{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:22:42Z","timestamp":1775438562578,"version":"3.50.1"},"reference-count":102,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>With modern medicine and a better understanding of the ulcerative colitis disease process, there have been many changes in how we manage ulcerative colitis-related dysplasia over the past 20 years. One of the biggest concerns for these patients, given the inflammatory nature of their disease, is the progression from chronic inflammation to cancer. Patients with ulcerative colitis have about a 2.4-fold increased risk of developing colorectal cancer compared to the general population, which is concerning since colorectal cancer is the 2nd leading cause of cancer-related deaths in the United States. Traditionally, surgery was the preferred treatment for ulcerative colitis patients with dysplasia, but now, with advances in surveillance such as high-definition colonoscopy and chromoendoscopy, the management approach is more nuanced. Understanding the risk for different individuals within this patient population is key to comprehensive and personalized care management. In this review article, we will explore risk factors, surveillance methods, and classification.<\/jats:p>","DOI":"10.3390\/cancers18071165","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:19:32Z","timestamp":1775434772000},"page":"1165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Evolution of the Management of Dysplasia in Ulcerative Colitis"],"prefix":"10.3390","volume":"18","author":[{"given":"Adrienne L.","family":"Vickers","sequence":"first","affiliation":[{"name":"Department of Surgery, Weill Cornell Medicine, NewYork-Presbyterian, 1300 York Avenue, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-4413","authenticated-orcid":false,"given":"Alessandro","family":"Fichera","sequence":"additional","affiliation":[{"name":"Section of Colon and Rectal Surgery, Department of Surgery, Weill Cornell Medicine, NewYork-Presbyterian, 1300 York Avenue, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"ref_1","first-page":"145","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/ibd\/izab164","article-title":"Colorectal cancer prevention in inflammatory bowel disease: A systematic analysis of the overall quality of guideline recommendations","volume":"28","author":"Weissman","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2021.10.035","article-title":"Colorectal cancer in inflammatory bowel disease: Mechanisms and management","volume":"162","author":"Shah","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"103269","DOI":"10.1016\/j.eclinm.2025.103269","article-title":"Colorectal cancer risk in ulcerative colitis: An updated population-based systematic review and meta-analysis","volume":"84","author":"Zhang","year":"2025","journal-title":"eClinicalMedicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00000441-192508010-00006","article-title":"The sigmoidoscopic picture of chronic ulcerative colitis (nonspecific)","volume":"170","author":"Crohn","year":"1925","journal-title":"Am. J. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: From 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/jgh.12859","article-title":"Emerging leadership lecture: Inflammatory bowel disease in Asia: Emergence of a \u201cWestern\u201d disease","volume":"30","author":"Ng","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2011.01.057","article-title":"Intestinal inflammation and cancer","volume":"140","author":"Ullman","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kritzinger, J., Kotrri, G., Lakatos, P.L., Bessissow, T., and Wild, G. (2025). The Role of Biomarkers in Surveillance of Ulcerative Colitis-Associated Colorectal Cancer: A Scoping Review. J. Clin. Med., 14.","DOI":"10.20944\/preprints202507.1913.v1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.humpath.2021.03.002","article-title":"Targeted next-generation sequencing supports serrated epithelial change as an early precursor to inflammatory bowel disease\u2013associated colorectal neoplasia","volume":"112","author":"Singhi","year":"2021","journal-title":"Hum. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.giec.2019.02.008","article-title":"Management of IBD-associated dysplasia in the modern era","volume":"29","author":"Shah","year":"2019","journal-title":"Gastrointest. Endosc. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1158\/1940-6207.CAPR-16-0124","article-title":"Colorectal cancer and dysplasia in inflammatory bowel disease: A review of disease epidemiology, pathophysiology, and management","volume":"9","author":"Dulai","year":"2016","journal-title":"Cancer Prev. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.gtc.2023.09.005","article-title":"Pathology and clinical significance of inflammatory bowel disease-associated colorectal dysplastic lesions","volume":"53","author":"Harpaz","year":"2024","journal-title":"Gastroenterol. Clin."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Reznicek, E., Afreen, M., Shen, B., and Ghouri, Y.A. (2021). Colorectal dysplasia and cancer surveillance in ulcerative colitis. Diseases, 9.","DOI":"10.3390\/diseases9040086"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10151-019-1926-2","article-title":"Colorectal cancer in inflammatory bowel disease: Review of the evidence","volume":"23","author":"Keller","year":"2019","journal-title":"Tech. Coloproctology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: A meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/MIB.0b013e31828029c0","article-title":"Declining risk of colorectal cancer in inflammatory bowel disease: An updated meta-analysis of population-based cohort studies","volume":"19","author":"Lutgens","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ibd.20766","article-title":"Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohn\u2019s disease of the colon","volume":"15","author":"Ullman","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mge.2002.125367","article-title":"Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and ulcerative colitis: A meta-analysis","volume":"56","author":"Soetikno","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0016-5085(98)70077-0","article-title":"Familial predisposition for colorectal cancer in chronic ulcerative colitis: A case-control study","volume":"115","author":"Nuako","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal cancer in ulcerative colitis: A Scandinavian population-based cohort study","volume":"395","author":"Erichsen","year":"2020","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/j.gastro.2021.05.063","article-title":"AGA clinical practice update on endoscopic surveillance and management of colorectal dysplasia in inflammatory bowel diseases: Expert review","volume":"161","author":"Murthy","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/lap.2020.0974","article-title":"Management of Dysplasia in Ulcerative Colitis","volume":"31","author":"Bhama","year":"2021","journal-title":"J. Laparoendosc. Adv. Surg. Tech."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0140-6736(94)90813-3","article-title":"Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?","volume":"343","author":"Shanahan","year":"1994","journal-title":"Lancet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.gie.2012.11.030","article-title":"Evolving endoscopic strategies for detection and treatment of neoplastic lesions in inflammatory bowel disease","volume":"77","author":"Murthy","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1001\/jama.2023.15389","article-title":"Ulcerative colitis in adults: A review","volume":"330","author":"Gros","year":"2023","journal-title":"JAMA"},{"key":"ref_29","first-page":"564","article-title":"Ulcerative colitis\u2014Diagnostic and therapeutic algorithms","volume":"117","author":"Kucharzik","year":"2020","journal-title":"Dtsch. \u00c4rzteblatt Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.14309\/ajg.0000000000000152","article-title":"ACG clinical guideline: Ulcerative colitis in adults","volume":"114","author":"Rubin","year":"2019","journal-title":"Am. Coll. Gastroenterol. ACG"},{"key":"ref_31","first-page":"442","article-title":"British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease","volume":"73","author":"East","year":"2025","journal-title":"Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ecco-jcc\/jjac187","article-title":"ECCO guidelines on inflammatory bowel disease and malignancies","volume":"17","author":"Gordon","year":"2023","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_33","unstructured":"National Comprehensive Cancer Center (2026, March 26). Colorectal Cancer Screening Version 2. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colorectal_screening.pdf."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1053\/j.gastro.2015.01.031","article-title":"SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease","volume":"148","author":"Laine","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.cgh.2013.06.015","article-title":"Advanced endoscopic imaging: A review of commercially available technologies","volume":"12","author":"Subramanian","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ibd.23002","article-title":"Comparison of high definition with standard white light endoscopy for detection of dysplastic lesions during surveillance colonoscopy in patients with colonic inflammatory bowel disease","volume":"19","author":"Subramanian","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gtc.2012.01.016","article-title":"Chromoendoscopy in inflammatory bowel disease","volume":"41","author":"Kiesslich","year":"2012","journal-title":"Gastroenterol. Clin."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.21037\/tgh.2019.12.06","article-title":"Chromoendoscopy: Role in modern endoscopic imaging","volume":"5","author":"Singh","year":"2020","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1751-2980.12714","article-title":"Systematic review with meta-analysis: Chromoendoscopy versus white light endoscopy in detection of dysplasia in patients with inflammatory bowel disease","volume":"20","author":"Wan","year":"2019","journal-title":"J. Dig. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/ibd\/izaa011","article-title":"Meta-analysis of Virtual-based Chromoendoscopy Compared with Dye-spraying Chromoendoscopy Standard and High-definition White Light Endoscopy in Patients with Inflammatory Bowel Disease at Increased Risk of Colon Cancer","volume":"26","author":"Chen","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"AB172","DOI":"10.1016\/j.gie.2016.03.147","article-title":"722 Comparison between newly-developed narrow band imaging and panchromoendoscopy for surveillance colonoscopy in patients with longstanding ulcerative colitis: A prospective multicenter randomized controlled trial, navigator study","volume":"83","author":"Watanabe","year":"2016","journal-title":"Gastrointest. Endosc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/00365520801909686","article-title":"High-grade dysplastic adenoma-like mass lesions are not an indication for colectomy in patients with ulcerative colitis","volume":"43","author":"Blonski","year":"2008","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/gut.2006.106294","article-title":"Endoscopic mucosal resection for flat neoplasia in chronic ulcerative colitis: Can we change the endoscopic management paradigm?","volume":"56","author":"Hurlstone","year":"2007","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1136\/gut.2005.075531","article-title":"Sporadic adenoma in ulcerative colitis: Endoscopic resection is an adequate treatment","volume":"55","author":"Vieth","year":"2006","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1055\/a-2304-3219","article-title":"Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline\u2013update 2024","volume":"56","author":"Ferlitsch","year":"2024","journal-title":"Endoscopy"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Schiavone, S.C., Biancone, L., Fiorillo, M., Divizia, A., Mancone, R., and Neri, B. (2025). Colitis-Associated Dysplasia in Inflammatory Bowel Disease: Features and Endoscopic Management. Cancers, 17.","DOI":"10.3390\/cancers17050784"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.3748\/wjg.14.2962","article-title":"Endoscopic submucosal dissection for gastrointestinal neoplasms","volume":"14","author":"Kakushima","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5946\/ce.2023.205","article-title":"Efficacy and safety of endoscopic submucosal dissection for colorectal dysplasia in patients with inflammatory bowel disease: A systematic review and meta-analysis","volume":"57","author":"Malik","year":"2024","journal-title":"Clin. Endosc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ecco-jcc\/jjaa158","article-title":"Endoscopic submucosal dissection for visible dysplasia treatment in ulcerative colitis patients: Cases series and systematic review of literature","volume":"15","author":"Manta","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/ueg2.12118","article-title":"Treatment outcomes of endoscopic submucosal dissection and surgery for colorectal neoplasms in patients with ulcerative colitis","volume":"9","author":"Kasuga","year":"2021","journal-title":"United Eur. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1111\/codi.15746","article-title":"Endoscopic submucosal dissection is safe and feasible, allowing for ongoing surveillance and organ preservation in patients with inflammatory bowel disease","volume":"23","author":"Lightner","year":"2021","journal-title":"Color. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E354","DOI":"10.1055\/a-1783-8756","article-title":"Endoscopic submucosal dissection for colorectal dysplasia in inflammatory bowel disease: A US multicenter study","volume":"10","author":"Ngamruengphong","year":"2022","journal-title":"Endosc. Int. Open"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.gie.2015.02.052","article-title":"Curative endoscopic submucosal dissection of large nonpolypoid superficial neoplasms in ulcerative colitis (with videos)","volume":"82","author":"Iacopini","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/ibd\/izx113","article-title":"Outcomes of endoscopic resections of large laterally spreading colorectal lesions in inflammatory bowel disease: A single United Kingdom center experience","volume":"24","author":"Gulati","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1055\/s-0043-114410","article-title":"Endoscopic submucosal dissection of colitis-related dysplasia","volume":"49","author":"Suzuki","year":"2017","journal-title":"Endoscopy"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1093\/ibd\/izy101","article-title":"Endoscopic submucosal dissection for flat colonic polyps in patients with inflammatory bowel disease, a single-center experience","volume":"24","author":"Kochhar","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/jgh.14623","article-title":"Outcomes of ulcerative colitis-associated dysplasia patients referred for potential endoscopic submucosal dissection","volume":"34","author":"Yang","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000503341","article-title":"Long-term outcomes after endoscopic submucosal dissection for ulcerative colitis-associated dysplasia","volume":"102","author":"Matsumoto","year":"2021","journal-title":"Digestion"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E994","DOI":"10.1055\/a-0953-2021","article-title":"Outcome of endoscopic resection of colonic polyps larger than 10 mm in patients with inflammatory bowel disease","volume":"7","author":"Yadav","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/jgh.15207","article-title":"An endoscopic treatment strategy for superficial tumors in patients with ulcerative colitis","volume":"36","author":"Nishio","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.gie.2017.10.035","article-title":"The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis","volume":"87","author":"Kinoshita","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1055\/a-2524-3553","article-title":"Outcomes of endoscopic submucosal dissection for high-risk colorectal colitis-associated neoplasia in inflammatory bowel disease","volume":"57","author":"Maselli","year":"2025","journal-title":"Endoscopy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cgh.2013.07.024","article-title":"Cancer risk after resection of polypoid dysplasia in patients with longstanding ulcerative colitis: A meta-analysis","volume":"12","author":"Wanders","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.gie.2017.12.016","article-title":"Assessment of peri-polyp biopsy specimens of flat mucosa in patients with inflammatory bowel disease","volume":"87","author":"Cleveland","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.gie.2018.05.005","article-title":"Polyp-adjacent biopsies no longer required in inflammatory bowel disease","volume":"88","author":"Lahiff","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cgh.2018.07.041","article-title":"AGA institute clinical practice update: Endoscopic submucosal dissection in the United States","volume":"17","author":"Draganov","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1055\/s-0043-1762559","article-title":"Management of Dysplasia in Inflammatory Bowel Disease","volume":"37","author":"Rubens","year":"2024","journal-title":"Clin. Colon Rectal Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1053\/j.gastro.2016.10.006","article-title":"Changing paradigms in detection of dysplasia and management of patients with inflammatory bowel disease: Is colectomy still necessary?","volume":"152","author":"Velayos","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/codi.13721","article-title":"Segmental resection is a safe oncological alternative to total proctocolectomy in elderly patients with ulcerative colitis and malignancy","volume":"19","author":"Khan","year":"2017","journal-title":"Color. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e17278","DOI":"10.1111\/codi.17278","article-title":"Segmental colectomy versus total proctocolectomy for ulcerative colitis: A systematic review and meta-analysis","volume":"27","author":"Lincango","year":"2025","journal-title":"Color. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s13304-020-00719-4","article-title":"Modern surgery for ulcerative colitis","volume":"72","author":"Murphy","year":"2020","journal-title":"Updates Surg."},{"key":"ref_72","first-page":"289","article-title":"Surgical management of ulcerative colitis","volume":"105","author":"Nguyen","year":"2025","journal-title":"Surg. Clin."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1055\/s-0042-1758228","article-title":"Dysplasia at the Anal transition zone after IPAA","volume":"35","author":"Church","year":"2022","journal-title":"Clin. Colon Rectal Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1053\/j.gastro.2010.05.085","article-title":"Preoperative colorectal neoplasia increases risk for pouch neoplasia in patients with restorative proctocolectomy","volume":"139","author":"Kariv","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"The ASGE IBD Endoscopy Consensus Panel, Shen, B., Abreu, M.T., Cohen, E.R., Farraye, F.A., Fischer, M., Feuerstadt, P., Kapur, S., Ko, H.M., and Kochhar, G.S. (2025). Endoscopic diagnosis and management of adult inflammatory bowel disease: A consensus document from the American Society for Gastrointestinal Endoscopy IBD Endoscopy Consensus Panel. Gastrointest. Endosc., 101, 295\u2013314.","DOI":"10.1016\/j.gie.2024.08.034"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Diaconu, C., State, M., Birligea, M., Ifrim, M., Bajdechi, G., Georgescu, T., Mateescu, B., and Voiosu, T. (2023). The role of artificial intelligence in monitoring inflammatory bowel disease\u2014The future is now. Diagnostics, 13.","DOI":"10.3390\/diagnostics13040735"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"E1004","DOI":"10.1055\/a-1846-0642","article-title":"Clinical application and diagnostic accuracy of artificial intelligence in colonoscopy for inflammatory bowel disease: Systematic review","volume":"10","author":"Yang","year":"2022","journal-title":"Endosc. Int. Open"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.7326\/M22-3678","article-title":"Real-time computer-aided detection of colorectal neoplasia during colonoscopy: A systematic review and meta-analysis","volume":"176","author":"Hassan","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.7326\/ANNALS-24-00981","article-title":"Artificial intelligence\u2013assisted colonoscopy for polyp detection: A systematic review and meta-analysis","volume":"177","author":"Soleymanjahi","year":"2024","journal-title":"Ann. Intern. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"E273","DOI":"10.1055\/a-1261-2944","article-title":"Can artificial intelligence help to detect dysplasia in patients with ulcerative colitis?","volume":"53","author":"Maeda","year":"2021","journal-title":"Endoscopy"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1093\/ibd\/izaf180","article-title":"Computer-Aided Detection Colonoscopy for Surveillance in IBD Patients: Insights from a Single-Center Experience","volume":"31","author":"Goldman","year":"2025","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/jgh.15904","article-title":"The diagnostic ability to classify neoplasias occurring in inflammatory bowel disease by artificial intelligence and endoscopists: A pilot study","volume":"37","author":"Yamamoto","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/gutjnl-2023-330718","article-title":"New AI model for neoplasia detection and characterisation in inflammatory bowel disease","volume":"73","author":"Abdelrahim","year":"2024","journal-title":"Gut"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"17562848251348574","DOI":"10.1177\/17562848251348574","article-title":"The impact of artificial intelligence on the endoscopic assessment of inflammatory bowel disease-related neoplasia","volume":"18","author":"Urquhart","year":"2025","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Dell\u2019Anna, G., Mandarino, F., Centanni, L., Lodola, I., Fanizza, J., Fasulo, E., Bencardino, S., Fuccio, L., Facciorusso, A., and Donatelli, G. (2025). Transforming gastrointestinal diagnosis with molecular endoscopy: Challenges and opportunities. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104834"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/ecco-jcc\/jjv131","article-title":"Confocal laser endomicroscopy in inflammatory bowel disease\u2013a systematic review","volume":"9","author":"Rasmussen","year":"2015","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.dld.2025.02.009","article-title":"Endoscopic healing in IBD: Still the target to achieve?","volume":"57","author":"Buda","year":"2025","journal-title":"Dig. Liver Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.3462","article-title":"In Vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn\u2019s disease","volume":"20","author":"Atreya","year":"2014","journal-title":"Nat. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.giec.2024.07.006","article-title":"Advanced Endoscopic Imaging for Dysplasia Characterization in Inflammatory Bowel Disease","volume":"35","author":"Jans","year":"2025","journal-title":"Gastrointest. Endosc. Clin."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1053\/j.gastro.2007.01.048","article-title":"Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis","volume":"132","author":"Kiesslich","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4253\/wjge.v4.i9.414","article-title":"Diagnostic accuracy of confocal laser endomicroscopy in diagnosing dysplasia in patients affected by long-standing ulcerative colitis","volume":"4","author":"Rispo","year":"2012","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1097\/MIB.0000000000000176","article-title":"Surveillance in ulcerative colitis: Is chromoendoscopy-guided endomicroscopy always better than conventional colonoscopy? A randomized trial","volume":"20","author":"Freire","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-0030-1255954","article-title":"Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitis","volume":"43","author":"Stokkers","year":"2011","journal-title":"Endoscopy"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1097\/MIB.0b013e318281f3f8","article-title":"Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis","volume":"19","author":"Gounaris","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tcb.2010.12.002","article-title":"Proteolytic networks in cancer","volume":"21","author":"Mason","year":"2011","journal-title":"Trends Cell Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/den.14659","article-title":"Role of ultra-high definition endoscopy (endomicroscopy and endocytoscopy) and real-time histologic examination in inflammatory bowel disease: Scoping review","volume":"36","author":"Pal","year":"2024","journal-title":"Dig. Endosc."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Alfarone, L., Parigi, T.L., Gabbiadini, R., Dal Buono, A., Spinelli, A., Hassan, C., Iacucci, M., Repici, A., and Armuzzi, A. (2022). Technological advances in inflammatory bowel disease endoscopy and histology. Front. Med., 9.","DOI":"10.3389\/fmed.2022.1058875"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"ASGE Technology Committee, Kwon, R.S., Wong Kee Song, L.M., Adler, D.G., Conway, J.D., Diehl, D.L., Farraye, F.A., Kantsevoy, S.V., Kaul, V., and Kethu, S.R. (2009). Endocytoscopy. Gastrointest. Endosc., 70, 610\u2013613.","DOI":"10.1016\/j.gie.2009.06.030"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/den.13964","article-title":"Combined endocytoscopy with pit pattern diagnosis in ulcerative colitis-associated neoplasia: Pilot study","volume":"34","author":"Kudo","year":"2022","journal-title":"Dig. Endosc."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.cgh.2025.06.035","article-title":"Advancing inflammatory bowel disease-driven colorectal cancer management: Molecular insights and endoscopic breakthroughs towards precision medicine","volume":"23","author":"Iacucci","year":"2025","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_101","first-page":"673","article-title":"Colorectal neoplasia in the setting of inflammatory bowel disease","volume":"104","author":"Walsh","year":"2024","journal-title":"Surg. Clin."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/apt.14023","article-title":"Systematic review with meta-analysis: Use of 5-aminosalicylates and risk of colorectal neoplasia in patients with inflammatory bowel disease","volume":"45","author":"Bonovas","year":"2017","journal-title":"Aliment. Pharmacol. Ther."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/7\/1165\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:29:56Z","timestamp":1775435396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/7\/1165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":102,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cancers18071165"],"URL":"https:\/\/doi.org\/10.3390\/cancers18071165","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,4]]}}}