{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:59:49Z","timestamp":1790197189016,"version":"4.1.0"},"reference-count":201,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>In this review, we explore the evolving role of endoscopic ultrasound (EUS) in diagnosing and managing pancretobiliary malignancies. For solid pancreatic lesions, techniques like fine-needle biopsy (FNB), contrast-enhanced EUS (CE-EUS), and macroscopic on-site evaluation (MOSE) improve sample quality and diagnostic accuracy. In cystic pancreatic lesions, fine-needle aspiration (FNA), molecular testing, and confocal laser endomicroscopy (nCLE) aid in distinguishing benign from malignant cysts. For cholangiocarcinoma, EUS guided sampling is more accurate than CT in assessing distal lesions and lymph node metastases, while combining EUS with magnetic resonance cholangiography (MRC) enhances diagnostic sensitivity. In gallbladder cancer, EUS surpasses CT and MRI in detecting lymphadenopathy and staging tumors. EUS-FNB (Fine needle biopsy) improves biopsy accuracy, especially for unresectable cases. These advancements highlight EUS as a critical tool for early cancer detection, staging, and tissue acquisition. Beyond diagnosis, EUS plays a pivotal therapeutic role in managing complications such as malignant biliary obstruction and gastric outlet obstruction, offering minimally invasive alternatives like EUS-guided biliary drainage and gastroenterostomy with high clinical success and improved patient outcomes.<\/jats:p>","DOI":"10.3390\/cancers18121864","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T02:32:46Z","timestamp":1780885966000},"page":"1864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of Endoscopic Ultrasonography in Management of Pancreaticobiliary Cancers: Recent Trends and Advances"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0461-6312","authenticated-orcid":false,"given":"Shivangini","family":"Duggal","sequence":"first","affiliation":[{"name":"Department of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz","family":"Kalas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6662-5883","authenticated-orcid":false,"given":"Mohamed H.","family":"Eldesouki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, New York Medical College at Saint Michael\u2019s Medical Center, Newark, NJ 07102, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-9172","authenticated-orcid":false,"given":"M. Ammar","family":"Kalas","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif E.","family":"Elhanafi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA"},{"name":"Division of Gastroenterology, University of Texas at Tyler School of Medicine, Tyler, TX 75708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(80)91122-8","article-title":"Ultrasonic endoscope","volume":"315","author":"Dimagno","year":"1980","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0016-5107(94)70113-X","article-title":"Endosonography-guided real-time fine-needle aspiration biopsy","volume":"40","author":"Wiersema","year":"1994","journal-title":"Gastrointest. Endosc."},{"key":"ref_3","first-page":"9","article-title":"Use of endoscopic ultrasonography in small pancreatic cancer","volume":"102","author":"Yasuda","year":"1984","journal-title":"Scand. J. Gastroenterol. Suppl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"E160","DOI":"10.1055\/s-0034-1377384","article-title":"Prospective, randomized, comparative study of delineation capability of radial scanning and curved linear array endoscopic ultrasound for the pancreaticobiliary region","volume":"2","author":"Kaneko","year":"2014","journal-title":"Endosc. Int. Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1053\/j.gastro.2017.12.046","article-title":"EUS-Guided Transluminal Interventions","volume":"154","author":"Siddiqui","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.3748\/wjg.v16.i23.2841","article-title":"Endoscopic ultrasound for the diagnosis of chronic pancreatitis","volume":"16","author":"Stevens","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3109\/00365521.2012.719930","article-title":"A comparison of electronic radial and curvilinear endoscopic ultrasonography in the detection of pancreatic malignant tumor","volume":"47","author":"Kanazawa","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cgh.2008.07.015","article-title":"Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal disease","volume":"6","author":"Gleeson","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3748\/wjg.v9.i3.612","article-title":"Endosonography with linear array instead of endoscopic retrograde cholangiography as the diagnostic tool in patients with moderate suspicion of common bile duct stones","volume":"9","author":"Kohut","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.gie.2005.11.042","article-title":"EUS diagnosis and simultaneous endoscopic retrograde cholangiography treatment of common bile duct stones by using an oblique-viewing echoendoscope","volume":"63","author":"Rocca","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jamaoncol.2024.1930","article-title":"Pancreatic Cancer Surveillance and Survival of High-Risk Individuals","volume":"10","author":"Blackford","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_12","unstructured":"American Cancer Society (2021, July 15). Key Statistics for Pancreatic Cancer. Available online: https:\/\/www.cancer.org\/cancer\/pancreatic-cancer\/about\/key-statistics.html."},{"key":"ref_13","first-page":"145","article-title":"Colorectal Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bpg.2007.10.022","article-title":"Cystic and solid lesions of the pancreas","volume":"22","author":"Degen","year":"2008","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.surg.2016.04.005","article-title":"Neuroendocrine tumors of the pancreas: Degree of cystic component predicts prognosis","volume":"160","author":"Cloyd","year":"2016","journal-title":"Surgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/modpathol.3800446","article-title":"Pancreatic ductal adenocarcinomas with cystic features: Neither rare nor uniform","volume":"18","author":"Kosmahl","year":"2005","journal-title":"Mod. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1016\/j.cgh.2019.04.046","article-title":"Endoscopic Ultrasound Placement of Preloaded Fiducial Markers Shortens Procedure Time Compared to Back-Loaded Markers","volume":"17","author":"Machicado","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.21037\/jovs.2016.07.10","article-title":"Endoscopic ultrasound of pancreatic lesions","volume":"2","author":"Chong","year":"2016","journal-title":"J. Vis. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.14366\/usg.22103","article-title":"The efficiency of contrast-enhanced endoscopic ultrasound (EUS) combined with EUS elastography for pancreatic cancer diagnosis: A systematic review and meta-analysis","volume":"42","author":"Shin","year":"2023","journal-title":"Ultrasonography"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13212","DOI":"10.3748\/wjg.v21.i47.13212","article-title":"Endoscopic ultrasound elastography: Current status and future perspectives","volume":"21","author":"Cui","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.gie.2021.06.028","article-title":"Contrast-enhanced EUS for the characterization of mural nodules within pancreatic cystic neoplasms: Systematic review and meta-analysis","volume":"94","author":"Lisotti","year":"2021","journal-title":"Gastrointest. Endosc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4103\/eus.eus_24_18","article-title":"Discriminating chronic pancreatitis from pancreatic cancer: Contrast-enhanced EUS and multidetector computed tomography in direct comparison","volume":"7","author":"Harmsen","year":"2018","journal-title":"Endosc. Ultrasound"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MPA.0000000000001966","article-title":"Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound","volume":"51","author":"Kataoka","year":"2022","journal-title":"Pancreas"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1007\/s00261-015-0458-0","article-title":"Non-hyperfunctioning pancreatic endocrine tumors: Multimodality imaging features with histopathological correlation","volume":"40","author":"Humphrey","year":"2015","journal-title":"Abdom. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/den.13944","article-title":"Tissue harmonic versus contrast-enhanced harmonic endoscopic ultrasonography for the diagnosis of pancreatic tumors: Prospective multicenter study","volume":"34","author":"Omoto","year":"2021","journal-title":"Dig. Endosc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s10620-021-06931-5","article-title":"Efficacy of Contrast-Enhanced Harmonic Endoscopic Ultrasound for Pancreatic Solid Tumors with a Combination of Qualitative and Quantitative Analyses: A Prospective Pilot Study","volume":"67","author":"Iwasa","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/den.13862","article-title":"Utility of contrast-enhanced harmonic endoscopic ultrasonography fo0r predicting the prognosis of pancreatic neuroendocrine neoplasms","volume":"33","author":"Ishikawa","year":"2020","journal-title":"Dig. Endosc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.11152\/mu-3503","article-title":"Quantitative contrast-enhanced endoscopic ultrasound in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine tumors: Can we predict survival using perfusion parameters? A pilot study","volume":"24","author":"Constantin","year":"2022","journal-title":"Med. Ultrason."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/MPA.0b013e3182153b8c","article-title":"Comparison between endoscopic ultrasound and magnetic resonance imaging for the staging of pancreatic cancer","volume":"40","author":"Shami","year":"2011","journal-title":"Pancreas"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4253\/wjge.v14.i1.35","article-title":"Current role of endoscopic ultrasound in the diagnosis and management of pancreatic cancer","volume":"14","author":"Salom","year":"2022","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.pan.2018.07.008","article-title":"Endoscopic ultrasound elastography in the diagnosis of pancreatic masses: A meta-analysis","volume":"18","author":"Zhang","year":"2018","journal-title":"Pancreatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4103\/eus.eus_25_20","article-title":"Do we need elastography for EUS?","volume":"9","author":"Dietrich","year":"2020","journal-title":"Endosc. Ultrasound"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/jgh.12292","article-title":"Clinical utility of endoscopic ultrasound elastography for identification of malignant pancreatic masses: A meta-analysis","volume":"28","author":"Ying","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_35","first-page":"513","article-title":"Diagnostic accuracy of fine-needle aspiration of solid pancreatic lesions guided by endoscopic ultrasound elastography","volume":"31","author":"Facciorusso","year":"2018","journal-title":"Ann. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Gheorghiu, M., Sparchez, Z., Rusu, I., Bolboac\u0103, S.D., Seicean, R., Pojoga, C., and Seicean, A. (2022). Direct Comparison of Elastography Endoscopic Ultrasound Fine-Needle Aspiration and B-Mode Endoscopic Ultrasound Fine-Needle Aspiration in Diagnosing Solid Pancreatic Lesions. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031302"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/den.13791","article-title":"Diagnostic performance of endoscopic ultrasonography-guided elastography for solid pancreatic lesions: Shear-wave measurements versus strain elastography with histogram analysis","volume":"33","author":"Ohno","year":"2020","journal-title":"Dig. Endosc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"E1063","DOI":"10.1055\/a-2405-1170","article-title":"Detective flow imaging endoscopic ultrasound for locating optimal puncture site for a poorly vascularized pancreatic mass","volume":"12","author":"Otsuka","year":"2024","journal-title":"Endosc. Int. Open"},{"key":"ref_39","first-page":"955","article-title":"Novel endoscopic ultrasonography imaging technique for visualizing microcirculation without contrast enhancement in subepithelial lesions: Prospective study","volume":"33","author":"Yamashita","year":"2020","journal-title":"Dig. Endosc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/eus.0000000000000076","article-title":"Detective flow imaging versus contrast-enhanced EUS in solid pancreatic lesions","volume":"13","author":"Mulqui","year":"2024","journal-title":"Endosc. Ultrasound"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/den.14889","article-title":"Endoscopic ultrasonography for microvascular imaging without contrast enhancement in the differential diagnosis of pancreatic lesions","volume":"37","author":"Yamashita","year":"2025","journal-title":"Dig. Endosc."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Miwa, H., Sugimori, K., Yonei, S., Yoshimura, H., Endo, K., Oishi, R., Funaoka, A., Tsuchiya, H., Kaneko, T., and Numata, K. (2024). Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography. Diagnostics, 14.","DOI":"10.20944\/preprints202403.1795.v1"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Oza, V.M., Yekula, A., and Kothari, T.H. (2026). Recent Advances in Endoscopic Ultrasound (EUS) for Pancreatic Cystic Lesions. J. Dig. Endosc.","DOI":"10.1055\/s-0045-1814381"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.gie.2020.04.071","article-title":"Deep learning\u2013based pancreas segmentation and station recognition system in EUS: Development and validation of a useful training tool (with video)","volume":"92","author":"Zhang","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.gie.2018.02.009","article-title":"Training in EUS and ERCP: Standardizing methods to assess competence","volume":"87","author":"Wani","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.pan.2025.05.011","article-title":"Towards automating risk stratification of intraductal papillary mucinous Neoplasms: Artificial intelligence advances beyond human expertise with confocal laser endomicroscopy","volume":"25","author":"Krishna","year":"2025","journal-title":"Pancreatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17562848221093873","article-title":"Application of artificial intelligence in diagnosis of pancreatic malignancies by endoscopic ultrasound: A systemic review","volume":"15","author":"Goyal","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E500","DOI":"10.1055\/a-1625-3396","article-title":"Application of a novel artificial intelligence system in guiding the targeted puncture of a pancreatic mass","volume":"54","author":"Wang","year":"2021","journal-title":"Endoscopy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4103\/EUS-D-21-00063","article-title":"Pooled diagnostic parameters of artificial intelligence in EUS image analysis of the pancreas: A descriptive quantitative review","volume":"11","author":"Mohan","year":"2022","journal-title":"Endosc. Ultrasound"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.amsu.2020.10.028","article-title":"A retrospective study of histological outcome for IPMN after surgery in Lausanne, Switzerland: A case series","volume":"60","author":"Litchinko","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"eaav4772","DOI":"10.1126\/scitranslmed.aav4772","article-title":"A multimodality test to guide the management of patients with a pancreatic cyst","volume":"11","author":"Springer","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.clinre.2020.02.002","article-title":"Differentiation of solid-pseudopapillary tumors of the pancreas from pancreatic neuroendocrine tumors by using endoscopic ultrasound","volume":"44","author":"Liu","year":"2020","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pan.2018.11.014","article-title":"Systematic review and meta-analysis: Prevalence of incidentally detected pancreatic cystic lesions in asymptomatic individuals","volume":"19","author":"Zerboni","year":"2019","journal-title":"Pancreatology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/bjs.10787","article-title":"Risk of malignancy in resected pancreatic mucinous cystic neoplasms","volume":"105","author":"Keane","year":"2018","journal-title":"BJS"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1136\/gutjnl-2015-309638","article-title":"Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)","volume":"65","author":"Jais","year":"2015","journal-title":"Gut"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Rangwani, S., Juakiem, W., Krishna, S.G., and El-Dika, S. (2023). Role of Endoscopic Ultrasound in the Evaluation of Pancreatic Cystic Neoplasms: A Concise Review. Diagnostics, 13.","DOI":"10.3390\/diagnostics13040705"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.pan.2017.07.007","article-title":"Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas","volume":"17","author":"Tanaka","year":"2017","journal-title":"Pancreatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cgh.2013.02.010","article-title":"Cyst features and risk of malignancy in intraductal papillary mucinous neoplasms of the pancreas: A meta-analysis","volume":"11","author":"Anand","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.surg.2018.01.009","article-title":"Systematic review, meta-analysis, and a high-volume center experience supporting the new role of mural nodules proposed by the updated 2017 international guidelines on IPMN of the pancreas","volume":"163","author":"Marchegiani","year":"2018","journal-title":"Surgery"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/den.13408","article-title":"Usefulness of septal thickness measurement on endoscopic ultrasound as a predictor of malignancy of branched-duct and mixed-type intraductal papillary mucinous neoplasm of the pancreas","volume":"31","author":"Iwaya","year":"2019","journal-title":"Dig. Endosc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/jamasurg.2016.3598","article-title":"Association of Preoperative Risk Factors With Malignancy in Pancreatic Mucinous Cystic Neoplasms","volume":"152","author":"Postlewait","year":"2017","journal-title":"JAMA Surg."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Olar, M.P., Bolboac\u0103, S.D., Pojoga, C., Mo\u0219teanu, O., Gheorghiu, M., Seicean, R., Rusu, I., Sparchez, Z., Al Hajjar, N., and Seicean, A. (2022). Clinical Utility of the Contrast-Enhanced Endoscopic Ultrasound Guided Fine Needle Aspiration in the Diagnosis of Pancreatic Cyst. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092209"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"(2018). The European Study Group on Cystic Tumours of the Pancreas. European evidence-based guidelines on pancreatic cystic neoplasms. Gut, 67, 789\u2013804.","DOI":"10.1136\/gutjnl-2018-316027"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"478","DOI":"10.14309\/ajg.0000000000001623","article-title":"Intracystic Glucose and Carcinoembryonic Antigen in Differentiating Histologically Confirmed Pancreatic Mucinous Neoplastic Cysts","volume":"117","author":"Smith","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.gie.2020.12.014","article-title":"Molecular analysis of EUS-acquired pancreatic cyst fluid for KRAS and GNAS mutations for diagnosis of intraductal papillary mucinous neoplasia and mucinous cystic lesions: A systematic review and meta-analysis","volume":"93","author":"McCarty","year":"2021","journal-title":"Gastrointest. Endosc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2022.09.028","article-title":"Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts","volume":"164","author":"Paniccia","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4253\/wjge.v14.i3.129","article-title":"Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions: A single-center study","volume":"14","author":"Olmos","year":"2022","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/EUS-D-20-00172","article-title":"EUS-guided biopsy versus confocal laser endomicroscopy in patients with pancreatic cystic lesions: A systematic review and meta-analysis","volume":"10","author":"Kovacevic","year":"2021","journal-title":"Endosc. Ultrasound"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.gie.2019.09.014","article-title":"EUS-guided confocal laser endomicroscopy: Prediction of dysplasia in intraductal papillary mucinous neoplasms (with video)","volume":"91","author":"Krishna","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Vilas-Boas, F., Ribeiro, T., Afonso, J., Cardoso, H., Lopes, S., Moutinho-Ribeiro, P., Ferreira, J., Mascarenhas-Saraiva, M., and Macedo, G. (2022). Deep Learning for Automatic Differentiation of Mucinous versus Non-Mucinous Pancreatic Cystic Lesions: A Pilot Study. Diagnostics, 12.","DOI":"10.3390\/diagnostics12092041"},{"key":"ref_71","first-page":"415","article-title":"Accurate prediction of histological grading of intraductal papillary mucinous neoplasia using deep learning","volume":"55","author":"Schulz","year":"2022","journal-title":"Endoscopy"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Minaga, K., Takenaka, M., Kamata, K., Yoshikawa, T., Nakai, A., Omoto, S., Miyata, T., Yamao, K., Imai, H., and Sakamoto, H. (2018). Alleviating Pancreatic Cancer-Associated Pain Using Endoscopic Ultrasound-Guided Neurolysis. Cancers, 10.","DOI":"10.3390\/cancers10020050"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4103\/eus.eus_97_17","article-title":"Practice guidelines for endoscopic ultrasound-guided celiac plexus neurolysis","volume":"6","author":"Sun","year":"2017","journal-title":"Endosc. Ultrasound"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Xu, R., Zhang, K., Ge, N., and Sun, S. (2024). EUS-guided interventional therapies for pancreatic diseases. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1329676"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.gie.2018.09.007","article-title":"Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer","volume":"89","author":"DeWitt","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Rimba\u0219, M., Dumitru, A.-C., Tripodi, G., and Larghi, A. (2024). EUS-Guided Radiofrequency Ablation Therapy for Pancreatic Neoplasia. Diagnostics, 14.","DOI":"10.3390\/diagnostics14192111"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Yousaf, M.N., Ehsan, H., Muneeb, A., Wahab, A., Sana, M.K., Neupane, K., and Chaudhary, F.S. (2021). Role of Radiofrequency Ablation in the Management of Unresectable Pancreatic Cancer. Front. Med., 7.","DOI":"10.3389\/fmed.2020.624997"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pan.2020.12.016","article-title":"Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) technique and analgesic efficacy in patients with pancreatic cancer: A systematic review and meta-analysis","volume":"21","author":"Koulouris","year":"2021","journal-title":"Pancreatology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/20009666.2021.1929049","article-title":"EUS-guided celiac plexus neurolysis for pain in pancreatic cancer patients\u2014A meta-analysis and systematic review","volume":"11","author":"Asif","year":"2021","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Yoon, W.J., Oh, Y., Yoo, C., Jang, S., Cho, S.-S., Suh, J.-H., Choi, S.-S., and Park, D.H. (2020). EUS-Guided Versus Percutaneous Celiac Neurolysis for the Management of Intractable Pain Due to Unresectable Pancreatic Cancer: A Randomized Clinical Trial. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061666"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1007\/s10147-022-02160-6","article-title":"Efficacy of EUS-guided celiac plexus neurolysis in combination with EUS-guided celiac ganglia neurolysis for pancreatic cancer-associated pain: A multicenter prospective trial","volume":"27","author":"Kamata","year":"2022","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cgh.2018.08.040","article-title":"Combined Celiac Ganglia and Plexus Neurolysis Shortens Survival, Without Benefit, vs Plexus Neurolysis Alone","volume":"17","author":"Levy","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e27103","DOI":"10.1097\/MD.0000000000027103","article-title":"EUS-CGN versus EUS-CPN in pancreatic cancer: A qualitative systematic review","volume":"100","author":"Li","year":"2021","journal-title":"Medicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.gie.2018.08.005","article-title":"EUS-guided celiac ganglion radiofrequency ablation versus celiac plexus neurolysis for palliation of pain in pancreatic cancer: A randomized controlled trial (with videos)","volume":"89","author":"Bang","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.vgie.2020.04.022","article-title":"EUS-guided celiac plexus radiofrequency ablation using a novel device","volume":"5","author":"Houmani","year":"2020","journal-title":"VideoGIE"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/jgh.14540","article-title":"Comparison of endoscopic ultrasound tissue acquisition methods for genomic analysis of pancreatic cancer","volume":"34","author":"Elhanafi","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Karamitopoulou, E. (2022). Molecular Pathology of Pancreatic Cancer. Cancers, 14.","DOI":"10.3390\/cancers14061523"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/jnci\/djac106","article-title":"The Molecular Landscape of Pancreatobiliary Cancers for Novel Targeted Therapies From Real-World Genomic Profiling","volume":"114","author":"Umemoto","year":"2022","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"ref_89","first-page":"376","article-title":"Comparison of endoscopic ultrasound-guided fine-needle biopsy versus fine-needle aspiration for genomic profiling and DNA yield in pancreatic cancer: A randomized crossover trial","volume":"53","author":"Kandel","year":"2020","journal-title":"Endoscopy"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cas.14674","article-title":"Comprehensive genomic profiling for patients with chemotherapy-na\u00efve advanced cancer","volume":"112","author":"Kondo","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5009\/gnl19011","article-title":"Factors of Endoscopic Ultrasound-Guided Tissue Acquisition for Successful Next-Generation Sequencing in Pancreatic Ductal Adenocarcinoma","volume":"14","author":"Park","year":"2019","journal-title":"Gut Liver"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1055\/a-0982-2997","article-title":"Diagnostic yield of Franseen and Fork-Tip biopsy needles for endoscopic ultrasound-guided tissue acquisition: A meta-analysis","volume":"07","author":"Facciorusso","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"E955","DOI":"10.1055\/a-0903-2565","article-title":"Comparison of tissue and molecular yield between fine-needle biopsy (FNB) and fine-needle aspiration (FNA): A randomized study","volume":"7","author":"Asokkumar","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/hepr.13312","article-title":"Utility of ultrasound-guided liver tumor biopsy for next-generation sequencing-based clinical sequencing","volume":"49","author":"Eso","year":"2019","journal-title":"Hepatol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1055\/a-2481-7048","article-title":"Diagnostic work-up of bile duct strictures: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"57","author":"Facciorusso","year":"2025","journal-title":"Endoscopy"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.gie.2024.06.003","article-title":"American Society for Gastrointestinal Endoscopy guideline on role of endoscopy in the diagnosis and management of solid pancreatic masses: Methodology and review of evidence","volume":"100","author":"Machicado","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_97","first-page":"129","article-title":"Endoscopic ultrasound-guided fine-needle biopsy with or without macroscopic on-site evaluation: A randomized controlled noninferiority trial","volume":"55","author":"Mangiavillano","year":"2022","journal-title":"Endoscopy"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/jama.2019.6190","article-title":"Screening for Pancreatic Cancer: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"322","author":"Henrikson","year":"2019","journal-title":"JAMA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1053\/j.gastro.2020.03.088","article-title":"AGA Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals: Expert Review","volume":"159","author":"Aslanian","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.pan.2018.04.002","article-title":"Screening\/surveillance programs for pancreatic cancer in familial high-risk individuals: A systematic review and proportion meta-analysis of screening results","volume":"18","author":"Paiella","year":"2018","journal-title":"Pancreatology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1053\/j.gastro.2018.05.035","article-title":"Risk of Neoplastic Progression in Individuals at High Risk for Pancreatic Cancer Undergoing Long-term Surveillance","volume":"155","author":"Canto","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11605-019-04230-z","article-title":"Surgical Outcomes After Pancreatic Resection of Screening-Detected Lesions in Individuals at High Risk for Developing Pancreatic Cancer","volume":"24","author":"Canto","year":"2020","journal-title":"J. Gastrointest. Surg."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.gie.2021.12.001","article-title":"ASGE guideline on screening for pancreatic cancer in individuals with genetic susceptibility: Summary and recommendations","volume":"95","author":"Sawhney","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes","volume":"110","author":"Syngal","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1055\/a-0824-7067","article-title":"Endoscopic ultrasound-guided radiofrequency ablation for pancreatic neuroendocrine tumors and pancreatic cystic neoplasms: A prospective multicenter study","volume":"51","author":"Barthet","year":"2019","journal-title":"Endoscopy"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"E1754","DOI":"10.1055\/a-1261-9359","article-title":"Endoscopic ultrasound-guided radiofrequency ablation of pancreatic neuroendocrine tumors: A case series","volume":"8","author":"Imperatore","year":"2020","journal-title":"Endosc. Int. Open"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2174\/1871530323666230411141412","article-title":"Endoscopic Ultrasound-Guided Therapies in Patients with Pancreatic Neuroendocrine Tumors","volume":"23","author":"Morgan","year":"2023","journal-title":"Endocr. Metab. Immune Disord.-Drug Targets"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.21037\/apm-20-1468","article-title":"Endoscopic ultrasound-guided radiofrequency ablation of unresectable pancreatic cancer with low ablation power and multiple applications: A preliminary study of 11 patients","volume":"10","author":"Wang","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"67","DOI":"10.15403\/jgld.2014.1121.271.eus","article-title":"EUS-guided Radiofrequency Ablation (EUS-RFA) of Solid Pancreatic Neoplasm Using an 18-gauge Needle Electrode: Feasibility, Safety, and Technical Success","volume":"27","author":"Bernardoni","year":"2018","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0016-5107(03)02361-7","article-title":"EUS-guided photodynamic therapy of the pancreas: A pilot study","volume":"59","author":"Chan","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.gie.2013.04.178","article-title":"US-guided application of Nd:YAG laser in porcine pancreatic tissue: An ex vivo study and numerical simulation","volume":"78","author":"Martino","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1055\/s-0034-1392150","article-title":"Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter","volume":"47","author":"Choi","year":"2015","journal-title":"Endoscopy"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.3748\/wjg.v22.i37.8257","article-title":"Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety","volume":"22","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/den.12833","article-title":"Endoscopic ultrasonography-guided tumor ablation","volume":"29","author":"Lakhtakia","year":"2017","journal-title":"Dig. Endosc."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4253\/wjge.v9.i2.41","article-title":"Endoscopy-guided ablation of pancreatic lesions: Technical possibilities and clinical outlook","volume":"9","author":"Signoretti","year":"2017","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1200\/JOP.2017.023044","article-title":"Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update Summary","volume":"13","author":"Khorana","year":"2017","journal-title":"J. Oncol. Pract."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.4103\/eus.eus_70_17","article-title":"EUS-guided solid pancreatic tumor ablation","volume":"6","author":"Dabizzi","year":"2017","journal-title":"Endosc. Ultrasound"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/gastro\/gou057","article-title":"Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: A systematic review and meta-analysis","volume":"3","author":"Navaneethan","year":"2014","journal-title":"Gastroenterol. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Shin, D.W., Moon, S.-H., and Kim, J.H. (2023). Diagnosis of Cholangiocarcinoma. Diagnostics, 13.","DOI":"10.3390\/diagnostics13020233"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/gutjnl-2023-330029","article-title":"British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma","volume":"73","author":"Rushbrook","year":"2023","journal-title":"Gut"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.soc.2019.06.007","article-title":"Staging of biliary and primary liver tumors: Current recommendations and workup","volume":"28","author":"Krampitz","year":"2019","journal-title":"Surg. Oncol. Clin."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.gie.2015.09.024","article-title":"Diagnostic yield of EUS-guided FNA for malignant biliary stricture: A systematic review and meta-analysis","volume":"83","author":"Sadeghi","year":"2016","journal-title":"Gastrointest. Endosc."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"417","DOI":"10.5946\/ce.2019.053","article-title":"Endoscopic Ultrasound-Guided Fine Needle Aspiration and Endoscopic Retrograde Cholangiopancreatography-Based Tissue Sampling in Suspected Malignant Biliary Strictures: A Meta-Analysis of Same-Session Procedures","volume":"53","author":"Ryou","year":"2020","journal-title":"Clin. Endosc."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"American Society for Gastrointestinal Endoscopy (ASGE) Standards of Practice Committee, Anderson, M.A., Appalaneni, V., Ben-Menachem, T., Decker, G.A., Early, D.S., Evans, J.A., Fanelli, R.D., Fisher, D.A., and Fisher, L.R. (2013). The role of endoscopy in the evaluation and treatment of patients with biliary neoplasia. Gastrointest. Endosc., 77, 167\u2013174.","DOI":"10.1016\/j.gie.2012.09.029"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2303.2006.00319.x","article-title":"Endoscopic ultrasound-guided FNA biopsy of bile duct and gallbladder: Analysis of 53 cases","volume":"17","author":"Meara","year":"2006","journal-title":"Cytopathology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/hep.32771","article-title":"AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma","volume":"77","author":"Bowlus","year":"2022","journal-title":"Hepatology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1477-2574.2011.00298.x","article-title":"Trans-peritoneal fine needle aspiration biopsy of hilar cholangiocarcinoma is associated with disease dissemination","volume":"13","author":"Heimbach","year":"2011","journal-title":"HPB"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.gie.2008.10.036","article-title":"Early detection of extrahepatic bile-duct carcinomas in the nonicteric stage by using MRCP followed by EUS","volume":"70","author":"Sai","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.gie.2010.08.050","article-title":"Role of EUS for preoperative evaluation of cholangiocarcinoma: A large single-center experience","volume":"73","author":"Mohamadnejad","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5114\/ceh.2019.85166","article-title":"Epidemiology of gallbladder cancer","volume":"5","author":"Rawla","year":"2019","journal-title":"Clin. Exp. Hepatol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Hijioka, S., Nagashio, Y., Ohba, A., Maruki, Y., and Okusaka, T. (2021). The Role of EUS and EUS-FNA in Differentiating Benign and Malignant Gallbladder Lesions. Diagnostics, 11.","DOI":"10.3390\/diagnostics11091586"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Tamura, T., Ashida, R., and Kitano, M. (2022). The usefulness of endoscopic ultrasound in the diagnosis of gallbladder lesions. Front. Med., 9.","DOI":"10.3389\/fmed.2022.957557"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.gie.2013.03.1328","article-title":"Utility of contrast-enhanced harmonic EUS in the diagnosis of malignant gallbladder polyps (with videos)","volume":"78","author":"Choi","year":"2013","journal-title":"Gastrointest. Endosc."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s10620-014-3115-5","article-title":"Contrast-enhanced harmonic endoscopic ultrasonography in the differential diagnosis of gallbladder wall thickening","volume":"59","author":"Imazu","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1001\/archsurg.138.7.741","article-title":"Strategies for surgical treatment of gallbladder carcinoma based on information available before resection","volume":"138","author":"Kokudo","year":"2003","journal-title":"Arch. Surg."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Takahashi, K., Ozawa, E., Shimakura, A., Mori, T., Miyaaki, H., and Nakao, K. (2024). Recent Advances in Endoscopic Ultrasound for Gallbladder Disease Diagnosis. Diagnostics, 14.","DOI":"10.3390\/diagnostics14040374"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/den.14576","article-title":"Diagnostic performance and safety of endoscopic ultrasound-guided fine-needle aspiration\/biopsy for gallbladder lesions","volume":"36","author":"Kuraishi","year":"2023","journal-title":"Dig. Endosc."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.gie.2024.03.022","article-title":"EUS-guided FNA and biopsy for cytohistologic diagnosis of gallbladder cancer: A multicenter retrospective study","volume":"100","author":"Kang","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"967472","DOI":"10.1155\/2015\/967472","article-title":"Gallbladder Cancer in the 21st Century","volume":"2015","author":"Kanthan","year":"2015","journal-title":"J. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00132751","article-title":"Comments on hematogenous metastatic patterns in humans as revealed by autopsy","volume":"10","author":"Weiss","year":"1992","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_141","first-page":"7","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/EUS-D-20-00178","article-title":"Role of EUS in detection of liver metastasis not seen by computed tomography or magnetic resonance imaging during staging of pancreatic, gastrointestinal, and thoracic malignancies","volume":"10","author":"Okasha","year":"2021","journal-title":"Endosc. Ultrasound"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0002-9610(02)01092-9","article-title":"Preoperative evaluation of hepatic lesions for the staging of hepatocellular and metastatic liver carcinoma using endoscopic ultrasonography","volume":"184","author":"Awad","year":"2002","journal-title":"Am. J. Surg."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/2303-9027.204813","article-title":"Endoscopic ultrasound-guided fine-needle aspiration can target right liver mass","volume":"6","author":"Seo","year":"2017","journal-title":"Endosc. Ultrasound"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2169\/internalmedicine.6183-20","article-title":"Comparative Study of an Ultrasound-guided Percutaneous Biopsy and Endoscopic Ultrasound-guided Fine-needle Aspiration for Liver Tumors","volume":"60","author":"Takano","year":"2021","journal-title":"Intern. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"15","DOI":"10.15386\/cjmed-1066","article-title":"Diagnostic yield of endoscopic ultrasound-guided biopsy of focal liver lesions","volume":"92","author":"Ichim","year":"2019","journal-title":"Med. Pharm. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13000-020-00965-5","article-title":"Fine needle biopsy of malignant tumors of the liver: A retrospective study of 624 cases from a single institution experience","volume":"15","author":"Zhang","year":"2020","journal-title":"Diagn. Pathol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.gie.2018.10.018","article-title":"Efficacy and safety of EUS-guided liver biopsy: A systematic review and meta-analysis","volume":"89","author":"Mohan","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Chen, Q.-W., Cheng, C.-S., Chen, H., Ning, Z.-Y., Tang, S.-F., Zhang, X., Zhu, X.-Y., Vargulick, S., Shen, Y.-H., and Hua, Y.-Q. (2014). Effectiveness and complications of ultrasound guided fine needle aspiration for primary liver cancer in a Chinese population with serum \u03b1-fetoprotein levels\u2264 200 ng\/ml-a study based on 4,312 patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101536"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.dld.2019.01.006","article-title":"Comparison of EUS-guided versus percutaneous and transjugular approaches for the performance of liver biopsies","volume":"51","author":"Shuja","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"583","DOI":"10.5946\/ce.2019.211","article-title":"Endoscopic Ultrasound-Guided, Percutaneous, and Transjugular Liver Biopsy: A Comparative Systematic Review and Meta-Analysis","volume":"53","author":"McCarty","year":"2020","journal-title":"Clin. Endosc."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1055\/a-0659-9864","article-title":"Endoscopic biliary stenting: Indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline\u2014Updated October 2017","volume":"50","author":"Dumonceau","year":"2018","journal-title":"Endoscopy"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Lambin, T., Leblanc, S., and Napol\u00e9on, B. (2025). Advances in EUS-Guided Biliary Drainage for the Management of Pancreatic Cancer. Cancers, 17.","DOI":"10.3390\/cancers17213428"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41395-018-0122-8","article-title":"EUS-guided biliary drainage versus ERCP for the primary palliation of malignant biliary obstruction: A multicenter randomized clinical trial","volume":"113","author":"Paik","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_155","first-page":"602","article-title":"Comparative efficacy of endoscopic ultrasound-guided biliary drainage versus endoscopic retrograde cholangiopancreatography as first-line palliation in malignant distal biliary obstruction: A systematic review and meta-analysis","volume":"37","author":"Ginnaram","year":"2024","journal-title":"Ann. Gastroenterol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4103\/eus.eus_51_18","article-title":"EUS-guided antegrade metal stenting with hepaticoenterostomy using a dedicated plastic stent with a review of the literature (with video)","volume":"7","author":"Itoi","year":"2018","journal-title":"Endosc. Ultrasound"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5946\/ce.2024.031","article-title":"Endoscopic ultrasound-guided hepaticogastrostomy and endoscopic retrograde cholangiopancreatography-guided biliary drainage for distal malignant biliary obstruction due to pancreatic cancer with asymptomatic duodenal invasion: A retrospective, single-center study in Japan","volume":"58","author":"Takahara","year":"2025","journal-title":"Clin. Endosc."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/eus.eus_68_19","article-title":"Risk factors for adverse events associated with bile leak during EUS-guided hepaticogastrostomy","volume":"9","author":"Nishioka","year":"2020","journal-title":"Endosc. Ultrasound"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1756283X16671671","article-title":"Optimal biliary access point and learning curve for endoscopic ultrasound-guided hepaticogastrostomy with transmural stenting","volume":"10","author":"Oh","year":"2016","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17562848231188562","article-title":"Liver impaction technique improves technical success rate of guidewire insertion during EUS-guided hepaticogastrostomy (with video)","volume":"16","author":"Nakamura","year":"2023","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.3748\/wjg.v22.i15.3945","article-title":"Technical tips for endoscopic ultrasound-guided hepaticogastrostomy","volume":"22","author":"Ogura","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0045-1811571","article-title":"Technical Review on Endoscopic Ultrasound-Guided Hepaticogastrostomy","volume":"16","author":"Singh","year":"2025","journal-title":"J. Dig. Endosc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jhbp.631","article-title":"Clinical practice guidelines for safe performance of endoscopic ultrasound\/ultrasonography-guided biliary drainage: 2018","volume":"26","author":"Isayama","year":"2019","journal-title":"J. Hepato-Biliary-Pancreat. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"651","DOI":"10.5946\/ce.2021.020-KDDW","article-title":"Technical Review of Developments in Endoscopic Ultrasound-Guided Hepaticogastrostomy","volume":"54","author":"Ogura","year":"2021","journal-title":"Clin. Endosc."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Alsakarneh, S., Madi, M.Y., Dahiya, D.S., Jaber, F., Kilani, Y., Ahmed, M., Beran, A., Abdallah, M., Al Ta\u2019ani, O., and Mittal, A. (2024). Is Endoscopic Ultrasound-Guided Hepaticogastrostomy Safe and Effective after Failed Endoscopic Retrograde Cholangiopancreatography?\u2014A Systematic Review and Meta-Analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133883"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/ueg2.12552","article-title":"Long-term outcomes of endoscopic ultrasound-guided hepaticogastrostomy in patients with malignant biliary obstruction","volume":"12","author":"Hedjoudje","year":"2024","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Li, J., Tang, J., Liu, F., and Fang, J. (2022). Comparison of Choledochoduodenostomy and Hepaticogastrostomy for EUS-Guided Biliary Drainage: A Meta-Analysis. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.811005"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/eus.0000000000000055","article-title":"Efficacy and safety of EUS-guided hepatogastrostomy: A systematic review and meta-analysis","volume":"13","author":"Moond","year":"2024","journal-title":"Endosc. Ultrasound"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1055\/a-2282-3350","article-title":"Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy: A meta-regression analysis","volume":"56","author":"Binda","year":"2024","journal-title":"Endoscopy"},{"key":"ref_170","first-page":"49","article-title":"Prospective evaluation study of EUS-guided hepaticogastrostomy without tract dilation: Comparison to with tract dilation","volume":"15","author":"Tomita","year":"2026","journal-title":"Endosc. Ultrasound"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.gie.2020.03.3856","article-title":"Long-term outcomes of a long, partially covered metal stent for EUS-guided hepaticogastrostomy in patients with malignant biliary obstruction (with video)","volume":"92","author":"Nakai","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Facciorusso, A., Mangiavillano, B., Paduano, D., Binda, C., Crin\u00f2, S.F., Gkolfakis, P., Ramai, D., Fugazza, A., Tarantino, I., and Lisotti, A. (2022). Methods for Drainage of Distal Malignant Biliary Obstruction after ERCP Failure: A Systematic Review and Network Meta-Analysis. Cancers, 14.","DOI":"10.3390\/cancers14133291"},{"key":"ref_173","first-page":"1037","article-title":"Efficacy of lumen-apposing metal stents or self-expandable metal stents for endoscopic ultrasound-guided choledochoduodenostomy: A systematic review and meta-analysis","volume":"53","author":"Amato","year":"2020","journal-title":"Endoscopy"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5946\/ce.2023.169","article-title":"Advances in self-expandable metal stents for endoscopic ultrasound-guided interventions","volume":"57","author":"Jang","year":"2024","journal-title":"Clin. Endosc."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.gie.2024.05.024","article-title":"Indirect comparison of various lumen-apposing metal stents for EUS-guided biliary and gallbladder drainage: A systematic review and meta-analysis","volume":"100","author":"Singh","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"E1801","DOI":"10.1055\/a-1526-1208","article-title":"Common bile duct size in malignant distal obstruction and lumen-apposing metal stents: A multicenter prospective study","volume":"09","author":"Anderloni","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-0045-1810606","article-title":"Clinical Outcomes and Predictors of Early Adverse Events in Primary EUS-Guided Choledochoduodenostomy for Malignant Distal Biliary Obstruction","volume":"16","author":"Okuno","year":"2025","journal-title":"J. Dig. Endosc."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1111\/jgh.16614","article-title":"Adverse events in endoscopic ultrasound-guided choledochoduodenostomy with lumen-apposing metal stents: A systematic review and meta-analysis","volume":"39","author":"Li","year":"2024","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1007\/s00464-020-07484-w","article-title":"Effectiveness and safety of EUS-guided choledochoduodenostomy using lumen-apposing metal stents (LAMS): A systematic review and meta-analysis","volume":"34","author":"Krishnamoorthi","year":"2020","journal-title":"Surg. Endosc."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1055\/a-2541-2973","article-title":"Technical failure of endoscopic ultrasound-guided choledochoduodenostomy: Multicenter study on rescue techniques, consequences, and risk factors","volume":"57","author":"Beunon","year":"2025","journal-title":"Endoscopy"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1055\/a-2340-0697","article-title":"Endoscopic ultrasound- versus ERCP-guided primary drainage of inoperable malignant distal biliary obstruction: Systematic review and meta-analysis of randomized controlled trials","volume":"56","author":"Khoury","year":"2024","journal-title":"Endoscopy"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"E456","DOI":"10.1055\/a-2271-2145","article-title":"Outcomes predictors in endoscopic ultrasound-guided choledochoduodenostomy with lumen-apposing metal stent: Systematic review and meta-analysis","volume":"12","author":"Fugazza","year":"2024","journal-title":"Endosc. Int. Open"},{"key":"ref_183","first-page":"540","article-title":"Endoscopic ultrasound-guided choledochoduodenostomy with electrocautery-enhanced lumen-apposing stents: A retrospective analysis","volume":"51","author":"Jacques","year":"2018","journal-title":"Endoscopy"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1002\/deo2.8","article-title":"Technical tips and recent development of endoscopic ultrasound-guided choledochoduodenostomy","volume":"1","author":"Ogura","year":"2021","journal-title":"DEN Open"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/EUS-D-22-00120","article-title":"Risk factors for stent dysfunction during long-term follow-up after EUS-guided biliary drainage using lumen-apposing metal stents: A prospective study","volume":"12","author":"Geyl","year":"2023","journal-title":"Endosc. Ultrasound"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"E110","DOI":"10.1055\/a-1313-6850","article-title":"Endoscopic ultrasound-guided biliary drainage of malignant stenosis, not treatable with endoscopic retrograde cholangiopancreatography: A single-center, prospective observational study","volume":"9","author":"Tarantino","year":"2021","journal-title":"Endosc. Int. 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Gastroenterol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ueg2.12576","article-title":"Adverse events with endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction\u2014A systematic review and meta-analysis","volume":"12","author":"Giri","year":"2024","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/eus.eus_70_19","article-title":"EUS-guided gastroenterostomy for the management of gastric outlet obstruction: A systematic review and meta-analysis","volume":"9","author":"Iqbal","year":"2020","journal-title":"Endosc. 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Diagnostics, 13.","DOI":"10.3390\/diagnostics13213308"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1007\/s00464-024-10897-6","article-title":"Endoscopic ultrasound-guided gastrojejunostomy for benign gastric outlet obstruction (GOO): A retrospective analysis of patients and outcomes","volume":"38","author":"Abel","year":"2024","journal-title":"Surg. Endosc."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e70170","DOI":"10.1002\/deo2.70170","article-title":"Role of Endoscopic Ultrasound-guided Gastroenterostomy for Benign Gastric Outlet Obstruction","volume":"6","author":"Giri","year":"2025","journal-title":"DEN Open"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"100472","DOI":"10.4253\/wjge.v17.i1.100472","article-title":"Revisiting malignant gastric outlet obstruction: Where do we stand?","volume":"17","author":"Govindarajan","year":"2025","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/gutjnl-2025-336339","article-title":"Endoscopic or surgical gastroenterostomy for malignant gastric outlet obstruction: A randomised trial","volume":"75","author":"Bang","year":"2025","journal-title":"Gut"},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"Ziogas, D., Vasilakis, T., Kapizioni, C., Koukoulioti, E., Tziatzios, G., Gkolfakis, P., Facciorusso, A., and Papanikolaou, I.S. (2024). Revealing Insights: A Comprehensive Overview of Gastric Outlet Obstruction Management, with Special Emphasis on EUS-Guided Gastroenterostomy. Med. Sci., 12.","DOI":"10.3390\/medsci12010009"},{"key":"ref_200","first-page":"a25097671","article-title":"Endoscopic ultrasound gastroenterostomy vs duodenal stenting for malignant gastric outlet obstruction: Cost-effectiveness study","volume":"13","author":"Ramai","year":"2025","journal-title":"Endosc. Int. 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