{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:31:32Z","timestamp":1785407492898,"version":"3.56.0"},"reference-count":143,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Pediatric Cancer Foundation"},{"id":[{"id":"https:\/\/ror.org\/01fqjf794","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32CA229102"],"award-info":[{"award-number":["T32CA229102"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaul Pediatric Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The primary goal in the treatment of pediatric malignancies is to maintain effective cancer control while minimizing toxicities and late effects. Radiotherapy is a component of standard therapy against many pediatric cancers, but tumor cell DNA damage repair mechanisms and the hypoxic tumor microenvironment may limit the effectiveness of this modality. Additionally, irradiated cancer cells often acquire resistance to radiotherapy that permits cancer cell survival or stimulates tumor regrowth after treatment, further limiting the efficacy of radiotherapy. Various preclinical studies have investigated the potential of combining chemotherapy or immunotherapy with radiotherapy, with the goal of inducing a more lethal amount of DNA damage and prohibiting cells from acquiring radiotherapy resistance. This review provides an overview of the current strategies to enhance cancer cell response to radiotherapy, providing a framework to improve outcomes for children with solid tumors.<\/jats:p>","DOI":"10.3390\/cancers18132103","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:49:33Z","timestamp":1782712173000},"page":"2103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Strategies to Improve Sensitivity to Radiotherapy in Pediatric Solid Tumors"],"prefix":"10.3390","volume":"18","author":[{"given":"Maryam G.","family":"Shaikh","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-8244","authenticated-orcid":false,"given":"Morgan L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-1263","authenticated-orcid":false,"given":"Jamie M.","family":"Aye","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-0527","authenticated-orcid":false,"given":"Elizabeth A.","family":"Beierle","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jso.27038","article-title":"Advances in the Treatment of Pediatric Solid Tumors: A 50-year Perspective","volume":"126","author":"LaQuaglia","year":"2022","journal-title":"J. Surg. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Shen, C.J., and Terezakis, S.A. (2021). The Evolving Role of Radiotherapy for Pediatric Cancers with Advancements in Molecular Tumor Characterization and Targeted Therapies. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.679701"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101123","DOI":"10.1016\/j.adro.2022.101123","article-title":"Efficacy and Safety of Stereotactic Body Radiation Therapy for Pediatric Malignancies: The LITE-SABR Systematic Review and Meta-Analysis","volume":"8","author":"Singh","year":"2023","journal-title":"Adv. Radiat. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1016\/j.ijrobp.2021.07.672","article-title":"Clinical Outcomes and Efficacy of Stereotactic Body Radiation Therapy in Metastatic Pediatric Solid Tumors","volume":"111","author":"Baliga","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ncponc0139","article-title":"Intensity-Modulated Radiation Therapy for the Treatment of Pediatric Cancer Patients","volume":"2","author":"Rembielak","year":"2005","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20190601","DOI":"10.1259\/bjr.20190601","article-title":"Paediatric Proton Therapy","volume":"93","author":"Thomas","year":"2020","journal-title":"Br. J. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MOP.0000000000000724","article-title":"Proton Beam Therapy in Pediatric Oncology","volume":"31","author":"Baliga","year":"2019","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.radmp.2023.10.005","article-title":"The Clinical Prospect of FLASH Radiotherapy","volume":"4","author":"Liu","year":"2023","journal-title":"Radiat. Med. Prot."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.ijrobp.2009.09.031","article-title":"Ototoxicity After Intensity-Modulated Radiation Therapy and Cisplatin-Based Chemotherapy in Children with Medulloblastoma","volume":"78","author":"Paulino","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1200\/JCO.2018.78.1492","article-title":"Endocrine Deficiency as a Function of Radiation Dose to the Hypothalamus and Pituitary in Pediatric and Young Adult Patients with Brain Tumors","volume":"36","author":"Vatner","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic Health Conditions in Adult Survivors of Childhood Cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1200\/JCO.2008.21.2738","article-title":"Late Effects of Conformal Radiation Therapy for Pediatric Patients with Low-Grade Glioma: Prospective Evaluation of Cognitive, Endocrine, and Hearing Deficits","volume":"27","author":"Merchant","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Qiu, B., Kline, C., and Mueller, S. (2021). Radiation in Combination with Targeted Agents and Immunotherapies for Pediatric Central Nervous System Tumors\u2014Progress, Opportunities, and Challenges. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.674596"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41392-022-01102-y","article-title":"Radiotherapy Combined with Immunotherapy: The Dawn of Cancer Treatment","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e000537","DOI":"10.1136\/jitc-2020-000537","article-title":"Low-Dose Radiation Treatment Enhances Systemic Antitumor Immune Responses by Overcoming the Inhibitory Stroma","volume":"8","author":"Barsoumian","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41388-019-0971-7","article-title":"Microparticles from Tumors Exposed to Radiation Promote Immune Evasion in Part by PD-L1","volume":"39","author":"Timaner","year":"2020","journal-title":"Oncogene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s40425-019-0542-z","article-title":"Radiotherapy Enhances Responses of Lung Cancer to CTLA-4 Blockade","volume":"7","author":"Wilkins","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1158\/0008-5472.CAN-15-2644","article-title":"In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments","volume":"76","author":"Morris","year":"2016","journal-title":"Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ctrv.2017.05.006","article-title":"Limitations and Opportunities for Immune Checkpoint Inhibitors in Pediatric Malignancies","volume":"58","author":"Park","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.21037\/tlcr-20-304","article-title":"An Overview of the Published and Running Randomized Phase 3 Clinical Results of Radiotherapy in Combination with Immunotherapy","volume":"10","author":"Vanneste","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-Damage Response in Human Biology and Disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molcel.2007.11.015","article-title":"The DNA Damage Response: Ten Years After","volume":"28","author":"Harper","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1007\/s00018-013-1307-3","article-title":"Checkpoint Kinase 1 in DNA Damage Response and Cell Cycle Regulation","volume":"70","author":"Patil","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA Damage, Repair, and Mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Li, L., Guan, Y., Chen, X., Yang, J., and Cheng, Y. (2021). DNA Repair Pathways in Cancer Therapy and Resistance. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.629266"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Alhmoud, J.F., Woolley, J.F., Al Moustafa, A.-E., and Malki, M.I. (2020). DNA Damage\/Repair Management in Cancers. Cancers, 12.","DOI":"10.3390\/cancers12041050"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41573-024-01060-w","article-title":"DNA Damage Response Inhibitors in Cancer Therapy: Lessons from the Past, Current Status and Future Implications","volume":"24","author":"Drew","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.18632\/oncotarget.4061","article-title":"Ataxia-Telangiectasia Mutated (ATM) Silencing Promotes Neuroblastoma Progression through a MYCN Independent Mechanism","volume":"6","author":"Mandriota","year":"2015","journal-title":"Oncotarget"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.1038\/s41467-022-32023-7","article-title":"Therapeutic Targeting of ATR in Alveolar Rhabdomyosarcoma","volume":"13","author":"Pusch","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature25748","article-title":"EWS\u2013FLI1 Increases Transcription to Cause R-Loops and Block BRCA1 Repair in Ewing Sarcoma","volume":"555","author":"Gorthi","year":"2018","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/14737140.2022.2124970","article-title":"Targeting the DNA Damage Response in Pediatric Malignancies","volume":"22","author":"Gedminas","year":"2022","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hayman, T.J., and Glazer, P.M. (2021). Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312761"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1158\/0008-5472.CAN-04-1525","article-title":"Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes","volume":"64","author":"Garnett","year":"2004","journal-title":"Cancer Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1084\/jem.20052494","article-title":"Radiation Modulates the Peptide Repertoire, Enhances MHC Class I Expression, and Induces Successful Antitumor Immunotherapy","volume":"203","author":"Reits","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00262-004-0603-z","article-title":"Expression of MHC Class I, MHC Class II, and Cancer Germline Antigens in Neuroblastoma","volume":"54","author":"Jungbluth","year":"2005","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11060-010-0378-3","article-title":"Characterization of Signaling Function and Expression of HLA Class I Molecules in Medulloblastoma","volume":"103","author":"Smith","year":"2011","journal-title":"J. Neuro-Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.adro.2018.08.017","article-title":"The DNA Damage Response in Immunotherapy and Radiation","volume":"3","author":"Samstein","year":"2018","journal-title":"Adv. Radiat. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molcel.2020.07.026","article-title":"DNA Damage and Cancer Immunotherapy: A STING in the Tale","volume":"80","author":"Groelly","year":"2020","journal-title":"Mol. Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semradonc.2014.07.005","article-title":"Radiotherapy and Immunogenic Cell Death","volume":"25","author":"Golden","year":"2015","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Pathania, A.S. (2024). Immune Microenvironment in Childhood Cancers: Characteristics and Therapeutic Challenges. Cancers, 16.","DOI":"10.3390\/cancers16122201"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.canrad.2021.11.018","article-title":"Guide for Paediatric Radiotherapy Procedures","volume":"26","author":"Laprie","year":"2022","journal-title":"Cancer\/Radioth\u00e9rapie"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Camero, S., Cassandri, M., Pomella, S., Milazzo, L., Vulcano, F., Porrazzo, A., Barillari, G., Marchese, C., Codenotti, S., and Tomaciello, M. (2022). Radioresistance in Rhabdomyosarcomas: Much More than a Question of Dose. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1016894"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.3892\/ijo.2014.2614","article-title":"Radiation-Induced Signaling Pathways That Promote Cancer Cell Survival (Review)","volume":"45","author":"Hein","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Buck, J., Dyer, P.J.C., Hii, H., Carline, B., Kuchibhotla, M., Byrne, J., Howlett, M., Whitehouse, J., Ebert, M.A., and McDonald, K.L. (2021). Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.633344"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1158\/1078-0432.CCR-20-1729","article-title":"AsiDNA Is a Radiosensitizer with No Added Toxicity in Medulloblastoma Pediatric Models","volume":"26","author":"Ferreira","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1158\/0008-5472.CAN-17-3691","article-title":"Dual HDAC and PI3K Inhibition Abrogates NF\u03baB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas","volume":"78","author":"Pal","year":"2018","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/neuonc\/noz053","article-title":"Inhibition of Mutant PPM1D Enhances DNA Damage Response and Growth Suppressive Effects of Ionizing Radiation in Diffuse Intrinsic Pontine Glioma","volume":"21","author":"Akamandisa","year":"2019","journal-title":"Neuro-Oncology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12645-021-00081-z","article-title":"Development of Fe3O4 Core\u2013TiO2 Shell Nanocomposites and Nanoconjugates as a Foundation for Neuroblastoma Radiosensitization","volume":"12","author":"Liu","year":"2021","journal-title":"Cancer Nanotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.cdd.4401181","article-title":"Nitric Oxide Promotes P53 Nuclear Retention and Sensitizes Neuroblastoma Cells to Apoptosis by Ionizing Radiation","volume":"10","author":"Wang","year":"2003","journal-title":"Cell Death Differ."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dolman, M.E.M., Van Der Ploeg, I., Koster, J., Bate-Eya, L.T., Versteeg, R., Caron, H.N., and Molenaar, J.J. (2015). DNA-Dependent Protein Kinase as Molecular Target for Radiosensitization of Neuroblastoma Cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145744"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.canlet.2011.03.010","article-title":"Cooperation of the HDAC Inhibitor Vorinostat and Radiation in Metastatic Neuroblastoma: Efficacy and Underlying Mechanisms","volume":"306","author":"Mueller","year":"2011","journal-title":"Cancer Lett."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1748-717X-5-66","article-title":"Association of Telomerase Activity with Radio- and Chemosensitivity of Neuroblastomas","volume":"5","author":"Wesbuer","year":"2010","journal-title":"Radiat. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"111149","DOI":"10.1016\/j.cbi.2024.111149","article-title":"Arsenic Sulfide Enhances Radiosensitivity in Rhabdomyosarcoma via Activating NFATc3-RAG1 Mediated DNA Double Strand Break (DSB)","volume":"399","author":"Cai","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.canlet.2019.07.009","article-title":"Pro-Differentiating and Radiosensitizing Effects of Inhibiting HDACs by PXD-101 (Belinostat) in in Vitro and in Vivo Models of Human Rhabdomyosarcoma Cell Lines","volume":"461","author":"Marampon","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cassandri, M., Pomella, S., Rossetti, A., Petragnano, F., Milazzo, L., Vulcano, F., Camero, S., Codenotti, S., Cicchetti, F., and Maggio, R. (2021). MS-275 (Entinostat) Promotes Radio-Sensitivity in PAX3-FOXO1 Rhabdomyosarcoma Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910671"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41420-024-02115-y","article-title":"HDAC3 Genetic and Pharmacologic Inhibition Radiosensitizes Fusion Positive Rhabdomyosarcoma by Promoting DNA Double-Strand Breaks","volume":"10","author":"Cassandri","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tranon.2016.07.008","article-title":"Effect of Repeat Dosing of Engineered Oncolytic Herpes Simplex Virus on Preclinical Models of Rhabdomyosarcoma","volume":"9","author":"Waters","year":"2016","journal-title":"Transl. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.ijrobp.2017.09.049","article-title":"Mithramycin a Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting from DNA Damage","volume":"100","author":"Scroggins","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_59","first-page":"4007","article-title":"Curcumin-Altered P53-Response Genes Regulate Radiosensitivity in P53-Mutant Ewing\u2019s Sarcoma Cells","volume":"30","author":"Veeraraghavan","year":"2010","journal-title":"Anticancer Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Seidel, C., Heider, S., Hau, P., Glasow, A., Dietzsch, S., and Kortmann, R.-D. (2021). Radiotherapy in Medulloblastoma\u2014Evolution of Treatment, Current Concepts and Future Perspectives. Cancers, 13.","DOI":"10.3390\/cancers13235945"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clon.2019.01.001","article-title":"Radiotherapy Advances in Paediatric Medulloblastoma Treatment","volume":"31","author":"Padovani","year":"2019","journal-title":"Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/neuonc\/noaa102","article-title":"Excellent Outcome of Young Children with Nodular Desmoplastic Medulloblastoma Treated on \u201cHead Start\u201d III: A Multi-Institutional, Prospective Clinical Trial","volume":"22","author":"Dhall","year":"2020","journal-title":"Neuro-Oncology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1158\/0008-5472.CAN-21-0871","article-title":"Loss of H3K27 Trimethylation Promotes Radiotherapy Resistance in Medulloblastoma and Induces an Actionable Vulnerability to BET Inhibition","volume":"82","author":"Gabriel","year":"2022","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2162-3619-2-26","article-title":"ABC Transporter Activity Linked to Radiation Resistance and Molecular Subtype in Pediatric Medulloblastoma","volume":"2","author":"Ingram","year":"2013","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1101\/gad.1627008","article-title":"PI3K Pathway Regulates Survival of Cancer Stem Cells Residing in the Perivascular Niche Following Radiation in Medulloblastoma in Vivo","volume":"22","author":"Hambardzumyan","year":"2008","journal-title":"Genes Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/bpa.12837","article-title":"Pathology, Diagnostics, and Classification of Medulloblastoma","volume":"30","author":"Orr","year":"2020","journal-title":"Brain Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A Summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/CCO.0000000000000577","article-title":"Diffuse Intrinsic Pontine Glioma: Molecular Landscape and Emerging Therapeutic Targets","volume":"31","author":"Monje","year":"2019","journal-title":"Curr. Opin. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00018-017-2714-7","article-title":"Signaling Pathways and Mesenchymal Transition in Pediatric High-Grade Glioma","volume":"75","author":"Meel","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11912-020-0877-0","article-title":"Targeting and Therapeutic Monitoring of H3K27M-Mutant Glioma","volume":"22","author":"Wierzbicki","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/nop\/npu022","article-title":"Management of High-Grade Gliomas in the Pediatric Patient: Past, Present, and Future","volume":"1","author":"Vanan","year":"2014","journal-title":"Neuro-Oncol. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.1158\/1078-0432.CCR-19-0126","article-title":"TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)","volume":"25","author":"Werbrouck","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Buczkowicz, P., and Hawkins, C. (2015). Pathology, Molecular Genetics, and Epigenetics of Diffuse Intrinsic Pontine Glioma. Front. Oncol., 5.","DOI":"10.3389\/fonc.2015.00147"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1158\/1541-7786.MCR-19-0507","article-title":"Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib","volume":"18","author":"Wang","year":"2020","journal-title":"Mol. Cancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"142158","DOI":"10.1172\/JCI142158","article-title":"Tumor Genotype Dictates Radiosensitization after Atm Deletion in Primary Brainstem Glioma Models","volume":"131","author":"Deland","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Metselaar, D.S., Du Chatinier, A., Stuiver, I., Kaspers, G.J.L., and Hulleman, E. (2021). Radiosensitization in Pediatric High-Grade Glioma: Targets, Resistance and Developments. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.662209"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/neuonc\/nos315","article-title":"Phase I Trial of Capecitabine Rapidly Disintegrating Tablets and Concomitant Radiation Therapy in Children with Newly Diagnosed Brainstem Gliomas and High-Grade Gliomas","volume":"15","author":"Kilburn","year":"2013","journal-title":"Neuro-Oncology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/neuonc\/now038","article-title":"Phase 2 Study of Concurrent Radiotherapy and Temozolomide Followed by Temozolomide and Lomustine in the Treatment of Children with High-Grade Glioma: A Report of the Children\u2019s Oncology Group ACNS0423 Study","volume":"18","author":"Jakacki","year":"2016","journal-title":"Neuro-Oncology"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jazmati, D., Butzer, S., Hero, B., Ahmad Khalil, D., Merta, J., B\u00e4umer, C., Plum, G., Fuchs, J., Koerber, F., and Steinmeier, T. (2021). Proton Beam Therapy for Children with Neuroblastoma: Experiences from the Prospective KiProReg Registry. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.617506"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1200\/JCO.2008.16.6785","article-title":"The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report","volume":"27","author":"Cohn","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Krystal, J., and Foster, J.H. (2023). Treatment of High-Risk Neuroblastoma. Children, 10.","DOI":"10.3390\/children10081302"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1056\/NEJMoa1001527","article-title":"Outcome after Reduced Chemotherapy for Intermediate-Risk Neuroblastoma","volume":"363","author":"Baker","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1038\/s41388-021-01746-0","article-title":"Tumor Resistance to Radiotherapy Is Triggered by an ATM\/TAK1-Dependent-Increased Expression of the Cellular Prion Protein","volume":"40","author":"Siberchicot","year":"2021","journal-title":"Oncogene"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Yan, H., Zhai, B., Yang, F., Chen, Z., Zhou, Q., Paiva-Santos, A.C., Yuan, Z., and Zhou, Y. (2022). Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.908713"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1128\/MCB.16.3.1126","article-title":"Cytoplasmic Sequestration of Wild-Type P53 Protein Impairs the G1 Checkpoint after DNA Damage","volume":"16","author":"Moll","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1158\/0008-5472.CAN-07-5831","article-title":"Inhibition of Telomerase Activity Enhances Hyperthermia-Mediated Radiosensitization","volume":"68","author":"Agarwal","year":"2008","journal-title":"Cancer Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/cancers6010112","article-title":"Proton Radiotherapy for Pediatric Sarcoma","volume":"6","author":"Ladra","year":"2014","journal-title":"Cancers"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e29511","DOI":"10.1002\/pbc.29511","article-title":"An Update on Rhabdomyosarcoma Risk Stratification and the Rationale for Current and Future Children\u2019s Oncology Group Clinical Trials","volume":"69","author":"Haduong","year":"2022","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_89","first-page":"e388","article-title":"Radiotherapy Is Important for Local Control at Primary and Metastatic Sites in Pediatric Rhabdomyosarcoma","volume":"7","author":"Skamene","year":"2015","journal-title":"Cureus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1667\/RR14237.1","article-title":"C-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines","volume":"185","author":"Gravina","year":"2016","journal-title":"Radiat. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"200","DOI":"10.14348\/molcells.2023.2164","article-title":"DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair","volume":"46","author":"Lee","year":"2023","journal-title":"Mol. Cells"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1158\/1535-7163.MCT-08-0570","article-title":"MEK\/ERK Inhibitor U0126 Affects in Vitro and in Vivo Growth of Embryonal Rhabdomyosarcoma","volume":"8","author":"Marampon","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00432-019-02851-0","article-title":"NRF2 Orchestrates the Redox Regulation Induced by Radiation Therapy, Sustaining Embryonal and Alveolar Rhabdomyosarcoma Cells Radioresistance","volume":"145","author":"Marampon","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Camero, S., Vitali, G., Pontecorvi, P., Ceccarelli, S., Anastasiadou, E., Cicchetti, F., Flex, E., Pomella, S., Cassandri, M., and Rota, R. (2021). DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma. Cells, 10.","DOI":"10.3390\/cells10112956"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"10063","DOI":"10.1200\/JCO.2024.42.16_suppl.10063","article-title":"Effect of Oncolytic Herpes Simplex Virus on Fusion-Positive Rhabdomyosarcoma to Radiotherapy","volume":"42","author":"Shaikh","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0003-x","article-title":"Ewing Sarcoma","volume":"4","author":"Surdez","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1200\/JCO.2011.41.5703","article-title":"Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report from the Children\u2019s Oncology Group","volume":"30","author":"Womer","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1200\/JCO.2001.19.6.1818","article-title":"Localized Ewing Tumor of Bone: Final Results of the Cooperative Ewing\u2019s Sarcoma Study CESS 86","volume":"19","author":"Paulussen","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1200\/JCO.2004.01.041","article-title":"Treatment of Metastatic Ewing\u2019s Sarcoma or Primitive Neuroectodermal Tumor of Bone: Evaluation of Combination Ifosfamide and Etoposide\u2014A Children\u2019s Cancer Group and Pediatric Oncology Group Study","volume":"22","author":"Miser","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/cncr.30589","article-title":"Treatment Pathway of Bone Sarcoma in Children, Adolescents, and Young Adults","volume":"123","author":"Reed","year":"2017","journal-title":"Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/pbc.10472","article-title":"Ewing Sarcoma: Radiation Dose and Target Volume","volume":"42","author":"Donaldson","year":"2004","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.3949\/ccjm.77.s1.06","article-title":"Use of Radiation Therapy for Patients with Soft-Tissue and Bone Sarcomas","volume":"77","author":"Sheplan","year":"2010","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1878-0261.12655","article-title":"Transcriptome Profiling of Ewing Sarcomas\u2014Treatment Resistance Pathways and IGF-dependency","volume":"14","author":"Chen","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.ijrobp.2020.12.010","article-title":"Mithramycin A Radiosensitizes EWS:Fli1+ Ewing Sarcoma Cells by Inhibiting Double Strand Break Repair","volume":"109","author":"Lin","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1200\/JCO.18.01972","article-title":"Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children\u2019s Oncology Group AREN0532 and AREN0533 Study Report","volume":"37","author":"Dix","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1200\/JCO.2011.35.8747","article-title":"Treatment of Pulmonary Metastases in Children with Stage IV Nephroblastoma with Risk-Based Use of Pulmonary Radiotherapy","volume":"30","author":"Verschuur","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/SLA.0b013e318222015e","article-title":"Tumor Biology Influences the Prognosis of Nephroblastoma Patients with Primary Pulmonary Metastases: Results from SIOP 93-01\/GPOH and SIOP 2001\/GPOH","volume":"254","author":"Warmann","year":"2011","journal-title":"Ann. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pbc.21267","article-title":"Treatment of Wilms Tumor Relapsing after Initial Treatment with Vincristine, Actinomycin D, and Doxorubicin. A Report from the National Wilms Tumor Study Group","volume":"50","author":"Malogolowkin","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijrobp.2009.01.046","article-title":"Intraoperative Spillage of Favorable Histology Wilms Tumor Cells: Influence of Irradiation and Chemotherapy Regimens on Abdominal Recurrence. A Report from the National Wilms Tumor Study Group","volume":"76","author":"Kalapurakal","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1200\/JCO.2017.76.3441","article-title":"Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review","volume":"36","author":"Haupt","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"ref_111","first-page":"e1202","article-title":"Advances and Challenges in Pediatric Cancers","volume":"2","author":"Agrawal","year":"2019","journal-title":"Cancer Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s40263-020-00766-w","article-title":"Overview of Current Drug Delivery Methods Across the Blood\u2013Brain Barrier for the Treatment of Primary Brain Tumors","volume":"34","author":"Haumann","year":"2020","journal-title":"CNS Drugs"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1148\/radiol.2202001804","article-title":"Noninvasive MR Imaging\u2013Guided Focal Opening of the Blood-Brain Barrier in Rabbits","volume":"220","author":"Hynynen","year":"2001","journal-title":"Radiology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"E680","DOI":"10.1093\/neuros\/nyaa301","article-title":"Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma","volume":"87","author":"Sasaki","year":"2020","journal-title":"Neurosurgery"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"288","DOI":"10.18433\/J3NC79","article-title":"Intranasal Drug Delivery: How, Why and What For?","volume":"12","author":"Pires","year":"2009","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11060-015-1846-6","article-title":"Intraarterial Drug Delivery for Glioblastoma Mutiforme: Will the Phoenix Rise Again?","volume":"124","author":"Joshi","year":"2015","journal-title":"J. Neuro-Oncol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11060-017-2681-8","article-title":"New Therapeutic Approaches for Brainstem Tumors: A Comparison of Delivery Routes Using Nanoliposomal Irinotecan in an Animal Model","volume":"136","author":"Louis","year":"2018","journal-title":"J. Neuro-Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1667\/RR3276","article-title":"Models for Evaluating Agents Intended for the Prophylaxis, Mitigation and Treatment of Radiation Injuries Report of an NCI Workshop, December 3\u20134, 2003","volume":"162","author":"Stone","year":"2004","journal-title":"Radiat. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3109\/0284186X.2013.862596","article-title":"Late Toxicity Following Craniospinal Radiation for Early-Stage Medulloblastoma","volume":"53","author":"Christopherson","year":"2014","journal-title":"Acta Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1200\/JCO.2008.20.2267","article-title":"Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer","volume":"28","author":"Tukenova","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrc3007","article-title":"Strategies to Improve Radiotherapy with Targeted Drugs","volume":"11","author":"Begg","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ctrv.2016.03.001","article-title":"Optimize and Refine Therapeutic Index in Radiation Therapy: Overview of a Century","volume":"45","author":"Chargari","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jnci\/djs629","article-title":"Combining Radiotherapy and Cancer Immunotherapy: A Paradigm Shift","volume":"105","author":"Formenti","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imr.12572","article-title":"Immunomodulation by Ionizing Radiation\u2014Impact for Design of Radio-immunotherapies and for Treatment of Inflammatory Diseases","volume":"280","author":"Frey","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41571-022-00719-w","article-title":"Therapy with Oncolytic Viruses: Progress and Challenges","volume":"20","author":"Shalhout","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jha2.356","article-title":"CAR T Cell Therapy in Solid Tumors: A Review of Current Clinical Trials","volume":"3","author":"Patel","year":"2022","journal-title":"eJHaem"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2217\/imt-2017-0082","article-title":"Radiation Therapy and Immunotherapy: What Is the Optimal Timing or Sequencing?","volume":"10","author":"Aliru","year":"2018","journal-title":"Immunotherapy"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1158\/2326-6066.CIR-22-0840","article-title":"Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-Cell Therapy Efficacy","volume":"11","author":"Quach","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"eadu4417","DOI":"10.1126\/sciadv.adu4417","article-title":"Low-Dose Radiation by Radiopharmaceutical Therapy Enhances GD2 TRAC -CAR T Cell Efficacy in Localized Neuroblastoma","volume":"11","author":"Sodji","year":"2025","journal-title":"Sci. Adv."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1158\/2159-8290.CD-24-1465","article-title":"Evolving CAR T-Cell Therapy to Overcome the Barriers in Treating Pediatric Central Nervous System Tumors","volume":"15","author":"Timpanaro","year":"2025","journal-title":"Cancer Discov."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1182\/blood-2009-05-222190","article-title":"NK Cells Mediate Reduction of GVHD by Inhibiting Activated, Alloreactive T Cells While Retaining GVT Effects","volume":"115","author":"Olson","year":"2010","journal-title":"Blood"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In Search of the \u2018Missing Self\u2019: MHC Molecules and NK Cell Recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol. Today"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"e27783","DOI":"10.1002\/pbc.27783","article-title":"Expression of Carcinoma, Apoptosis, and Cell-death\u2013Related Genes Are Determinants for Sensitivity of Pediatric Cancer Cell Lines to Lysis by Natural Killer Cells","volume":"66","author":"Ray","year":"2019","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1186\/s12967-024-05724-4","article-title":"Radiotherapy Enhances the Anti-Tumor Effect of CAR-NK Cells for Hepatocellular Carcinoma","volume":"22","author":"Lin","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_135","unstructured":"Baude, J., Limagne, E., Ladjohounlou, R., and Mirjolet, C. (2023). Combining Radiotherapy and NK Cell-Based Therapies: The Time Has Come. International Review of Cell and Molecular Biology, Elsevier."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"343","DOI":"10.5603\/RPOR.a2022.0038","article-title":"FLASH Radiotherapy: An Emerging Approach in Radiation Therapy","volume":"27","author":"Matuszak","year":"2022","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"102183","DOI":"10.1016\/j.tranon.2024.102183","article-title":"FLASH Radiotherapy Combined with Immunotherapy: From Biological Mechanisms to Blockbuster Therapeutics","volume":"51","author":"Wang","year":"2025","journal-title":"Transl. Oncol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Wang, X., Wang, Y., Zhang, Y., Shi, H., Liu, K., Wang, F., Wang, Y., Chen, H., Shi, Y., and Wang, R. (2024). Immune Modulatory Roles of Radioimmunotherapy: Biological Principles and Clinical Prospects. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1357101"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s43018-025-00905-6","article-title":"FLASH Radiation Reprograms Lipid Metabolism and Macrophage Immunity and Sensitizes Medulloblastoma to CAR-T Cell Therapy","volume":"6","author":"Ni","year":"2025","journal-title":"Nat. Cancer"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.trecan.2025.02.005","article-title":"Harnessing FLASH Irradiation to Improve Immunotherapy of Medulloblastoma","volume":"11","author":"Lira","year":"2025","journal-title":"Trends Cancer"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/cncr.33306","article-title":"A Multi-institutional Phase 2 Trial of Stereotactic Body Radiotherapy in the Treatment of Bone Metastases in Pediatric and Young Adult Patients with Sarcoma","volume":"127","author":"Elledge","year":"2021","journal-title":"Cancer"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0360-3016(83)90105-0","article-title":"Iso-Effect Tables for Tolerance of Irradiated Normal Human Tissues","volume":"9","author":"Cohen","year":"1983","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ijrobp.2023.09.005","article-title":"A User\u2019s Guide and Summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation Dose-Volume Response for Adverse Effects After Childhood Cancer Therapy and Future Directions","volume":"119","author":"Constine","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. 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