{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:49:22Z","timestamp":1781128162895,"version":"3.54.1"},"reference-count":34,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IMAGINE-Niedersachsen","award":["01KD2401A"],"award-info":[{"award-number":["01KD2401A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Endometrial cancer is one of the most common malignancies of the female reproductive system. Fortunately, risk-adapted therapy offers a promising chance of recovery, even from locally advanced disease. In particular, older patients with higher risk factors benefit markedly from adjuvant radiotherapy with or without chemotherapy. Nevertheless, this also carries a risk of higher cumulative toxicity thereafter. Although this phenomenon has been observed in older patients, it has not yet been adequately evaluated. Methods: This retrospective study compared the clinical features of patients receiving adjuvant radiotherapy with or without sequential chemotherapy or radiotherapy with concomitant chemotherapy between 2011 and 2023. The cohort was divided into two groups: patients over 65 years old and those under 65. Results: 100 patients received adjuvant radiotherapy at our center between 2011 and 2023. The mean age of patients was 66.87 years. We observed that neither diabetes, obesity, concurrent, sequential chemotherapy, nor para-aortic field irradiation was associated with an increased incidence of acute radiogenic side effects such as cystitis, diarrhea, proctitis, radiodermatitis, nausea, or vaginal dryness according to CTCAE \u2265 2 (all p &gt; 0.50). No difference was found between the two groups in terms of the incidence of radiotherapy-associated toxicity. Conclusions: We found no increase in toxicity in elderly patients after adjuvant radiotherapy with or without chemotherapy.<\/jats:p>","DOI":"10.3390\/cancers18071061","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:07:13Z","timestamp":1774433233000},"page":"1061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Real-Life Data on Toxicity in Elderly Patients Undergoing Adjuvant External Beam Radiotherapy for Endometrial Carcinoma"],"prefix":"10.3390","volume":"18","author":[{"given":"Kateryna","family":"Zarour","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Michael","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"},{"name":"Center for Radiotherapy and Radiooncology Bremen and Westerstede, An der H\u00f6ssen 34, 26655 Westerstede, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Center for Radiotherapy and Radiooncology Bremen and Westerstede, An der H\u00f6ssen 34, 26655 Westerstede, Germany"},{"name":"Department of Radiation Oncology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric Oliver","family":"Carl","sequence":"additional","affiliation":[{"name":"Center for Radiotherapy and Radiooncology Bremen and Westerstede, An der H\u00f6ssen 34, 26655 Westerstede, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Cieslak","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"},{"name":"Center for Radiotherapy and Radiooncology Bremen and Westerstede, An der H\u00f6ssen 34, 26655 Westerstede, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Meinecke","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-4962","authenticated-orcid":false,"given":"Mathias Alexander","family":"Sonnhoff","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Hannover Medical School, Carl-Neuberg-Stra\u00dfe 1, 30625 Hannover, Germany"},{"name":"Center for Radiotherapy and Radiooncology Bremen and Westerstede, An der H\u00f6ssen 34, 26655 Westerstede, Germany"},{"name":"IMAGINE-Niedersachsen, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1470-2045(23)00646-0","article-title":"Complete cancer prevalence in Europe in 2020 by disease duration and country (EUROCARE-6): A population-based study","volume":"25","author":"Demuru","year":"2024","journal-title":"Lancet Oncol."},{"key":"ref_2","unstructured":"Hillienhof, A. 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Int."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/7\/1061\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:27:09Z","timestamp":1774434429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/7\/1061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cancers18071061"],"URL":"https:\/\/doi.org\/10.3390\/cancers18071061","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}