{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:48:49Z","timestamp":1782283729982,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Hematologic malignancies account for a significant proportion of the global cancer burden. Immunotherapy is currently one of the key treatment modalities used in the management of these diseases. Objective: This study aimed to assess the physical fitness of patients with chronic lymphoid malignancies receiving monoclonal antibody-based therapy compared with healthy individuals. Materials and Methods: The study included 99 ambulatory patients being treated for hematologic malignancies\u201433 with chronic lymphocytic leukemia, 32 with multiple myeloma, and 34 with follicular lymphoma\u2014as well as 43 healthy individuals. All participants underwent the Two-Minute Step Test, the 30-Second Sit-to-Stand Test, and the Timed Up and Go Test. Results: Patients with hematologic malignancies, regardless of diagnosis, were characterized by significantly lower lower-limb strength (H(3, N = 142) = 24.779, p &lt; 0.0001), as well as poorer agility and dynamic balance (H(3, N = 142) = 24.993, p &lt; 0.0001). Patients diagnosed with multiple myeloma and follicular lymphoma also exhibited lower cardiorespiratory endurance (H(3, N = 142) = 13.223, p = 0.0042). Age was a significant predictor of physical fitness. However, in an analysis treating diagnosis as a categorical variable with the control group as the reference category, patients with hematologic malignancies also had significantly lower physical fitness scores than controls. Conclusions: Patients with chronic lymphoid malignancies receiving monoclonal antibody-based therapy exhibit reduced physical fitness regardless of hematologic diagnosis. Patient age is an additional factor associated with physical fitness.<\/jats:p>","DOI":"10.3390\/cancers18132040","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:37:17Z","timestamp":1782279437000},"page":"2040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physical Fitness in Ambulatory Patients with Chronic Lymphoid Malignancies Receiving Monoclonal Antibody-Based Therapy: A Case\u2013Control Study"],"prefix":"10.3390","volume":"18","author":[{"given":"Ma\u0142gorzata","family":"Pude\u0142ek","sequence":"first","affiliation":[{"name":"Lower Silesian Oncology, Pulmonology and Hematology Center, 53-439 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-2887","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Dybko","sequence":"additional","affiliation":[{"name":"Lower Silesian Oncology, Pulmonology and Hematology Center, 53-439 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-001X","authenticated-orcid":false,"given":"Iwona","family":"Malicka","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sun, K., Wu, H., Zh, Q., Gu, K., Wei, H., Wang, S., Li, L., Wu, C., Chen, R., and Pang, Y. (2025). Global landscape and trends in lifetime risks of haematologic malignancies in 185 countries: Population-based estimates from GLOBOCAN 2022. eClinicalMedicine, 83.","DOI":"10.1016\/j.eclinm.2025.103193"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/CM9.0000000000003969","article-title":"Disease burden of hematological malignancies worldwide. in China and in the United States based on the GLOBOCAN 2022 and Global Burden of Disease 2021 data","volume":"139","author":"Lin","year":"2026","journal-title":"Chin. Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrc3236","article-title":"Antibody therapy of cancer","volume":"12","author":"Scott","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Shaver, A.L., Sharma, S., Nikita, N., Lefler, D.S., Basu-Mallick, A., Johnson, J.M., Butryn, M., and Lu-Yao, G. (2021). The effects of physical activity on cancer patients undergoing treatment with immune checkpoint inhibitors: A scoping review. Cancers, 13.","DOI":"10.3390\/cancers13246364"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"12715","DOI":"10.1038\/s41598-023-39280-6","article-title":"Decisional conflict and its determinants among patients with cancer undergoing immunotherapy combined with chemotherapy or targeted therapy: A cross-sectional study","volume":"13","author":"Lee","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Hollenbach, L., Rogahn, J., le Coutre, P., Schulze, S., Muegge, L.O., Geissler, J., and Felser, S. (2024). Physical exercise recommendations for patients with chronic myeloid leukemia based on individual preferences identified in a large international patient survey study of the East German Study Group for Hematology and Oncology (OSHO# 97). Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1345050"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1182\/bloodadvances.2024013744","article-title":"Fitness assessment in acute myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet","volume":"9","author":"Venditti","year":"2025","journal-title":"Blood Adv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102527","DOI":"10.1016\/j.coph.2025.102527","article-title":"Fitness in acute myeloid leukemia. state of the art and future directions","volume":"83","author":"Palmieri","year":"2025","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hendrik, S., Huisman, M.G., Ghignone, F., Vigano, A., de Liguori Carino, N., Farinella, E., Girocchi, R., Audisio, R.A., van Munster, B.C., and de Bock, G.H. (2022). Timed up and go test and long-term survival in older adults after oncologic surgery. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-03585-4"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Huisman, M.G., Van Leeuwen, B.L., Ugolini, G., Montroni, I., Spiliotis, J., Stabilini, C., de\u2019Liguori Carino, N., Farinella, E., de Bock, G.H., and Audisio, R.A. (2014). \u201cTimed Up & Go\u201d: A screening tool for predicting 30-day morbidity in onco-geriatric surgical patients? A multicenter cohort study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086863"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.17219\/acem\/193825","article-title":"Assessment of the physical fitness status of patients with hematological malignancies qualified for hematopoietic stem cell transplantation","volume":"34","author":"Chmielewski","year":"2025","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jpainsymman.2018.02.015","article-title":"Patient-reported functional status in outpatients with advanced cancer: Correlation with physician-reported scores and survival","volume":"55","author":"Popovic","year":"2018","journal-title":"J. Pain Symptom Manag."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/bjsports-2024-108671","article-title":"Association of muscle strength and cardiorespiratory fitness with all-cause and cancer-specific mortality in patients diagnosed with cancer: A systematic review with meta-analysis","volume":"59","author":"Bettariga","year":"2025","journal-title":"Br. J. Sports Med."},{"key":"ref_14","first-page":"7111","article-title":"The Effect of Exercise and Nutrition Interventions on Physical Functioning in Patients Undergoing Haematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis","volume":"29","author":"Prins","year":"2021","journal-title":"Support Care Cancer"},{"key":"ref_15","first-page":"1160","article-title":"Effects of Physical Exercise in Patients Undergoing Haematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analysis","volume":"33","year":"2025","journal-title":"Support Care Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Morales-Rodriguez, E., P\u00e9rez-Bilbao, T., San Juan, A.F., and Calvo, J.L. (2022). Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031288"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1984","DOI":"10.1002\/pri.1984","article-title":"The 2 min step test: A reliable and valid measure of functional capacity in older adults post coronary revascularisation","volume":"28","author":"Chow","year":"2023","journal-title":"Physiother. Res. Int."},{"key":"ref_18","first-page":"8251","article-title":"Thirty-Second Sit-to-Stand Test as an Alternative for Estimating Peak Oxygen Uptake and 6-Min Walking Distance in Women with Breast Cancer: A Cross-Sectional Study","volume":"30","year":"2022","journal-title":"Support Care Cancer"},{"key":"ref_19","first-page":"497","article-title":"Exercise capacity prior to major cancer surgery: A cross-sectional observational study of the validity of the 6-minute walk and 30-second sit-to-stand tests","volume":"20","author":"Butson","year":"2024","journal-title":"Asia-Pac. J. Clin. Oncol."},{"key":"ref_20","unstructured":"Lenhard, W., and Lenhard, A. (2022). Computation of Effect Sizes. Psychometrica, Available online: https:\/\/www.psychometrica.de\/effect_size.html."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1002\/cam4.4746","article-title":"Impact of physical exercise in advanced-stage cancer patients: Systematic review and meta-analysis","volume":"11","year":"2022","journal-title":"Cancer Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2165\/00007256-200131080-00001","article-title":"Physical fitness and changes in mortality: The survival of the fittest","volume":"31","author":"Erikssen","year":"2001","journal-title":"Sports Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.clon.2020.03.011","article-title":"Falls and cancer","volume":"32","author":"Morris","year":"2020","journal-title":"Clin. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102057","DOI":"10.1016\/j.arr.2023.102057","article-title":"Sarcopenia and malignancies: Epidemiology, clinical classification and implications","volume":"91","author":"Zhang","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_25","first-page":"e952307","article-title":"Levels of Physical Activity and Sedentary Lifestyle in Patients with Hematological Cancer Treated with Monoclonal Antibodies as a Monotherapy or Combination Therapy (Immunochemotherapy): A Comparative Study with Healthy Individuals","volume":"32","author":"Dybko","year":"2026","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.arr.2018.07.005","article-title":"The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans","volume":"47","author":"Wilkinson","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"151504","DOI":"10.1016\/j.soncn.2023.151504","article-title":"Effects of exercise rehabilitation on physical function in adults with hematological cancer receiving active treatment: A systematic review and meta-analysis","volume":"Volume 39","author":"Moore","year":"2023","journal-title":"Seminars in Oncology Nursing"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00277-013-1689-1","article-title":"Physical activity. physical fitness and the effect of exercise training interventions in lymphoma patients: A systematic review","volume":"92","author":"Vermaete","year":"2013","journal-title":"Ann. Hematol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1038\/s41598-025-89703-9","article-title":"Changes in physical fitness in acute leukemia patients during chemotherapy","volume":"15","author":"Xu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Larsen, R.F., Jarden, M., Minet, L.R., Fr\u00f8lund, U.C., M\u00f6ller, S., and Abildgaard, N. (2020). Physical function in patients newly diagnosed with multiple myeloma; a Danish cohort study. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-6637-6"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"de Boer, A.G., Taskila, T.K., Tamminga, S.J., Frings-Dresen, M.H., Feuerstein, M., and Verbeek, J.H. (2011). Interventions to enhance return-to-work for cancer patients. Cochrane Database Syst. Rev., 16.","DOI":"10.1002\/14651858.CD007569.pub2"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/13\/2040\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:05:18Z","timestamp":1782281118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/18\/13\/2040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":31,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["cancers18132040"],"URL":"https:\/\/doi.org\/10.3390\/cancers18132040","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}