{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:29:12Z","timestamp":1787682552151,"version":"build-2784847793"},"reference-count":98,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer-associated thrombosis (CAT) is a leading cause of morbidity and mortality in patients with malignancy, yet its imaging manifestations extend far beyond the conventional diagnosis of deep vein thrombosis and pulmonary embolism. This comprehensive review examines the full spectrum of CAT as encountered by radiologists, from routine venous thromboembolism to unusual-site thromboses, arterial thromboembolic events, catheter-related complications, and endovascular management strategies. Patients with cancer face a four- to seven-fold increased risk of venous thromboembolism compared with the general population, and arterial thromboembolism occurs at more than twice the expected rate, particularly within the first six months following cancer diagnosis. The radiologist\u2019s role spans detection, characterization, and therapeutic guidance across multiple vascular territories. Key diagnostic challenges addressed include the distinction between bland and tumor thrombus\u2014a determination with direct implications for TNM staging, surgical planning, and systemic therapy selection\u2014and the recognition of incidental thromboembolism, which carries prognostic weight equivalent to symptomatic events and warrants similar clinical management. Emerging applications of diffusion-weighted MRI, contrast-enhanced ultrasound, and FDG-PET\/CT provide a multiparametric toolkit for thrombus characterization, while artificial intelligence and machine learning show promise for improving patient selection and reducing unnecessary imaging. The expanding recognition of cancer-associated arterial disease, including cerebrovascular, coronary, and peripheral arterial events, requires that cardiovascular structures receive systematic attention on routine oncologic imaging. Interventional radiology contributes actively to CAT management through inferior vena cava filtration, catheter-directed thrombolysis, and thrombolytic-sparing mechanical thrombectomy, the latter being particularly relevant in oncology patients with elevated bleeding risk. Conclusions: Realizing the full potential of imaging in CAT requires not only technical proficiency with individual modalities but a synthesized, oncology-informed interpretive approach that incorporates the patient\u2019s treatment history, biomarker status, and thrombotic risk profile at the time of image interpretation, positioning the radiologist as a central rather than peripheral figure in oncologic care.<\/jats:p>","DOI":"10.3390\/cancers18111732","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:02:51Z","timestamp":1779793371000},"page":"1732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["When Cancer Clots: An Extensive Radiologic Analysis of Cancer-Associated Thromboembolism"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-0842","authenticated-orcid":false,"given":"Joshua","family":"Brooks","sequence":"first","affiliation":[{"name":"Department of Radiology, University of Chicago, Chicago, IL 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3502-6529","authenticated-orcid":false,"given":"Ola A. E.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, NY 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia H.","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Chicago, Chicago, IL 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidy","family":"Megahed","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-1937","authenticated-orcid":false,"given":"Ahmed","family":"Hamimi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Chicago, Chicago, IL 79409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jjcc.2018.02.011","article-title":"Mechanism and management of cancer-associated thrombosis","volume":"72","author":"Mukai","year":"2018","journal-title":"J. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0049-3848(16)30092-5","article-title":"Cancer associated thrombosis: Risk factors and outcomes","volume":"140","author":"Eichinger","year":"2016","journal-title":"Thromb. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100739","DOI":"10.1016\/j.lanepe.2023.100739","article-title":"Impact of venous thromboembolism on the mortality in patients with cancer: A population-based cohort study","volume":"34","author":"Sorensen","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11912-019-0767-5","article-title":"Anticoagulation in Cancer Patients: A Summary of Pitfalls to Avoid","volume":"21","author":"Patel","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jacc.2017.06.047","article-title":"Risk of Arterial Thromboembolism in Patients With Cancer","volume":"70","author":"Navi","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1053\/j.seminhematol.2011.08.005","article-title":"Unusual site thrombosis","volume":"48","author":"Donadini","year":"2011","journal-title":"Semin. Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1160\/TH10-12-0789","article-title":"Symptomatic and incidental thromboembolism are both associated with mortality in pancreatic cancer","volume":"106","author":"Menapace","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaccao.2021.03.001","article-title":"Venous and Arterial Thromboembolism in Patients With Cancer: JACC: CardioOncology State-of-the-Art Review","volume":"3","author":"Gervaso","year":"2021","journal-title":"JACC CardioOncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/archinte.166.4.458","article-title":"Incidence of venous thromboembolism and its effect on survival among patients with common cancers","volume":"166","author":"Chew","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJM200012213432504","article-title":"Prognosis of cancers associated with venous thromboembolism","volume":"343","author":"Sorensen","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e00229","DOI":"10.1016\/j.heliyon.2016.e00229","article-title":"Analysis of clinical factors affecting the rates of fatal pulmonary embolism and bleeding in cancer patients with venous thromboembolism","volume":"3","author":"Martos","year":"2017","journal-title":"Heliyon"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jtha.2023.02.029","article-title":"Cancer-associated thrombosis: Enhanced awareness and pathophysiologic complexity","volume":"21","author":"Falanga","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.thromres.2020.06.034","article-title":"Performance of 18F-fluorodesoxyglucose positron-emission tomography\/computed tomography for cancer screening in patients with unprovoked venous thromboembolism: Results from an individual patient data meta-analysis","volume":"194","author":"Robin","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1470-2045(15)00480-5","article-title":"Limited screening with versus without 18F-fluorodeoxyglucose PET\/CT for occult malignancy in unprovoked venous thromboembolism: An open-label randomised controlled trial","volume":"17","author":"Robin","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12959-025-00719-7","article-title":"Cancer-associated venous thromboembolism: A comprehensive review","volume":"23","author":"Wan","year":"2025","journal-title":"Thromb. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1001\/archinte.168.21.2377","article-title":"Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer","volume":"168","author":"Khorana","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1093\/eurheartj\/ehx003","article-title":"Diagnosis and management of acute deep vein thrombosis: A joint consensus document from the European Society of Cardiology working groups of aorta and peripheral vascular diseases and pulmonary circulation and right ventricular function","volume":"39","author":"Mazzolai","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1016\/S0140-6736(16)30514-1","article-title":"Deep vein thrombosis and pulmonary embolism","volume":"388","author":"Buller","year":"2016","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1160\/TH14-06-0530","article-title":"Venous thromboembolism diagnosis: Unresolved issues","volume":"113","author":"Righini","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"D\u2019Oria, M., Girardi, L., Amgad, A., Sherif, M., Piffaretti, G., Ruaro, B., Calvagna, C., Dueppers, P., Lepidi, S., and Donadini, M.P. (2025). Expert-Based Narrative Review on Compression UltraSonography (CUS) for Diagnosis and Follow-Up of Deep Venous Thrombosis (DVT). Diagnostics, 15.","DOI":"10.3390\/diagnostics15010082"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1148\/rg.2020200047","article-title":"Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion","volume":"40","author":"LeGout","year":"2020","journal-title":"Radiographics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.21037\/cdt.2017.12.01","article-title":"Imaging of acute pulmonary embolism: An update","volume":"8","author":"Moore","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1016\/j.thromres.2010.02.010","article-title":"Incidental venous thromboembolism in cancer patients: Prevalence and consequence","volume":"125","author":"Douma","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/j.1538-7836.2010.03929.x","article-title":"High rates of symptomatic and incidental thromboembolic events in gastrointestinal cancer patients","volume":"8","author":"Singh","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1538-7836.2011.04565.x","article-title":"Incidental diagnosis of a deep vein thrombosis in consecutive patients undergoing a computed tomography scan of the abdomen: A retrospective cohort study","volume":"10","author":"Ageno","year":"2012","journal-title":"J. Thromb. Haemost."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1200\/JCO.2010.34.0984","article-title":"Risk of recurrent venous thromboembolism and mortality in patients with cancer incidentally diagnosed with pulmonary embolism: A comparison with symptomatic patients","volume":"29","author":"Hooijer","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1002\/cncr.25941","article-title":"Incidence of pulmonary embolism in oncologic outpatients at a tertiary cancer center","volume":"117","author":"Shinagare","year":"2011","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.5853\/jos.2023.04098","article-title":"Inpatient Outcomes of Cerebral Venous Thrombosis in Patients With Malignancy Throughout the United States","volume":"26","author":"Vazqez","year":"2024","journal-title":"J. Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1161\/STR.0000000000000456","article-title":"Diagnosis and Management of Cerebral Venous Thrombosis: A Scientific Statement From the American Heart Association","volume":"55","author":"Saposnik","year":"2024","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1055\/s-0040-1722607","article-title":"Cancer-Associated Splanchnic Vein Thrombosis","volume":"47","author":"Cohen","year":"2021","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMra2207738","article-title":"Primary Budd-Chiari Syndrome","volume":"388","author":"Valla","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.3174\/ajnr.A4846","article-title":"Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)","volume":"37","author":"Finelli","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102393","DOI":"10.1016\/j.rpth.2024.102393","article-title":"Cancer and arterial thrombosis: Therapeutic options","volume":"8","author":"Cheong","year":"2024","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S1474-4422(25)00232-7","article-title":"Posterior reversible encephalopathy syndrome: Evolving insights in diagnosis, management, and outcomes","volume":"24","author":"Fugate","year":"2025","journal-title":"Lancet Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.jacc.2022.08.743","article-title":"Advances in Multimodality Imaging in Cardio-Oncology: JACC State-of-the-Art Review","volume":"80","author":"Baldassarre","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.thromres.2014.10.008","article-title":"Performance of 18F fluoro-2-desoxy-D-glucose positron emission tomography\/computed tomography for the diagnosis of venous thromboembolism","volume":"135","author":"Robin","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/CIRCULATIONAHA.114.008902","article-title":"18F-fluorodeoxyglucose positron emission tomography\/computed tomography enables the detection of recurrent same-site deep vein thrombosis by illuminating recently formed, neutrophil-rich thrombus","volume":"130","author":"Hara","year":"2014","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/RLU.0b013e3182638934","article-title":"18F-FDG PET in the evaluation of acuity of deep vein thrombosis","volume":"37","author":"Rondina","year":"2012","journal-title":"Clin. Nucl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/MNM.0b013e32834774c8","article-title":"18F-FDG PET-CT in the diagnosis of tumor thrombus: Can it be differentiated from benign thrombus?","volume":"32","author":"Sharma","year":"2011","journal-title":"Nucl. Med. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1097\/RLU.0b013e318266d53e","article-title":"The value of 18F-FDG PET\/contrast-enhanced CT in detection of tumor thrombus","volume":"38","author":"Lee","year":"2013","journal-title":"Clin. Nucl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/MNM.0000000000001708","article-title":"Role of 18F-FDG PET\/CT in the diagnosis of benign vs. malignant tumor thrombus","volume":"44","author":"Sarswat","year":"2023","journal-title":"Nucl. Med. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41598-021-04541-9","article-title":"Diagnostic value of 18F-FDG PET\/CT versus contrast-enhanced MRI for venous tumour thrombus and venous bland thrombus in renal cell carcinoma","volume":"12","author":"Zhu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/MNM.0000000000002090","article-title":"Imaging tumor thrombus across malignancies: Current concepts and the expanding role of PET\/computed tomography","volume":"47","author":"Kumar","year":"2026","journal-title":"Nucl. Med. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MD.0000000000000009","article-title":"The spectrum of paraneoplastic cutaneous vasculitis in a defined population: Incidence and clinical features","volume":"92","author":"Loricera","year":"2013","journal-title":"Medicine"},{"key":"ref_46","first-page":"294","article-title":"Paraneoplastic vasculitis in patients with solid tumors: Report of 15 cases","volume":"35","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10067-022-06363-0","article-title":"Cancer-associated vasculitides: A single-centre case series","volume":"42","author":"Do","year":"2023","journal-title":"Clin. Rheumatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1093\/rheumatology\/keae711","article-title":"Immune checkpoint inhibitors-associated vasculitis: A heterogeneous condition with possible severe disease course","volume":"64","author":"Chanson","year":"2025","journal-title":"Rheumatology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"152440","DOI":"10.1016\/j.semarthrit.2024.152440","article-title":"A scoping review of vasculitis as an immune-related adverse event from checkpoint inhibitor therapy of cancer: Unraveling the complexities at the intersection of immunology and vascular pathology","volume":"66","author":"Lee","year":"2024","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0140-6736(25)01436-9","article-title":"Large-vessel vasculitis","volume":"406","author":"Cacoub","year":"2025","journal-title":"Lancet"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2967\/jnumed.122.265016","article-title":"Role of 18F-FDG PET\/CT in Large Vessel Vasculitis and Polymyalgia Rheumatica","volume":"64","author":"Slart","year":"2023","journal-title":"J. Nucl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/art.40379","article-title":"18F-Fluorodeoxyglucose-Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis","volume":"70","author":"Grayson","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/rheumatology\/keab591","article-title":"Fluorodeoxyglucose positron emission tomography-computed tomography findings in a first series of 10 patients with polyarteritis nodosa","volume":"61","author":"Fagart","year":"2022","journal-title":"Rheumatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s10067-021-06039-1","article-title":"Imaging features of 18F-FDG PET\/CT in different types of systemic vasculitis","volume":"41","author":"Chen","year":"2022","journal-title":"Clin. Rheumatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41584-025-01252-7","article-title":"Arterial and venous thrombosis in systemic and monogenic vasculitis","volume":"21","author":"Bello","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e30615","DOI":"10.1016\/j.heliyon.2024.e30615","article-title":"Thrombosis in vasculitis: An updated review of etiology, pathophysiology, and treatment","volume":"10","author":"Zhu","year":"2024","journal-title":"Heliyon"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1007\/s10067-021-05790-9","article-title":"Mechanisms of thrombosis in ANCA-associated vasculitis","volume":"40","author":"Misra","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1007\/s10067-021-05589-8","article-title":"Incidence and risk factors of venous thromboembolism in ANCA-associated vasculitis: A metaanalysis and metaregression","volume":"40","author":"Hansrivijit","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1093\/rheumatology\/keab057","article-title":"Venous thromboembolism in ANCA-associated vasculitis: A population-based cohort study","volume":"60","author":"Liapi","year":"2021","journal-title":"Rheumatology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1148\/radiol.09090304","article-title":"Differentiation of malignant thrombus from bland thrombus of the portal vein in patients with hepatocellular carcinoma: Application of diffusion-weighted MR imaging","volume":"254","author":"Catalano","year":"2010","journal-title":"Radiology"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/lt.25345","article-title":"Distinguishing Tumor From Bland Portal Vein Thrombus in Liver Transplant Candidates With Hepatocellular Carcinoma: The A-VENA Criteria","volume":"25","author":"Sherman","year":"2019","journal-title":"Liver Transplant."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jama.2024.12848","article-title":"Renal Cell Carcinoma: A Review","volume":"332","author":"Rose","year":"2024","journal-title":"JAMA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jtcvs.2011.11.035","article-title":"Cardiovascular magnetic resonance imaging in assessment of intracaval and intracardiac extension of renal cell carcinoma","volume":"144","author":"Raj","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Expert Panel on Cardiac Imaging, Renapurkar, R.D., Rajiah, P.S., Bartel, T.B., El-Sherief, A.H., Francois, C.J., Hanneman, K., Hsu, J.Y., Jackson, C.D., and Lenge de Rosen, V. (2025). ACR Appropriateness Criteria\u00ae Imaging for Pulmonary Embolism, Known Clot. J. Am. Coll. Radiol., 22, S261\u2013S273.","DOI":"10.1016\/j.jacr.2025.02.028"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.amjmed.2015.01.027","article-title":"Peripherally Inserted Central Catheter-associated Deep Vein Thrombosis: A Narrative Review","volume":"128","author":"Fallouh","year":"2015","journal-title":"Am. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lopez-Rubio, M., Lago-Rodriguez, M.O., Ordieres-Ortega, L., Oblitas, C.M., Moragon-Ledesma, S., Alonso-Beato, R., Alvarez-Sala-Walther, L.A., and Galeano-Valle, F. (2024). A Comprehensive Review of Catheter-Related Thrombosis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13247818"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMcp1008740","article-title":"Deep-vein thrombosis of the upper extremities","volume":"364","author":"Kucher","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"483","DOI":"10.6004\/jnccn.2024.0046","article-title":"Cancer-Associated Venous Thromboembolic Disease, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology","volume":"22","author":"Streiff","year":"2024","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0140-6736(09)60220-8","article-title":"Management of occlusion and thrombosis associated with long-term indwelling central venous catheters","volume":"374","author":"Baskin","year":"2009","journal-title":"Lancet"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1016\/S1470-2045(22)00160-7","article-title":"2022 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer, including patients with COVID-19","volume":"23","author":"Farge","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1182\/blood-2016-08-693671","article-title":"How I treat central venous access device-related upper extremity deep vein thrombosis","volume":"129","author":"Rajasekhar","year":"2017","journal-title":"Blood"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1055\/s-0045-1812083","article-title":"Endovascular Management of Deep Venous Thrombosis in Cancer Patients","volume":"42","author":"Dongmo","year":"2025","journal-title":"Semin. Interv. Radiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1055\/s-0036-1581090","article-title":"The Role of Inferior Vena Cava Filters in Cancer Patients","volume":"33","author":"Pandhi","year":"2016","journal-title":"Semin. Interv. Radiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/1358863X211042930","article-title":"Catheter-directed thrombolysis for deep vein thrombosis: 2021 update","volume":"26","author":"Goldhaber","year":"2021","journal-title":"Vasc. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1056\/NEJMoa1615066","article-title":"Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis","volume":"377","author":"Vedantham","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s00270-024-03691-3","article-title":"Mechanical Venous Thrombectomy for Deep Venous Thrombosis in Cancer Patients: A Single-Center Retrospective Study","volume":"47","author":"Patel","year":"2024","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1161\/CIRCULATIONAHA.124.072364","article-title":"Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial","volume":"151","author":"Jaber","year":"2025","journal-title":"Circulation"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00330-022-09071-0","article-title":"Incidental pulmonary embolism in patients with cancer: Prevalence, underdiagnosis and evaluation of an AI algorithm for automatic detection of pulmonary embolism","volume":"33","author":"Wiklund","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/RLI.0000000000001122","article-title":"Implementation of an AI Algorithm in Clinical Practice to Reduce Missed Incidental Pulmonary Embolisms on Chest CT and Its Impact on Short-Term Survival","volume":"60","author":"Graeve","year":"2025","journal-title":"Investig. Radiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e2431067","DOI":"10.2214\/AJR.24.31067","article-title":"Prospective Evaluation of Artificial Intelligence Triage of Incidental Pulmonary Emboli on Contrast-Enhanced CT Examinations of the Chest or Abdomen","volume":"223","author":"Savage","year":"2024","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15814","DOI":"10.1038\/s41598-021-95249-3","article-title":"Deep learning for pulmonary embolism detection on computed tomography pulmonary angiogram: A systematic review and meta-analysis","volume":"11","author":"Soffer","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e230702","DOI":"10.1148\/radiol.230702","article-title":"Prospective Evaluation of AI Triage of Pulmonary Emboli on CT Pulmonary Angiograms","volume":"309","author":"Rothenberg","year":"2023","journal-title":"Radiology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1055\/s-0044-1785482","article-title":"Machine Learning as a Diagnostic and Prognostic Tool for Predicting Thrombosis in Cancer Patients: A Systematic Review","volume":"50","author":"Coroneos","year":"2024","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jtha.2024.11.001","article-title":"Machine learning models for risk prediction of cancer-associated thrombosis: A systematic review and meta-analysis","volume":"23","author":"Chen","year":"2025","journal-title":"J. Thromb. Haemost."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/s41591-024-03195-0","article-title":"DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism","volume":"30","author":"Jee","year":"2024","journal-title":"Nat. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e240885","DOI":"10.1148\/radiol.240885","article-title":"Constructing a Large Language Model to Generate Impressions from Findings in Radiology Reports","volume":"312","author":"Zhang","year":"2024","journal-title":"Radiology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e2513921","DOI":"10.1001\/jamanetworkopen.2025.13921","article-title":"Efficiency and Quality of Generative AI-Assisted Radiograph Reporting","volume":"8","author":"Huang","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41746-025-01671-6","article-title":"Patient perceptions of empathy in physician and artificial intelligence chatbot responses to patient questions about cancer","volume":"8","author":"Chen","year":"2025","journal-title":"npj Digit. Med."},{"key":"ref_89","first-page":"1","article-title":"Beyond the Algorithm: Quick review of Real-World Hurdles for Radiology AI","volume":"30","author":"Montasser","year":"2025","journal-title":"Cancer Ther. Oncol. Int. J."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Salehi, S., Keishing, V., Singh, Y., Wei, D., Khosravi, A., Habibi, P., Jagtap, J., and Erickson, B.J. (2026). Systematic Review: Agentic AI in Neuroradiology: Technical Promise with Limited Clinical Evidence. J. Imaging Inform. Med., ahead of print.","DOI":"10.1007\/s10278-025-01839-2"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1007\/s11604-025-01810-9","article-title":"Navigating the AI revolution: Will radiology sink or soar?","volume":"43","author":"Schlemmer","year":"2025","journal-title":"Jpn. J. Radiol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Diaz-Lorenzo, I., Alonso-Burgos, A., Friera Reyes, A., Pacios Blanco, R.E., de Benavides Bernaldo de Quiros, M.D.C., and Gallardo Madueno, G. (2024). Current Role of CT Pulmonary Angiography in Pulmonary Embolism: A State-of-the-Art Review. J. Imaging, 10.","DOI":"10.20944\/preprints202408.0042.v1"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"112311","DOI":"10.1016\/j.ejrad.2025.112311","article-title":"Recognising errors in AI implementation in radiology: A narrative review","volume":"191","author":"Stogiannos","year":"2025","journal-title":"Eur. J. Radiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41586-019-1799-6","article-title":"International evaluation of an AI system for breast cancer screening","volume":"577","author":"McKinney","year":"2020","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"100084","DOI":"10.1016\/j.metrad.2024.100084","article-title":"Unbiasing Fairness Evaluation of Radiology AI Model","volume":"2","author":"Liang","year":"2024","journal-title":"Meta Radiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e2549963","DOI":"10.1001\/jamanetworkopen.2025.49963","article-title":"Vulnerability of Large Language Models to Prompt Injection When Providing Medical Advice","volume":"8","author":"Lee","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Goisauf, M., and Cano Abadia, M. (2022). Ethics of AI in Radiology: A Review of Ethical and Societal Implications. Front. Big Data, 5.","DOI":"10.3389\/fdata.2022.850383"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Santra, S., Kukreja, P., Saxena, K., Gandhi, S., and Singh, O.V. (2024). Navigating regulatory and policy challenges for AI enabled combination devices. Front. Med. Technol., 6.","DOI":"10.3389\/fmedt.2024.1473350"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/11\/1732\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:17:02Z","timestamp":1779794222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/11\/1732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":98,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["cancers18111732"],"URL":"https:\/\/doi.org\/10.3390\/cancers18111732","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]}}}