{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:33:58Z","timestamp":1777322038126,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Preparing patients for oncological therapy requires the elimination of foci of infection in accordance with Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO) guidelines. Complications of dental caries, such as abscesses, can lead to sepsis. In Poland, the pre-oncologic dental treatment of patients with hematopoietic disorders does not yet meet MASCC\/ISOO standards; however, an inventory of the current status of dental care for these patients is ongoing. The aim of this study was to investigate the frequency of dental caries and to define the local caries risk factors in adult patients prior to Hematopoietic Stem Cell Transplantation (HSCT) as a part of anticancer therapy. Additionally, the time available for dental treatment was assessed. Methods: A total of 302 patients were examined. Dental status was determined based on the number of decayed, missing and filled teeth and on treatment needs. Local caries risk factors, such as poor dietary habits, insufficient oral hygiene, and symptoms of reduced salivary flow, were examined. The diet was assessed using a questionnaire; tooth cleaning efficiency was assessed as a percentage of dental surfaces with biofilm. Symptoms of reduced salivary flow were determined by subjective and clinical signs of low salivary secretion. Results: Active (progressive) dental caries was diagnosed in 85.2% of patients. Insufficient oral hygiene had been found in 71.52% of those examined. Symptoms of hyposalivation were present in 85% of patients. In 31% of cases, time available for dental treatment prior to HSCT was too short. Conclusions: Tooth decay, the presence of caries risk factors, and insufficient time for oral treatment in patients submitted to HSCT represent a serious clinical problem. There is a clear need to establish comprehensive oral health protocols aimed at providing patients with appropriate, urgent dental care. Furthermore, coordination between oncologists and dentists in Poland must be improved. Currently patients are rarely referred to a dentist before starting anticancer therapy; those scheduled to hematopoietic stem cell transplantation, usually see a dentist too late.<\/jats:p>","DOI":"10.3390\/cancers18091383","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:24:51Z","timestamp":1777317891000},"page":"1383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Dental Caries in Adults Scheduled for Hematopoietic Stem Cell Transplantation: A Multicenter Study in a Polish Population"],"prefix":"10.3390","volume":"18","author":[{"given":"Agnieszka","family":"Bogus\u0142awska-Kapa\u0142a","sequence":"first","affiliation":[{"name":"Department of Comprehensive Dental Care, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-1487","authenticated-orcid":false,"given":"Andrzej","family":"Miskiewicz","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kocha\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-1469","authenticated-orcid":false,"given":"Aida","family":"Kusiak","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-3673","authenticated-orcid":false,"given":"Barbara A.","family":"Jereczek-Fossa","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy"},{"name":"Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Banatkiewicz","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dental Care, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Gordon-Piotrowska","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dental Care, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7058-3614","authenticated-orcid":false,"given":"Izabela","family":"Stru\u017cycka","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dental Care, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-4332","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"G\u00f3rski","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Diseases, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-574X","authenticated-orcid":false,"given":"Aniela","family":"Brodzikowska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","unstructured":"(2024, February 08). Available online: http:\/\/gco.iarc.fr\/tomorrow."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/s41409-021-01227-8","article-title":"Hematopoietic cell transplantation and cellular therapy survey of the EBMT: Monitoring of activities and trends over 30 years","volume":"56","author":"Passweg","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"ref_3","first-page":"223","article-title":"Basic oral care for hematology\u2013oncology patients and hematopoietic stem cell transplantation recipients: A position paper from the joint task force of the Multinational Association of Supportive Care in Cancer\/International Society of Oral Oncology (MASCC\/ISOO) and the European Society for Blood and Marrow Transplantation (EBMT)","volume":"23","author":"Elad","year":"2015","journal-title":"Support Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1007\/s00784-020-03749-9","article-title":"Oral microorganisms and bloodstream infection in allogeneic hematopoietic stem cell transplantation","volume":"25","author":"Ohbayashi","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_5","first-page":"2231","article-title":"Dental status and risk of odontogenic complication in patients undergoing hematopoietic stem cell transplant","volume":"29","author":"Hansen","year":"2021","journal-title":"Support Care Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000503309","article-title":"Terminology of Dental Caries and Dental Caries Management: Consensus Report of a Workshop Organized by ORCA and Cariology Research Group of IADR","volume":"54","author":"Machiulskiene","year":"2020","journal-title":"Caries Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105545","DOI":"10.1016\/j.archoralbio.2022.105545","article-title":"A critical review on the association of hyposalivation and dental caries in children and adolescents","volume":"144","author":"Siqueira","year":"2022","journal-title":"Arch. Oral Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cden.2019.06.005","article-title":"Dietary Implications for Dental Caries: A Practical Approach on Dietary Counseling","volume":"63","author":"Marshall","year":"2019","journal-title":"Dent. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Giacaman, R.A., Fern\u00e1ndez, C.E., Mu\u00f1oz-Sandoval, C., Le\u00f3n, S., Garc\u00eda-Manr\u00edquez, N., Echeverr\u00eda, C., Vald\u00e9s, S., Castro, R.J., and Gambetta-Tessini, K. (2022). Understanding dental caries as a non-communicable and behavioral disease: Management implications. Front. Oral Health, 3.","DOI":"10.3389\/froh.2022.764479"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-9657.1995.tb00476.x","article-title":"Bacteremia in conjunction with endodontic therapy","volume":"11","author":"Debelian","year":"1995","journal-title":"Endod. Dent. Traumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.7717\/peerj.14040","article-title":"Dental caries as a risk factor for bacterial blood stream infection (BSI) in children undergoing hematopoietic cell transplantation (HCT)","volume":"10","author":"Lu","year":"2022","journal-title":"PeerJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1532-849X.2007.00223.x","article-title":"Occlusal changes following posterior tooth loss in adults. Part 2. Clinical parameters associated with movement of teeth adjacent to the site of posterior tooth loss","volume":"16","author":"Craddock","year":"2007","journal-title":"J. Prosthodont."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdent.2017.10.012","article-title":"Does tooth loss affect dietary intake and nutritional status? A systematic review of longitudinal studies","volume":"67","author":"Gaewkhiew","year":"2017","journal-title":"J. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/0022034518814829","article-title":"Tooth loss predicts myocardial infarction, heart failure, stroke, and death","volume":"98","author":"Lee","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/joor.12984","article-title":"Functional oral health-related quality of life impact: A systematic review in populations with tooth loss","volume":"48","author":"Schierz","year":"2021","journal-title":"J. Oral Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4103\/1119-3077.122831","article-title":"Comparison of chemotherapy and hematopoietic stem cell transplantation pre and postterm DMFT scores: A preliminary study","volume":"17","author":"Ertas","year":"2014","journal-title":"Niger. J. Clin. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/sj.bdj.2009.304","article-title":"Dental assessment prior to stem cell transplant: Treatment need and barriers to care","volume":"206","author":"Durey","year":"2009","journal-title":"Br. Dent. J."},{"key":"ref_18","unstructured":"Olczak-Kowalczyk, D., Mielczarek, A., Kaczmarek, U., Turska-Szybka, A., Rusyan, E., and Adamczyk, K. (2021, January 15). Caries Disease and the Condition of Periodontal Tissues in the Polish Population. Summary of Research Results From 2016\u20132019, Available online: https:\/\/www.gov.pl\/attachment\/e837445b-41ef-4b49-b261-d21d869e0018."},{"key":"ref_19","unstructured":"Petersen, P.E., and Baez, R.J. (2013). WHO Oral Health Surveys Basic Methods, World Health Organization. [5th ed.]."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0030-4220(88)90268-X","article-title":"Xerostomia. Part I: Relationship to other symptoms and salivary gland hypofunction","volume":"66","author":"Sreebny","year":"1988","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_21","first-page":"1039","article-title":"A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life","volume":"18","author":"Jensen","year":"2010","journal-title":"Support Care Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2147\/TCRM.S76282","article-title":"Diagnosis and management of xerostomia and hyposalivation","volume":"22","author":"Villa","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1601-0825.2010.01715.x","article-title":"Investigating the relationship between hyposalivation and mucosal wetness","volume":"17","author":"Osailan","year":"2011","journal-title":"Oral Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/cdoe.12025","article-title":"International Caries Detection and Assessment System (ICDAS) and its International Caries Classification and Management System (ICCMS)\u2014Methods for staging of the caries process and enabling dentists to manage caries","volume":"41","author":"Pitts","year":"2013","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5005\/jp-journals-10005-1089","article-title":"International Caries Detection and Assessment System (ICDAS): A New Concept","volume":"4","author":"Gugnani","year":"2011","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2341\/06-63","article-title":"Detection and activity assessment of primary coronal caries lesions: A methodologic study","volume":"32","author":"Ekstrand","year":"2007","journal-title":"Oper. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000016526","article-title":"Reliability of a new caries diagnostic system differentiating between active and inactive caries lesions","volume":"334","author":"Nyvad","year":"1999","journal-title":"Caries Res."},{"key":"ref_28","first-page":"2050","article-title":"Evaluation of Oral Health Status Based on the Decayed, Missing and Filled Teeth (DMFT) Index","volume":"48","author":"Moradi","year":"2019","journal-title":"Iran. J. Public Health."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000492676","article-title":"Dental Caries in European Adults and Senior Citizens 1996\u20132016: ORCA Saturday Afternoon Symposium in Greifswald, Germany\u2013Part II","volume":"53","author":"Carvalho","year":"2019","journal-title":"Caries Res."},{"key":"ref_30","first-page":"636","article-title":"Treatment Needs for Dental Caries, Restorative Care Index, and Index of Extractions in Adolescents 12 and 15 Years Old","volume":"62","year":"2013","journal-title":"West Indian Med. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-051X.2005.00716.x","article-title":"Approximal plaque and gingival sulcus bleeding in routine dental care patients: Relations to life stress, somatization and depression","volume":"32","author":"Klages","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_32","first-page":"400","article-title":"Oral Complications of Cancer and Cancer Therapy: From Cancer Treatment to Survivorship","volume":"62","author":"Epstein","year":"2012","journal-title":"CA Cancer J. Clin."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.oraloncology.2010.02.025","article-title":"Oral and dental health care of oral cancer patients: Hyposalivation, caries and infections","volume":"46","author":"Meurman","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000525599","article-title":"Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation","volume":"56","author":"Bulthuis","year":"2022","journal-title":"Caries Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Skallsj\u00f6, K., von B\u00fcltzingsl\u00f6wen, I., Hass\u00e9us, B., Johansson, J.E., \u00d6hman, J., Raber-Durlacher, J.E., Huysmans, M.C.D., Laheij, A.M., van Leeuwen, S.J., and Hovan, A.J. (2023). Oral health in patients scheduled foR hematopoietic stem cell transplantation in the Orastem study. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0285615"},{"key":"ref_36","first-page":"97","article-title":"Health awareness and behaviours among adults aged 35\u201344 years in Poland in the years 2010\u20132017","volume":"3","author":"Rusyan","year":"2020","journal-title":"Borgis-New Med."},{"key":"ref_37","first-page":"553","article-title":"Subjective symptoms possibly associated with disorders of saliva secretion in patients in the late period after allogeneic hematopoietic cell transplantation","volume":"64","author":"Piekarska","year":"2011","journal-title":"J. Stoma."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/07315724.2013.834802","article-title":"Late Effects of Multiagent Chemotherapy on Salivary Secretion in Children Cancer Survivors","volume":"33","author":"Nemeth","year":"2014","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.17219\/acem\/28998","article-title":"An assessment of the number of cariogenic bacteria in the saliva of children with chemotherapy-induced neutropenia","volume":"25","author":"Olszewska","year":"2016","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_40","first-page":"4587","article-title":"Taste disorders following cancer treatment: Report of a case series","volume":"27","author":"Epstein","year":"2019","journal-title":"Support Care Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Moussa, C., Estrade, L., Glomet, J., Rochefort, G.Y., Denis, F., and Daou, M.H. (2025). The Impact of Preventive Protocols on Oral Health Outcomes in Cancer Patients Undergoing Chemotherapy or Radiotherapy: A Systematic Review and Meta-Analysis. Diseases, 13.","DOI":"10.3390\/diseases13060186"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/9\/1383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:41:49Z","timestamp":1777318909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/9\/1383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["cancers18091383"],"URL":"https:\/\/doi.org\/10.3390\/cancers18091383","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}