{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:19:02Z","timestamp":1790266742897,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/objectives: Open right hemicolectomy (ORH) remains the standard approach for locally advanced right-sided colon cancer. Minimally invasive techniques are increasingly applied in earlier disease stages; however, evidence regarding long-term oncologic outcomes in advanced tumors remains limited. This study aimed to compare the perioperative and oncologic outcomes of ORH versus robotic right hemicolectomy (RRH). Methods: In this single-center study, a prospectively maintained database of consecutive right hemicolectomy patients (2010\u20132020) was analyzed. The primary endpoint was overall survival (OS). Secondary endpoints included disease-free survival (DFS), perioperative outcomes, and histopathological quality. Additionally, a subgroup analysis was performed for T4 tumors. Results: A total of 198 patients was included, comprising 77 that underwent ORH and 121 that underwent RRH. RRH achieved oncologic outcomes comparable with ORH, with similar R0 resection rates (96% vs. 97.5%, p = 0.547) and lymph node yields (median of 18 nodes in both groups, p = 0.828). OS did not differ significantly (ORH, 45.3 months vs. RRH, 49.9 months, p = 0.130). DFS was longer in RRH (ORH, 42.2 months vs. RRH, 49.1 months, p = 0.029; HR = 0.575, 95% CI 0.349\u20130.947); however, this difference disappeared after adjustment for tumor stage. No survival advantage was observed in the T4 subgroup. Conclusions: RRH provides oncologic outcomes comparable to open surgery while offering perioperative advantages, even in locally advanced colon cancer. When performed in experienced high-volume centers, RRH represents a safe and oncologically sound alternative to ORH and may contribute to expanding MIC beyond early-stage disease.<\/jats:p>","DOI":"10.3390\/cancers18081310","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:45Z","timestamp":1776771765000},"page":"1310","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Robotic Right Hemicolectomy Provides Equivalent Oncologic Outcomes and Improved Perioperative Recovery Compared with Open Surgery"],"prefix":"10.3390","volume":"18","author":[{"given":"Hatice","family":"Altin","sequence":"first","affiliation":[{"name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum, 44801 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-4763","authenticated-orcid":false,"given":"Thorsten","family":"Brechmann","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum, 44801 Bochum, Germany"},{"name":"Department of Gastroenterology and Oncology, Knappschaft Kliniken Bottrop, 46242 Bottrop, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Mazgaldzhi","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum, 44801 Bochum, Germany"},{"name":"Clinic for General, Visceral and Robotic Surgery, Augutsa-Klinikum Bochum Mitte, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Marie","family":"Wilk","sequence":"additional","affiliation":[{"name":"English Divison, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Mann","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum, 44801 Bochum, Germany"},{"name":"Clinic for General, Visceral and Robotic Surgery, Augutsa-Klinikum Bochum Mitte, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Wilk","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum, 44801 Bochum, Germany"},{"name":"Clinic for General, Visceral and Robotic Surgery, Augutsa-Klinikum Bochum Mitte, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101174","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Transl. Oncol."},{"key":"ref_2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1308\/rcsann.2022.0051","article-title":"Robotic colectomy with CME versus laparoscopic colon resection with or without CME for colon cancer: A systematic review and meta-analysis","volume":"105","author":"Oweira","year":"2023","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s11701-020-01166-4","article-title":"Surgical resection of T4 colon cancers: An NCDB propensity score-matched analysis of open, laparoscopic, and robotic approaches","volume":"15","author":"Parascandola","year":"2021","journal-title":"J. Robot. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/17434440.2025.2486481","article-title":"How robotic platforms are revolutionizing colorectal surgery techniques: A comparative review","volume":"22","author":"Hussain","year":"2025","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Willis, F., Amati, A.L., Reichert, M., Hecker, A., Vilz, T.O., Kalff, J.C., Willis, S., and Kroplin, M.A. (2025). Current Evidence in Robotic Colorectal Surgery. Cancers, 17.","DOI":"10.3390\/cancers17152503"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.21037\/ales.2019.12.01","article-title":"A current review of robotic colorectal surgery","volume":"5","author":"Wright","year":"2020","journal-title":"Ann. Laparosc. Endosc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s00464-014-3835-9","article-title":"Robotic right colectomy with intracorporeal anastomosis compared with laparoscopic right colectomy with extracorporeal and intracorporeal anastomosis: A retrospective multicentre study","volume":"29","author":"Trastulli","year":"2015","journal-title":"Surg. Endosc."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Trastulli, S., Cirocchi, R., Desiderio, J., Coratti, A., Guarino, S., Renzi, C., Corsi, A., Boselli, C., Santoro, A., and Minelli, L. (2015). Robotic versus Laparoscopic Approach in Colonic Resections for Cancer and Benign Diseases: Systematic Review and Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134062"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s13304-020-00722-9","article-title":"Robotic versus laparoscopic right colectomy within a systematic ERAS protocol: A propensity-weighted analysis","volume":"73","author":"Migliore","year":"2021","journal-title":"Updates Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1111\/codi.15843","article-title":"The learning curve in robotic colorectal surgery compared with laparoscopic colorectal surgery: A systematic review","volume":"23","author":"Flynn","year":"2021","journal-title":"Color. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1477-7819-12-274","article-title":"Robotic versus laparoscopic right colectomy: A meta-analysis","volume":"12","author":"Xu","year":"2014","journal-title":"World J. Surg. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11701-024-01862-5","article-title":"Robotic versus laparoscopic right hemicolectomy: A systematic review of the evidence","volume":"18","author":"Meyer","year":"2024","journal-title":"J. Robot. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Tschann, P., Szeverinski, P., Weigl, M.P., Rauch, S., Lechner, D., Adler, S., Girotti, P.N.C., Clemens, P., Tschann, V., and Presl, J. (2022). Short- and Long-Term Outcome of Laparoscopic- versus Robotic-Assisted Right Colectomy: A Systematic Review and Meta-Analysis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092387"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/DCR.0000000000002323","article-title":"The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Colon Cancer","volume":"65","author":"Vogel","year":"2022","journal-title":"Dis. Colon Rectum"},{"key":"ref_17","unstructured":"Onkologie, L. (2026, February 10). Kolorektales Karzinom. Version 30 AWMF Registernummer: 021-007OL. September 2025. Available online: https:\/\/register.awmf.org\/assets\/guidelines\/021-007OLl_S3_Kolorektales-Karzinom_2026-03_1.pdf."},{"key":"ref_18","unstructured":"(2025, March 31). NCCN Clinical Practice Guidelines in Oncology Version 2.2025. Available online: www.nccn.org."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1007\/s00464-017-5544-7","article-title":"Laparoscopic surgery for T4 colon cancer: A systematic review and meta-analysis","volume":"31","author":"Klaver","year":"2017","journal-title":"Surg. Endosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/codi.17089","article-title":"Robotic versus laparoscopic right colectomy for nonmetastatic pT4 colon cancer: A European multicentre propensity score-matched analysis","volume":"26","author":"Schena","year":"2024","journal-title":"Color. Dis."},{"key":"ref_21","unstructured":"Lenhard, W., and Lenhard, A. (2025, November 04). Calculation of Effect Sizes. Available online: https:\/\/www.psychometrica.de\/effektstaerke.html."},{"key":"ref_22","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavorial Sciences, Routledge. [2nd ed.]."},{"key":"ref_23","first-page":"m2917","article-title":"Prospective validation of classification of intraoperative adverse events (ClassIntra): International, multicentre cohort study","volume":"370","author":"Gomes","year":"2020","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.surg.2013.02.007","article-title":"Validation of the International Study Group of Rectal Cancer definition and severity grading of anastomotic leakage","volume":"153","author":"Kulu","year":"2013","journal-title":"Surgery"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00428-017-2276-y","article-title":"Eighth Edition of the UICC Classification of Malignant Tumours: An overview of the changes in the pathological TNM classification criteria-What has changed and why?","volume":"472","author":"Bertero","year":"2018","journal-title":"Virchows Arch."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1245\/s10434-018-6462-1","article-title":"AJCC 8th Edition: Colorectal Cancer","volume":"25","author":"Weiser","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1463-1318.2008.01735.x","article-title":"Standardized surgery for colonic cancer: Complete mesocolic excision and central ligation--technical notes and outcome","volume":"11","author":"Hohenberger","year":"2009","journal-title":"Color. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1007\/s00464-018-6267-0","article-title":"Laparoscopic right hemicolectomy with CME: Standardization using the \u201ccritical view\u201d concept","volume":"32","author":"Strey","year":"2018","journal-title":"Surg. Endosc."},{"key":"ref_30","unstructured":"Backhaus, K., Erichson, B., Plinke, W., and Weiber, R. (2006). Multivariate Analysemethoden: Eine Anwendungsorientierte Einf\u00fchrung, Springer. [11th ed.]."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chaouch, M.A., Hussain, M.I., Carneiro da Costa, A., Mazzotta, A., Krimi, B., Gouader, A., Cotte, E., Khan, J., and Oweira, H. (2024). Robotic versus laparoscopic total mesorectal excision with lateral lymph node dissection for advanced rectal cancer: A systematic review and meta-analysis. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0304031"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/bjs.8841","article-title":"Randomized clinical trial of robot-assisted versus standard laparoscopic right colectomy","volume":"99","author":"Park","year":"2012","journal-title":"Br. J. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1245\/s10434-018-6752-7","article-title":"Robotic Versus Laparoscopic Right Colectomy with Complete Mesocolic Excision for the Treatment of Colon Cancer: Perioperative Outcomes and 5-Year Survival in a Consecutive Series of 202 Patients","volume":"25","author":"Spinoglio","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1007\/s00464-019-06672-7","article-title":"Comparison of outcome and cost between the open, laparoscopic, and robotic surgical treatments for colon cancer: A propensity score-matched analysis using nationwide hospital record database","volume":"33","author":"Chiu","year":"2019","journal-title":"Surg. Endosc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00104-024-02077-y","article-title":"Robotic vs. laparoscopic right hemicolectomy-An analysis of costs","volume":"95","author":"Wittmann","year":"2024","journal-title":"Chirurgie"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11701-021-01246-z","article-title":"Comparison of outcome and costs of robotic and laparoscopic right hemicolectomies","volume":"16","author":"Ahmadi","year":"2022","journal-title":"J. Robot. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/SLA.0000000000003196","article-title":"Cost-effectiveness Evaluation of Laparoscopic Versus Robotic Minimally Invasive Colectomy","volume":"272","author":"Simianu","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"110167","DOI":"10.1016\/j.ejso.2025.110167","article-title":"Robot-assisted liver surgery reduces complication rates while maintaining equivalent outcome quality compared to open liver surgery","volume":"51","author":"Wilk","year":"2025","journal-title":"Eur. J. Surg. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1310\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:04:41Z","timestamp":1776773081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":38,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cancers18081310"],"URL":"https:\/\/doi.org\/10.3390\/cancers18081310","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}