{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:45:09Z","timestamp":1785422709199,"version":"3.56.0"},"reference-count":82,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R21 CA277418, R01 CA79716"],"award-info":[{"award-number":["R21 CA277418, R01 CA79716"]}]},{"award":["R21 CA277418, R01 CA79716"],"award-info":[{"award-number":["R21 CA277418, R01 CA79716"]}],"id":[{"id":"https:\/\/ror.org\/044zkrt47","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The taxane family of compounds, including paclitaxel, docetaxel (Taxotere), and cabazitaxel (Jevtana), are common drugs used in chemotherapy for the frontline treatment of most major types of cancer. Alopecia, the dramatic loss of hair, is a common side effect that became a symbol of the suffering of many cancer patients. Concerted efforts have been made to understand the mechanism of taxane toxicity to hair follicles and, thus, prevention methods. Taxanes act by stabilizing cellular microtubules, which consequently cause mitotic arrest and then failure, as microtubules play critical functions in chromosome segregation. Hair follicle matrix cells are highly proliferative and thus are exceedingly sensitive to taxanes. We review the cellular mechanism-based strategies under investigation to counter taxane-induced hair follicle damage. These include the application of cyclin kinase inhibitors to block mitotic entry, the practical method using scalp cooling to reduce exposure of scalp hair follicles to drugs during infusion, the requirement of p53 action for hair follicle damage, and the recently discovered method of using low-intensity ultrasound to break taxane-stabilized microtubules and thus reverse taxane toxicity in hair follicle matrix cells. The concept of low-intensity ultrasound as an antidote to taxanes may have the potential to provide a practical and compelling strategy to counter alopecia in cancer treatment using taxanes. Tweet: Taxanes (paclitaxel\/docetaxel) are powerful microtubule-stabilizing cancer drugs, but they also cause adverse effects, including alopecia. New research discoveries of temporary microtubule disruption by low-intensity ultrasound may counteract taxane toxicity and prevent alopecia during cancer chemotherapy. \u201cMechanistic-based strategies for the prevention of taxane-induced hair follicle damage in cancer chemotherapy\u201d OUTLINE: 1. Taxane\/paclitaxel mechanism of action in cancer therapy. 2. Taxane side effects: Alopecia (hair loss). 3. p53 dependence of taxane-induced hair follicle damage. 4. Research efforts to counter taxane -induced alopecia by CDK4\/6i. 5. Prevention of taxane chemotherapy side effects using scalp cooling. 6. Discovery of low-intensity ultrasound as an antidote for taxane cytotoxicity, and potential prevention of alopecia in chemotherapy using taxanes. 7. Summary and prospective.<\/jats:p>","DOI":"10.3390\/cancers18091351","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T17:04:59Z","timestamp":1776963899000},"page":"1351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism-Based Strategies for Prevention of Taxane-Induced Hair Follicle Damage in Cancer Chemotherapy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-3494","authenticated-orcid":false,"given":"Celina","family":"Amaya","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"},{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0257-7327","authenticated-orcid":false,"given":"Matthew P.","family":"Schlumbrecht","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA"},{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-7986","authenticated-orcid":false,"given":"Tongyu C.","family":"Wikramanayake","sequence":"additional","affiliation":[{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA"},{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Xi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"},{"name":"Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"i58","DOI":"10.1093\/annonc\/mdw088","article-title":"Optimal primary therapy of ovarian cancer","volume":"27","author":"Bookman","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/cncr.2820710442","article-title":"Taxol in ovarian cancer","volume":"71","author":"Runowicz","year":"1993","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/277665a0","article-title":"Promotion of microtubule assembly in vitro by taxol","volume":"277","author":"Schiff","year":"1979","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1073\/pnas.77.3.1561","article-title":"Taxol stabilizes microtubules in mouse fibroblast cells","volume":"77","author":"Schiff","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrc1317","article-title":"Microtubules as a target for anticancer drugs","volume":"4","author":"Jordan","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_6","first-page":"225","article-title":"Retrospective evaluation of Penguin Cold Caps for chemotherapy-induced alopecia","volume":"32","author":"Weaver","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_7","first-page":"S3","article-title":"Taxol (paclitaxel): Mechanisms of action","volume":"5","author":"Horwitz","year":"1994","journal-title":"Ann. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2174\/092986709787846488","article-title":"Tubulin: A target for antineoplastic drugs into the cancer cells but also in the peripheral nervous system","volume":"16","author":"Canta","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e11031","DOI":"10.15252\/emmm.201911031","article-title":"CDK4\/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia","volume":"11","author":"Purba","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_10","first-page":"86","article-title":"Breaking malignant nuclei as a non-mitotic mechanism of taxol\/paclitaxel","volume":"2","author":"Smith","year":"2021","journal-title":"J. Cancer Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Xu, A.P., Xu, L.B., Smith, E.R., Fleishman, J.S., Chen, Z.S., and Xu, X.X. (2024). Cell death in cancer chemotherapy using taxanes. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1338633"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Xu, L.B., Smith, E.R., Koutouratsas, V., Chen, Z.S., and Xu, X.X. (2025). The Persistent Power of the Taxane\/Platin Chemotherapy. Cancers, 17.","DOI":"10.3390\/cancers17071208"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gaumond, S.I., Beraja, G.E., Kamholtz, I., Ferrari, L.M., Mahmoud, R.H., and Jimenez, J.J. (2025). Chemotherapy-Induced Alopecia in Ovarian Cancer: Incidence, Mechanisms, and Impact Across Treatment Regimens. Cancers, 17.","DOI":"10.3390\/cancers17030411"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.3390\/curroncol31090423","article-title":"Chemotherapy-Induced Alopecia by Docetaxel: Prevalence, Treatment and Prevention","volume":"31","author":"Perez","year":"2024","journal-title":"Curr. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJM199504133321507","article-title":"Paclitaxel (taxol)","volume":"332","author":"Rowinsky","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1056\/NEJM199908123410706","article-title":"The biology of hair follicles","volume":"341","author":"Paus","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-genom-021610-131501","article-title":"Biology and genetics of hair","volume":"11","author":"Shimomura","year":"2010","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1523-1747.2003.12175.x","article-title":"Molecular mechanisms of chemotherapy-induced hair loss","volume":"8","author":"Botchkarev","year":"2003","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.sder.2008.12.001","article-title":"Chemotherapy-induced alopecia","volume":"28","year":"2009","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/S1470-2045(12)70553-3","article-title":"Pathobiology of chemotherapy-induced hair loss","volume":"14","author":"Paus","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.jaad.2011.02.026","article-title":"Chemotherapy-induced alopecia","volume":"67","author":"Chon","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/jocd.12308","article-title":"Chemotherapy-induced alopecia management: Clinical experience and practical advice","volume":"16","author":"Rossi","year":"2017","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.3390\/curroncol30040275","article-title":"Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?","volume":"30","author":"Wikramanayake","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"45366","DOI":"10.1038\/srep45366","article-title":"Minoxidil is a potential neuroprotective drug for paclitaxel-induced peripheral neuropathy","volume":"7","author":"Chen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_25","first-page":"5002","article-title":"p53 is essential for chemotherapy-induced hair loss","volume":"60","author":"Botchkarev","year":"2000","journal-title":"Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/S0002-9440(10)64659-7","article-title":"p53 Involvement in the control of murine hair follicle regression","volume":"158","author":"Botchkarev","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1523-1747.2003.12022.x","article-title":"Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss","volume":"120","author":"Sharov","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.1158\/0008-5472.CAN-04-1367","article-title":"Fas signaling is involved in the control of hair follicle response to chemotherapy","volume":"64","author":"Sharov","year":"2004","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1084\/jem.190.2.253","article-title":"Bcl-2-mediated drug resistance: Inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT) induced Fas ligand transcription","volume":"190","author":"Srivastava","year":"1999","journal-title":"J. Exp. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1012203110027","article-title":"Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL","volume":"225","author":"Biswas","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000077435","article-title":"Paclitaxel treatment of breast cancer cell lines modulates Fas\/Fas ligand expression and induces apoptosis which can be inhibited through the CD40 receptor","volume":"66","author":"Stumm","year":"2004","journal-title":"Oncology"},{"key":"ref_32","first-page":"203","article-title":"Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas\/FasL (CD95\/APO1) signaling pathway","volume":"6","author":"Ferreira","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4161\/cbt.53","article-title":"Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death","volume":"1","author":"Blagosklonny","year":"2002","journal-title":"Cancer Biol. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.291.5501.134","article-title":"Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors","volume":"291","author":"Davis","year":"2001","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1126\/science.10.1126\/SCIENCE.291.5501.25A","article-title":"Preventing hair loss from chemotherapy","volume":"291","author":"Marx","year":"2001","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1126\/science.298.5602.2327b","article-title":"Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors","volume":"298","author":"Davis","year":"2002","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1470-2045(14)71159-3","article-title":"The cyclin-dependent kinase 4\/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1\/TRIO-18): A randomised phase 2 study","volume":"16","author":"Finn","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10549-017-4385-3","article-title":"Cyclin-dependent kinase 4\/6 inhibitors in breast cancer: Palbociclib, ribociclib, and abemaciclib","volume":"166","author":"Kwapisz","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.2217\/fon-2020-1264","article-title":"CDK4\/6 inhibitors in HR+\/HER2- advanced\/metastatic breast cancer: A systematic literature review of real-world evidence studies","volume":"17","author":"Harbeck","year":"2021","journal-title":"Future Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1126\/scitranslmed.aal3986","article-title":"Transient CDK4\/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion","volume":"9","author":"He","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5590","DOI":"10.21037\/apm-21-1096","article-title":"effects of CDK4\/6 inhibitors in the treatment of HR+\/HER2- advanced breast cancer: A systematic review and meta-analysis of randomized controlled trials","volume":"10","author":"Yang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_42","first-page":"6943","article-title":"The scalp cooling therapy for hair loss in breast cancer patients undergoing chemotherapy: A systematic review and meta-analysis","volume":"29","author":"Wang","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ad.2021.09.003","article-title":"Chemotherapy, Alopecia, and Scalp Cooling Systems","volume":"113","author":"Amarillo","year":"2022","journal-title":"Actas Dermosifiliogr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108225","DOI":"10.1016\/j.pec.2024.108225","article-title":"More than just hair","volume":"123","author":"Novice","year":"2024","journal-title":"Patient Educ Couns."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1111\/tbj.13711","article-title":"Use of scalp cooling device to prevent alopecia for early breast cancer patients receiving chemotherapy: A prospective study","volume":"26","author":"Giarratano","year":"2020","journal-title":"Breast J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/jama.2016.21038","article-title":"Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer","volume":"317","author":"Rugo","year":"2017","journal-title":"JAMA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/0959-8049(94)00280-I","article-title":"Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer","volume":"30","author":"Tollenaar","year":"1994","journal-title":"Eur. J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/jama.2016.20939","article-title":"Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial","volume":"317","author":"Nangia","year":"2017","journal-title":"JAMA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ygyno.2024.06.012","article-title":"Scalp hypothermia to reduce chemotherapy-induced alopecia: A systematic review and meta-analysis","volume":"188","author":"Lambert","year":"2024","journal-title":"Gynecol. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/NCC.0000000000001234","article-title":"Effectiveness of Scalp Cooling to Prevent Chemotherapy-Induced Alopecia in Patients Undergoing Breast Cancer Treatment: A Systematic Review and Meta-analysis","volume":"47","author":"Contreras","year":"2024","journal-title":"Cancer Nurs."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2022.03.031","article-title":"Low temperature mitigating the paclitaxel-induced damages in mouse cell and hair follicle model","volume":"603","author":"Chen","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dunnill, C., Ibraheem, K., Peake, M., Ioannou, M., Palmer, M., Smith, A., Collett, A., and Georgopoulos, N.T. (2020). Cooling-mediated protection from chemotherapy drug-induced cytotoxicity in human keratinocytes by inhibition of cellular drug uptake. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240454"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10549-025-07858-5","article-title":"Adverse effects of scalp cooling for the reduction of chemotherapy-induced alopecia: A systematic review and meta-analysis","volume":"215","author":"Kearney","year":"2025","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3892\/mco.2013.178","article-title":"Determination of the most effective cooling temperature for the prevention of chemotherapy-induced alopecia","volume":"1","author":"Ekwall","year":"2013","journal-title":"Mol. Clin. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e12888","DOI":"10.1111\/ijn.12888","article-title":"Efficacy of the DigniCap System in preventing chemotherapy-induced alopecia in breast cancer patients is not related to patient characteristics or side effects of the device","volume":"27","author":"Pedersini","year":"2021","journal-title":"Int. J. Nurs. Pract."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40487-020-00120-6","article-title":"Integration of Physician and Nursing Professional Efforts to Deliver Supportive Scalp Cooling Care to Oncology Patients at Risk for Alopecia","volume":"8","author":"Peterson","year":"2020","journal-title":"Oncol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.tiv.2014.07.011","article-title":"Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity","volume":"28","author":"Dunnill","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.7150\/jca.71263","article-title":"Low Intensity Ultrasound as an Antidote to Taxane\/Paclitaxel-induced Cytotoxicity","volume":"13","author":"Amaya","year":"2022","journal-title":"J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Amaya, C., Luo, S., Baigorri, J., Baucells, R., Smith, E.R., and Xu, X.X. (2021). Exposure to low intensity ultrasound removes paclitaxel cytotoxicity in breast and ovarian cancer cells. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08722-7"},{"key":"ref_60","first-page":"55","article-title":"Disassembly of microtubules due to low intensity ultrasound","volume":"39","author":"Adler","year":"1993","journal-title":"Folia Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jbiomech.2017.06.003","article-title":"Ultrasound induced strain cytoskeleton rearrangement: An experimental and simulation study","volume":"60","author":"Samandari","year":"2017","journal-title":"J. Biomech."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.bioeng.6.040803.140126","article-title":"Mechanical bioeffects of ultrasound","volume":"6","author":"Dalecki","year":"2004","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0092-8674(79)90157-0","article-title":"Mechanisms of regulating tubulin synthesis in cultured mammalian cells","volume":"17","author":"Farmer","year":"1979","journal-title":"Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/317648a0","article-title":"Autoregulation of tubulin synthesis in enucleated cells","volume":"317","author":"Caron","year":"1985","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Gasic, I., Boswell, S.A., and Mitchison, T.J. (2019). Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues. PLoS Biol., 17.","DOI":"10.1101\/533224"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.jid.2023.02.033","article-title":"Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity","volume":"143","author":"Cheret","year":"2023","journal-title":"J. Investig. Dermatol."},{"key":"ref_67","unstructured":"Amaya, C., Luo, S.H., Smith, E.R., Cheret, J., Schlumbrecht, M.P., Wikramanayake, T.C., Paus, R., and Xu, X.X. (Preprint, 2026). Disruption of microtubules with low intensity ultrasound rescues hair follicle damage by paclitaxel, Preprint, Submitted."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1016\/j.ultrasmedbio.2020.07.002","article-title":"Low-Frequency (20 kHz) Ultrasonic Modulation of Drug Action","volume":"46","author":"Venslauskas","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pbiomolbio.2012.01.004","article-title":"Bio-effects and safety of low-intensity, low-frequency ultrasonic exposure","volume":"108","author":"Ahmadi","year":"2012","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"623","DOI":"10.7863\/jum.2012.31.4.623","article-title":"Overview of Therapeutic Ultrasound Applications and Safety Considerations","volume":"31","author":"Miller","year":"2012","journal-title":"J. Ultrasound Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pbiomolbio.2006.07.005","article-title":"Therapeutic applications of ultrasound","volume":"93","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/S0959-8049(98)00238-X","article-title":"Therapeutic ultrasound for osteoradionecrosis: An in vitro comparison between 1 MHz and 45 kHz machines","volume":"34","author":"Reher","year":"1998","journal-title":"Eur. J. Cancer."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/ptj\/81.7.1339","article-title":"A Review of Therapeutic Ultrasound: Effectiveness Studies","volume":"81","author":"Robertson","year":"2001","journal-title":"Physical. Therapy"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0003-9993(95)80513-3","article-title":"Subaqueous ultrasound: 45kHz and 1MHz machines compared","volume":"76","author":"Robertson","year":"1995","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jacc.2006.03.046","article-title":"Noninvasive low-frequency ultrasound energy causes vasodilation in humans","volume":"48","author":"Iida","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1121\/1.4812875","article-title":"Low-frequency (<100 kHz), low-intensity (<100 mW\/cm(2)) ultrasound to treat venous ulcers: A human study and in vitro experiments","volume":"134","author":"Samuels","year":"2013","journal-title":"J. Acoust. Soc. Am."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/01.CIR.84.4.1783","article-title":"Ultrasonic energy. Effects on vascular function and integrity","volume":"84","author":"Fischell","year":"1991","journal-title":"Circulation"},{"key":"ref_78","first-page":"193260","article-title":"Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells","volume":"2009","author":"Scarponi","year":"2009","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.ultras.2012.03.004","article-title":"Optimization of un-tethered, low voltage, 20\u2013100 kHz flexural transducers for biomedical ultrasonics applications","volume":"52","author":"Sunny","year":"2012","journal-title":"Ultrasonics"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1038\/s41598-020-61328-0","article-title":"Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement","volume":"10","author":"Liao","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_81","first-page":"2486","article-title":"Phase I clinical and pharmacokinetic study of taxol","volume":"47","author":"Wiernik","year":"1987","journal-title":"Cancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1245\/s10434-006-9305-4","article-title":"Short-term exposure of cancer cells to micromolar doses of paclitaxel, with or without hyperthermia, induces long-term inhibition of cell proliferation and cell death in vitro","volume":"14","author":"Michalakis","year":"2007","journal-title":"Ann. Surg. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/9\/1351\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:11:35Z","timestamp":1778127095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/9\/1351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":82,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["cancers18091351"],"URL":"https:\/\/doi.org\/10.3390\/cancers18091351","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]}}}