{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:14:06Z","timestamp":1776694446025,"version":"3.51.2"},"reference-count":31,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Stereotactic body radiation therapy (SBRT) provides improved pain response and local control for spinal metastases. However, management of local failure after initial SBRT is challenging. We report institutional outcomes, dosimetry, and toxicity for reSBRT following SBRT. Methods: We retrospectively reviewed 61 lesions (55 patients) treated with reSBRT after prior SBRT. Both SBRT courses delivered a median dose of 27 Gy. Patients underwent clinical and radiological evaluation every three months. Toxicity was graded using CTCAE v5.0. Dosimetric parameters for the spinal cord (SC), cauda equina (CE), planning organ-at-risk volumes (PRV), and thecal sac were converted to equivalent dose in 2 Gy fractions (EQD2) using the linear\u2013quadratic model (\u03b1\/\u03b2 = 2). Results: Median follow-up was 10.3 months. Forty lesions (65%) were cervicothoracic and 21 (35%) were lumbosacral. One- and two-year overall survival (OS) were 45% and 29%, respectively, and one- and two-year local control (LC) were 89% and 88%, respectively. Gastrointestinal primary tumors were associated with inferior LC (HR 2.41, 95% CI 1.11\u20135.23, p = 0.026). Fifteen patients (27%) reported myelitis\/neuropathic symptoms during follow-up; four (7%) developed new post-radiation myelitis or neuropathy (RMN) without radiologic progression. Five patients (9%) developed vertebral compression fractures (VCF). Cumulative EQD2 was not significantly associated with RMN (p = 0.344); all affected patients had thecal sac EQD2 &gt; 95.5 Gy and relevant nerve roots EQD2 &gt; 108 Gy. Conclusions: ReSBRT provided a favorable LC with acceptable toxicity. High cumulative dose to the thecal sac and nerve roots may contribute to neurologic toxicity as peripheral nerve injury.<\/jats:p>","DOI":"10.3390\/cancers18081301","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:22:47Z","timestamp":1776691367000},"page":"1301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes and Patterns of Neurological Toxicity After Stereotactic Body Radiotherapy Reirradiation (reSBRT) of Spine Metastases Previously Treated with SBRT"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1316-0809","authenticated-orcid":false,"given":"Ahmed N.","family":"Elguindy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"},{"name":"Department of Radiation Oncology, El-Demerdash Hospitals, Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Cochran","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled N.","family":"Dibs","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Addington","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-8195","authenticated-orcid":false,"given":"Eugene","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Handschuh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-7141","authenticated-orcid":false,"given":"Dominic J.","family":"DiCostanzo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Lonser","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Boulter","sequence":"additional","affiliation":[{"name":"Department of Radiology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C.","family":"Bourekas","sequence":"additional","affiliation":[{"name":"Department of Radiology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Konieczkowski","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0850-6690","authenticated-orcid":false,"given":"Simeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Grecula","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-8721","authenticated-orcid":false,"given":"Arnab","family":"Chakravarti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3311-0129","authenticated-orcid":false,"given":"Joshua D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dukagjin M.","family":"Blakaj","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The James Cancer Hospital\/Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100446","DOI":"10.1016\/j.jbo.2022.100446","article-title":"Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review","volume":"35","author":"Cornips","year":"2022","journal-title":"J. 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Cancers, 13.","DOI":"10.3390\/diagnostics13061164"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1301\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:33:29Z","timestamp":1776692009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cancers18081301"],"URL":"https:\/\/doi.org\/10.3390\/cancers18081301","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}