdag Namik Kemal University, 59030 Tekirdag, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Bilen","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, University of Health Sciences, Bursa Sehir Training and Research Hospital, 16110 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-134X","authenticated-orcid":false,"given":"Fahir","family":"\u00d6zkalemka\u015f","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s13054-025-05743-7","article-title":"Early Mortality in Patients with Acute Promyelocytic Leukemia: A Systematic Review and Meta-Analysis","volume":"29","author":"Chean","year":"2025","journal-title":"Crit. Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1200\/JCO.2016.67.1982","article-title":"Improved Outcomes with Retinoic Acid and Arsenic Trioxide Compared with Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial","volume":"35","author":"Platzbecker","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41408-021-00425-3","article-title":"Acute Myeloid Leukemia: Current Progress and Future Directions","volume":"11","author":"Kantarjian","year":"2021","journal-title":"Blood Cancer J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1080\/10428194.2019.1613540","article-title":"Acute Promyelocytic Leukemia (APL): Remaining Challenges towards a Cure for All","volume":"60","author":"Stahl","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1300874","article-title":"Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia","volume":"369","author":"Avvisati","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3324\/haematol.2021.280093","article-title":"A Risk Score Based on Real-World Data to Predict Early Death in Acute Promyelocytic Leukemia","volume":"107","author":"Maia","year":"2022","journal-title":"Haematologica"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00277-022-04798-8","article-title":"The Evaluation of Risk Factors Leading to Early Deaths in Patients with Acute Promyelocytic Leukemia: A Retrospective Study","volume":"101","author":"Baysal","year":"2022","journal-title":"Ann. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/jamaoncol.2024.7033","article-title":"Academic Community Partnership in Acute Promyelocytic Leukemia and Early Mortality: The ECOG-ACRIN EA9131 Trial","volume":"11","author":"Jillella","year":"2025","journal-title":"JAMA Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/leu.2011.78","article-title":"Continuing High Early Death Rate in Acute Promyelocytic Leukemia: A Population-Based Report from the Swedish Adult Acute Leukemia Registry","volume":"25","author":"Lehmann","year":"2011","journal-title":"Leukemia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1007\/s00277-023-05422-z","article-title":"Predictors of Very Early Death in Acute Promyelocytic Leukemia: A Retrospective Real-World Cohort Study","volume":"102","author":"Infante","year":"2023","journal-title":"Ann. Hematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/ejh.14177","article-title":"Disseminated Intravascular Coagulation Score Evolution in 48 h Predicts Early Death in Acute Promyelocytic Leukemia Patients","volume":"112","author":"Infante","year":"2024","journal-title":"Eur. J. Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1182\/blood-2007-07-100669","article-title":"Causes and Prognostic Factors of Remission Induction Failure in Patients with Acute Promyelocytic Leukemia Treated with All-Trans Retinoic Acid and Idarubicin","volume":"111","author":"Montesinos","year":"2008","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/leu.2017.71","article-title":"Early Death Rates Remain High in High-Risk APL: Update from the Swedish Acute Leukemia Registry 1997\u20132013","volume":"31","author":"Lehmann","year":"2017","journal-title":"Leukemia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1080\/10428194.2020.1742910","article-title":"An Effective Early Death Scoring System for Predicting Early Death Risk in de Novo Acute Promyelocytic Leukemia","volume":"61","author":"Cai","year":"2020","journal-title":"Leuk. Lymphoma"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-2141.2000.01936.x","article-title":"Early Haemorrhagic Morbidity and Mortality during Remission Induction with or without All-Trans Retinoic Acid in Acute Promyelocytic Leukaemia","volume":"108","author":"Avvisati","year":"2000","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yu, J.W., Yang, C.J., Yang, J.F., and Fang, J.J. (2025). Relationship of Endothelial Activation and Stress Index on Concurrent Acute Kidney Injury in Patients with Heart Failure during Intensive Care Unit: A Competing Risk Model Analysis. BMC Cardiovasc. Disord., 26.","DOI":"10.1186\/s12872-025-05403-2"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kamaci Sener, D., Haki, C., Koc Yamanyar, G., Kandemir, F.N., Kamisli, S., and Sarac, K. (2025). Association of Endothelial Activation and Stress Index with Prognosis in Posterior Circulation Infarcts Treated with Recanalization Therapy. Diagnostics, 15.","DOI":"10.3390\/diagnostics15243234"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1007\/s00277-023-05437-6","article-title":"Endothelial Activation and Stress Index as a Prognostic Factor of Diffuse Large B-Cell Lymphoma: The Report from the Nationwide Multi-Center Thai Lymphoma Study Group","volume":"102","author":"Thanhakun","year":"2023","journal-title":"Ann. Hematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2519974","DOI":"10.1080\/16078454.2025.2519974","article-title":"Endothelial Activation and Stress Index (EASIX) as a Predictive Biomarker for Survival in Patients with T-Cell Lymphoma","volume":"30","author":"Li","year":"2025","journal-title":"Hematology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109527","DOI":"10.1016\/j.thromres.2025.109527","article-title":"Bone Marrow Blasts- and Modified EASIX-Guided Risk Stratification for Coagulopathy and Outcomes after CAR-T Therapy in Relapsed\/Refractory B-ALL","volume":"256","author":"Li","year":"2025","journal-title":"Thromb. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20406207251387409","DOI":"10.1177\/20406207251387409","article-title":"Clinical Practice of the Endothelial Activation and Stress Index and Its Modified Versions in Multiple Myeloma and the Effects on Prognosis","volume":"17","author":"Gursoy","year":"2026","journal-title":"Ther. Adv. Hematol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hunutlu, F.\u00c7., \u00d6ztop, H., G\u00fcrsoy, V., Ersal, T., Elg\u00fcn, E., Yavuz, \u015e., \u0130ldemir Ekizo\u011flu, S., Ekizo\u011flu, A.A., \u00d6zkocaman, V., and \u00d6zkalemka\u015f, F. (2025). Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Based Therapy. Diagnostics, 15.","DOI":"10.3390\/diagnostics15020185"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1182\/bloodadvances.2022007381","article-title":"Dynamic EASIX Scores Closely Predict Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation","volume":"6","author":"Nawas","year":"2022","journal-title":"Blood Adv."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Escribano-Serrat, S., Salas, M.Q., Pascual-Izquierdo, C., Fern\u00e1ndez Villalobos, M., G\u00f3mez-Segu\u00ed, I., Fidalgo, T., Fern\u00e1ndez Docampo, M., Mart\u00ednez Nieto, J., Lamas, \u00d3., and Lozano, M. (2025). EASIX, a New Tool to Predict Response and Refractoriness in Immune-Mediated Thrombotic Thrombocytopenic Purpura. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1700907"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1182\/blood-2019-01-894980","article-title":"Management of Acute Promyelocytic Leukemia: Updated Recommendations from an Expert Panel of the European LeukemiaNet","volume":"133","author":"Sanz","year":"2019","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1182\/blood.V94.4.1192","article-title":"A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic leukemia","volume":"94","author":"Fenaux","year":"1999","journal-title":"Blood"},{"key":"ref_27","first-page":"3015","article-title":"A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML\/RARalpha-positive acute promyelocytic leukemia","volume":"94","author":"Sanz","year":"1999","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1182\/blood-2010-03-276196","article-title":"Front-Line Treatment of Acute Promyelocytic Leukemia with AIDA Induction Followed by Risk-Adapted Consolidation for Adults Younger than 61 Years: Results of the AIDA-2000 Trial of the GIMEMA Group","volume":"116","author":"Avvisati","year":"2010","journal-title":"Blood"},{"key":"ref_29","first-page":"1247","article-title":"Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: A joint study of the PETHEMA and GIMEMA cooperative groups","volume":"96","author":"Sanz","year":"2000","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","article-title":"Guidelines for the Diagnosis and Management of Disseminated Intravascular Coagulation","volume":"145","author":"Levi","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_31","first-page":"35","article-title":"Retinoic Acid Syndrome in Acute Promyelocytic Leukemia","volume":"96","author":"Sentero","year":"1997","journal-title":"Wis. Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.1016\/S2352-3026(17)30108-4","article-title":"EASIX in Patients with Acute Graft-versus-Host Disease: A Retrospective Cohort Analysis","volume":"4","author":"Luft","year":"2017","journal-title":"Lancet Haematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41409-019-0703-1","article-title":"EASIX and Mortality after Allogeneic Stem Cell Transplantation","volume":"55","author":"Luft","year":"2020","journal-title":"Bone Marrow Transplant."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.clml.2022.11.005","article-title":"Improvement of Early Death in Acute Promyelocytic Leukemia: A Population-Based Analysis","volume":"23","author":"Li","year":"2023","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1182\/blood.2024026186","article-title":"Acute Promyelocytic Leukemia: Long-Term Outcomes from the HARMONY Project","volume":"145","author":"Voso","year":"2025","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1200\/JCO-25-00535","article-title":"Arsenic Trioxide and All-Trans Retinoic Acid Combination Therapy for the Treatment of High-Risk Acute Promyelocytic Leukemia: Results from the APOLLO Trial","volume":"43","author":"Platzbecker","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s12032-013-0478-y","article-title":"International Society of Thrombosis and Hemostasis Scoring System for Disseminated Intravascular Coagulation \u2265 6: A New Predictor of Hemorrhagic Early Death in Acute Promyelocytic Leukemia","volume":"30","author":"Mitrovic","year":"2013","journal-title":"Med. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1016\/j.thromres.2018.01.038","article-title":"Predictive Factors of Fatal Bleeding in Acute Promyelocytic Leukemia","volume":"164","author":"Mantha","year":"2018","journal-title":"Thromb. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/MOH.0000000000000221","article-title":"What\u2019s New in the Pathogenesis of the Coagulopathy in Acute Promyelocytic Leukemia?","volume":"23","author":"Mantha","year":"2016","journal-title":"Curr. Opin. Hematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1182\/blood.V92.1.143.413k18_143_151","article-title":"Cancer Procoagulant and Tissue Factor Are Differently Modulated All- Trans-Retinoic Acid in Acute Promyelocytic Leukemia Cells","volume":"92","author":"Falanga","year":"1998","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MOH.0000000000000880","article-title":"Hemostatic Abnormalities in Acute Promyelocytic Leukemia: Clinical Implications and Mechanisms","volume":"32","author":"Hisada","year":"2025","journal-title":"Curr. Opin. Hematol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Hambley, B.C., Tomuleasa, C., and Ghiaur, G. (2021). Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?. Front. Med., 8.","DOI":"10.3389\/fmed.2021.722614"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00277-013-1676-6","article-title":"Increased Promyelocytic-Derived Microparticles: A Novel Potential Factor for Coagulopathy in Acute Promyelocytic Leukemia","volume":"92","author":"Ma","year":"2013","journal-title":"Ann. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, C., Zuo, N., Yang, H., Fang, S., and Shi, J. (2022). Extracellular Traps Increase Burden of Bleeding by Damaging Endothelial Cell in Acute Promyelocytic Leukaemia. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.841445"},{"key":"ref_45","first-page":"4647252","article-title":"Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer","volume":"2019","author":"Yang","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/cimb46010006","article-title":"Arsenic Trioxide Decreases Lymphangiogenesis by Inducing Apoptotic Pathways and Inhibition of Important Endothelial Cell Receptors","volume":"46","author":"Hrgovic","year":"2024","journal-title":"Curr. Issues Mol. Biol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/5\/843\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T13:22:23Z","timestamp":1772716943000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/5\/843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["cancers18050843"],"URL":"https:\/\/doi.org\/10.3390\/cancers18050843","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}