{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:14:03Z","timestamp":1778577243638,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tunisian Ministry of Higher Education and Scientific Research","award":["LR16IPT09"],"award-info":[{"award-number":["LR16IPT09"]}]},{"name":"Pasteur Institute of Tunisia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: The rapid expansion of targeted therapies has reshaped oncology by exploiting ligand-receptor interactions (LRI) to improve treatment specificity and patient outcomes. However, the data describing these ligands remain fragmented across multiple sources, limiting accessibility for researchers and clinicians. To address this gap, we developed the OncoSolidDB, the first curated and oncology-focused bioinformatics database dedicated to ligands associated with solid malignancies. Methods: OncoSolidDB integrates and harmonizes data from reliable repositories, including ChEMBL, DrugBank and the Anti-Cancer Fund, consolidating curated structural, chemical, pharmacological, and clinical annotations along with standardized identifiers. Results: The database currently encompasses 243 ligands across 15 major solid tumor types including breast, lung, colorectal, melanoma, prostate, gastric, ovarian, cervical, bladder, esophageal, head and neck, thyroid, pancreatic, renal and liver cancer (Hepatocellular Carcinoma, HCC). Each entry is annotated by standardized identifiers (DrugBank, ChEMBL), approval year, chemical structures (SMILES strings, 2D images), and downloadable protein structure files (PDB format). Temporal coverage spans 1953\u20132025, enabling exploration of historical trends in oncology drug approvals. The database content is suitable for bioinformatics analysis, molecular docking, virtual screening, ligand-based modeling, and drug repurposing studies. Outputs are available through a freely accessible web interface that supports search browsing by cancer type. Conclusions: By consolidating oncology-specific ligand data into a single, structured platform, OncoSolidDB offers a valuable resource for advancing drug discovery, repurposing strategies, and the rational design of next-generation targeted therapies for solid tumors. OncoSolidDB is accessible via our Bioinformatics Research PortalEinstein.<\/jats:p>","DOI":"10.3390\/cancers18101559","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:49:09Z","timestamp":1778572149000},"page":"1559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OncoSolidDB: An Oncology-Focused Curated Database of Ligand\u2013Target Interactions for Precision Medicine Across Major Solid Cancers"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-5705","authenticated-orcid":false,"given":"Oussema","family":"Khamessi","sequence":"first","affiliation":[{"name":"Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS-LAB) (LR16IPT09), Institut Pasteur de Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, Tunis 1002, Tunisia"},{"name":"Higher Institute of Biotechnology Sidi Thabet ISBST, BiotechP\u00f4le, BP-66, University of Manouba, Ariana  2020, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2038-2556","authenticated-orcid":false,"given":"Rihab","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS-LAB) (LR16IPT09), Institut Pasteur de Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, Tunis 1002, Tunisia"},{"name":"Higher Institute of Biotechnology Sidi Thabet ISBST, BiotechP\u00f4le, BP-66, University of Manouba, Ariana  2020, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7823-1540","authenticated-orcid":false,"given":"Ghada","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS-LAB) (LR16IPT09), Institut Pasteur de Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, Tunis 1002, Tunisia"},{"name":"Higher Institute of Biotechnology Sidi Thabet ISBST, BiotechP\u00f4le, BP-66, University of Manouba, Ariana  2020, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-6493","authenticated-orcid":false,"given":"Kais","family":"Ghedira","sequence":"additional","affiliation":[{"name":"Laboratory of Bioinformatics, Biomathematics and Biostatistics (BIMS-LAB) (LR16IPT09), Institut Pasteur de Tunis, University of Tunis El Manar, 13 Place Pasteur, BP74, Tunis 1002, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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