{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:56:38Z","timestamp":1787453798561,"version":"build-2736575974"},"reference-count":102,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Reduced quality of life, cancer-related fatigue, and functional impairment are common during and after oncologic treatment. Although therapeutic exercise is effective, evidence on brief, supervised programs of moderate to vigorous intensity remains limited, despite their greater clinical feasibility. This study evaluated the effectiveness of a six-week multimodal Therapeutic Exercise Program (TEP) in patients with cancer. Methods: A randomized controlled clinical trial (NCT05816187) was conducted with 110 patients with cancer (stages I\u2013III), assigned to either an intervention group (supervised TEP, three sessions per week for six weeks) or a control group (usual care). The program included cardiorespiratory and strength training with intensity monitored using the Rating of Perceived Exertion (RPE), as well as stretching exercises. Quality of life (QoL) was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), fatigue using the Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F), functional capacity using the Six Minute Walk Test (6MWT), and muscle strength using the 30 Second Sit to Stand Test (30s-STST) and handgrip dynamometry (HGT). Analyses of covariance (ANCOVA), responder analyses based on the Minimal Clinically Important Difference (MCID), and effect sizes (\u03b7p2) were performed. Results: The intervention group showed significant and clinically meaningful improvements in fatigue (FACIT-F: +4.53; p &lt; 0.001; \u03b7p2 = 0.135), global QoL (+9.22; p = 0.006), physical function, functional capacity (+24.16 m in the 6MWT; p = 0.006), and muscle strength (30s-STST: +2.71 repetitions; handgrip: +3.32 kg; p &lt; 0.001). A total of 63.3% of participants were responders for fatigue compared with 13.3% in the control group (NNT = 2.00). Functional improvements showed moderate correlations with fatigue and global health status. Among symptoms, only insomnia demonstrated a significant reduction. Conclusions: A brief, supervised, multimodal TEP of moderate to vigorous intensity appears to be an effective, safe, and clinically relevant intervention to improve fatigue, QoL, and functional capacity in patients with cancer, with potential applicability in multidisciplinary oncologic care.<\/jats:p>","DOI":"10.3390\/cancers18060947","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:36:48Z","timestamp":1773423408000},"page":"947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of a 6-Week Supervised Multimodal Exercise Program on Cancer-Related Fatigue, Quality of Life and Physical Function During Active Treatment: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9499-2905","authenticated-orcid":false,"given":"Arturo","family":"Cano-Uceda","sequence":"first","affiliation":[{"name":"Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Faculty of Health Sciences, Alfonso X El Sabio University, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5406-5440","authenticated-orcid":false,"given":"Paloma","family":"Pareja-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9275-8586","authenticated-orcid":false,"given":"Esther","family":"S\u00e1nchez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2480-4017","authenticated-orcid":false,"given":"David","family":"Fraguas-Ramos","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mart\u00edn-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Asencio-Vicente","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaya","family":"Rivero-de la Villa","sequence":"additional","affiliation":[{"name":"Physiotherapy, Occupational Therapy and Speech Therapy Unit, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"P\u00e9rez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Medical Oncology Service, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta Mar\u00eda","family":"Obispo-Portero","sequence":"additional","affiliation":[{"name":"Medical Oncology Service, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morales-Ruiz","sequence":"additional","affiliation":[{"name":"Rehabilitation Service, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8518-061X","authenticated-orcid":false,"given":"Rosal\u00eda","family":"de Dios-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Rehabilitation Service, Infanta Leonor University Hospital, Vallecas, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-578X","authenticated-orcid":false,"given":"Lara","family":"Sanchez-Barroso","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, Physiotherapy and Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"InveCuid, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5986-8432","authenticated-orcid":false,"given":"Luis","family":"De Sousa-De 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1158\/1541-7786.MCR-23-0411","article-title":"Updating the Definition of Cancer","volume":"21","author":"Brown","year":"2023","journal-title":"Mol. Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.arcmed.2022.11.003","article-title":"Cancer Epigenetics: An Overview","volume":"53","year":"2022","journal-title":"Arch. Med. Res."},{"key":"ref_3","unstructured":"(2025). GBD 2023 Cancer Collaborators. The Global, Regional, and National Burden of Cancer, 1990\u20132023, with Forecasts to 2050: A Systematic Analysis for the Global Burden of Disease Study 2023. Lancet, 406, 1565\u20131586."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13045-024-01640-8","article-title":"Global Burden of Cancer and Associated Risk Factors in 204 Countries and Territories, 1980\u20132021: A Systematic Analysis for the GBD 2021","volume":"17","author":"Wu","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_5","first-page":"394","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 Cancer Estimates: Data Sources, Methods, and a Snapshot of the Cancer Burden Worldwide","volume":"156","author":"Filho","year":"2025","journal-title":"Int. J. Cancer"},{"key":"ref_7","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.3390\/cancers3033279","article-title":"Assessment of the Evolution of Cancer Treatment Therapies","volume":"3","author":"Arruebo","year":"2011","journal-title":"Cancers"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e22900","DOI":"10.1002\/jbt.22900","article-title":"The Current Knowledge Concerning Solid Cancer and Therapy","volume":"35","author":"Najafi","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107534","DOI":"10.1016\/j.phrs.2024.107534","article-title":"Targeted and Cytotoxic Inhibitors Used in the Treatment of Breast Cancer","volume":"210","author":"Roskoski","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Barbari, C., Fontaine, T., Parajuli, P., Lamichhane, N., Jakubski, S., Lamichhane, P., and Deshmukh, R.R. (2020). Immunotherapies and Combination Strategies for Immuno-Oncology. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145009"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-020-0306-5","article-title":"A Guide to Cancer Immunotherapy: From T Cell Basic Science to Clinical Practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/annonc\/mdz298","article-title":"Differential Impact of Endocrine Therapy and Chemotherapy on Quality of Life of Breast Cancer Survivors: A Prospective Patient-Reported Outcomes Analysis","volume":"30","author":"Ferreira","year":"2019","journal-title":"Ann. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jpainsymman.2019.03.017","article-title":"The Impact of Radiodermatitis on Breast Cancer Patients\u2019 Quality of Life During Radiotherapy: A Prospective Cohort Study","volume":"58","author":"Fuzissaki","year":"2019","journal-title":"J. Pain Symptom Manag."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1007\/s11136-023-03460-8","article-title":"Associations between Treatments, Comorbidities and Multidimensional Aspects of Quality of Life among Patients with Advanced Cancer in the Netherlands\u2014A 2017\u20132020 Multicentre Cross-Sectional Study","volume":"32","author":"Malhotra","year":"2023","journal-title":"Qual. Life Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e70816","DOI":"10.1002\/cam4.70816","article-title":"Comparative Efficacy of Various Exercise Types on Cancer-Related Fatigue for Cancer Survivors: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials","volume":"14","author":"Zhou","year":"2025","journal-title":"Cancer Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/cncr.34507","article-title":"Treatment-Related Adverse Events of Antibody\u2013Drug Conjugates in Clinical Trials: A Systematic Review and Meta-Analysis","volume":"129","author":"Zhu","year":"2023","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejca.2021.10.005","article-title":"Health-Related Quality of Life in Cancer Patients Treated with Immune Checkpoint Inhibitors in Randomised Controlled Trials: A Systematic Review and Meta-Analysis","volume":"159","author":"Boutros","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Muzellec, L., Bourien, H., and Edeline, J. (2022). Patients\u2019 Experience of Systemic Treatment of Hepatocellular Carcinoma: A Review of the Impact on Quality of Life. Cancers, 14.","DOI":"10.3390\/cancers14010179"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113374","DOI":"10.1016\/j.ejca.2023.113374","article-title":"Systematic Review of Adoption, Reporting and Impact of Health-Related Quality of Life in Phase III Non-Inferiority Trials of Systemic Oncology Treatments","volume":"195","author":"Notarnicola","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"ref_21","first-page":"12","article-title":"Quality of Life during Palliative Systemic Therapy for Esophagogastric Cancer: Systematic Review and Meta-Analysis","volume":"112","author":"Schokker","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12955-024-02227-0","article-title":"Health-Related Quality of Life and Its Determinants among Cancer Patients: Evidence from 12,148 Patients of Indian Database","volume":"22","author":"Dixit","year":"2024","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.3390\/ijerph17196938","article-title":"Quality of Life of Cancer Patients Treated with Chemotherapy","volume":"17","author":"Lewandowska","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12943-025-02305-x","article-title":"Advances in Cancer Immunotherapy: Historical Perspectives, Current Developments, and Future Directions","volume":"24","author":"Zhang","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S1470-2045(21)00333-8","article-title":"Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitor-Based Combination Therapies in Clinical Trials: A Systematic Review and Meta-Analysis","volume":"22","author":"Zhou","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1164\/rccm.202210-1963ST","article-title":"Cancer-Related Fatigue in Lung Cancer: A Research Agenda An Official American Thoracic Society Research Statement","volume":"207","author":"Bade","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-Related Fatigue\u2013Mechanisms, Risk Factors, and Treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0140-6736(22)00242-2","article-title":"Management of Common Clinical Problems Experienced by Survivors of Cancer","volume":"399","author":"Emery","year":"2022","journal-title":"Lancet"},{"key":"ref_29","first-page":"3733","article-title":"Routine Cancer Treatments and Their Impact on Physical Function, Symptoms of Cancer-Related Fatigue, Anxiety, and Depression","volume":"30","author":"Grusdat","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1634\/theoncologist.12-S1-4","article-title":"Cancer-Related Fatigue: The Scale of the Problem","volume":"12","author":"Hofman","year":"2007","journal-title":"Oncologist"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"769","DOI":"10.31557\/APJCP.2023.24.3.769","article-title":"Prevalence and Impact of Fatigue on Quality of Life (QOL) of Cancer Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis","volume":"24","author":"Muthanna","year":"2023","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xu, J., Li, Q., Gao, Z., Ji, P., Ji, Q., Song, M., Chen, Y., Sun, H., Wang, X., and Zhang, L. (2025). Impact of Cancer-Related Fatigue on Quality of Life in Patients with Cancer: Multiple Mediating Roles of Psychological Coherence and Stigma. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-13468-7"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/ijc.34152","article-title":"Late Effects, Long-Term Problems and Unmet Needs of Cancer Survivors","volume":"151","author":"Schmidt","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1200\/JCO.2016.67.7450","article-title":"Cancer-Related Fatigue in Patients with and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration","volume":"34","author":"Behringer","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1200\/JCO.22.00687","article-title":"Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline","volume":"40","author":"Ligibel","year":"2022","journal-title":"J. Clin. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1200\/JCO.24.00541","article-title":"Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update","volume":"42","author":"Bower","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/bjsports-2024-109392","article-title":"Impact of Exercise on Health Outcomes in People with Cancer: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomised Controlled Trials","volume":"59","author":"Bai","year":"2025","journal-title":"Br. J. Sports Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ctrv.2016.11.010","article-title":"Effects and Moderators of Exercise on Quality of Life and Physical Function in Patients with Cancer: An Individual Patient Data Meta-Analysis of 34 RCTs","volume":"52","author":"Buffart","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cano-Uceda, A., Garc\u00eda-Fern\u00e1ndez, P., Peuyad\u00e9-Rueda, B., Ca\u00f1uelo-Marquez, A.M., Sol\u00eds-Menc\u00eda, C., Lucio-Allende, C., De Sousa-De Sousa, L., and Mat\u00e9-Mu\u00f1oz, J.L. (2025). From Evidence to Practice: A Systematic Review and Meta-Analysis on the Effects of Supervised Exercise on Fatigue in Breast and Prostate Cancer Survivors. Appl. Sci., 15.","DOI":"10.3390\/app15158399"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cano-Uceda, A., De Sousa-De Sousa, L., Bueno-Fermoso, R., Rozal\u00e9n-Bust\u00edn, M., Lucio-Allende, C., Barba-Ruiz, M., S\u00e1nchez-Barroso, L., Mat\u00e9-Mu\u00f1oz, J.L., and Garc\u00eda-Fern\u00e1ndez, P. (2025). Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer. J. Funct. Morphol. Kinesiol., 10.","DOI":"10.3390\/jfmk10040453"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cano-Uceda, A., Pareja-Garc\u00eda, P., S\u00e1nchez-Rodr\u00edguez, E., Fraguas-Ramos, D., Mart\u00edn-\u00c1lvarez, L., Asencio-Vicente, R., Rivero-de la Villa, A., P\u00e9rez-P\u00e9rez, M.d.M., Obispo-Portero, B.M., and Morales-Ruiz, L. (2024). Effects of a Short-Term Supervised Exercise Program in Women with Breast Cancer. Appl. Sci., 14.","DOI":"10.3390\/app14156553"},{"key":"ref_42","first-page":"CD015518","article-title":"Resistance Training for Fatigue in People with Cancer","volume":"11","author":"Ernst","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.apmr.2023.01.008","article-title":"Effectiveness of Therapeutic Exercise Models on Cancer-Related Fatigue in Patients with Cancer Undergoing Chemotherapy: A Systematic Review and Network Meta-Analysis","volume":"104","author":"Calatayud","year":"2023","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1249\/MSS.0000000000002154","article-title":"Moderators of Exercise Effects on Cancer-Related Fatigue: A Meta-Analysis of Individual Patient Data","volume":"52","author":"Sweegers","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_45","first-page":"CD015517","article-title":"Cardiovascular Training for Fatigue in People with Cancer","volume":"20","author":"Wagner","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_46","first-page":"10421","article-title":"Effects of Exercise Interventions on Cancer-Related Fatigue in Breast Cancer Patients: An Overview of Systematic Reviews","volume":"30","author":"Zhou","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, T., Deng, J., Li, W., Zhang, Q., Yan, H., and Liu, Y. (2025). The Effects of Aerobic Exercise in Patients with Cancer-Related Fatigue: A Systematic Review and Meta-Analysis. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0325100"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.jval.2018.03.013","article-title":"General Population Norms for the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale","volume":"21","author":"Montan","year":"2018","journal-title":"Value Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1183\/09031936.00150314","article-title":"An Official European Respiratory Society\/American Thoracic Society Technical Standard: Field Walking Tests in Chronic Respiratory Disease","volume":"44","author":"Holland","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100886","DOI":"10.1016\/j.dhjo.2020.100886","article-title":"Feasibility and Reliability of a Physical Fitness Tests Battery for Adults with Intellectual Disabilities: The SAMU DIS-FIT Battery","volume":"13","year":"2020","journal-title":"Disabil. Health J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/02701367.1999.10608028","article-title":"A 30-s chair-stand test as a measure of lower body strength in community-residing older adults","volume":"70","author":"Jones","year":"1999","journal-title":"Res. Q. Exerc. Sport"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-019-00545-w","article-title":"Assessment of Muscle Function and Physical Performance in Daily Clinical Practice: A Position Paper Endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)","volume":"105","author":"Beaudart","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.2147\/CIA.S62002","article-title":"Clinical Effectiveness of Grip Strength in Predicting Ambulation of Elderly Inpatients","volume":"9","author":"Beseler","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12955-019-1090-4","article-title":"The Impact of an Exercise Program on Quality of Life in Older Breast Cancer Survivors Undergoing Aromatase Inhibitor Therapy: A Randomized Controlled Trial","volume":"17","author":"Paulo","year":"2019","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_56","unstructured":"Field, A. (2013). Discovering Statistics Using IBM SPSS Statistics, Sage. [4th ed.]."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.MLR.0000062554.74615.4C","article-title":"Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation","volume":"41","author":"Norman","year":"2003","journal-title":"Med. Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0885-3924(02)00529-8","article-title":"Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales","volume":"24","author":"Cella","year":"2002","journal-title":"J. Pain Symptom Manag."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s11136-014-0853-y","article-title":"Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients\u2019 supportive care needs","volume":"24","author":"Snyder","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jpainsymman.2019.09.010","article-title":"Exercise Training for Improving Patient-Reported Outcomes in Patients with Advanced-Stage Cancer: A Systematic Review and Meta-Analysis","volume":"59","author":"Chen","year":"2020","journal-title":"J. Pain Symptom Manag."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Fernandez-Rodriguez, E.J., Sanchez-Gomez, C., Mendez-Sanchez, R., Recio-Rodriguez, J.I., Puente-Gonzalez, A.S., Gonzalez-Sanchez, J., Cruz-Hernandez, J.J., and Rihuete-Galve, M.I. (2023). Multimodal Physical Exercise and Functional Rehabilitation Program in Oncological Patients with Cancer-Related Fatigue\u2014A Randomized Clinical Trial. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064938"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/bjsports-2017-097891","article-title":"Which Exercise Prescriptions Improve Quality of Life and Physical Function in Patients with Cancer during and Following Treatment? A Systematic Review and Meta-Analysis of Randomised Controlled Trials","volume":"52","author":"Sweegers","year":"2018","journal-title":"Br. J. Sports Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1249\/MSS.0000000000003452","article-title":"Resistance Exercise and Skeletal Muscle-Related Outcomes in Patients with Cancer: A Systematic Review","volume":"56","author":"Kang","year":"2024","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1249\/MSS.0000000000003095","article-title":"Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Therapy","volume":"55","author":"Houben","year":"2023","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11764-016-0592-x","article-title":"Evaluation of Resistance Training to Improve Muscular Strength and Body Composition in Cancer Patients Undergoing Neoadjuvant and Adjuvant Therapy: A Meta-Analysis","volume":"11","author":"Padilha","year":"2017","journal-title":"J. Cancer Surviv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.119.043483","article-title":"Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients with Primary Breast Cancer: A Randomized Controlled Trial","volume":"141","author":"Scott","year":"2020","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e997","DOI":"10.1161\/CIR.0000000000000679","article-title":"Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors: A Scientific Statement from the American Heart Association","volume":"139","author":"Gilchrist","year":"2019","journal-title":"Circulation"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12955-025-02357-z","article-title":"Psychosocial Factors Associated with Quality of Life in Cancer Patients Undergoing Treatment: An Umbrella Review","volume":"23","author":"Marzorati","year":"2025","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Alfonsd\u00f3ttir, S.\u00c1., Hj\u00f6rd\u00edsar J\u00f3nsd\u00f3ttir, H.L., \u00deorvaldsd\u00f3ttir, G.H., Einarsd\u00f3ttir, S.E., Torfad\u00f3ttir, J.E., and Gunnarsd\u00f3ttir, S. (2025). The Quality of Life of Cancer Survivors: The Role of Social Factors. Cancers, 17.","DOI":"10.3390\/cancers17193145"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e2528882","DOI":"10.1001\/jamanetworkopen.2025.28882","article-title":"Work Status, Absenteeism, Presenteeism, and Quality of Life in Young Adult Cancer Survivors","volume":"8","author":"Bhatt","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/bjc.2013.146","article-title":"Independent Contributors to Overall Quality of Life in People with Advanced Cancer","volume":"108","author":"Mayo","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1161\/CIR.0000000000000461","article-title":"Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement from the American Heart Association","volume":"134","author":"Ross","year":"2016","journal-title":"Circulation"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Gonzalo-Encabo, P., Maldonado, G., Valad\u00e9s, D., Ferragut, C., and P\u00e9rez-L\u00f3pez, A. (2021). The Role of Exercise Training on Low-Grade Systemic Inflammation in Adults with Overweight and Obesity: A Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182413258"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"113309","DOI":"10.1016\/j.ijpsycho.2025.113309","article-title":"The Effects of Acute Aerobic Exercise on Stressor-Evoked Physiological and Psychological Responses","volume":"220","author":"Ginty","year":"2025","journal-title":"Int. J. Psychophysiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10865-024-00470-w","article-title":"The Effects of Acute Exercise on Stress Reactivity Assessed via a Multidimensional Approach: A Systematic Review","volume":"47","author":"Morava","year":"2024","journal-title":"J. Behav. Med."},{"key":"ref_76","first-page":"509","article-title":"Patient Attitudes and Experiences towards Exercise during Oncological Treatment. A Qualitative Systematic Review","volume":"32","author":"Finch","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12966-021-01116-9","article-title":"Factors Influencing Physical Activity Participation among People Living with or beyond Cancer: A Systematic Scoping Review","volume":"18","author":"Elshahat","year":"2021","journal-title":"Int. J. Behav. Nutr. Phys. Act"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102604","DOI":"10.1016\/j.cpr.2025.102604","article-title":"Comparative Effects of Different Physical Exercises on Cognitive Function and Intervention Adherence in Older Adults with Cognitive Impairment: A Systematic Review and Network Meta-Analysis","volume":"120","author":"Li","year":"2025","journal-title":"Clin. Psychol. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Cheng, J.O.S., and Cheng, S.T. (2019). Effectiveness of Physical and Cognitive-Behavioural Intervention Programmes for Chronic Musculoskeletal Pain in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0223367"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"D\u00fczel, S., Drewelies, J., Polk, S.E., Misgeld, C., Porst, J., Wolfarth, B., K\u00fchn, S., Brandmaier, A.M., and Wenger, E. (2022). No Evidence for a Boost in Psychosocial Functioning in Older Age After a 6-Months Physical Exercise Intervention. Front. Hum. Neurosci., 16.","DOI":"10.3389\/fnhum.2022.825454"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.3390\/ijerph192315896","article-title":"Effects of Exercise Programs on Psychoemotional and Quality-of-Life Factors in Adult Patients with Cancer and Hematopoietic Stem Cell Transplantation or Bone Marrow Transplantation: A Systematic Review","volume":"19","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.breast.2022.03.014","article-title":"Effects of Physical Exercise on Cognitive Function of Breast Cancer Survivors Receiving Chemotherapy: A Systematic Review of Randomized Controlled Trials","volume":"63","author":"Ren","year":"2022","journal-title":"Breast"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1002\/cam4.4746","article-title":"Impact of Physical Exercise in Advanced-Stage Cancer Patients: Systematic Review and Meta-Analysis","volume":"11","year":"2022","journal-title":"Cancer Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1007\/s11764-023-01392-3","article-title":"Moderators of Exercise Effects on Self-Reported Cognitive Functioning in Cancer Survivors: An Individual Participant Data Meta-Analysis","volume":"18","author":"Hiensch","year":"2024","journal-title":"J. Cancer Surviv."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10549-023-07220-7","article-title":"Effects of Physical Exercise during Adjuvant Chemotherapy for Breast Cancer on Long-Term Tested and Perceived Cognition: Results of a Pragmatic Follow-up Study","volume":"205","author":"Naaktgeboren","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Xie, Y., Liu, S., Chen, X.J., Yu, H.H., Yang, Y., and Wang, W. (2021). Effects of Exercise on Sleep Quality and Insomnia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.664499"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"108681","DOI":"10.1016\/j.sleep.2025.108681","article-title":"Exercise as a Therapeutic Strategy for Insomnia: Current Mechanisms and Clinical Relevance","volume":"138","author":"Saadh","year":"2025","journal-title":"Sleep Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"pkz037","DOI":"10.1093\/jncics\/pkz037","article-title":"Minimally Important Differences for Interpreting EORTC QLQ-C30 Scores in Patients with Advanced Breast Cancer","volume":"3","author":"Musoro","year":"2019","journal-title":"JNCI Cancer Spectr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpainsymman.2020.07.037","article-title":"Prevalence of Fatigue in Patients with Cancer: A Systematic Review and Meta-Analysis","volume":"61","author":"Tanash","year":"2021","journal-title":"J. Pain Symptom Manag."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"12815","DOI":"10.1038\/s41598-023-39046-0","article-title":"Prevalence of Cancer-Related Fatigue Based on Severity: A Systematic Review and Meta-Analysis","volume":"13","author":"Kang","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e7293","DOI":"10.1002\/cam4.7293","article-title":"Prevalence and Biopsychosocial Indicators of Fatigue in Cancer Patients","volume":"13","author":"Zeilinger","year":"2024","journal-title":"Cancer Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Fritzen, A.M., Andersen, S.P., Qadri, K.A.N., Th\u00f8gersen, F.D., Krag, T., \u00d8rngreen, M.C., Vissing, J., and Jeppesen, T.D. (2020). Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103113"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Tam, E., Bruseghini, P., Capelli, C., Oliboni, E., Pezzato, A., Pogliaghi, S., Mucelli, R.P., Schena, F., and Calabria, E. (2018). Effect of Endurance and Strength Training on the Slow Component of VO2 Kinetics in Elderly Humans. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01353"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Wender, C.L.A., Manninen, M., and O\u2019Connor, P.J. (2022). The Effect of Chronic Exercise on Energy and Fatigue States: A Systematic Review and Meta-Analysis of Randomized Trials. Front. Psychol., 13.","DOI":"10.3389\/fpsyg.2022.907637"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cpr.2015.05.009","article-title":"Differential Effects of Behavioral Interventions with a Graded Physical Activity Component in Patients Suffering from Chronic Fatigue (Syndrome): An Updated Systematic Review and Meta-Analysis","volume":"40","author":"Marques","year":"2015","journal-title":"Clin. Psychol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1634\/theoncologist.12-S1-35","article-title":"Cancer-Related Fatigue and Sleep Disorders","volume":"12","author":"Roscoe","year":"2007","journal-title":"Oncologist"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/jcm11010269","article-title":"Effectiveness of Therapeutic Exercise and Patient Education on Cancer-Related Fatigue in Breast Cancer Survivors: A Randomised, Single-Blind, Controlled Trial with a 6-Month Follow-Up","volume":"11","year":"2022","journal-title":"J. Clin. Med."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Pepera, G., Antoniou, V., Karagianni, E., Batalik, L., and Su, J.J. (2025). Validity and Reliability of the Six-Minute Walking Test Compared to Cardiopulmonary Exercise Test in Individuals with Heart Failure Systematic Review and Meta-Analysis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14238303"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1183\/09031936.00150414","article-title":"An Official Systematic Review of the European Respiratory Society\/American Thoracic Society: Measurement Properties of Field Walking Tests in Chronic Respiratory Disease","volume":"44I","author":"Singh","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.chest.2019.10.014","article-title":"Six-Minute Walk Test: Clinical Role, Technique, Coding, and Reimbursement","volume":"157","author":"Agarwala","year":"2020","journal-title":"Chest"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1113\/JP277250","article-title":"The Increase in Muscle Force after 4 Weeks of Strength Training Is Mediated by Adaptations in Motor Unit Recruitment and Rate Coding","volume":"597","author":"Casolo","year":"2019","journal-title":"J. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1093\/gerona\/glaa011","article-title":"Longitudinal Association between Energy Regulation and Fatigability in Mid-to-Late Life","volume":"75","author":"Schrack","year":"2020","journal-title":"J. Gerontol.-Ser. A Biol. Sci. Med. 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