{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:51:47Z","timestamp":1782208307950,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Non-colorectal cancer liver metastases (NCRLMs) represent a therapeutically challenging condition with poorly defined locoregional treatment options. This study evaluates the safety, oncological efficacy, and survival outcomes of microwave ablation (MWA) for NCRLMs in a large single-centre series. Methods: Retrospective analysis of patients undergoing MWA for NCRLM between January 2010 and December 2024 at a high-volume hepatobiliary centre. Endpoints were safety, efficacy, textbook outcome (TO) achievement, and overall survival (OS). Results: A total of 138 patients underwent 172 MWA procedures across eight primary tumour categories via a video-assisted (n = 110, 64%) or percutaneous (n = 62, 36%) approach. Major complications (Clavien\u2013Dindo \u2265 3) occurred in 1.8% of procedures, with a median hospital stay of 2 days and a 90-day mortality of 1.7%. The median follow-up was 24.9 (10.3, 55.8) months. Complete response (CR) was achieved in 77% of procedures and TO in 54%, with incomplete response as the main driver of TO failure. The 5-year OS varied by histology, from 100% (GIST) and 80.0% (GEP-NET) to 44.7% (breast) and 0% (pancreatic adenocarcinoma). The video-assisted ablation was associated with superior OS compared to the percutaneous one (5-year OS 54.4% vs. 26.0%, p = 0.00025). In the multivariable analysis, the percutaneous approach (HR 2.44), ECOG PS \u2265 2 (HR 6.06) and a higher tumour burden score (HR 1.09) independently predicted worse OS, whereas the histological group was not independently associated with OS. Repeat MWA was the most frequent treatment for first hepatic recurrence, and 50% of patients reached no evidence of disease (NED) at last follow-up. Conclusions: MWA is a safe and repeatable locoregional treatment for NCRLMs, with outcomes shaped by tumour biology, disease burden, patient fitness and procedural approach. The high rate of liver-dominant recurrence treated with repeat MWA, combined with a final NED rate of 50%, supports MWA as a platform for iterative locoregional disease control in selected patients.<\/jats:p>","DOI":"10.3390\/cancers18132026","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T08:19:52Z","timestamp":1782202792000},"page":"2026","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microwave Ablation for the Treatment of Non-Colorectal Cancer Liver Metastasis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-7918","authenticated-orcid":false,"given":"Jacopo","family":"Lanari","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-8536","authenticated-orcid":false,"given":"Sara","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-3254","authenticated-orcid":false,"given":"Ilaria","family":"Billato","sequence":"additional","affiliation":[{"name":"Department of Biology (DiBio), University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Naldini","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8177-6358","authenticated-orcid":false,"given":"Clarissa","family":"De Nardi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Tamponi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Volpato","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7459-0793","authenticated-orcid":false,"given":"Alessandro","family":"Furlanetto","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-8521","authenticated-orcid":false,"given":"Francesco Enrico","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8308","authenticated-orcid":false,"given":"Alessandro","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-7306","authenticated-orcid":false,"given":"Enrico","family":"Gringeri","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2310-0245","authenticated-orcid":false,"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35128 Padua, Italy"},{"name":"General Surgery and Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, Padua University Hospital, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lanari, J., Caregari, S., Billato, I., Gringeri, E., D\u2019amico, F., Gemo, G., Bassi, D., D\u2019amico, F.E., Boetto, R., and Bertacco, A. (2023). Textbook Outcome of Laparoscopic Microwave Ablation for Hepatocellular Carcinoma. Cancers, 15.","DOI":"10.3390\/cancers15020436"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ettorre, G.M. (2023). Percutaneous and Laparoscopic-Assisted Ablation of Hepatocellular Carcinoma. Hepatocellular Carcinoma, Springer International Publishing.","DOI":"10.1007\/978-3-031-09371-5"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/jso.25651","article-title":"Videolaparoscopic microwave ablation in patients with HCC at a European high-volume center: Results of 815 procedures","volume":"120","author":"Cillo","year":"2019","journal-title":"J. Surg. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/cco-22-13","article-title":"Non-colorectal non-neuroendocrine liver metastasis: A narrative review of surgical treatment","volume":"11","author":"Usai","year":"2022","journal-title":"Chin. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.hoc.2024.08.004","article-title":"Is There a Role for Locoregional Therapies for Non-colorectal Gastrointestinal Malignancies?","volume":"39","author":"Fonseca","year":"2025","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/hpb.12264","article-title":"Laparoscopic microwave ablation in patients with hepatocellular carcinoma: A prospective cohort study","volume":"16","author":"Cillo","year":"2014","journal-title":"HPB"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00464-015-4468-3","article-title":"Long-term outcome of laparoscopic ablation therapies for unresectable hepatocellular carcinoma: A single European center experience of 426 patients","volume":"30","author":"Santambrogio","year":"2016","journal-title":"Surg. Endosc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/SLA.0000000000002064","article-title":"The Tumor Burden Score: A New \u201cMetro-ticket\u201d Prognostic Tool For Colorectal Liver Metastases Based on Tumor Size and Number of Tumors","volume":"267","author":"Sasaki","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00268-015-3003-y","article-title":"Definition and Classification of Intraoperative Complications (CLASSIC): Delphi Study and Pilot Evaluation","volume":"39","author":"Rosenthal","year":"2015","journal-title":"World J. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.sla.0000189131.90876.9e","article-title":"The \u201c50-50 Criteria\u201d on Postoperative Day 5","volume":"242","author":"Balzan","year":"2005","journal-title":"Ann. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of Surgical Complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0b013e318296c732","article-title":"The comprehensive complication index: A novel continuous scale to measure surgical morbidity","volume":"258","author":"Slankamenac","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/SLA.0000000000003043","article-title":"Comprehensive Complication Index Validates Improved Outcomes Over Time Despite Increased Complexity in 3707 Consecutive Hepatectomies","volume":"271","author":"Cloyd","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_15","unstructured":"European Association for the Study of the Liver (2025). EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma. J. Hepatol., 82, 315\u2013374."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.hpb.2021.09.016","article-title":"Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma: A textbook outcome analysis","volume":"24","author":"Serra","year":"2022","journal-title":"HPB"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(24)00660-0","article-title":"Thermal ablation versus surgical resection of small-size colorectal liver metastases (COLLISION): An international, randomised, controlled, phase 3 non-inferiority trial","volume":"26","author":"Puijk","year":"2025","journal-title":"Lancet Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/S1470-2045(13)70362-0","article-title":"Recommendations for management of patients with neuroendocrine liver metastases","volume":"15","author":"Frilling","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"115691","DOI":"10.1016\/j.ejca.2025.115691","article-title":"Hepatic metastases management: A comparative review of surgical resection, thermal ablation, and stereotactic body radiation therapy","volume":"228","author":"Torielli","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Narayanan, G., Ruiz, E.M., Dijkstra, M., Gentile, N.T., Donahue, D., Gandhi, R.T., Mahtani, R.L., Mautner, S., and Bemd, B.A.T.v.D. (2025). Clinical Efficacy of Percutaneous Image-Guided Ablation in Breast Cancer Metastases to the Liver. Cancers, 17.","DOI":"10.3390\/cancers17233823"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1002\/cncr.34931","article-title":"American Radium Society Appropriate Use Criteria for the use of liver-directed therapies for nonsurgical management of liver metastases: Systematic review and guidelines","volume":"129","author":"Hallemeier","year":"2023","journal-title":"Cancer"},{"key":"ref_22","first-page":"524","article-title":"Hepatic resection for noncolorectal nonendocrine liver metastases: Analysis of 1452 patients and development of a prognostic model","volume":"244","author":"Adam","year":"2006","journal-title":"Am. Surg. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejca.2023.03.038","article-title":"A prospective multicentre trial on survival after Microwave Ablation VErsus Resection for Resectable Colorectal liver metastases (MAVERRIC)","volume":"187","author":"Tinguely","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1200\/JCO.2008.19.6329","article-title":"Multi-Institutional Phase I\/II Trial of Stereotactic Body Radiation Therapy for Liver Metastases","volume":"27","author":"Rusthoven","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.ijrobp.2020.11.045","article-title":"The Dutch\u2013Belgian Registry of Stereotactic Body Radiation Therapy for Liver Metastases: Clinical Outcomes of 515 Patients and 668 Metastases","volume":"109","author":"Romero","year":"2021","journal-title":"Int. J. Radiat. Oncol. Boil. Phys."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijrobp.2017.12.288","article-title":"Local Control After Stereotactic Body Radiation Therapy for Liver Tumors","volume":"110","author":"Ohri","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.radonc.2019.12.004","article-title":"Comparisons between radiofrequency ablation and stereotactic body radiotherapy for liver malignancies: Meta-analyses and a systematic review","volume":"145","author":"Lee","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ijrobp.2016.03.050","article-title":"Radiosensitivity Differences Between Liver Metastases Based on Primary Histology Suggest Implications for Clinical Outcomes After Stereotactic Body Radiation Therapy","volume":"95","author":"Ahmed","year":"2016","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"djx031","DOI":"10.1093\/jnci\/djx031","article-title":"Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype","volume":"109","author":"Hong","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/annonc\/mdx738","article-title":"Pan-Asian adapted ESMO consensus guidelines for the management of patients with metastatic colorectal cancer: A JSMO\u2013ESMO initiative endorsed by CSCO, KACO, MOS, SSO and TOS","volume":"29","author":"Yoshino","year":"2018","journal-title":"Ann. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/13\/2026\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:28:26Z","timestamp":1782206906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/13\/2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":30,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cancers18132026"],"URL":"https:\/\/doi.org\/10.3390\/cancers18132026","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}