{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:53:01Z","timestamp":1773553981202,"version":"3.50.1"},"reference-count":13,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"crossref","award":["269639-PROSNI"],"award-info":[{"award-number":["269639-PROSNI"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"crossref","award":["PROINPEP 2021"],"award-info":[{"award-number":["PROINPEP 2021"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CONACyT-Mexico","award":["Frontera-2020-552265"],"award-info":[{"award-number":["Frontera-2020-552265"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>We sincerely thank Roesler and Isolan [...]<\/jats:p>","DOI":"10.3390\/cancers18060931","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:26:19Z","timestamp":1773390379000},"page":"931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reply to Roesler, R.; Isolan, G.R. Comment on \u201cSantana-Bejarano et al. NRP1 and GFAP Expression in the Medulloblastoma Microenvironment: Implications for Angiogenesis and Tumor Progression. Cancers 2025, 17, 2417\u201d"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-1017","authenticated-orcid":false,"given":"Marisol","family":"God\u00ednez-Rub\u00ed","sequence":"first","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-7821","authenticated-orcid":false,"given":"Margarita Belem","family":"Santana-Bejarano","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Diagn\u00f3stica e Inmunohistoqu\u00edmica, Centro de Investigaci\u00f3n y Diagn\u00f3stico en Patolog\u00eda, Departamento de Microbiolog\u00eda y Patolog\u00eda, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"},{"name":"Doctorado en Ciencias en Biolog\u00eda Molecular en Medicina, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-8722","authenticated-orcid":false,"given":"Mar\u00eda Paulina","family":"Reyes-Mata","sequence":"additional","affiliation":[{"name":"Departamento de Disciplinas Filos\u00f3fico, Metodol\u00f3gicas e Instrumentales, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-6184","authenticated-orcid":false,"given":"Jos\u00e9 de Jes\u00fas","family":"Guerrero-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Banco de Sangre Central, Unidad M\u00e9dica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro M\u00e9dico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico"},{"name":"Departamento de Farmacobiolog\u00eda, Centro Universitario de Ciencias Exactas e Ingenier\u00edas (CUCEI), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-2514","authenticated-orcid":false,"given":"Daniel","family":"Ortu\u00f1o-Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunobiolog\u00eda Molecular, Instituto de Neurociencias Translacionales, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Roesler, R., and Isolan, G.R. (2026). Comment on Santana-Bejarano et al. NRP1 and GFAP Expression in the Medulloblastoma Microenvironment: Implications for Angiogenesis and Tumor Progression. Cancers 2025, 17, 2417. Cancers, 18.","DOI":"10.3390\/cancers18060913"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41576-020-0258-4","article-title":"mRNAs, Proteins and the Emerging Principles of Gene Expression Control","volume":"21","author":"Buccitelli","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1101\/gr.216721.116","article-title":"Co-Expression Networks Reveal the Tissue-Specific Regulation of Transcription and Splicing","volume":"27","author":"Saha","year":"2017","journal-title":"Genome Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"De Ara\u00fajo, M.A., Malafaia, O., Ribas Filho, J.M., Fratini, L., Roesler, R., and Isolan, G.R. (2023). Low Expression of the NRP1 Gene Is Associated with Shorter Overall Survival in Patients with Sonic Hedgehog and Group 3 Medulloblastoma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411601"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Santana-Bejarano, M.B., Reyes-Mata, M.P., Guerrero-Garc\u00eda, J.D.J., Ortu\u00f1o-Sahag\u00fan, D., and God\u00ednez-Rub\u00ed, M. (2025). NRP1 and GFAP Expression in the Medulloblastoma Microenvironment: Implications for Angiogenesis and Tumor Progression. Cancers, 17.","DOI":"10.3390\/cancers17152417"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"The UniProt Consortium, Bateman, A., Martin, M.-J., Orchard, S., Magrane, M., Adesina, A., Ahmad, S., Bowler-Barnett, E.H., Bye-A-Jee, H., and Carpentier, D. (2025). UniProt: The Universal Protein Knowledgebase in 2025. Nucleic Acids Res., 53, D609\u2013D617.","DOI":"10.1093\/nar\/gkae1010"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Varanasi, S.M., Gulani, Y., Rachamala, H.K., Mukhopadhyay, D., and Angom, R.S. (2025). Neuropilin-1: A Multifaceted Target for Cancer Therapy. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32040203"},{"key":"ref_8","unstructured":"National Center for Biotechnology Information (NCBI) (2026, January 08). Gene ID: 8829, Available online: https:\/\/www.ncbi.nlm.nih.gov\/gene?Db=gene&Cmd=DetailsSearch&Term=8829."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1073\/pnas.040337597","article-title":"Identification of a Natural Soluble Neuropilin-1 That Binds Vascular Endothelial Growth Factor: In Vivo Expression and Antitumor Activity","volume":"97","author":"Gagnon","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Graziani, G., and Lacal, P.M. (2015). Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Front. Oncol., 5.","DOI":"10.3389\/fonc.2015.00125"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s12935-019-0963-2","article-title":"The miR-141\/Neuropilin-1 Axis Is Associated with the Clinicopathology and Contributes to the Growth and Metastasis of Pancreatic Cancer","volume":"19","author":"Ma","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10456-013-9394-1","article-title":"miR-320 Regulates Tumor Angiogenesis Driven by Vascular Endothelial Cells in Oral Cancer by Silencing Neuropilin 1","volume":"17","author":"Wu","year":"2014","journal-title":"Angiogenesis"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1038\/s41467-019-11580-4","article-title":"N-Glycosylation-Defective Splice Variants of Neuropilin-1 Promote Metastasis by Activating Endosomal Signals","volume":"10","author":"Huang","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/6\/931\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:15:46Z","timestamp":1773551746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/6\/931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["cancers18060931"],"URL":"https:\/\/doi.org\/10.3390\/cancers18060931","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}