{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:02:38Z","timestamp":1779771758263,"version":"3.53.1"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Minnesota Department of Medicine Women\u2019s Early Research Career program"},{"name":"Marrow on the Move"},{"name":"Hematology, Oncology, Transplantation Translational Team Science Award"},{"name":"OHSU Center for Women\u2019s Health Circle of Giving"},{"DOI":"10.13039\/100007269","name":"OHSU School of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"OHSU Integrated Genomics Laboratory","award":["SCR_022651"],"award-info":[{"award-number":["SCR_022651"]}]},{"name":"KCVI Epigenetics Consortium"},{"name":"Oregon National Primate Research Center Bioinformatics & Biostatistics Core","award":["P51 OD011092"],"award-info":[{"award-number":["P51 OD011092"]}]},{"name":"Knight Cancer Institute Biostatistics Shared Resource","award":["P30 CA069533"],"award-info":[{"award-number":["P30 CA069533"]}]},{"name":"laboratory of Scott W. Wong","award":["R01 CA275042"],"award-info":[{"award-number":["R01 CA275042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Chemotherapy and radiation accelerate aging of multiple systems, including the immune and musculoskeletal systems. Resistance training may mitigate some of the late physiologic effects of cancer therapy. Methods: We developed a community-based pilot study of resistance training for long-term cancer survivors meeting criteria for pre-frailty or frailty (N = 8; 6 allogeneic hematopoietic cell transplant, 1 autologous hematopoietic transplant, 1 breast cancer survivor) and their caregivers (N = 8 healthy controls) consisting of a baseline assessment, 10 weeks of personalized resistance training at least once weekly as a group and as many additional times on an individual basis as their schedule allowed, and an end-of-study assessment to measure change in strength and body composition. Blood samples were collected at the start of the study and after the 10-week training program to assess changes in peripheral blood mononuclear cell DNA methylation patterns, gene expression measured by RNA sequencing, and stool microbiome analysis using metagenomics. The median number of resistance training sessions was 25 sessions. Results: Cancer survivors and controls both more than doubled their squat and press volume after 10 weeks. At baseline, cancer survivors exhibited a pro-inflammatory transcriptomic and epigenetic profile with elevated interferon signaling and reduced na\u00efve T cell signatures compared to healthy controls, consistent with immune senescence. After 10 weeks of resistance training, these differences normalized, suggesting that exercise exerted anti-inflammatory and immune-restorative effects in cancer survivors at both gene expression and methylation levels. Ten fecal microbial pathways that were lower in relative abundance in patients compared with controls at baseline were no longer significantly different post-exercise. Conclusions: Our data suggest that in addition to beneficial changes in body composition, resistance training may exert an immune restorative effect in cancer survivors.<\/jats:p>","DOI":"10.3390\/cancers18111710","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:30:33Z","timestamp":1779669033000},"page":"1710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuation of Immune Senescence Markers After Intensive Cancer Therapy Through Resistance Training: A Pilot Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Laura F.","family":"Newell","sequence":"first","affiliation":[{"name":"Knight Cancer Institute, Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Twohey","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Sweetnam","sequence":"additional","affiliation":[{"name":"Personal Trainer, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Skendzel","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Stingle","sequence":"additional","affiliation":[{"name":"M Health Fairview, Nutrition Services, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina A.","family":"Vartanian","sequence":"additional","affiliation":[{"name":"Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Ray","sequence":"additional","affiliation":[{"name":"Bioinformatics & Biostatistics Core, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97239, USA"},{"name":"Biostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-2890","authenticated-orcid":false,"given":"Suzanne S.","family":"Fei","sequence":"additional","affiliation":[{"name":"Bioinformatics & Biostatistics Core, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97239, USA"},{"name":"Biostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Karstens","sequence":"additional","affiliation":[{"name":"Biostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA"},{"name":"Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA"},{"name":"Division of Informatics, Clinical Epidemiology and Translational Data Science, Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"He","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-9655","authenticated-orcid":false,"given":"Najla","family":"El Jurdi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-4810","authenticated-orcid":false,"given":"Anne H.","family":"Blaes","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Meyers","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute, Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR 97239, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel J.","family":"Cook","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute, Hematology and Medical Oncology, Oregon 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