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The Galician CRC screening programme was progressively implemented between 2013 and 2019. Methods: We conducted a population-based ecological time-series study using data from the Galician Tumour Registry (ICD-10 C18\u2013C21) for 2015\u20132023. Age-standardised mortality (ASMR) and incidence (ASIR) rates were analysed. They were calculated using the direct standardisation method, applying age-specific rates to the 2013 European Standard Population (ESP2013). Structural changes associated with programme implementation were evaluated using interrupted time-series (ITS) models, estimating annual percent change (APC) before and after implementation and the net change in slope (\u0394APC). Absolute and relative changes in ASMR and ASIR were calculated by comparing 2015\u20132017 and 2019\u20132023. Analyses were performed for the overall population and for individuals aged 50\u201369 years. Results: Between 2015 and 2023, overall CRC mortality declined significantly (APC \u22123.00%; 95% CI \u22123.37 to \u22122.63). ITS analysis demonstrated a marked modification of mortality trajectories following programme implementation. Mortality shifted from an increasing pre-implementation slope (APC +13.70%; 95% CI 10.12, 17.39) to a significant annual decline post-implementation (APC \u22123.62%; 95% CI \u22124.47, \u22122.76), yielding a \u0394APC of \u221217.32. In individuals aged 50\u201369 years, the structural change was more pronounced (\u0394APC \u221219.88), with post-implementation mortality decreasing by \u22128.08% annually (95% CI \u221210.43, \u22125.66). Incidence showed a comparable structural modification. Overall APC changed from +15.26% (95% CI 5.48, 25.95) before implementation to \u22122.48% (95% CI \u22125.29, 0.41) afterwards (\u0394APC \u221217.74). In the screening-eligible population, APC shifted from +21.32% (95% CI 4.60, 40.71) to \u22123.74% (95% CI \u22127.62, 0.30), corresponding to a \u0394APC of \u221225.06. Descriptively, ASMR declined from 41.92 to 35.91 per 100,000 (\u221214.33%), and ASIR from 98.37 to 85.16 per 100,000 (\u221213.42%) between 2015 and 2017 and between 2019 and 2023. Relative reductions were larger in individuals aged 50\u201369 years and were more pronounced for colon cancer than for rectal cancer. Conclusions: Implementation of an organised FIT-based screening programme was associated with a structural change in CRC mortality and incidence trends, particularly among individuals aged 50\u201369 years.<\/jats:p>","DOI":"10.3390\/cancers18081313","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:42:45Z","timestamp":1776771765000},"page":"1313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Organised Colorectal Cancer Screening and Changes in Mortality and Incidence Trends: A Population-Based Study"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8822-2991","authenticated-orcid":false,"given":"Astrid","family":"D\u00edez-Mart\u00edn","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Oncolog\u00eda Digestiva-Ourense, Fundaci\u00f3n P\u00fablica Gallega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Castro","sequence":"additional","affiliation":[{"name":"Registro Gallego de Tumores, Direcci\u00f3n Xeral de Sa\u00fade P\u00fablica, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isolina","family":"Santiago","sequence":"additional","affiliation":[{"name":"Servizo de Informaci\u00f3n de Sa\u00fade, Direcci\u00f3n Xeral de Sa\u00fade P\u00fablica, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Servizo de Detecci\u00f3n Precoz de Enfermidades, Direcci\u00f3n Xeral de Sa\u00fade P\u00fablica, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"G\u00f3mez-Amor\u00edn","sequence":"additional","affiliation":[{"name":"Servizo de Detecci\u00f3n Precoz de Enfermidades, Direcci\u00f3n Xeral de Sa\u00fade P\u00fablica, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Regueiro-Exp\u00f3sito","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Oncolog\u00eda Digestiva-Ourense, Fundaci\u00f3n P\u00fablica Gallega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Davila-Pi\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Oncolog\u00eda Digestiva-Ourense, Fundaci\u00f3n P\u00fablica Gallega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-4831","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Cubiella","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Oncolog\u00eda Digestiva-Ourense, Fundaci\u00f3n P\u00fablica Gallega de Investigaci\u00f3n Biom\u00e9dica Galicia Sur, \u00c1rea Sanitaria de Ourense, Ver\u00edn e O Barco de Valdeorras, Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.21037\/tgh.2019.12.13","article-title":"Programmed Colorectal Cancer Screening Decreases Incidence and Mortality","volume":"4","author":"Cervantes","year":"2019","journal-title":"Transl. 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Cancers, 15.","DOI":"10.20944\/preprints202308.1530.v1"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1313\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:25:38Z","timestamp":1776918338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/8\/1313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["cancers18081313"],"URL":"https:\/\/doi.org\/10.3390\/cancers18081313","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]}}}