{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:00:29Z","timestamp":1785416429112,"version":"3.56.0"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2020-02445"],"award-info":[{"award-number":["2020-02445"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2020-02445"],"award-info":[{"award-number":["2020-02445"]}],"id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"publisher","award":["25 4355 Pj"],"award-info":[{"award-number":["25 4355 Pj"]}],"id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["R01 AR078785"],"award-info":[{"award-number":["R01 AR078785"]}]},{"name":"UM Macao Fellow scheme of the UM Talent Programme of the University of Macau","award":["UMTP2023-MF02"],"award-info":[{"award-number":["UMTP2023-MF02"]}]},{"award":["UMTP2023-MF02"],"award-info":[{"award-number":["UMTP2023-MF02"]}],"id":[{"id":"https:\/\/ror.org\/01r4q9n85","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objectives: The genetic architecture of B-cell lymphomas is not fully characterized. We aimed to identify novel candidate variants associated with four common B-cell lymphoma subtypes\u2014diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), chronic lymphocytic leukemia (CLL), and marginal zone lymphoma (MZL)\u2014through cross-trait analyses with correlated idiopathic inflammatory myopathies subtypes, dermatomyositis (DM) and polymyositis (PM). Methods: Leveraging shared genetic susceptibility with DM and PM, we applied a pleiotropy-informed conditional false discovery rate (condFDR) method to recompute nominal single nucleotide polymorphism association p-values for each B-cell lymphoma subtype. Associations were considered significant at condFDR &lt;0.01. Functional annotation was performed using FUMA (Functional Mapping and Annotation of Genome-Wide Association Studies), followed by Gene Ontology (GO) enrichment analysis via clusterProfiler, with similar GO terms clustered for interpretation and visualization. Results: We identified 4, 2, 13, and 6 novel candidate loci for DLBCL, FL, CLL, and MZL, respectively. Most loci exhibited regulatory effects on genes involved in adaptive immune responses and cell death pathways. Notably, for DLBCL locus 1q23.3 affects SLAMF genes implicated in natural killer and lymphocyte activation. A trans-eQTL at 2q13 for FL was associated with BCL11A, a multifunctional oncogene. For CLL, a novel locus at 16q24.1 regulates IRF8, a known CLL risk gene. Functional mapping of previously reported CLL risk loci revealed RIPK1 (6p25.2), linked to necroptosis. No enriched biological pathways were detected for MZL risk-associated genes. Conclusions: These findings advance our understanding of the genetic architecture of four B-cell lymphoma subtypes and aim to inform future genetic and functional studies.<\/jats:p>","DOI":"10.3390\/cancers18101536","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:05:22Z","timestamp":1778501122000},"page":"1536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Novel Risk Loci for Common B-Cell Lymphoma Subtypes Through Cross-Trait Analysis with Idiopathic Inflammatory Myopathies"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-2024","authenticated-orcid":false,"given":"Weng Ian","family":"Che","sequence":"first","affiliation":[{"name":"Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macau SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Center for Indigenous Health, University of Washington School of Medicine, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"International Lymphoma Epidemiology Consortium (InterLymph)","family":"International Lymphoma Epidemiology Consortium (InterLymph)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IMACS Genetics Group (MYOGEN)","family":"IMACS Genetics Group (MYOGEN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, 171 64 Stockholm, Sweden"},{"name":"ME Gastro, Derm and Rheuma, Theme Inflammation and Aging, Karolinska University Hospital, 171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, 171 64 Stockholm, Sweden"},{"name":"Hematology Center, Karolinska University Hospital, 171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-0539","authenticated-orcid":false,"given":"Janine A.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health Group, School of Health Sciences, The University of Manchester, Manchester M13 9PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8996-5260","authenticated-orcid":false,"given":"Marie","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"ME Gastro, Derm and Rheuma, Theme Inflammation and Aging, Karolinska University Hospital, 171 76 Stockholm, Sweden"},{"name":"Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/joim.12684","article-title":"The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections","volume":"282","author":"Smedby","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(23)02705-8","article-title":"B-cell non-Hodgkin lymphomas","volume":"403","author":"Silkenstedt","year":"2024","journal-title":"Lancet"},{"key":"ref_3","first-page":"489","article-title":"Global patterns and trends in the incidence of non-Hodgkin lymphoma","volume":"30","author":"Pineros","year":"2019","journal-title":"Cancer Causes Control"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of Mature Lymphoid Neoplasms: A report from the Clinical Advisory Committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jncimonographs\/lgu013","article-title":"Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: The InterLymph Non-Hodgkin Lymphoma Subtypes Project","volume":"2014","author":"Morton","year":"2014","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/jnci\/dji293","article-title":"Family history of hematopoietic malignancy and risk of lymphoma","volume":"97","author":"Chang","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/ng.3105","article-title":"Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma","volume":"46","author":"Cerhan","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ajhg.2014.09.004","article-title":"Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region","volume":"95","author":"Skibola","year":"2014","journal-title":"Am. J. Hum. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1038\/ncomms6751","article-title":"A genome-wide association study of marginal zone lymphoma shows association to the HLA region","volume":"6","author":"Vijai","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1038\/ncomms10933","article-title":"Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia","volume":"7","author":"Berndt","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41375-024-02503-4","article-title":"Genetic susceptibility of diffuse large B-cell lymphoma: A meta genome-wide association study in Asian population","volume":"39","author":"Cui","year":"2025","journal-title":"Leukemia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/ng.2666","article-title":"Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population","volume":"45","author":"Tan","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"14175","DOI":"10.1038\/ncomms14175","article-title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","volume":"8","author":"Law","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E5272","DOI":"10.1073\/pnas.1419064111","article-title":"Measuring missing heritability: Inferring the contribution of common variants","volume":"111","author":"Golan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"djv279","DOI":"10.1093\/jnci\/djv279","article-title":"Analysis of heritability and shared heritability based on genome-wide association studies for 13 cancer types","volume":"107","author":"Sampson","year":"2015","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41572-021-00321-x","article-title":"Idiopathic inflammatory myopathies","volume":"7","author":"Lundberg","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0140-6736(00)03540-6","article-title":"Frequency of specific cancer types in dermatomyositis and polymyositis: A population-based study","volume":"357","author":"Hill","year":"2001","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1054\/bjoc.2001.1699","article-title":"Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: A Scottish population-based cohort study","volume":"85","author":"Stockton","year":"2001","journal-title":"Br. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e515","DOI":"10.1038\/bcj.2016.123","article-title":"Familial associations of lymphoma and myeloma with autoimmune diseases","volume":"7","author":"Hemminki","year":"2017","journal-title":"Blood Cancer J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e006035","DOI":"10.1136\/rmdopen-2025-006035","article-title":"Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region","volume":"11","author":"Che","year":"2025","journal-title":"RMD Open"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Andreassen, O.A., Thompson, W.K., Schork, A.J., Ripke, S., Mattingsdal, M., Kelsoe, J.R., Kendler, K.S., O\u2019Donovan, M.C., Rujescu, D., and Werge, T. (2013). Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003455"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/gene.2015.28","article-title":"Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes","volume":"16","author":"Miller","year":"2015","journal-title":"Genes Immun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/art.38137","article-title":"Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap with Other Autoimmune Disorders","volume":"65","author":"Miller","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/art.43088","article-title":"Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses","volume":"77","author":"Zhu","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"ref_26","unstructured":"R Core Team (2021). R: A Language and Environment for Statistical Computing, R Foundation for Statistical Computing."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1093\/bioinformatics\/btab665","article-title":"MungeSumstats: A Bioconductor package for the standardization and quality control of many GWAS summary statistics","volume":"37","author":"Murphy","year":"2021","journal-title":"Bioinformatics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Kundaje","year":"2015","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/art.41929","article-title":"Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort","volume":"74","author":"Bianchi","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1136\/annrheumdis-2015-208119","article-title":"Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups","volume":"75","author":"Rothwell","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/art.42434","article-title":"Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation","volume":"75","author":"Rothwell","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/annrheumdis-2018-214127","article-title":"Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases","volume":"78","author":"Kerick","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/joim.12633","article-title":"Genetic landscape and deregulated pathways in B-cell lymphoid malignancies","volume":"282","author":"Rosenquist","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1038\/s41375-022-01711-0","article-title":"Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes","volume":"36","author":"Berndt","year":"2022","journal-title":"Leukemia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41408-025-01351-4","article-title":"Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: A multi-trait genome-wide association study","volume":"15","author":"Guler","year":"2025","journal-title":"Blood Cancer J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1182\/blood-2024-211262","article-title":"Genome-Wide Meta-Analysis Identifies Multiple Germline Genetic Variants Associated with Increased Risk of Follicular Lymphoma","volume":"144","author":"Joseph","year":"2024","journal-title":"Blood"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/hmg\/ddz228","article-title":"Inherited variants at 3q13.33 and 3p24.1 are associated with risk of diffuse large B-cell lymphoma and implicate immune pathways","volume":"29","author":"Kleinstern","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ng.510","article-title":"Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk","volume":"42","author":"Broderick","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.2843","article-title":"A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia","volume":"46","author":"Speedy","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/ng.2652","article-title":"Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia","volume":"45","author":"Berndt","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/gepi.22242","article-title":"Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes","volume":"43","author":"Din","year":"2019","journal-title":"Genet. Epidemiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature12912","article-title":"Discovery and saturation analysis of cancer genes across 21 tumour types","volume":"505","author":"Lawrence","year":"2014","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood-2015-10-674572","article-title":"Whole-exome sequencing in relapsing chronic lymphocytic leukemia: Clinical impact of recurrent RPS15 mutations","volume":"127","author":"Ljungstrom","year":"2016","journal-title":"Blood"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1073\/pnas.1205299110","article-title":"Genetic heterogeneity of diffuse large B-cell lymphoma","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"K\u013eoc, D., Kurhajec, S., Huniadi, M., S\u00fdkora, J., Guman, T., and \u0160ari\u0161sk\u00fd, M. (2024). SLAM Family Receptors in B Cell Chronic Lymphoproliferative Disorders. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25074014"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Yoon, H., Kim, E.K., and Ko, Y.H. (2020). SLAMF1 contributes to cell survival through the AKT signaling pathway in Farage cells. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0238791"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"24621","DOI":"10.18632\/oncotarget.15600","article-title":"LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells","volume":"8","author":"Yoon","year":"2017","journal-title":"Oncotarget"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"22947","DOI":"10.18632\/aging.203587","article-title":"A novel prognostic signature based on immune-related genes of diffuse large B-cell lymphoma","volume":"13","author":"Wu","year":"2021","journal-title":"Aging"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jcyt.2023.07.002","article-title":"2B4 inhibits the apoptosis of natural killer cells through phosphorylated extracellular signal-related kinase\/B-cell lymphoma 2 signal pathway","volume":"25","author":"Mou","year":"2023","journal-title":"Cytotherapy"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-025-02308-8","article-title":"SLAMF receptors: Key regulators of tumor progression and emerging targets for cancer immunotherapy","volume":"24","author":"Li","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/bjh.17383","article-title":"Pathogenesis of follicular lymphoma: Genetics to the microenvironment to clinical translation","volume":"194","author":"Kumar","year":"2021","journal-title":"Br. J. Haematol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41580-018-0089-8","article-title":"Regulation of apoptosis in health and disease: The balancing act of BCL-2 family proteins","volume":"20","author":"Singh","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"BSR20190604","DOI":"10.1042\/BSR20190604","article-title":"BCL11A: A potential diagnostic biomarker and therapeutic target in human diseases","volume":"39","author":"Yin","year":"2019","journal-title":"Biosci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1182\/blood.V98.12.3413","article-title":"The BCL11 gene family: Involvement of BCL11A in lymphoid malignancies","volume":"98","author":"Satterwhite","year":"2001","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eaav5599","DOI":"10.1126\/scitranslmed.aav5599","article-title":"Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma","volume":"11","author":"Jain","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Frezzato, F., Gattazzo, C., Martini, V., Trimarco, V., Teramo, A., Carraro, S., Cabrelle, A., Ave, E., Facco, M., and Zambello, R. (2012). HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039902"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/gcc.22004","article-title":"t(11;14)(q23;q32) involving IGH and DDX6 in nodal marginal zone lymphoma","volume":"52","author":"Stary","year":"2013","journal-title":"Genes. Chromosom. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/bjh.16102","article-title":"Molecular pathogenesis of chronic lymphocytic leukaemia","volume":"186","author":"Crassini","year":"2019","journal-title":"Br. J. Haematol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41571-019-0239-8","article-title":"Chronic lymphocytic leukaemia: From genetics to treatment","volume":"16","author":"Bosch","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/leu.2011.357","article-title":"Dysregulation of TNFalpha-induced necroptotic signaling in chronic lymphocytic leukemia: Suppression of CYLD gene by LEF1","volume":"26","author":"Liu","year":"2012","journal-title":"Leukemia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1182\/blood-2014-01-552067","article-title":"Somatic mutation as a mechanism of Wnt\/beta-catenin pathway activation in CLL","volume":"124","author":"Wang","year":"2014","journal-title":"Blood"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000355714","article-title":"UGT1A1*28 polymorphism in chronic lymphocytic leukemia: The first investigation of the polymorphism in disease susceptibility and its specific cytogenetic abnormalities","volume":"132","author":"Karakosta","year":"2014","journal-title":"Acta Haematol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/ng.219","article-title":"A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia","volume":"40","author":"Broderick","year":"2008","journal-title":"Nat. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ajhg.2017.02.003","article-title":"Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits","volume":"100","author":"Yao","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"Vosa","year":"2021","journal-title":"Nat. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(05)70434-4","article-title":"Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: A report from the InterLymph Consortium","volume":"7","author":"Rothman","year":"2006","journal-title":"Lancet Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/10\/1536\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:50:24Z","timestamp":1779108624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/10\/1536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["cancers18101536"],"URL":"https:\/\/doi.org\/10.3390\/cancers18101536","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]}}}