{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T05:09:01Z","timestamp":1778389741338,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: This study evaluated the performance of a commercial offline adaptive radiotherapy system for systematic monitoring of breast cancer treatment with nodal irradiation using helical tomotherapy. Methods: Thirty patients treated for invasive unilateral breast carcinoma were analysed. For each patient, three megavoltage CT scans acquired at the first, middle, and last treatment sessions were processed through the PreciseART (Accuray, US) offline ART workflow. Automatically deformed structures were compared with manually delineated reference structures. Geometric accuracy was assessed using the Dice similarity coefficient (DSC), Hausdorff distance (HD95), mean distance to agreement (MDA), and barycentre distance (BD). The dosimetric parameters included D2% and V95% for targets and Dmean\/Dmax\/V20Gy for organs at risk. Results: Median DSCs exceeded 0.9 for the CTVbreast, PTVbreast, heart, and ipsilateral lung and were above 0.8 for the remaining structures, except the CTVn and oesophagus. Dosimetric differences between deformed and reference structures were within 5% for D2% across all targets and for V95% of the CTVbreast and PTVbreast in 90% of the sessions. The ipsilateral lung V20Gy differed by less than 5% in more than 90% of the sessions. Larger deviations (up to 10%) were observed for the nodal PTVs and mean heart dose, while the greatest inconsistencies were found for the oesophagus and spinal canal. Conclusions: The evaluated offline ART system demonstrates sufficient accuracy for automated monitoring of breast and lung structures. However, cautious interpretation remains necessary for nodal targets, heart, and oesophagus dosimetry prior to clinical implementation.<\/jats:p>","DOI":"10.3390\/cancers18091386","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:24:51Z","timestamp":1777317891000},"page":"1386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Performance of a Vendor System for Systematic Offline Adaptive Breast Helical Radiotherapy"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-4737","authenticated-orcid":false,"given":"Philippe","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"},{"name":"Team IMAGeS, ICube Laboratory, University of Strasbourg, 67412 Illkirch, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Dossun","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Noel","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3394-3601","authenticated-orcid":false,"given":"Loris","family":"Barrier","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6390-5849","authenticated-orcid":false,"given":"Anthony","family":"Richert","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Arbor","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Niederst","sequence":"additional","affiliation":[{"name":"Department of Radiation Therapy, Centre Paul Strauss, 3 Rue de la Porte de l\u2019H\u00f4pital, 67000 Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1088\/0031-9155\/42\/1\/008","article-title":"Adaptive Radiation Therapy","volume":"42","author":"Yan","year":"1997","journal-title":"Phys. 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