{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T03:02:50Z","timestamp":1784516570750,"version":"3.55.0"},"reference-count":63,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Basal cell carcinoma (BCC) of the skin is the most common cancer in humans, and its incidence rises annually. Despite its low death rate, BCC causes significant morbidity because of its destructive nature to local tissues. The aim of this study was to review the state of the BCC research landscape using data published in Scopus from 1972 to 2023. Methods: Using the R package Bibliometrix, we first determined authors, countries, journals, and main topics behind the advancement of BCC research. The Latent Dirichlet Allocation (LDA), a probabilistic topic algorithm, was applied to automatically discover latent (hidden) thematic structures. Additionally, the HJ-Biplot was also chosen to visualize graphical representations of multivariate scientometric and bibliometric data to improve the LDA outcome. Results: Over five decades, we discovered 32 unique themes. BCC research has shifted from studying tumor and immunohistochemically characterization, epidemiology, and surgical\/histological clearance to the advancement of diagnostic and imaging techniques, like dermoscopy and reflectance confocal microscopy (RCM). Another exciting BCC research trend has been the discovery of aberrant activation within the Hedgehog signaling. Finally, patient treatment, especially surgery, radiotherapy, topical fluorouracil, and imiquimod, is an object of intense research. Conclusions: By displaying each topic as a group of related words, this in-depth exploration outlined emerging avenues in BCC evidence-based research that will benefit from the development of cutting-edge diagnostic procedures, as well as a deeper knowledge of BCC etiology and genetic underpinnings, the quality of life in BCC patients after surgery, and the application of artificial intelligence.<\/jats:p>","DOI":"10.3390\/cancers18142312","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:32:08Z","timestamp":1784514728000},"page":"2312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basal Cell Carcinoma Research Landscape Overview via Latent Dirichlet Allocation and HJ-Biplot Analysis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-0392","authenticated-orcid":false,"given":"Karime","family":"Montes-Escobar","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Agr\u00edcolas, Facultad de Ingenier\u00eda Agr\u00edcola, Universidad T\u00e9cnica de Manab\u00ed, Portoviejo 130105, Ecuador"},{"name":"Departamento de Formaci\u00f3n y Desarrollo Cient\u00edfico en Ingenier\u00eda, Facultad de Ingenier\u00eda, Ciencia y Tecnolog\u00eda, Universidad Bernardo O\u2019Higgins, Santiago 8370993, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"de La Hoz-Maestre","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00eda, Universidad del Magdalena, Santa Marta 470004, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-5109","authenticated-orcid":false,"given":"Humberto","family":"Llin\u00e1s-Solano","sequence":"additional","affiliation":[{"name":"Departamento de Matem\u00e1ticas y Estad\u00edstica, Division de Ciencias B\u00e1sicas, Universidad del Norte, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1641-1571","authenticated-orcid":false,"given":"Carlos Alfredo","family":"Salas-Macias","sequence":"additional","affiliation":[{"name":"Facultad de Ingenier\u00edas Agroambientales, Universidad T\u00e9cnica de Manab\u00ed, Portoviejo 130105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Fern\u00e1ndez-Moreira","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Complutense of Madrid (UCM), 28040 Madrid, Spain"},{"name":"Faculty of Health Sciences, Universidad Espiritu Santo, Samborond\u00f3n 092301, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-199X","authenticated-orcid":false,"given":"Martha","family":"Fors","sequence":"additional","affiliation":[{"name":"Medical School, Universidad de las Am\u00e9ricas (UDLA), Quito 170124, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago J.","family":"Ballaz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica (CENBIO), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170129, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hoc.2018.09.004","article-title":"Basal cell carcinoma review","volume":"33","author":"Kim","year":"2019","journal-title":"Hematol.\/Oncol. 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