{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:54:50Z","timestamp":1789646090164,"version":"4.0.0"},"reference-count":79,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Formidable Partners"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Talc, commonly used in products like baby powder and cosmetics, has been studied for a possible link to female genital cancers, especially ovarian cancer. However, evidence is inconclusive. We conducted a systematic review and meta-analysis to assess the association between talc exposure and the incidence and mortality of ovarian, cervical, and endometrial cancers, including ovarian cancer subtypes. Method: We searched MEDLINE (PubMed) and SCOPUS databases up to January 2026 for cohort and case\u2013control studies. Studies were assessed for quality using a modified Newcastle\u2013Ottawa Scale. Due to the nature of available data, meta-analysis was performed only on case\u2013control studies on ovarian cancer, using a random-effects model. Publication bias was assessed through funnel plots and Egger\u2019s test, and a leave-one-out sensitivity analysis was performed. Stratified analyses were conducted based on geographic location, year of publication, exposure source, and tumor characteristics. Additionally, a two-stage dose\u2013response meta-analysis was performed for ovarian cancer regarding frequency and duration of talc use. Results: Our review identified 37 studies related to ovarian cancer, one to cervical cancer, and six to endometrial cancer. Twenty-five case\u2013control studies were included in the meta-analysis. Results showed a positive association between talc use and ovarian cancer risk (RR 1.32; 95% CI: 1.25\u20131.39), with stronger associations observed for women who applied talc directly to the genital area (RR 1.38) and those who used talc after bathing (RR 1.30). The risk was also higher for specific ovarian cancer subtypes, such as serous (RR 1.36) and endometrioid tumors (RR 1.35). No evidence of publication bias was found. Results of the pooled analysis of four cohort studies showed no association (RR for ever-use 1.08; 95% CI: 0.99\u20131.17, no trend according to duration or frequency of use). For cervical and endometrial cancers, no significant associations with talc exposure were observed. Conclusions: Case\u2013control studies suggest a modest link between genital talc use and ovarian cancer risk, especially serous and endometrioid types. Cohort studies show no association, and no links were found for cervical or endometrial cancers. Accordingly, the results should be interpreted with caution, and the current evidence does not conclusively establish a causal relationship.<\/jats:p>","DOI":"10.3390\/cancers18101589","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:26:37Z","timestamp":1778689597000},"page":"1589","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Talc Exposure and Risk of Ovarian Cancer: A Systematic Review and Meta-Analysis with Limited Evidence on Cervical and Endometrial Cancers"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-9128","authenticated-orcid":false,"given":"Monireh Sadat","family":"Seyyedsalehi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Anthony","family":"Powley","sequence":"additional","affiliation":[{"name":"Formidable Partners, Boston, MA 01741, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3811-2791","authenticated-orcid":false,"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy"},{"name":"Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA"},{"name":"Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.3892\/ol.2020.11754","article-title":"Cervical cancer in low and middle-income countries","volume":"20","author":"Hull","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102983","DOI":"10.1016\/j.eclinm.2024.102983","article-title":"Worldwide patterns and trends in ovarian cancer incidence by histological subtype: A population-based analysis from 1988 to 2017","volume":"79","author":"Wei","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJWH.S197604","article-title":"Ovarian cancer in the world: Epidemiology and risk factors","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"04155","DOI":"10.7189\/jogh.14.04155","article-title":"Global burden of gynaecological cancers in 2022 and projections to 2050","volume":"14","author":"Zhu","year":"2024","journal-title":"J. Glob. Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13045-025-01660-y","article-title":"Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021","volume":"18","author":"Li","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"ref_7","first-page":"67","article-title":"Gynecologic cancers: Part I\u2014Risk Factors","volume":"4","author":"Lee","year":"2000","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12032-023-01957-3","article-title":"Epidemiological trends and risk factors of gynecological cancers: An update","volume":"40","author":"Keyvani","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_9","first-page":"e2024043","article-title":"Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure and Risk of Breast, and Female Genital Cancers: A Systematic Review and Meta-Analysis","volume":"115","author":"Seyyedsalehi","year":"2024","journal-title":"Med. Lav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/bs.apha.2021.03.008","article-title":"Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models","volume":"92","author":"Laws","year":"2021","journal-title":"Adv. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5604\/12321966.1152077","article-title":"Impact of heavy metals on the female reproductive system","volume":"22","author":"Rzymski","year":"2015","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.envpol.2015.07.001","article-title":"Reproductive endocrine-disrupting effects of triclosan: Population exposure, present evidence and potential mechanisms","volume":"206","author":"Wang","year":"2015","journal-title":"Environ. Pollut."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/CEJ.0000000000000340","article-title":"Genital use of talc and risk of ovarian cancer: A meta-analysis","volume":"27","author":"Berge","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.reprotox.2019.08.015","article-title":"Critical review of the association between perineal use of talc powder and risk of ovarian cancer","volume":"90","author":"Taher","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/10937404.2020.1755402","article-title":"A critical review of talc and ovarian cancer","volume":"23","author":"Goodman","year":"2020","journal-title":"J. Toxicol. Environ. Health Part B"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Seyyedsalehi, M., Powley, W., and Boffetta, P. (2026). Occupational exposure to asbestos-free talc and risk of respiratory cancers, including larynx, lung and mesothelioma: A systematic review and meta-analysis. J. Thorac. Oncol., 103710. in press.","DOI":"10.1016\/j.jtho.2026.103710"},{"key":"ref_17","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2014). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses, Ottawa Health Research Institute."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_21","unstructured":"Rothman, K.J., Greenland, S., and Lash, T.L. (2008). Meta-analysis. Modern Epidemiology, Wolters Kluwer. [3rd ed.]."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/jnci\/92.3.249","article-title":"Prospective Study of Talc Use and Ovarian Cancer","volume":"92","author":"Gertig","year":"2000","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/aje\/kwp314","article-title":"Risk Factors for Epithelial Ovarian Cancer by Histologic Subtype","volume":"171","author":"Gates","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"dju208","DOI":"10.1093\/jnci\/dju208","article-title":"Perineal Powder Use and Risk of Ovarian Cancer","volume":"106","author":"Houghton","year":"2014","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/EDE.0000000000000528","article-title":"Douching, Talc Use, and Risk of Ovarian Cancer","volume":"27","author":"Gonzalez","year":"2016","journal-title":"Epidemiology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.2019.20079","article-title":"Association of Powder Use in the Genital Area with Risk of Ovarian Cancer","volume":"323","author":"Tworoger","year":"2020","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/1097-0142(19820715)50:2<372::AID-CNCR2820500235>3.0.CO;2-S","article-title":"Ovarian cancer and talc. A case-control study","volume":"50","author":"Cramer","year":"1982","journal-title":"Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/oxfordjournals.aje.a115077","article-title":"Personal and environmental characteristics related to epithelial ovarian cancer. II. Exposures to talcum powder, tobacco, alcohol, and coffee","volume":"128","author":"Whittemore","year":"1988","journal-title":"Am. J. Epidemiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/bjc.1989.320","article-title":"Risk factors for ovarian cancer: A case-control study","volume":"60","author":"Booth","year":"1989","journal-title":"Br. J. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/oxfordjournals.aje.a115345","article-title":"A case-control study of borderline ovarian tumors: The influence of perineal exposure to talc","volume":"130","author":"Harlow","year":"1989","journal-title":"Am. J. Epidemiol."},{"key":"ref_31","first-page":"19","article-title":"Perineal exposure to talc and ovarian cancer risk","volume":"80","author":"Harlow","year":"1992","journal-title":"Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0090-8258(92)90485-2","article-title":"Mineral fiber exposure and the development of ovarian cancer","volume":"45","author":"Rosenblatt","year":"1992","journal-title":"Gynecol. Oncol."},{"key":"ref_33","first-page":"23","article-title":"Risk Factors for Epithelial Ovarian Cancer in Beijing, China","volume":"21","author":"Chen","year":"1992","journal-title":"Leuk. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/ijc.2910550313","article-title":"Hair dyes, analgesics, tranquilizers and perineal talc application as risk factors for ovarian cancer","volume":"55","author":"Tzonou","year":"1993","journal-title":"Int. J. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ijc.2910620606","article-title":"Reproductive and other factors and risk of epithelial ovarian cancer: An australian case-control study","volume":"62","author":"Purdie","year":"1995","journal-title":"Int. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/1047-2797(94)00098-E","article-title":"Epidemiologic evidence for uterine growth factors in the pathogenesis of ovarian cancer","volume":"5","author":"Cramer","year":"1995","journal-title":"Ann. Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/oxfordjournals.aje.a009128","article-title":"Perineal Powder Exposure and the Risk of Ovarian Cancer","volume":"145","author":"Cook","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1002\/(SICI)1097-0142(19970615)79:12<2396::AID-CNCR15>3.0.CO;2-M","article-title":"Perineal talc exposure and risk of ovarian carcinoma","volume":"79","author":"Chang","year":"1997","journal-title":"Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0002-9378(98)70372-2","article-title":"Risk factors for familial and sporadic ovarian cancer among French Canadians: A case-control study","volume":"179","author":"Godard","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_40","first-page":"372","article-title":"Perineal talc exposure and subsequent epithelial ovarian cancer: A case-control study","volume":"93","author":"Wong","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<351::AID-IJC7>3.0.CO;2-M","article-title":"Genital talc exposure and risk of ovarian cancer","volume":"81","author":"Cramer","year":"1999","journal-title":"Int. J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00001648-200003000-00006","article-title":"Factors Related to Inflammation of the Ovarian Epithelium and Risk of Ovarian Cancer","volume":"11","author":"Ness","year":"2000","journal-title":"Epidemiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ijc.20434","article-title":"Perineal talc exposure and epithelial ovarian cancer risk in the Central Valley of California","volume":"112","author":"Mills","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5271\/sjweh.823","article-title":"Ovarian cancer and occupational exposure among pulp and paper employees in Norway","volume":"30","author":"Langseth","year":"2004","journal-title":"Scand. J. Work. Environ. Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1158\/1055-9965.EPI-05-0035","article-title":"Conditions associated with antibodies against the tumor-associated antigen MUC1 and their relationship to risk for ovarian cancer","volume":"14","author":"Cramer","year":"2005","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/ijc.23017","article-title":"Australian Cancer Study (Ovarian Cancer); Australian Ovarian Cancer Study Group. Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer","volume":"122","author":"Merritt","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1158\/1055-9965.EPI-08-0399","article-title":"Talc Use, Variants of the GSTM1, GSTT1, and NAT2 Genes, and Risk of Epithelial Ovarian Cancer","volume":"17","author":"Gates","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/aje\/kwp176","article-title":"Ovarian Cancer Risk Factors in African-American and White Women","volume":"170","author":"Moorman","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_49","first-page":"737","article-title":"Genital powder exposure and the risk of epithelial ovarian cancer","volume":"22","author":"Rosenblatt","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1158\/1055-9965.EPI-12-0426","article-title":"Use of Fertility Drugs and Risk of Ovarian Cancer: Results from a U.S.-Based Case\u2013Control Study","volume":"21","author":"Kurta","year":"2012","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1158\/1940-6207.CAPR-13-0037","article-title":"Genital Powder Use and Risk of Ovarian Cancer: A Pooled Analysis of 8525 Cases and 9859 Controls","volume":"6","author":"Terry","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1158\/1055-9965.EPI-15-0023","article-title":"African Americans and Hispanics Remain at Lower Risk of Ovarian Cancer Than Non-Hispanic Whites after Considering Nongenetic Risk Factors and Oophorectomy Rates","volume":"24","author":"Wu","year":"2015","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/EDE.0000000000000434","article-title":"The Association Between Talc Use and Ovarian Cancer: A Retrospective Case-Control Study in Two US States","volume":"27","author":"Cramer","year":"2016","journal-title":"Epidemiology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-15-1281","article-title":"Association between Body Powder Use and Ovarian Cancer: The African American Cancer Epidemiology Study (AACES)","volume":"25","author":"Schildkraut","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1158\/1055-9965.EPI-19-0375","article-title":"Douching, Talc Use, and Risk for Ovarian Cancer and Conditions Related to Genital Tract Inflammation","volume":"28","author":"Gabriel","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1158\/1055-9965.EPI-21-0162","article-title":"Genital Powder Use and Risk of Epithelial Ovarian Cancer in the Ovarian Cancer in Women of African Ancestry Consortium","volume":"30","author":"Davis","year":"2021","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.fertnstert.2022.07.019","article-title":"Effects of risk factors for ovarian cancer in women with and without endometriosis","volume":"118","author":"Phung","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1136\/oemed-2022-108557","article-title":"Occupational environment and ovarian cancer risk","volume":"80","author":"Leung","year":"2023","journal-title":"Occup. Environ. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1002\/ijc.33470","article-title":"Genital powder use and risk of uterine cancer: A pooled analysis of prospective studies","volume":"148","author":"Tworoger","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1158\/1055-9965.EPI-09-1221","article-title":"Perineal use of talcum powder and endometrial cancer risk","volume":"19","author":"Karageorgi","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_61","first-page":"1673","article-title":"Perineal powder use and risk of endometrial cancer in postmenopausal women","volume":"23","author":"Crawford","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/EDE.0000000000001078","article-title":"Perineal Talc Use, Douching, and the Risk of Uterine Cancer","volume":"30","author":"Shi","year":"2019","journal-title":"Epidemiology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1200\/JCO.23.02037","article-title":"Intimate Care Products and Incidence of Hormone-Related Cancers: A Quantitative Bias Analysis","volume":"42","author":"Wentzensen","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_64","first-page":"513","article-title":"Use of talcum powder and endometrial cancer risk","volume":"23","author":"Neill","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"14836","DOI":"10.1038\/s41598-021-94447-3","article-title":"The association between douching, genital talc use, and the risk of prevalent and incident cervical cancer","volume":"11","author":"Weinberg","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14737140.2024.2352506","article-title":"Is there a link between talcum powder, oxidative stress, and ovarian cancer risk?","volume":"24","author":"Saed","year":"2024","journal-title":"Expert Rev. Anticancer. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"108676","DOI":"10.1016\/j.envres.2019.108676","article-title":"The effect of talc particles on phagocytes in co-culture with ovarian cancer cells","volume":"180","author":"Mandarino","year":"2019","journal-title":"Environ. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/ajcp\/aqz080","article-title":"Migration of Talc from the Perineum to Multiple Pelvic Organ Sites","volume":"152","author":"McDonald","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.taap.2018.01.018","article-title":"Safety assessment of starch-based personal care products: Nanocapsules and pickering emulsions","volume":"342","author":"Marto","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/10408444.2025.2585870","article-title":"The IARC re-classification of talc carcinogenicity: A move in the wrong direction?","volume":"55","author":"Korchevskiy","year":"2025","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/EDE.0000000000000745","article-title":"Perineal Talc Use and Ovarian Cancer: A Systematic Review and Meta-Analysis","volume":"29","author":"Penninkilampi","year":"2018","journal-title":"Epidemiology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ygyno.2021.07.032","article-title":"Talc, body powder, and ovarian cancer: A summary of the epidemiologic evidence","volume":"163","author":"Wentzensen","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1007\/s11606-022-07414-7","article-title":"Association Between the Frequent Use of Perineal Talcum Powder Products and Ovarian Cancer: A Systematic Review and Meta-analysis","volume":"37","author":"Woolen","year":"2022","journal-title":"J. Gen. Intern. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Lynch, H.N., Lauer, D.J., Leleck, O.M., Freid, R.D., Collins, J., Chen, K., Thompson, W.J., Ierardi, A.M., Urban, A., and Boffetta, P. (2023). Systematic review of the association between talc and female reproductive tract cancers. Front. Toxicol., 5.","DOI":"10.3389\/ftox.2023.1157761"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/10408444.2024.2351081","article-title":"A systematic review of the epidemiology evidence on talc and cancer","volume":"54","author":"Boon","year":"2024","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Tsokkou, S., Matsas, A., Konstantinidis, I., Stamoula, E., Stavros, S., Karopoulou, E., Potiris, A., and Troupis, T. (2025). Decoding the Link Between Talcum Powder and Ovarian Cancer: A Comprehensive Review. J. Clin. Med., 14.","DOI":"10.3390\/jcm14165746"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100203","DOI":"10.1016\/j.gloepi.2025.100203","article-title":"Talc, ovarian cancer, and recall bias in the sister study","volume":"9","author":"Goodman","year":"2025","journal-title":"Glob. Epidemiol."},{"key":"ref_78","unstructured":"IARC (International Agency for Research on Cancer) (2010). Carbon black, titanium dioxide, and talc. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, International Agency for Research on Cancer."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S1470-2045(24)00384-X","article-title":"Carcinogenicity of talc and acrylonitrile","volume":"25","author":"Stayner","year":"2024","journal-title":"Lancet Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/10\/1589\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:36:56Z","timestamp":1779269816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/10\/1589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":79,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["cancers18101589"],"URL":"https:\/\/doi.org\/10.3390\/cancers18101589","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}