{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T10:13:20Z","timestamp":1774779200771,"version":"3.50.1"},"reference-count":82,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Puerto Rican Hispanic\/Latino (PR H\/L) men experience a heightened incidence and mortality rate of aggressive forms of prostate cancer. The underlying causes of this increased disease burden likely include a complex interplay of socio-economic and biological factors. This pilot study leveraged the first cancer tissue biobank at a Hispanic-Serving Institution (Puerto Rico BioBank) and aimed to provide an initial description of the genomic features of prostate cancer in 35 PR H\/L men. Methods: Whole-exome and RNA sequencing were performed on prostate adenocarcinoma tumor samples to investigate the genomic features associated with prostate cancer. Results: Our analysis suggests that mutation profiles and gene expression pattern differences are observed in this population and may be associated with disease aggressiveness and progression. Notably, mutations in TP53 and TMPRSS2-ERG gene fusions, which are common in broader populations, were less prevalent in the PR H\/L cohort. Conclusions: While this study contributes to the understanding of ethnicity-specific genetic factors in prostate cancer, underscoring the need for inclusive genomic studies, continued expansion to larger cohorts of patients under-represented in large genomic studies will be needed to more robustly characterize the full range of genomic features of prostate cancer. A broader understanding of the genomic features of prostate cancer in PR H\/L men may lead to future opportunities for delivering more personalized prognoses and treatment options, helping to ensure that treatment advances and better outcomes are available to all patients.<\/jats:p>","DOI":"10.3390\/cancers18071091","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:32:47Z","timestamp":1774611167000},"page":"1091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Analysis of Puerto Rican Hispanic\/Latino Men with Prostate Cancer"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-0282","authenticated-orcid":false,"given":"Jamie K.","family":"Teer","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Ruiz Deya","sequence":"additional","affiliation":[{"name":"Urology Residency Program, Department of Surgery, Ponce Health Sciences University, St. Luke\u2019s Hospital, Ponce, PR 00717, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol V.","family":"P\u00e9rez-M\u00e1rtir","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Cancer Research, Comprehensive Cancer Center of the University of Puerto Rico, San Juan, PR 00921, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6384-6447","authenticated-orcid":false,"given":"Jong Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4954-3828","authenticated-orcid":false,"given":"Jose","family":"Oliveras","sequence":"additional","affiliation":[{"name":"Public Health Program, Ponce Research Institute, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Dutil","sequence":"additional","affiliation":[{"name":"Division of Clinical and Translational Cancer Research, Comprehensive Cancer Center of the University of Puerto Rico, San Juan, PR 00921, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-9021","authenticated-orcid":false,"given":"Jaime","family":"Matta","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ponce Research Institute, Ponce Health Sciences University, Ponce, PR 00716, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Posdzich, P., Darr, C., Hilser, T., Wahl, M., Herrmann, K., Hadaschik, B., and Grunwald, V. (2023). Metastatic Prostate Cancer-A Review of Current Treatment Options and Promising New Approaches. Cancers, 15.","DOI":"10.3390\/cancers15020461"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.21037\/tau-24-130","article-title":"Lost opportunities: The underutilization of castrate-resistant prostate cancer treatment in real-world settings","volume":"13","author":"Gatsinga","year":"2024","journal-title":"Transl. Androl. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.46883\/ONC.2020.3411.0460","article-title":"Incidence of Metastatic Prostate Cancer On the Rise","volume":"34","author":"Broderick","year":"2020","journal-title":"Oncology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-020-00243-0","article-title":"Prostate cancer","volume":"7","author":"Rebello","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","first-page":"485","article-title":"Prostate cancer statistics, 2025","volume":"75","author":"Kratzer","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","first-page":"277","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J. Clin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41391-022-00526-5","article-title":"Localized prostate cancer disparities in risk group at presentation and access to treatment for Hispanic men","volume":"26","author":"Swami","year":"2023","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_9","first-page":"317","article-title":"Incidence and mortality of the leading cancer types in Puerto Rico: 1987\u20132004","volume":"29","author":"Ortiz","year":"2010","journal-title":"P. R. Health Sci. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"69709","DOI":"10.18632\/oncotarget.19068","article-title":"Ethnic heterogeneity and prostate cancer mortality in Hispanic\/Latino men: A population-based study","volume":"8","author":"Chinea","year":"2017","journal-title":"Oncotarget"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.urology.2022.02.025","article-title":"Prostate Cancer Disparities in Hispanics Using the National Cancer Database","volume":"165","author":"Abern","year":"2022","journal-title":"Urology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e7012","DOI":"10.1002\/cam4.7012","article-title":"Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH","volume":"13","author":"Janes","year":"2024","journal-title":"Cancer Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lopez-Vallejo, D., Perez, C.M., Gonzalez-Sepulveda, L., and Soto-Salgado, M. (2025). Examining Health-Related Quality of Life in Cancer Survivors: Cross-Sectional Associations with Comorbidities, Navigation Services Use, and Perceived Social Support. Cancers, 17.","DOI":"10.3390\/cancers17233784"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Brown, C.R., Hambleton, I., Hercules, S.M., Unwin, N., Murphy, M.M., Nigel Harris, E., Wilks, R., MacLeish, M., Sullivan, L., and Sobers-Grannum, N. (2018). Social determinants of prostate cancer in the Caribbean: A systematic review and meta-analysis. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5696-y"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Munoz-Torres, F., Soto-Salgado, M., Ortiz-Ortiz, K.J., Lopez-Leon, X.S., Sanchez-Cabrera, Y., and Colon-Lopez, V. (2024). Cancer Treatment Disruption by Residence Region in the Aftermath of Hurricanes Irma and Maria in Puerto Rico. Int. J. Environ. Res. Public Health, 21.","DOI":"10.3390\/ijerph21101334"},{"key":"ref_16","first-page":"E15","article-title":"Using a socioeconomic position index to assess disparities in cancer incidence and mortality, Puerto Rico, 1995\u20132004","volume":"9","author":"Ortiz","year":"2012","journal-title":"Prev. Chronic Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1158\/1055-9965.EPI-25-0133","article-title":"Potential Exposure to Environmental Toxic Emissions and Increased Cancer Risk in Puerto Rico","volume":"34","author":"Ortiz","year":"2025","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kaya, D., Santiago, C., Pernas, E., Truong, S., Martinez, G., Mendez, L.B., and Delgado, Y. (2025). Air Pollutants in Puerto Rico: Key Pollutants and Carcinogenic Properties. Int. J. Environ. Res. Public Health, 22.","DOI":"10.20944\/preprints202508.1606.v1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2019.02.048","article-title":"The Missing Diversity in Human Genetic Studies","volume":"177","author":"Sirugo","year":"2019","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1200\/OP.22.00214","article-title":"The Problem of Hispanic\/Latinx Under-Representation in Cancer Clinical Trials","volume":"18","author":"Duma","year":"2022","journal-title":"JCO Oncol. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41467-025-56944-1","article-title":"Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases","volume":"16","author":"Mitchell","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155803","DOI":"10.1016\/j.prp.2024.155803","article-title":"BRCA1 and BRCA2 mutations testing in prostate cancer: Detection in formalin fixed paraffin embedded (FFPE) and blood samples","volume":"266","author":"Zannini","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/pros.23795","article-title":"The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta-analysis","volume":"79","author":"Oh","year":"2019","journal-title":"Prostate"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.prnil.2020.09.001","article-title":"Clinical implications of genomic evaluations for prostate cancer risk stratification, screening, and treatment: A narrative review","volume":"8","author":"Chung","year":"2020","journal-title":"Prostate Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1001\/jama.2015.17703","article-title":"Familial Risk and Heritability of Cancer Among Twins in Nordic Countries","volume":"315","author":"Mucci","year":"2016","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer","volume":"375","author":"Pritchard","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1200\/JCO.20.00046","article-title":"Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019","volume":"38","author":"Giri","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejca.2021.01.027","article-title":"Association between BRCA2 alterations and intraductal and cribriform histologies in prostate cancer","volume":"147","author":"Lozano","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1056\/NEJMoa1506859","article-title":"DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer","volume":"373","author":"Mateo","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/siuj5030027","article-title":"Prevalence of Genetic Mutations in Patients with Metastatic Prostate Cancer in a Cohort of Mexican Patients","volume":"5","author":"Osorio","year":"2024","journal-title":"Soci\u00e9t\u00e9 Int. D\u2019urologie J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature11125","article-title":"The mutational landscape of lethal castration-resistant prostate cancer","volume":"487","author":"Grasso","year":"2012","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.eururo.2013.05.029","article-title":"The mutational landscape of prostate cancer","volume":"64","author":"Barbieri","year":"2013","journal-title":"Eur. Urol."},{"key":"ref_35","unstructured":"(2015). Cancer Genome Atlas Research, N. The Molecular Taxonomy of Primary Prostate Cancer. Cell, 163, 1011\u20131025."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Valsecchi, A.A., Dionisio, R., Panepinto, O., Paparo, J., Palicelli, A., Vignani, F., and Di Maio, M. (2023). Frequency of Germline and Somatic BRCA1 and BRCA2 Mutations in Prostate Cancer: An Updated Systematic Review and Meta-Analysis. Cancers, 15.","DOI":"10.3390\/cancers15092435"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1158\/2159-8290.CD-23-0882","article-title":"The Germline and Somatic Origins of Prostate Cancer Heterogeneity","volume":"15","author":"Yamaguchi","year":"2025","journal-title":"Cancer Discov."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1158\/2159-8290.CD-13-0172","article-title":"Androgen receptor signaling regulates DNA repair in prostate cancers","volume":"3","author":"Polkinghorn","year":"2013","journal-title":"Cancer Discov."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/pros.24586","article-title":"Prostate cancer genetic alterations in Hispanic men","volume":"83","author":"Rhodes","year":"2023","journal-title":"Prostate"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"Gigascience"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","article-title":"Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs","volume":"28","author":"Saunders","year":"2012","journal-title":"Bioinformatics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-0716-2293-3_2","article-title":"MuSE: A Novel Approach to Mutation Calling with Sample-Specific Error Modeling","volume":"2493","author":"Ji","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/bioinformatics\/btr665","article-title":"SomaticSniper: Identification of somatic point mutations in whole genome sequencing data","volume":"28","author":"Larson","year":"2012","journal-title":"Bioinformatics"},{"key":"ref_48","unstructured":"Garrison, E., and Marth, G. (2012). Haplotype-based variant detection from short-read sequencing. arXiv."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Benjamin, D., Sato, T., Cibulskis, K., Getz, G., Stewart, C., and Lichtenstein, L. (2019). Calling Somatic SNVs and Indels with Mutect2. bioRxiv.","DOI":"10.1101\/861054"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41592-018-0051-x","article-title":"Strelka2: Fast and accurate calling of germline and somatic variants","volume":"15","author":"Kim","year":"2018","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s42003-018-0023-9","article-title":"Genome-wide somatic variant calling using localized colored de Bruijn graphs","volume":"1","author":"Narzisi","year":"2018","journal-title":"Commun. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13059-016-0893-4","article-title":"DeconstructSigs: Delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution","volume":"17","author":"Rosenthal","year":"2016","journal-title":"Genome Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/annonc\/mdu479","article-title":"Sequenza: Allele-specific copy number and mutation profiles from tumor sequencing data","volume":"26","author":"Favero","year":"2015","journal-title":"Ann. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"16910","DOI":"10.1073\/pnas.1009843107","article-title":"Allele-specific copy number analysis of tumors","volume":"107","author":"Nordgard","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Talevich, E., Shain, A.H., Botton, T., and Bastian, B.C. (2016). CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing. PLoS Comput. Biol., 12.","DOI":"10.1371\/journal.pcbi.1004873"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Li, B., and Dewey, C.N. (2011). RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinform., 12.","DOI":"10.1186\/1471-2105-12-323"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"lqaa078","DOI":"10.1093\/nargab\/lqaa078","article-title":"ComBat-seq: Batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom. Bioinform."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Nicorici, D., Satalan, M., Edgren, H., Kangaspeska, S., Murumagi, A., Kallioniemi, O., Virtanen, S., and Kilkku, O. (2014). FusionCatcher\u2014A tool for finding somatic fusion genes in paired-end RNA-sequencing. bioRxiv.","DOI":"10.1101\/011650"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1101\/gr.257246.119","article-title":"Accurate and efficient detection of gene fusions from RNA sequencing data","volume":"31","author":"Uhrig","year":"2021","journal-title":"Genome Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00011","article-title":"OncoKB: A Precision Oncology Knowledge Base","volume":"1","author":"Chakravarty","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1158\/2159-8290.CD-23-0467","article-title":"Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer","volume":"14","author":"Suehnholz","year":"2024","journal-title":"Cancer Discov."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1158\/1078-0432.CCR-21-2577","article-title":"Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors","volume":"28","author":"Stopsack","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"ref_66","first-page":"425","article-title":"Cancer Statistics for Hispanics\/Latinos, 2018","volume":"68","author":"Miller","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e259119","DOI":"10.1001\/jamanetworkopen.2025.9119","article-title":"Somatic Tumor Next-Generation Sequencing in US Veterans With Metastatic Prostate Cancer","volume":"8","author":"Valle","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"Alexandrov","year":"2020","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.1038\/s41467-021-27223-6","article-title":"The telomere length landscape of prostate cancer","volume":"12","author":"Livingstone","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Baughan, S., and Tainsky, M.A. (2021). K3326X and Other C-Terminal BRCA2 Variants Implicated in Hereditary Cancer Syndromes: A Review. Cancers, 13.","DOI":"10.3390\/cancers13030447"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"djv315","DOI":"10.1093\/jnci\/djv315","article-title":"BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers","volume":"108","author":"Meeks","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15594","DOI":"10.18632\/oncotarget.3709","article-title":"PBK\/TOPK enhances aggressive phenotype in prostate cancer via beta-catenin-TCF\/LEF-mediated matrix metalloproteinases production and invasion","volume":"6","author":"Shenoy","year":"2015","journal-title":"Oncotarget"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12935-024-03320-6","article-title":"Significance of PSCA as a novel prognostic marker and therapeutic target for cancer","volume":"24","author":"Doustmihan","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Samarzija, I., Troselj, K.G., and Konjevoda, P. (2023). Prognostic Significance of Amino Acid Metabolism-Related Genes in Prostate Cancer Retrieved by Machine Learning. Cancers, 15.","DOI":"10.3390\/cancers15041309"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Prieto-Fernandez, L., Menendez, S.T., Otero-Rosales, M., Montoro-Jimenez, I., Hermida-Prado, F., Garcia-Pedrero, J.M., and Alvarez-Teijeiro, S. (2022). Pathobiological functions and clinical implications of annexin dysregulation in human cancers. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1009908"},{"key":"ref_76","first-page":"107","article-title":"Prostate cancer incidence and mortality among Puerto Ricans: An updated analysis comparing men in Puerto Rico with US racial\/ethnic groups","volume":"31","author":"Suarez","year":"2012","journal-title":"P. R. Health Sci. J."},{"key":"ref_77","first-page":"28","article-title":"Initial efforts in community engagement with health care providers: Perceptions of barriers to care for cancer patients in Puerto Rico","volume":"30","author":"Simmons","year":"2011","journal-title":"P. R. Health Sci. J."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Castaneda-Avila, M.A., Latoni-Guillermety, D., Sabatino, M., Ortiz-Ortiz, K.J., and Lapane, K.L. (2025). Challenges oncologists face when caring for hispanics living in puerto rico with colorectal cancer and multiple chronic conditions. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14271-0"},{"key":"ref_79","first-page":"434","article-title":"Prevalence of the metabolic syndrome in San Juan, Puerto Rico","volume":"18","author":"Perez","year":"2008","journal-title":"Ethn. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"100981","DOI":"10.1016\/j.conctc.2022.100981","article-title":"Access to urologists for participation in research: An analysis of NCI\u2019s Community Oncology Research Program landscape survey","volume":"29","author":"Ellis","year":"2022","journal-title":"Contemp. Clin. Trials Commun."},{"key":"ref_81","first-page":"9","article-title":"Cardiovascular services and human resources in Puerto Rico\u20142008","volume":"101","year":"2009","journal-title":"Bol. Asoc. Med. P. R."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Via, M., Gignoux, C.R., Roth, L.A., Fejerman, L., Galanter, J., Choudhry, S., Toro-Labrador, G., Viera-Vera, J., Oleksyk, T.K., and Beckman, K. (2011). History shaped the geographic distribution of genomic admixture on the island of Puerto Rico. 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